The network for 'positive regulation of peptidyl tyrosine phosphorylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of peptidyl tyrosine phosphorylation

Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.

Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
cmyb transcription factor cmyb 0.454
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.329
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.309
cdh6 cadherin 6 0.296
nrp2a neuropilin 2a 0.236
nrp2b neuropilin 2b 0.232
itgb1a integrin, beta 1a 0.204
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.202
slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 0.179
sox10 SRY-box containing gene 10 0.174
hgfb hepatocyte growth factor b 0.168
ltk leukocyte tyrosine kinase 0.145
pax7b paired box gene 7b 0.137
bactin1 bactin1 0.132
LOC557072 caspase recruitment domain-containing protein 11-like 0.130
tert telomerase reverse transcriptase 0.117
nod1 nucleotide-binding oligomerization domain containing 1 0.112
sox7 SRY-box containing gene 7 0.112
tal1 T-cell acute lymphocytic leukemia 1 0.110
mesp2 mesoderm posterior 2 homolog (mouse) 0.104
cyp24a1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.103
ighz2 immunoglobulin heavy constant zeta2 0.101
ntrk3b neurotrophic tyrosine kinase, receptor, type 3b 0.096
ptk6a PTK6 protein tyrosine kinase 6a 0.093
tfec transcription factor EC 0.091
ptk2.1 protein tyrosine kinase 2a 0.091
cdkn1a cyclin-dependent kinase inhibitor 1A 0.090
igf2b insulin-like growth factor 2b 0.089
mnx1 motor neuron and pancreas homeobox 1 0.089
LOC555739 serine/threonine-protein kinase LMTK1-like 0.089
mpx myeloid-specific peroxidase 0.088
wt1b wilms tumor 1b 0.088
wnt3a wingless-type MMTV integration site family, member 3A 0.083
dcc deleted in colorectal carcinoma 0.082
alk anaplastic lymphoma kinase (Ki-1) 0.077
epha4a eph receptor A4a 0.077
lyz lysozyme 0.077
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.073
ccbe1 collagen and calcium binding EGF domains 1 0.073
ighm immunoglobulin heavy constant mu and immunoglobulin heavy constant mu 0.073
ntn2 netrin 2 0.072
angptl2 angiopoietin-like 2 0.071
mib mind bomb 0.070
il6st interleukin 6 signal transducer 0.069
LOC100148845 neurogenin-1-like 0.068
npy8br neuropeptide Y receptor Y8b 0.067
prox1 prospero-related homeobox gene 1 0.067
taf3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto 0.066
adora2b adenosine A2b receptor 0.065
pomt1 protein-O-mannosyltransferase 1 0.064
spon1b spondin 1b 0.064
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.063
si:dkey-8l13.4 si:dkey-8l13.4 0.063
card9 caspase recruitment domain family, member 9 0.061
fbln4 fibulin 4 0.059
wtip Wilms tumor 1 interacting protein 0.059
met met proto-oncogene (hepatocyte growth factor receptor) 0.057
ryk receptor-like tyrosine kinase 0.057
sc:d812 sc:d812 0.057
hif1ab hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b 0.057
il7r interleukin 7 receptor 0.056
plxna3 plexin A3 0.056
adra2b adrenergic, alpha-2B-, receptor 0.055
itgb1b integrin, beta 1b 0.055
egr2b early growth response 2b 0.054
fn1 fibronectin 1 0.054
dkk3l dickkopf homolog 3 like (Xenopus laevis) 0.053
mapk6 mitogen-activated protein kinase 6 0.053
LOC567405 novel protein similar to vertebrate megakaryocyte-associated tyrosine kinase (MATK) 0.053
olig1 oligodendrocyte lineage transcription factor 1 0.053
abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.053
ror2 receptor tyrosine kinase-like orphan receptor 2 0.052
erbb3a v-erb-b2 erythroblastic leukemia viral oncogene homolog 3a 0.052
si:ch211-173o4.2 si:ch211-173o4.2 0.052
st8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.051
lrp2 low density lipoprotein-related protein 2 0.051
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.051
mitfa microphthalmia-associated transcription factor a 0.050
mfn2 mitofusin 2 0.050
neurod neurogenic differentiation 0.049
ahcyl2 S-adenosylhomocysteine hydrolase-like 2 0.049
ddr2b discoidin domain receptor family, member 2b 0.048
bnc2 basonuclin 2 0.048
rtn4a reticulon 4a 0.048
dnm2 dynamin 2 0.048
si:dkey-19f21.3 si:dkey-19f21.3 0.048
hoxb1a homeo box B1a 0.047
cdx4 caudal type homeo box transcription factor 4 0.047
