The network for 'cellular response to organic substance' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to organic substance

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.

Caenorhabditis elegans
Name Description Probability Func Analog Organism
unc-9 Protein UNC-9 0.803
nhr-67 Protein NHR-67 0.770
vab-3 Protein VAB-3 0.691
F13H6.1 Protein F13H6.1 0.666
hsp-16.1 Protein HSP-16.1 0.611
abu-11 Protein ABU-11 0.604
pha-4 Protein PHA-4 0.584
hsp-3 Protein HSP-3 0.561
abu-6 Protein ABU-6 0.533
mat-3 Protein MAT-3 0.520
daf-11 Protein DAF-11 0.481
hsp-16.2 Protein HSP-16.2 0.469
tag-320 Protein TAG-320 0.464
egl-18 Protein EGL-18 0.463
hsp-4 Protein HSP-4 0.444
Y47D3B.6 Protein Y47D3B.6 0.428
hsp-16.41 Protein HSP-16.41 0.417
unc-104 Protein UNC-104 0.410
dlk-1 Protein DLK-1 0.410
bar-1 Protein BAR-1 0.407
abu-15 Protein ABU-15 0.398
nhr-45 Protein NHR-45 0.391
sas-5 Protein SAS-5 0.375
ceh-20 Protein CEH-20 0.359
egg-6 Protein EGG-6 0.353
vit-2 Protein VIT-2 0.353
egl-8 Protein EGL-8 0.347
hsp-1 Protein HSP-1 0.345
daf-1 Protein DAF-1 0.334
pkg-1 Protein PKG-1 0.326
F44E5.4 Protein F44E5.4 0.321
apl-1 Protein APL-1 0.314
abu-1 Protein ABU-1 0.310
peb-1 Protein PEB-1 0.300
tbb-2 Protein TBB-2 0.298
acs-4 Protein ACS-4 0.290
pry-1 Protein PRY-1 0.280
apc-2 Protein APC-2 0.273
let-60 Protein LET-60 0.270
hlh-2 Protein HLH-2 0.263
ifg-1 Protein IFG-1 0.260
pod-2 Protein POD-2 0.254
nhr-6 Protein NHR-6 0.247
soc-2 Protein SOC-2 0.246
plc-1 Protein PLC-1 0.244
faah-1 Protein FAAH-1 0.241
daf-14 Protein DAF-14 0.240
abu-14 Protein ABU-14 0.240
daf-12 Protein DAF-12 0.236
glp-1 Protein GLP-1 0.229
unc-70 Protein UNC-70 0.225
ccch-1 Protein CCCH-1 0.223
cam-1 Protein CAM-1 0.221
trap-3 Protein TRAP-3 0.219
lin-1 Protein LIN-1 0.219
hsp-70 Protein HSP-70 0.216
CELE_C18C4.5 Protein C18C4.5 0.213
hsp-16.48 Protein HSP-16.48 0.213
cpr-4 Protein CPR-4 0.210
sma-3 Protein SMA-3 0.210
unc-52 Protein UNC-52 0.209
smp-1 Protein SMP-1 0.206
ztf-22 Protein ZTF-22 0.205
imp-2 Protein IMP-2 0.205
npl-4.2 Protein NPL-4.2 0.205
ptr-14 Protein PTR-14 0.202
nra-4 Protein NRA-4 0.199
CELE_Y57A10A.13 Protein Y57A10A.13 0.199
sgt-1 Protein SGT-1 0.195
ace-3 Protein ACE-3 0.192
calu-1 Protein CALU-1 0.188
unc-83 Protein UNC-83 0.188
sup-17 Protein SUP-17 0.186
emb-9 Protein EMB-9 0.186
imb-2 Protein IMB-2 0.185
K03E6.7 Protein K03E6.7 0.185
fln-2 Protein FLN-2 0.185
csn-4 Protein CSN-4 0.184
lpd-6 Protein LPD-6 0.175
pqn-54 Protein PQN-54 0.175
osm-6 Protein OSM-6 0.174
lin-25 Protein LIN-25 0.172
F40F4.7 Protein F40F4.7 0.172
par-5 Protein PAR-5 0.171
pqn-59 Protein PQN-59 0.166
haly-1 Protein HALY-1 0.166
elt-6 Protein ELT-6 0.166
npp-1 Protein NPP-1 0.161
pde-4 Protein PDE-4 0.161
lmn-1 Protein LMN-1 0.161
fkh-2 Protein FKH-2 0.160
cat-1 Protein CAT-1 0.158
pmt-1 Protein PMT-1 0.158
pmk-1 Protein PMK-1 0.152
immt-1 Protein IMMT-1 0.152
atg-11 Protein ATG-11 0.152
C27A12.7 Protein C27A12.7 0.151
sek-1 Protein SEK-1 0.149
