The network for 'negative regulation of signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of signal transduction

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.

Caenorhabditis elegans
Name Description Probability Func Analog Organism
vab-3 Protein VAB-3 0.745
egl-18 Protein EGL-18 0.527
pry-1 Protein PRY-1 0.288
mec-2 Protein MEC-2 0.219
glp-1 Protein GLP-1 0.207
pha-4 Protein PHA-4 0.155
bar-1 Protein BAR-1 0.149
goa-1 Protein GOA-1 0.143
odr-3 Protein ODR-3 0.141
nhr-67 Protein NHR-67 0.128
K10D6.4 Protein K10D6.4 0.115
che-3 Protein CHE-3 0.108
pkg-1 Protein PKG-1 0.097
egl-8 Protein EGL-8 0.096
lin-25 Protein LIN-25 0.085
unc-7 Protein UNC-7 0.084
lin-66 Protein LIN-66 0.080
sax-7 Protein SAX-7 0.075
daf-10 Protein DAF-10 0.074
itr-1 Protein ITR-1 0.068
pat-12 Protein PAT-12 0.067
mes-3 Protein MES-3 0.066
mpk-1 Protein MPK-1 0.064
abl-1 Protein ABL-1 0.064
daf-12 Protein DAF-12 0.063
kle-2 Protein KLE-2 0.063
R05G6.10 Protein R05G6.10 0.061
eps-8 Protein EPS-8 0.060
akt-1 Protein AKT-1 0.058
inx-13 Protein INX-13 0.057
epg-2 Protein EPG-2 0.056
inx-4 Protein INX-4 0.056
eat-4 Protein EAT-4 0.056
sma-6 Protein SMA-6 0.056
egg-6 Protein EGG-6 0.054
mpz-2 Protein MPZ-2 0.054
peb-1 Protein PEB-1 0.052
zyg-8 Protein ZYG-8 0.052
vang-1 Protein VANG-1 0.048
egl-44 Protein EGL-44 0.048
ifa-1 Protein IFA-1 0.048
unc-42 Protein UNC-42 0.047
ifg-1 Protein IFG-1 0.047
efn-2 Protein EFN-2 0.047
ceh-44 Protein CEH-44 0.046
pad-1 Protein PAD-1 0.046
gpb-1 Protein GPB-1 0.046
gld-1 Protein GLD-1 0.046
ham-1 Protein HAM-1 0.046
soc-2 Protein SOC-2 0.045
skn-1 Protein SKN-1 0.045
exc-5 Protein EXC-5 0.045
C53B4.4 Protein C53B4.4 0.045
egl-27 Protein EGL-27 0.044
daf-6 Protein DAF-6 0.044
T09B4.5 Protein T09B4.5 0.044
sur-2 Protein SUR-2 0.044
pxf-1 Protein PXF-1 0.043
daf-15 Protein DAF-15 0.043
F57B10.4 Protein F57B10.4 0.043
dlk-1 Protein DLK-1 0.042
F31C3.2 Protein F31C3.2 0.042
lin-17 Protein LIN-17 0.042
inx-1 Protein INX-1 0.042
alg-1 Protein ALG-1 0.042
unc-51 Protein UNC-51 0.041
ajm-1 Protein AJM-1 0.041
F13C5.2 Protein F13C5.2 0.041
lag-1 Protein LAG-1 0.040
csnk-1 Protein CSNK-1 0.040
rnp-7 Protein RNP-7 0.039
unc-52 Protein UNC-52 0.039
gsk-3 Protein GSK-3 0.039
his-74 Protein HIS-74 0.039
etr-1 Protein ETR-1 0.039
hlh-2 Protein HLH-2 0.038
npp-7 Protein NPP-7 0.038
ncx-3 Protein NCX-3 0.038
rgs-3 Protein RGS-3 0.038
mig-5 Protein MIG-5 0.038
eor-1 Protein EOR-1 0.038
unc-9 Protein UNC-9 0.037
zen-4 Protein ZEN-4 0.037
nhr-25 Protein NHR-25 0.037
F42H10.3 Protein F42H10.3 0.036
smp-1 Protein SMP-1 0.036
vab-10 Protein VAB-10 0.036
T28F4.1 Protein T28F4.1 0.036
npp-4 Protein NPP-4 0.036
let-756 Protein LET-756 0.036
lin-49 Protein LIN-49 0.036
cst-1 Protein CST-1 0.035
grk-2 Protein GRK-2 0.035
hlh-1 Protein HLH-1 0.035
ant-1.1 Protein ANT-1.1 0.035
nud-2 Protein NUD-2 0.035
ima-3 Protein IMA-3 0.035
daf-2 Protein DAF-2 0.035
eor-2 Protein EOR-2 0.035
hmg-1.2 Protein HMG-1.2 0.035
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Danio rerio
Name Description Probability Func Analog Organism
cdh2 cadherin 2, neuronal 0.933
chd chordin 0.925
wnt11r wingless-type MMTV integration site family, member 11, related 0.859
tbx1 T-box 1 0.837
sox9b SRY-box containing gene 9b 0.786
ndr2 nodal-related 2 0.784