stat5.2 signal transducer and activator of transcription 5.2 0.046
zgc:112211 zgc:112211 0.046
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.046
kbp kif1-binding protein 0.046
smtnb smoothelin b 0.046
dyrk1b dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 0.046
pomt2 protein-O-mannosyltransferase 2 0.046
fes feline sarcoma oncogene 0.045
tpst1 tyrosylprotein sulfotransferase 1 0.045
si:ch211-195h23.3 si:ch211-195h23.3 0.045
tgfb3 transforming growth factor, beta 3 0.045
traf4a tnf receptor-associated factor 4a 0.044
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
HLHm7 E(spl) region transcript m7 0.648
HLHmgamma E(spl) region transcript mgamma 0.634
HLHmdelta E(spl) region transcript mdelta 0.502
E(spl) Enhancer of split 0.407
HLHm3 E(spl) region transcript m3 0.394
HLHmbeta E(spl) region transcript mbeta 0.329
mbc myoblast city 0.243
yki yorkie 0.189
sr stripe 0.180
HLHm5 E(spl) region transcript m5 0.177
Sara Smad anchor for receptor activation 0.168
bnl branchless 0.155
Tl Toll 0.145
par-1 CG8201 gene product from transcript CG8201-RA 0.135
malpha E(spl) region transcript malpha 0.121
sc scute 0.118
m2 E(spl) region transcript m2 0.116
Tom Twin of m4 0.115
NFAT NFAT homolog 0.115
repo reversed polarity 0.103
stai stathmin 0.102
Pk61C Protein kinase 61C 0.102
zfh1 Zn finger homeodomain 1 0.101
dec-1 defective chorion 1 0.101
scb scab 0.098
Rel Relish 0.095
inaD inactivation no afterpotential D 0.095
RASSF8 CG5053 gene product from transcript CG5053-RA 0.090
Rala Ras-related protein 0.088
Dad Daughters against dpp 0.087
Dhc64C Dynein heavy chain 64C 0.085
fra frazzled 0.084
eya eyes absent 0.079
kuz kuzbanian 0.077
htl heartless 0.074
ena enabled 0.071
TBPH CG10327 gene product from transcript CG10327-RC 0.069
shg shotgun 0.066
Grip Glutamate receptor binding protein 0.064
spas spastin 0.063
fs(1)Ya female sterile (1) Young arrest 0.061
caz cabeza 0.061
drpr draper 0.061
disp dispatched 0.060
Tm1 Tropomyosin 1 0.060
ato atonal 0.058
srp serpent 0.058
RhoL rho-like 0.055
Src42A Src oncogene at 42A 0.055
swa swallow 0.055
ttk tramtrack 0.054
aop anterior open 0.051
slp1 sloppy paired 1 0.050
hrg hiiragi 0.050
rols rolling pebbles 0.050
SoxN SoxNeuro 0.050
pyr pyramus 0.048
l(2)k16918 lethal (2) k16918 0.046
noc no ocelli 0.046
side sidestep 0.045
fng fringe 0.045
mew multiple edematous wings 0.045
shn schnurri 0.044
atl atlastin 0.044
ems empty spiracles 0.044
Pvr PDGF- and VEGF-receptor related 0.043
p120ctn Adherens junction protein p120 0.043
numb CG3779 gene product from transcript CG3779-RB 0.043
tap target of Poxn 0.042
wb wing blister 0.042
mys myospheroid 0.042
Nrx-IV Neurexin IV 0.042
LanB2 Laminin B2 0.042
CG12424 CG12424 gene product from transcript CG12424-RC 0.042
enc encore 0.042
Pvf1 PDGF- and VEGF-related factor 1 0.041
LanA Laminin A 0.040
insc inscuteable 0.039
ninaB neither inactivation nor afterpotential B 0.038
kni knirps 0.038
tok tolkin 0.038
bsk basket 0.038
slbo slow border cells 0.037
fs(1)M3 female sterile (1) M3 0.037
argos CG4531 gene product from transcript CG4531-RA 0.037
bib big brain 0.036
Lis-1 Lissencephaly-1 0.036
Cnx99A Calnexin 99A 0.036
Hcf Host cell factor 0.035
Adf1 Adh transcription factor 1 0.035
wee CG4488 gene product from transcript CG4488-RA 0.035
Akt1 CG4006 gene product from transcript CG4006-RA 0.035
twf twinfilin 0.035
g garnet 0.035
eg eagle 0.034
Vrp1 Verprolin 1 0.034
ari-2 ariadne 2 0.034
betaInt-nu beta[nu] integrin 0.034
chp chaoptic 0.034
pyd polychaetoid 0.034
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 1.000
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.000
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 1.000
BCAR1 breast cancer anti-estrogen resistance 1 0.999
TRAF1 TNF receptor-associated factor 1 0.998
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.996
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.996
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.995
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.989
FGF1 fibroblast growth factor 1 (acidic) 0.987
FHL2 four and a half LIM domains 2 0.984
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.972
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.967