spp-10 Protein SPP-10 0.148
ser-3 Protein SER-3 0.147
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Danio rerio
Name Description Probability Func Analog Organism
fgf8a fibroblast growth factor 8 a 0.943
bmp2b bone morphogenetic protein 2b 0.928
shha sonic hedgehog a 0.894
fgf3 fibroblast growth factor 3 0.859
apoeb apolipoprotein Eb 0.728
oep one-eyed pinhead 0.727
sox9a SRY-box containing gene 9a 0.710
pax6a paired box gene 6a 0.694
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.684
lef1 lymphocyte enhancer binding factor 1 0.679
dlc deltaC 0.671
chd chordin 0.667
efnb2a ephrin B2a 0.650
pax8 paired box gene 8 0.644
tfap2a transcription factor AP-2 alpha 0.631
flh floating head 0.616
spry4 sprouty (Drosophila) homolog 4 0.600
otpa orthopedia homolog a 0.597
notch1a notch homolog 1a 0.573
dlx5a distal-less homeobox gene 5a 0.565
tal1 T-cell acute lymphocytic leukemia 1 0.538
bmp4 bone morphogenetic protein 4 0.533
foxa3 forkhead box A3 0.530
snai1a snail homolog 1a (Drosophila) 0.515
ptch2 patched 2 0.495
sox9b SRY-box containing gene 9b 0.493
ndr2 nodal-related 2 0.492
igf1ra insulin-like growth factor 1a receptor 0.489
wnt10a wingless-type MMTV integration site family, member 10a 0.480
tbx18 T-box 18 0.471
osr1 odd-skipped related 1 (Drosophila) 0.460
plcg1 phospholipase C, gamma 1 0.441
nog3 noggin 3 0.435
cmyb transcription factor cmyb 0.407
hspa5 heat shock protein 5 0.405
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.379
fn1 fibronectin 1 0.371
vdra vitamin D receptor a 0.366
jag2 jagged 2 0.364
tgfb1a transforming growth factor, beta 1a 0.354
nanos3 nanos homolog 3 0.352
nadl1.1 neural adhesion molecule L1.1 0.351
cdh23 cadherin-like 23 0.351
pcna proliferating cell nuclear antigen 0.349
hspd1 heat shock 60kD protein 1 (chaperonin) 0.348
sparc secreted acidic cysteine rich glycoprotein 0.343
manf mesencephalic astrocyte-derived neurotrophic factor 0.340
lin28a lin-28 homolog A (C. elegans) 0.338
gro1 groucho 1 0.332
fzd5 frizzled homolog 5 0.323
fabp11a fatty acid binding protein 11a 0.321
si:dkey-27i16.2 si:dkey-27i16.2 0.310
nkx2.2a NK2 transcription factor related 2a 0.307
wnt2 wingless-type MMTV integration site family member 2 0.300
tbx1 T-box 1 0.295
gdf6a growth differentiation factor 6a 0.294
fgf10a fibroblast growth factor 10a 0.292
gli2a GLI-Kruppel family member GLI2a 0.291
esr1 estrogen receptor 1 0.290
neo1 neogenin 1 0.289
fgf4 fibroblast growth factor 4 0.284
cdx4 caudal type homeo box transcription factor 4 0.283
pycard PYD and CARD domain containing 0.281
wt1a wilms tumor 1a 0.280
pitx3 paired-like homeodomain transcription factor 3 0.278
jag1a jagged 1a 0.277
ef1a elongation factor 1-alpha 0.277
cdh2 cadherin 2, neuronal 0.272
igf1 insulin-like growth factor 1 0.269
dla deltaA 0.265
ptpra protein tyrosine phosphatase, receptor type, A 0.264
rag1 recombination activating gene 1 0.254
wu:fv91b12 wu:fv91b12 0.246
kif5bb kinesin family member 5B, b 0.245