gli1 GLI-Kruppel family member 1 0.752
cdh1 cadherin 1, epithelial 0.749
egr2b early growth response 2b 0.740
wnt4a wingless-type MMTV integration site family, member 4a 0.711
pea3 ETS-domain transcription factor pea3 0.707
bmp2b bone morphogenetic protein 2b 0.705
fgf8a fibroblast growth factor 8 a 0.695
per3 period homolog 3 (Drosophila) 0.630
fgf3 fibroblast growth factor 3 0.625
zbtb4 zinc finger and BTB domain containing 4 0.581
kdrl kinase insert domain receptor like 0.577
robo3 roundabout homolog 3 0.557
znf703 zinc finger protein 703 0.551
lhx2b LIM homeobox 2b 0.495
rarga retinoic acid receptor gamma a 0.487
spry4 sprouty (Drosophila) homolog 4 0.486
notch1a notch homolog 1a 0.449
egr1 early growth response 1 0.441
hmcn1 hemicentin 1 0.427
kif5bb kinesin family member 5B, b 0.423
tal1 T-cell acute lymphocytic leukemia 1 0.422
fn1 fibronectin 1 0.419
cxcr4b chemokine (C-X-C motif), receptor 4b 0.408
dlx6a distal-less homeobox gene 6a 0.404
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.383
mapk3 mitogen-activated protein kinase 3 0.383
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.380
ptch2 patched 2 0.377
wnt9b wingless-type MMTV integration site family, member 9B 0.370
flh floating head 0.358
rarab retinoic acid receptor, alpha b 0.353
tll1 tolloid-like 1 0.348
fzd8a frizzled homolog 8a 0.329
igf1rb insulin-like growth factor 1b receptor 0.329
bmp4 bone morphogenetic protein 4 0.321
cx43 connexin 43 0.320
lef1 lymphocyte enhancer binding factor 1 0.320
tbx16 T-box gene 16 0.318
fzd7a frizzled homolog 7a 0.315
tp53bp2 tumor protein p53 binding protein, 2 0.302
yap1 Yes-associated protein 1 0.298
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.297
otpa orthopedia homolog a 0.290
wnt3 wingless-type MMTV integration site family, member 3 0.290
wnt5b wingless-type MMTV integration site family, member 5b 0.282
irx3a iroquois homeobox protein 3a 0.277
brd4 bromodomain containing 4 0.276
fzd10 frizzled homolog 10 0.273
igf1ra insulin-like growth factor 1a receptor 0.270
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.268
acvr1b activin A receptor, type IB 0.265
runx2b runt-related transcription factor 2b 0.264
slc30a7 solute carrier family 30 (zinc transporter), member 7 0.257
frem1a Fras1 related extracellular matrix 1a 0.252
nf1a neurofibromin 1a 0.252
efnb2a ephrin B2a 0.248
csnk1da casein kinase 1, delta a 0.245
mapk1 mitogen-activated protein kinase 1 0.243
si:ch1073-351m12.1 si:ch1073-351m12.1 0.242
zeb2a zinc finger E-box binding homeobox 2a 0.241
ip6k2 inositol hexaphosphate kinase 2 0.241
itgb1b.2 integrin, beta 1b.2 0.241
twist3 twist3 0.240
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.239
wnt8b wingless-type MMTV integration site family, member 8b 0.238
bactin1 bactin1 0.234
nrg1 neuregulin 1 0.233
lama5 laminin, alpha 5 0.232
six4.3 sine oculis homeobox homolog 4.3 0.231
shhb sonic hedgehog b 0.230
pax8 paired box gene 8 0.230
fzd5 frizzled homolog 5 0.228
sema3aa semaphorin 3aa 0.225
epb4.1l4 erythrocyte protein band 4.1-like 4 0.225
dlb deltaB 0.224
axin1 axin 1 0.216
rbb4 retinoblastoma binding protein 4 0.210
ncf1 neutrophil cytosolic factor 1 0.209
rbfox2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.208
efna5a ephrin A5a 0.206
lft1 lefty1 0.206
hdac4 histone deacetylase 4 0.205
alcamb activated leukocyte cell adhesion molecule b 0.205
tob1a transducer of ERBB2, 1a 0.203
wnt10a wingless-type MMTV integration site family, member 10a 0.199
pbx4 pre-B-cell leukemia transcription factor 4 0.198
fras1 Fraser syndrome 1 0.196
fibin fin bud initiation factor 0.194
cry3 cryptochrome 3 0.194
kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.194
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.194
si:ch211-173b8.2 si:ch211-173b8.2 0.193
gpc4 glypican 4 0.191
baxa bcl2-associated X protein, a 0.191
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.997
krz kurtz 0.972
InR Insulin-like receptor 0.969
hep hemipterous 0.966
wts warts 0.957
rl rolled 0.957
Mad Mothers against dpp 0.956
sax saxophone 0.952
dally division abnormally delayed 0.946
numb CG3779 gene product from transcript CG3779-RB 0.940
kay kayak 0.939
tkv thickveins 0.939
dsh dishevelled 0.936
Akt1 CG4006 gene product from transcript CG4006-RA 0.921
hipk homeodomain interacting protein kinase 0.918
ci cubitus interruptus 0.903
Sulf1 Sulfated 0.879
rst roughest 0.857
dlg1 discs large 1 0.849
CkIIalpha Casein kinase II alpha subunit 0.835
smo smoothened 0.826
Ubx Ultrabithorax 0.825
shn schnurri 0.815
dco discs overgrown 0.813
Myo31DF Myosin 31DF 0.813
Egfr Epidermal growth factor receptor 0.813
ph-p polyhomeotic proximal 0.809
gig gigas 0.808
chic chickadee 0.797
mys myospheroid 0.794
wg wingless 0.788
S6k RPS6-p70-protein kinase 0.784
ac achaete 0.776
p38b CG7393 gene product from transcript CG7393-RA 0.766
EndoGI Endonuclease G inhibitor 0.753
fng fringe 0.740
flw flapwing 0.740
Pk61C Protein kinase 61C 0.731
l(2)gl lethal (2) giant larvae 0.709
sd scalloped 0.705
Moe Moesin 0.702
Chro Chromator 0.700
sgg shaggy 0.696
kis kismet 0.666
cher cheerio 0.662
Tsc1 CG6147 gene product from transcript CG6147-RA 0.641
toy twin of eyeless 0.640
wit wishful thinking 0.630
Sos Son of sevenless 0.629
nmo nemo 0.627
C3G CG42328 gene product from transcript CG42328-RC 0.627
Sin3A CG8815 gene product from transcript CG8815-RC 0.623
Ilk Integrin linked kinase 0.615
drk downstream of receptor kinase 0.613
Rac2 CG8556 gene product from transcript CG8556-RA 0.613
cindr CIN85 and CD2AP orthologue 0.605
Klp64D Kinesin-like protein at 64D 0.601
sbb scribbler 0.601
Su(H) Suppressor of Hairless 0.599
babo baboon 0.587
shi shibire 0.583
slmb supernumerary limbs 0.582
Ras85D Ras oncogene at 85D 0.564
dx deltex 0.563
Wnk CG7177 gene product from transcript CG7177-RA 0.561
lid little imaginal discs 0.560
Smox Smad on X 0.550
Sir2 CG5216 gene product from transcript CG5216-RA 0.547
tan tantalus 0.535
EcR Ecdysone receptor 0.533
msn misshapen 0.533
insc inscuteable 0.530
sns sticks and stones 0.529
bs blistered 0.524
Dad Daughters against dpp 0.521
hpo hippo 0.515
S6kII RPS6-protein kinase-II 0.515
ago archipelago 0.506
Chmp1 CG4108 gene product from transcript CG4108-RA 0.505
NFAT NFAT homolog 0.503
msps mini spindles 0.500
sog short gastrulation 0.498
CG8155 CG8155 gene product from transcript CG8155-RA 0.498
Rho1 CG8416 gene product from transcript CG8416-RB 0.498
Hsp27 Heat shock protein 27 0.493
arm armadillo 0.488
CG9772 CG9772 gene product from transcript CG9772-RB 0.487
eya eyes absent 0.483
Dcr-2 Dicer-2 0.482
Hs6st Heparan sulfate 6-O-sulfotransferase 0.478
NetB Netrin-B 0.467
tra transformer 0.467
not non-stop 0.461
CSN5 COP9 complex homolog subunit 5 0.457
Sfmbt Scm-related gene containing four mbt domains 0.456
sqz squeeze 0.456
pan pangolin 0.452
mam mastermind 0.452
Mkp3 Mitogen-activated protein kinase phosphatase 3 0.449
egr eiger 0.443
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Dusp6 dual specificity phosphatase 6 0.264
Calcrl calcitonin receptor-like 0.260
Cav1 caveolin 1, caveolae protein 0.258
Cnbp CCHC-type zinc finger, nucleic acid binding protein 0.246
Mpp2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.241
Dbp D site of albumin promoter (albumin D-box) binding protein 0.217
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.215
Ednra endothelin receptor type A 0.203
Jak2 Janus kinase 2 0.203
Slc25a3 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 0.195
Bcl2 B-cell CLL/lymphoma 2 0.186
Egr1 early growth response 1 0.182
Cugbp2 CUG triplet repeat, RNA binding protein 2 0.179
Itgam integrin, alpha M 0.174
Kitlg KIT ligand 0.173
Smad7 SMAD family member 7 0.166
Slit3 slit homolog 3 (Drosophila) 0.162
Klf2 Kruppel-like factor 2 (lung) 0.161
Dchs1 dachsous 1 (Drosophila) 0.149
Zfp36 zinc finger protein 36 0.143
Pctk1 PCTAIRE protein kinase 1 0.135
Csnk1g3 casein kinase 1, gamma 3 0.134
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.134
Sirpa signal-regulatory protein alpha 0.130
Fos FBJ osteosarcoma oncogene 0.130
Cish cytokine inducible SH2-containing protein 0.129
Usf2 upstream transcription factor 2, c-fos interacting 0.128
Junb jun B proto-oncogene 0.126
Cd83 CD83 molecule 0.126
Pacs1 phosphofurin acidic cluster sorting protein 1 0.123
Homer1 homer homolog 1 (Drosophila) 0.123
Akt1 v-akt murine thymoma viral oncogene homolog 1 0.120
Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.117
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.117
Eef2 eukaryotic translation elongation factor 2 0.116
Rgs9 regulator of G-protein signaling 9 0.114
Jak1 Janus kinase 1 0.113
Pim1 pim-1 oncogene 0.111
Fgfr2 fibroblast growth factor receptor 2 0.109
Atp5b ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 0.108
Lnpep leucyl/cystinyl aminopeptidase 0.107
Errfi1 ERBB receptor feedback inhibitor 1 0.107
Cmklr1 chemokine-like receptor 1 0.106
Slfn2 schlafen 2 0.105
Ptpn7 protein tyrosine phosphatase, non-receptor type 7 0.104
Kcnc3 potassium voltage gated channel, Shaw-related subfamily, member 3 0.100
Tcfe2a transcription factor E2a 0.100
Fgd4 FYVE, RhoGEF and PH domain containing 4 0.099
P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 0.095
Dcc deleted in colorectal carcinoma 0.094
Sdc3 syndecan 3 0.093
Pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.093
Nrg1 neuregulin 1 0.093
Inpp5d inositol polyphosphate-5-phosphatase D 0.092
Myo9a myosin IXA 0.090
Mmp9 matrix metallopeptidase 9 0.089
Creb1 cAMP responsive element binding protein 1 0.089
Dock8 dedicator of cytokinesis 8 0.087
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.086
Gzmb granzyme B 0.086
Egfr epidermal growth factor receptor 0.086
Grb2 growth factor receptor bound protein 2 0.086
Jun Jun oncogene 0.085
Prph2 peripherin 2 0.084
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.083
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.083
Rftn2 raftlin family member 2 0.083
Tcf21 transcription factor 21 0.083
Ddr1 discoidin domain receptor tyrosine kinase 1 0.082
Nrd1 nardilysin 1 0.081
Has2 hyaluronan synthase 2 0.081
Nfib nuclear factor I/B 0.081
Il1r1 interleukin 1 receptor, type I 0.080
Tcf4 transcription factor 4 0.080
Klf9 Kruppel-like factor 9 0.079
Tgfbr3 transforming growth factor, beta receptor III 0.079
Ampd1 adenosine monophosphate deaminase 1 (isoform M) 0.076
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.075
Bmp7 bone morphogenetic protein 7 0.075
Scarb1 scavenger receptor class B, member 1 0.075
Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.075
Gas7 growth arrest specific 7 0.075
Egr2 early growth response 2 0.074
LOC100362824 caveolin 2-like 0.074
Coro1a coronin, actin binding protein 1A 0.074
Slc30a1 solute carrier family 30 (zinc transporter), member 1 0.074
Myo1b myosin Ib 0.073
Jdp2 Jun dimerization protein 2 0.073
Ctnnd2 catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) 0.073
Csnk1g1 casein kinase 1, gamma 1 0.072
Syt8 synaptotagmin VIII 0.072
Gfi1 growth factor independent 1 transcription repressor 0.072
Fgb fibrinogen beta chain 0.072
Cel carboxyl ester lipase 0.071
Akap1 A kinase (PRKA) anchor protein 1 0.071
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.071
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.071
Dusp1 dual specificity phosphatase 1 0.070
Lcp1 lymphocyte cytosolic protein 1 0.070
Rho rhodopsin 0.070
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
KSS1 Kss1p 0.665
PPH21 Pph21p 0.640
SSN8 Ssn8p 0.509
ROM2 Rom2p 0.507
IRA1 Ira1p 0.462
SCH9 Sch9p 0.418
YOL087C hypothetical protein 0.388
GSC2 Gsc2p 0.315
CRZ1 Crz1p 0.274
REG1 Reg1p 0.258
MSG5 Msg5p 0.258
MKK1 Mkk1p 0.256
PKC1 Pkc1p 0.254
BOI1 Boi1p 0.227
KSP1 Ksp1p 0.225
BCK1 Bck1p 0.220
TPK1 Tpk1p 0.216
MSN2 Msn2p 0.202
PPE1 Ppe1p 0.202
FAR1 Far1p 0.189
ICE2 Ice2p 0.188
VPS36 Vps36p 0.187
PKH2 Pkh2p 0.180
CDC25 Cdc25p 0.162
LHS1 Lhs1p 0.156
RTS1 Rts1p 0.142
TIP41 Tip41p 0.141
BOI2 Boi2p 0.137
FUS3 Fus3p 0.136
RHO1 Rho1p 0.128
TPK3 Tpk3p 0.121
RTT101 Rtt101p 0.120
LSB1 Lsb1p 0.114
HSP60 Hsp60p 0.112
VPS4 Vps4p 0.111
ULA1 Ula1p 0.110
STE7 Ste7p 0.103
SCP1 Scp1p 0.103
CDC55 Cdc55p 0.097
SAC7 Sac7p 0.096
VPS5 Vps5p 0.094
CDC34 Cdc34p 0.094
SIZ1 Siz1p 0.092
DID4 Did4p 0.091
TPK2 Tpk2p 0.089
PBS2 Pbs2p 0.087
RAS2 Ras2p 0.086
PEP5 Pep5p 0.083
GPR1 Gpr1p 0.083
PSP2 Psp2p 0.082
YME1 Yme1p 0.081
VAM3 Vam3p 0.080
SLG1 Slg1p 0.078
SLX5 Slx5p 0.076
KIC1 Kic1p 0.076
BEM4 Bem4p 0.076
STE11 Ste11p 0.075
VPS8 Vps8p 0.075
FPK1 Fpk1p 0.074
HOG1 Hog1p 0.071
SLN1 Sln1p 0.070
BEM1 Bem1p 0.069
RUB1 Rub1p 0.068
TEC1 Tec1p 0.068
TSC11 Tsc11p 0.067
CRG1 Crg1p 0.063
IRA2 Ira2p 0.063
RPN4 Rpn4p 0.062
VPS15 Vps15p 0.061
PSY4 Psy4p 0.060
BCK2 Bck2p 0.059
BEM3 Bem3p 0.059
PTC1 Ptc1p 0.058
GPB2 Gpb2p 0.058
WHI2 Whi2p 0.058
POG1 Pog1p 0.058
STE5 Ste5p 0.058
SAP4 Sap4p 0.057
PRB1 Prb1p 0.057
EBS1 Ebs1p 0.054
PMR1 Pmr1p 0.054
OSH3 Osh3p 0.054
YIL001W hypothetical protein 0.053
RER2 Rer2p 0.053
SWI1 Swi1p 0.053
NOG2 Nog2p 0.052
URN1 Urn1p 0.052
VAM7 Vam7p 0.051
MDS3 Mds3p 0.051
RLM1 Rlm1p 0.051
MPT5 Mpt5p 0.051
UBA3 Uba3p 0.050
NTO1 Nto1p 0.050
CLA4 Cla4p 0.049
YCL042W hypothetical protein 0.048
GRX5 Grx5p 0.047
PRR1 Prr1p 0.046
VAC7 Vac7p 0.045
RAD23 Rad23p 0.044
HSV2 Hsv2p 0.044