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.965
FGFR2 fibroblast growth factor receptor 2 0.964
FN1 fibronectin 1 0.962
PTPRC protein tyrosine phosphatase, receptor type, C 0.960
PTK2 PTK2 protein tyrosine kinase 2 0.953
TEK TEK tyrosine kinase, endothelial 0.946
VEGFA vascular endothelial growth factor A 0.942
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.933
SOCS3 suppressor of cytokine signaling 3 0.933
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.929
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.928
PDIA3 protein disulfide isomerase family A, member 3 0.911
CCR5 chemokine (C-C motif) receptor 5 0.885
JAK2 Janus kinase 2 0.876
PLCG1 phospholipase C, gamma 1 0.874
MET met proto-oncogene (hepatocyte growth factor receptor) 0.871
SPRR2A small proline-rich protein 2A 0.827
SH2D1A SH2 domain containing 1A 0.808
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.806
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.793
SH2D4A SH2 domain containing 4A 0.761
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.759
IL6 interleukin 6 (interferon, beta 2) 0.716
VCAM1 vascular cell adhesion molecule 1 0.704
BIRC3 baculoviral IAP repeat containing 3 0.698
ENG endoglin 0.692
NRP1 neuropilin 1 0.685
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.679
WIPF1 WAS/WASL interacting protein family, member 1 0.679
CCL2 chemokine (C-C motif) ligand 2 0.676
AXL AXL receptor tyrosine kinase 0.669
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.667
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.664
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.658
THBS1 thrombospondin 1 0.624
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.611
EPHA2 EPH receptor A2 0.607
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.606
ICAM1 intercellular adhesion molecule 1 0.603
FLNA filamin A, alpha 0.592
ADAM15 ADAM metallopeptidase domain 15 0.548
GRB2 growth factor receptor-bound protein 2 0.547
EPOR erythropoietin receptor 0.532
TNF tumor necrosis factor 0.528
TAL1 T-cell acute lymphocytic leukemia 1 0.528
TRAF5 TNF receptor-associated factor 5 0.513
MPDZ multiple PDZ domain protein 0.507
SYK spleen tyrosine kinase 0.502
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.502
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.493
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.484
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.481
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.469
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.467
ESR1 estrogen receptor 1 0.446
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.441
SOCS1 suppressor of cytokine signaling 1 0.437
IL8 interleukin 8 0.423
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.422
GDF9 growth differentiation factor 9 0.420
CD247 CD247 molecule 0.414
IGF1R insulin-like growth factor 1 receptor 0.410
LAT linker for activation of T cells 0.403
ARRB1 arrestin, beta 1 0.393
IL4R interleukin 4 receptor 0.386
GH1 growth hormone 1 0.384
FGA fibrinogen alpha chain 0.380
CXCL9 chemokine (C-X-C motif) ligand 9 0.373
MUC1 mucin 1, cell surface associated 0.371
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.370
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.369
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.363
CCL4 chemokine (C-C motif) ligand 4 0.363
TLN1 talin 1 0.361
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.359
SOS1 son of sevenless homolog 1 (Drosophila) 0.337
TRAF3 TNF receptor-associated factor 3 0.329
MAGEA11 melanoma antigen family A, 11 0.329
CCL7 chemokine (C-C motif) ligand 7 0.327
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.322
IL6R interleukin 6 receptor 0.321
PRKCA protein kinase C, alpha 0.320
TRADD TNFRSF1A-associated via death domain 0.320
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.309
TBX5 T-box 5 0.309
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.307
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.306
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Il6st interleukin 6 signal transducer 0.995
Dab1 disabled homolog 1 (Drosophila) 0.989
Inpp5d inositol polyphosphate-5-phosphatase D 0.984