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.245
sema3aa semaphorin 3aa 0.236
notch3 notch homolog 3 0.234
etv2 ets variant gene 2 0.233
fras1 Fraser syndrome 1 0.232
her12 hairy-related 12 0.229
vasa vasa homolog 0.228
cav1 caveolin 1 0.228
met met proto-oncogene (hepatocyte growth factor receptor) 0.227
sulf1 sulfatase 1 0.221
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.219
vcanb versican b 0.218
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.215
cyp26a1 cytochrome P450, subfamily XXVIA, polypeptide 1 0.214
vcana versican a 0.211
sec61al1 Sec61 alpha like 1 0.210
hyou1 hypoxia up-regulated 1 0.210
mmp2 matrix metalloproteinase 2 0.209
lmo4a LIM domain only 4a 0.209
pcdh18b protocadherin 18b 0.205
fbn2b fibrillin 2b 0.203
btg2 B-cell translocation gene 2 0.203
pou5f1 POU domain, class 5, transcription factor 1 0.200
wnt8b wingless-type MMTV integration site family, member 8b 0.199
rarab retinoic acid receptor, alpha b 0.198
bmper BMP binding endothelial regulator 0.197
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Stat92E Signal-transducer and activator of transcription protein at 92E 0.954
Rac1 CG2248 gene product from transcript CG2248-RA 0.949
Mer Merlin 0.948
smt3 CG4494 gene product from transcript CG4494-RA 0.888
put punt 0.882
EcR Ecdysone receptor 0.864
Egfr Epidermal growth factor receptor 0.856
Ras85D Ras oncogene at 85D 0.829
ci cubitus interruptus 0.784
tkv thickveins 0.772
Rel Relish 0.761
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.738
sina seven in absentia 0.731
nej nejire 0.711
Fmr1 CG6203 gene product from transcript CG6203-RC 0.692
dac dachshund 0.683
Lis-1 Lissencephaly-1 0.670
Shc SHC-adaptor protein 0.666
CtBP C-terminal Binding Protein 0.627
p53 CG33336 gene product from transcript CG33336-RB 0.613
hep hemipterous 0.552
S6k RPS6-p70-protein kinase 0.551
Top2 Topoisomerase 2 0.550
Nrx-IV Neurexin IV 0.524
bowl brother of odd with entrails limited 0.510
Sfmbt Scm-related gene containing four mbt domains 0.509
Moe Moesin 0.478
fkh fork head 0.473
lwr lesswright 0.464
ash2 absent, small, or homeotic discs 2 0.462
ap apterous 0.455
Cdk4 Cyclin-dependent kinase 4 0.455
Atpalpha Na pump alpha subunit 0.452
rap retina aberrant in pattern 0.439
trx trithorax 0.423
Hop Hsp70/Hsp90 organizing protein homolog 0.422
Fas2 Fasciclin 2 0.411
CycJ Cyclin J 0.407
ftz-f1 ftz transcription factor 1 0.392
btl breathless 0.387
Smox Smad on X 0.384
phl pole hole 0.378
usp ultraspiracle 0.371
par-1 CG8201 gene product from transcript CG8201-RA 0.366
gcm glial cells missing 0.366
wts warts 0.360
InR Insulin-like receptor 0.353
Med Medea 0.351
Dad Daughters against dpp 0.350
Dcr-1 Dicer-1 0.344
rictor rapamycin-insensitive companion of Tor 0.344
Gyc76C Guanylyl cyclase at 76C 0.335
LamC Lamin C 0.332
p38b CG7393 gene product from transcript CG7393-RA 0.327
Su(H) Suppressor of Hairless 0.321
dsx doublesex 0.320
shn schnurri 0.320
hts hu li tai shao 0.320
lok loki 0.319
btz barentsz 0.317
Cdc42 CG12530 gene product from transcript CG12530-RA 0.311
N Notch 0.307
foxo forkhead box, sub-group O 0.303
dpp decapentaplegic 0.293
G-oalpha47A G protein oalpha 47A 0.289
mys myospheroid 0.285
mor moira 0.282
fz2 frizzled 2 0.278
emc extra macrochaetae 0.277
rut rutabaga 0.273
Ubqn Ubiquilin 0.273
eve even skipped 0.270
wun wunen 0.269
aPKC atypical protein kinase C 0.264
tou toutatis 0.260
hth homothorax 0.260
mask multiple ankyrin repeats single KH domain 0.257
dm diminutive 0.253
chico CG5686 gene product from transcript CG5686-RB 0.250
awd abnormal wing discs 0.249
Jarid2 CG3654 gene product from transcript CG3654-RD 0.242
Kr-h1 Kruppel homolog 1 0.242
ptc patched 0.240
kn knot 0.235
ey eyeless 0.233
key kenny 0.232
CdsA CDP diglyceride synthetase 0.231
botv brother of tout-velu 0.230
Hsf Heat shock factor 0.230
sfl sulfateless 0.228
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.226
neur neuralized 0.224
spz spatzle 0.223
imd immune deficiency 0.220
fu fused 0.219
ush u-shaped 0.213
crm cramped 0.210
dally division abnormally delayed 0.208
Caps Calcium activated protein for secretion 0.206
Cg25C Collagen type IV 0.205
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
FAR1 Far1p 0.991
STE11 Ste11p 0.984
STE5 Ste5p 0.964
STE4 Ste4p 0.945
BEM1 Bem1p 0.939
SST2 Sst2p 0.899
AGA1 Aga1p 0.889
CDC24 Cdc24p 0.848
FUS3 Fus3p 0.841
STE20 Ste20p 0.802
NBP2 Nbp2p 0.781
STE2 Ste2p 0.777
PTC1 Ptc1p 0.657
SLT2 Slt2p 0.655
STE7 Ste7p 0.651
GPA1 Gpa1p 0.639
RAS2 Ras2p 0.637
TOR1 Tor1p 0.629
CRZ1 Crz1p 0.628
CDC55 Cdc55p 0.621
HOG1 Hog1p 0.614
AGA2 Aga2p 0.614
PPH21 Pph21p 0.599
STE18 Ste18p 0.570
RTG3 Rtg3p 0.569
MFA1 Mfa1p 0.541
FUS1 Fus1p 0.523
YSC84 Ysc84p 0.490
SSK2 Ssk2p 0.483
HSP104 Hsp104p 0.481
KSS1 Kss1p 0.458
CLA4 Cla4p 0.455
STE50 Ste50p 0.454
FIG4 Fig4p 0.447
FIG2 Fig2p 0.429
PBS2 Pbs2p 0.429
RHO1 Rho1p 0.425
DBF2 Dbf2p 0.422
SSK1 Ssk1p 0.419
GLN3 Gln3p 0.415
ARF1 Arf1p 0.389
MKS1 Mks1p 0.387
FAR10 Far10p 0.381
CLB3 Clb3p 0.378
CHD1 Chd1p 0.378
PDE2 Pde2p 0.371
RLM1 Rlm1p 0.369
SIC1 Sic1p 0.362
TRA1 Tra1p 0.350
DIG1 Dig1p 0.350
CLN3 Cln3p 0.346
MSN2 Msn2p 0.341
SGV1 Sgv1p 0.338
RRI1 Rri1p 0.336
FAR11 Far11p 0.335
KDX1 Kdx1p 0.310
FUS2 Fus2p 0.308
MSN5 Msn5p 0.305
SWI6 Swi6p 0.301
GFA1 Gfa1p 0.300
PPZ1 Ppz1p 0.299
ROM2 Rom2p 0.296
AQY2 Aqy2p 0.293
RTF1 Rtf1p 0.292
AQR1 Aqr1p 0.283
SSE2 Sse2p 0.279
CDC48 Cdc48p 0.277
KRE1 Kre1p 0.276
SHO1 Sho1p 0.276
NOG1 Nog1p 0.274
SAC7 Sac7p 0.273
RPN4 Rpn4p 0.270
STE3 Ste3p 0.268
CGI121 Cgi121p 0.265
MPH1 Mph1p 0.258
MKK1 Mkk1p 0.254
UBP15 Ubp15p 0.252
RIM101 Rim101p 0.252
CYC8 Cyc8p 0.251
ASG1 Asg1p 0.251
TCP1 Tcp1p 0.246
BMH1 Bmh1p 0.243
HRD1 Hrd1p 0.243
YJR084W hypothetical protein 0.241
FPK1 Fpk1p 0.239
PRM1 Prm1p 0.239
CDC28 Cdc28p 0.238
YPT1 Ypt1p 0.235
HSP60 Hsp60p 0.235
CAK1 Cak1p 0.234
SLG1 Slg1p 0.229
PHO80 Pho80p 0.228
BNI1 Bni1p 0.227
YAK1 Yak1p 0.224
BAR1 Bar1p 0.221
PMT2 Pmt2p 0.221
SGT2 Sgt2p 0.219
RRI2 Rri2p 0.219
KSP1 Ksp1p 0.219
HSP82 Hsp82p 0.214