Kit kit oncogene 0.969
Emx2 empty spiracles homolog 2 (Drosophila) 0.942
Lyz2 lysozyme 2 0.938
Esr1 estrogen receptor 1 (alpha) 0.930
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.919
Cd44 CD44 antigen 0.914
Stat3 signal transducer and activator of transcription 3 0.904
Emx1 empty spiracles homolog 1 (Drosophila) 0.902
Fyn Fyn proto-oncogene 0.891
Plcg1 phospholipase C, gamma 1 0.848
Nos2 nitric oxide synthase 2, inducible 0.827
Ctnnb1 catenin (cadherin associated protein), beta 1 0.827
Apoe apolipoprotein E 0.821
Lhx3 LIM homeobox protein 3 0.817
Gata4 GATA binding protein 4 0.798
Pten phosphatase and tensin homolog 0.796
Hes5 hairy and enhancer of split 5 (Drosophila) 0.782
Trp53 transformation related protein 53 0.780
Pax2 paired box gene 2 0.780
Fgf8 fibroblast growth factor 8 0.777
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.765
Cd28 CD28 antigen 0.741
Tnf tumor necrosis factor 0.735
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.729
Prf1 perforin 1 (pore forming protein) 0.722
Src Rous sarcoma oncogene 0.703
Ephb2 Eph receptor B2 0.698
Cd19 CD19 antigen 0.680
Drd2 dopamine receptor D2 0.676
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.670
Otx2 orthodenticle homolog 2 (Drosophila) 0.668
Gli3 GLI-Kruppel family member GLI3 0.650
Meox2 mesenchyme homeobox 2 0.648
Flt4 FMS-like tyrosine kinase 4 0.647
Pax8 paired box gene 8 0.640
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.628
Nog noggin 0.627
Slamf1 signaling lymphocytic activation molecule family member 1 0.616
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.605
Grb2 growth factor receptor bound protein 2 0.604
Ptk2 PTK2 protein tyrosine kinase 2 0.602
Flt1 FMS-like tyrosine kinase 1 0.575
Ikzf1 IKAROS family zinc finger 1 0.572
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.570
Cbl Casitas B-lineage lymphoma 0.564
Ccl2 chemokine (C-C motif) ligand 2 0.556
Plxna1 plexin A1 0.535
Adrb1 adrenergic receptor, beta 1 0.520
Fgfr1 fibroblast growth factor receptor 1 0.519
Mtor mechanistic target of rapamycin (serine/threonine kinase) 0.505
Lat linker for activation of T cells 0.499
Il4 interleukin 4 0.493
Cd40 CD40 antigen 0.482
Lepr leptin receptor 0.479
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.477
Rag1 recombination activating gene 1 0.476
Ptprc protein tyrosine phosphatase, receptor type, C 0.458
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.446
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.442
Lck lymphocyte protein tyrosine kinase 0.416
Csf1 colony stimulating factor 1 (macrophage) 0.413
Efnb2 ephrin B2 0.412
Foxf1a forkhead box F1a 0.394
Pax3 paired box gene 3 0.380
Tbx3 T-box 3 0.375
S1pr2 sphingosine-1-phosphate receptor 2 0.372
Adam17 a disintegrin and metallopeptidase domain 17 0.367
Ins2 insulin II 0.364
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.360
Tal1 T-cell acute lymphocytic leukemia 1 0.359
Hes1 hairy and enhancer of split 1 (Drosophila) 0.350
Sox10 SRY-box containing gene 10 0.341
Eng endoglin 0.334
Smad3 MAD homolog 3 (Drosophila) 0.334
Wnt3a wingless-related MMTV integration site 3A 0.331
Pgr progesterone receptor 0.330
Nodal nodal 0.325
Ntf3 neurotrophin 3 0.316
Igh immunoglobulin heavy chain complex 0.315
Rxra retinoid X receptor alpha 0.314
Icos inducible T-cell co-stimulator 0.298
Smad4 MAD homolog 4 (Drosophila) 0.296
Sox7 SRY-box containing gene 7 0.289
Psen1 presenilin 1 0.288
Smad6 MAD homolog 6 (Drosophila) 0.286
Ifng interferon gamma 0.283
Fgd1 FYVE, RhoGEF and PH domain containing 1 0.282
Foxc2 forkhead box C2 0.282
Mmp9 matrix metallopeptidase 9 0.278
Pitx2 paired-like homeodomain transcription factor 2 0.273
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.272
Hck hemopoietic cell kinase 0.272
Il6 interleukin 6 0.271
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.267
Il1r1 interleukin 1 receptor, type I 0.260
Foxn1 forkhead box N1 0.260
Acvrl1 activin A receptor, type II-like 1 0.260
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Ptafr platelet-activating factor receptor 0.012
Pld4 phospholipase D family, member 4 0.011
Fgfr2 fibroblast growth factor receptor 2 0.010
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism