The network for 'cellular response to stress' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

Name Description Probability Func Analog Organism
abu-15 Protein ABU-15 0.848
egl-18 Protein EGL-18 0.826
glp-1 Protein GLP-1 0.601
csn-5 Protein CSN-5 0.549
vab-1 Protein VAB-1 0.549
abu-11 Protein ABU-11 0.499
F58B3.6 Protein F58B3.6 0.451
acs-4 Protein ACS-4 0.440
spd-2 Protein SPD-2 0.417
mes-4 Protein MES-4 0.408
mat-3 Protein MAT-3 0.399
hsp-16.1 Protein HSP-16.1 0.399
hsp-16.2 Protein HSP-16.2 0.394
CELE_T05E11.3 Protein T05E11.3 0.376
hsr-9 Protein HSR-9 0.371
pme-3 Protein PME-3 0.368
retr-1 Protein RETR-1 0.361
let-502 Protein LET-502 0.353
dpf-3 Protein DPF-3 0.345
abu-8 Protein ABU-8 0.338
gon-4 Protein GON-4 0.337
dao-5 Protein DAO-5 0.327
mel-28 Protein MEL-28 0.325
npl-4.2 Protein NPL-4.2 0.324
pas-6 Protein PAS-6 0.316
pqn-54 Protein PQN-54 0.310
rpt-2 Protein RPT-2 0.310
R11A8.7 Protein R11A8.7 0.306
abu-1 Protein ABU-1 0.304
rpn-11 Protein RPN-11 0.299
CELE_Y69A2AR.16 Protein Y69A2AR.16 0.295
dnj-12 Protein DNJ-12 0.293
rpt-5 Protein RPT-5 0.278
Y110A7A.4 Protein Y110A7A.4 0.275
C34E10.8 Protein C34E10.8 0.274
dnj-13 Protein DNJ-13 0.274
plc-1 Protein PLC-1 0.273
soc-2 Protein SOC-2 0.270
nhr-6 Protein NHR-6 0.254
tbb-2 Protein TBB-2 0.252
crt-1 Protein CRT-1 0.250
hsp-3 Protein HSP-3 0.244
rpt-3 Protein RPT-3 0.243
lin-37 Protein LIN-37 0.242
mek-2 Protein MEK-2 0.241
CELE_T06E4.9 Protein T06E4.9 0.241
mrt-2 Protein MRT-2 0.237
rpa-1 Protein RPA-1 0.236
zyg-8 Protein ZYG-8 0.235
eef-1A.1 Protein EEF-1A.1 0.233
chk-1 Protein CHK-1 0.231
ifg-1 Protein IFG-1 0.219
mbk-1 Protein MBK-1 0.217
Y47D3B.6 Protein Y47D3B.6 0.216
nhr-69 Protein NHR-69 0.213
mcm-7 Protein MCM-7 0.212
C27A12.7 Protein C27A12.7 0.211
Y44E3A.6 Protein Y44E3A.6 0.210
hsp-16.41 Protein HSP-16.41 0.209
csn-4 Protein CSN-4 0.207
vang-1 Protein VANG-1 0.207
air-1 Protein AIR-1 0.207
mix-1 Protein MIX-1 0.206
hus-1 Protein HUS-1 0.204
pbs-5 Protein PBS-5 0.204
unc-51 Protein UNC-51 0.201
CELE_F42F12.3 Protein F42F12.3 0.199
ire-1 Protein IRE-1 0.198
ftt-2 Protein FTT-2 0.198
prp-21 Protein PRP-21 0.198
dpy-30 Protein DPY-30 0.196
polh-1 Protein POLH-1 0.193
mis-12 Protein MIS-12 0.190
elt-6 Protein ELT-6 0.187
his-62 Protein HIS-62 0.186
zyg-9 Protein ZYG-9 0.185
abu-6 Protein ABU-6 0.185
lin-35 Protein LIN-35 0.184
hpo-21 Protein HPO-21 0.183
lag-1 Protein LAG-1 0.181
ucr-2.3 Protein UCR-2.3 0.180
T05E8.3 Protein T05E8.3 0.180
gst-1 Protein GST-1 0.179
cash-1 Protein CASH-1 0.178
CELE_C12D8.1 Protein C12D8.1 0.178
npp-20 Protein NPP-20 0.177
rpt-1 Protein RPT-1 0.177
smp-1 Protein SMP-1 0.176
dct-18 Protein DCT-18 0.176
mig-5 Protein MIG-5 0.175
cyn-4 Protein CYN-4 0.174
ifd-1 Protein IFD-1 0.174
ykt-6 Protein YKT-6 0.173
lin-5 Protein LIN-5 0.173
itx-1 Protein ITX-1 0.173
knl-1 Protein KNL-1 0.173
sec-22 Protein SEC-22 0.171
Y82E9BR.13 Protein Y82E9BR.13 0.169
eri-1 Protein ERI-1 0.169
ect-2 Protein ECT-2 0.168
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Danio rerio
Name Description Probability Func Analog Organism
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.577
jag2 jagged 2 0.430
notch3 notch homolog 3 0.384
spry4 sprouty (Drosophila) homolog 4 0.333
csnk1da casein kinase 1, delta a 0.333
dkk1b dickkopf 1b 0.316
ran ras-related nuclear protein 0.313
rspo3 R-spondin 3 homolog (Xenopus laevis) 0.301
ripk2 receptor-interacting serine-threonine kinase 2 0.300
dag1 dystroglycan 1 0.290
her15.1 hairy and enhancer of split-related 15.1 0.270
junb jun B proto-oncogene 0.222
tbx16 T-box gene 16 0.211
fen1 flap structure-specific endonuclease 1 0.211
flh floating head 0.205
tgfb3 transforming growth factor, beta 3 0.191
ctsl1a cathepsin L, 1 a 0.190
tbx6 T-box gene 6 0.187
fech ferrochelatase 0.178
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.170
mych myelocytomatosis oncogene homolog 0.170
psmb1 proteasome (prosome, macropain) subunit, beta type, 1 0.164
mapk14a mitogen-activated protein kinase 14a 0.163
odc1 ornithine decarboxylase 1 0.160
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.159
psma6a proteasome (prosome, macropain) subunit, alpha type, 6a 0.157
psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.156
neurod neurogenic differentiation 0.156
gata5 GATA-binding protein 5 0.151
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.148
myod1 myogenic differentiation 1 0.147
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.141
ctsl1b cathepsin L, 1 b 0.141
tgif1 TGFB-induced factor homeobox 1 0.137
brd2a bromodomain-containing 2a 0.136
fn1 fibronectin 1 0.136
lamc1 laminin, gamma 1 0.135
si:dkey-8l13.4 si:dkey-8l13.4 0.133
hspd1 heat shock 60kD protein 1 (chaperonin) 0.131
mmp9 matrix metalloproteinase 9 0.125
gro1 groucho 1 0.125
tbx1 T-box 1 0.123
pcdh18b protocadherin 18b 0.122
fgf3 fibroblast growth factor 3 0.118
tram1 translocating chain-associating membrane protein 1 0.117
ube2i ubiquitin-conjugating enzyme E2I 0.116
osr1 odd-skipped related 1 (Drosophila) 0.114
slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 0.114
hsp90b1 heat shock protein 90, beta (grp94), member 1 0.114
gsc goosecoid 0.113
twist1a twist1a 0.113
per3 period homolog 3 (Drosophila) 0.112
maff v-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian) 0.112
eif3ja eukaryotic translation initiation factor 3, subunit Ja 0.111
hsp90a.2 heat shock protein 90-alpha 2 0.109
sox32 SRY-box containing gene 32 0.109
rhoab ras homolog gene family, member Ab 0.107
ndrg4 N-myc downstream regulated gene 4 0.106
manf mesencephalic astrocyte-derived neurotrophic factor 0.106
traf4a tnf receptor-associated factor 4a 0.105
cct8 chaperonin containing TCP1, subunit 8 (theta) 0.105
akt2 v-akt murine thymoma viral oncogene homolog 2 0.105
grnb granulin b 0.103
mcl1a myeloid cell leukemia sequence 1a 0.103
mapk1 mitogen-activated protein kinase 1 0.102
zfyve26 zinc finger, FYVE domain containing 26 0.102
dcc deleted in colorectal carcinoma 0.102
ywhae1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 0.102
sox9b SRY-box containing gene 9b 0.102
gdnf glial cell derived neurotrophic factor 0.102
myf5 myogenic factor 5 0.102
chek1 CHK1 checkpoint homolog (S. pombe) 0.101
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.101
cct5 chaperonin containing TCP1, subunit 5 (epsilon) 0.100
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.099
alcama activated leukocyte cell adhesion molecule a 0.099
srsf6b serine/arginine-rich splicing factor 6b 0.099
ncor1 nuclear receptor co-repressor 1 0.098
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.098
cdh1 cadherin 1, epithelial 0.098
rasl11b RAS-like, family 11, member B 0.097
atoh1a atonal homolog 1a 0.097
her9 hairy-related 9 0.096
wdr76 WD repeat domain 76 0.096
tbx2a T-box gene 2a 0.096
mdm2 transformed 3T3 cell double minute 2 homolog (mouse) 0.096
gdf11 growth differentiation factor 11 0.095
ppm1aa protein phosphatase, Mg2+/Mn2+ dependent, 1Aa 0.094
tcf7l1a transcription factor 7-like 1a (T-cell specific, HMG-box) 0.093
mpz myelin protein zero 0.092
dvl2 dishevelled, dsh homolog 2 (Drosophila) 0.091
bon bonnie and clyde 0.091
hspa5 heat shock protein 5 0.090
flt4 fms-related tyrosine kinase 4 0.090
wnt5a wingless-type MMTV integration site family, member 5a 0.088
tuba1l tubulin, alpha 1, like 0.088
cav1 caveolin 1 0.087
adh5 alcohol dehydrogenase 5 0.087
snrpa small nuclear ribonucleoprotein polypeptide A 0.086
appa amyloid beta (A4) precursor protein a 0.086
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.660
S100a10 S100 calcium binding protein A10 0.635
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.627
Jak1 Janus kinase 1 0.539
Jun Jun oncogene 0.535
Zfp36 zinc finger protein 36 0.527
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.500
Alas2 aminolevulinate, delta-, synthase 2 0.499
Hbb hemoglobin, beta 0.492
Oaz1 ornithine decarboxylase antizyme 1 0.481
Mapk1 mitogen activated protein kinase 1 0.480
Anxa2 annexin A2 0.476
Lgals3 lectin, galactoside-binding, soluble, 3 0.469
Psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.455
LOC689064 beta-globin 0.443
Il18 interleukin 18 0.443
Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.438
Gstp1 glutathione S-transferase pi 1 0.427
Gadd45a growth arrest and DNA-damage-inducible, alpha 0.425
Rab7a RAB7A, member RAS oncogene family 0.413
Ftl ferritin, light polypeptide 0.408
Vegfa vascular endothelial growth factor A 0.408
Klf4 Kruppel-like factor 4 (gut) 0.403
S100a9 S100 calcium binding protein A9 0.402
Socs3 suppressor of cytokine signaling 3 0.388
Hspb1 heat shock protein 1 0.383
LOC100364500 RT1 class I, locus CE11-like 0.380
Mapk9 mitogen-activated protein kinase 9 0.377
RGD1565859 RGD1565859 0.368
Cd44 Cd44 molecule 0.367
Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 0.365
Prkcg protein kinase C, gamma 0.363
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.357
Tp53 tumor protein p53 0.349
Dusp1 dual specificity phosphatase 1 0.345
Junb jun B proto-oncogene 0.345
Myo1b myosin Ib 0.345
Sf1 splicing factor 1 0.344
Psme2 proteasome (prosome, macropain) activator subunit 2 0.344
Il6 interleukin 6 0.343
Ier3 immediate early response 3 0.338
LOC100134871 beta globin minor gene 0.336
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.333
Met met proto-oncogene 0.326
Foxa2 forkhead box A2 0.325
Btg2 BTG family, member 2 0.320
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.308
Tspo translocator protein 0.303
Edn1 endothelin 1 0.303
Prkg2 protein kinase, cGMP-dependent, type II 0.294
LOC100362824 caveolin 2-like 0.293
Cfp complement factor properdin 0.289
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.285
Wdr26 WD repeat domain 26 0.283
Dctn4 dynactin 4 0.275
Fxyd4 FXYD domain-containing ion transport regulator 4 0.272
Olr226 olfactory receptor 226 0.271
Pak2 p21 protein (Cdc42/Rac)-activated kinase 2 0.270
Ctdsp1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 0.269
Gja6 gap junction protein, alpha 6 0.268
Slc5a5 solute carrier family 5 (sodium iodide symporter), member 5 0.267
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.266
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform 0.261
Hes3 hairy and enhancer of split 3 (Drosophila) 0.258
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.257
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.254
Add2 adducin 2 (beta) 0.253
Hba-a2 hemoglobin alpha, adult chain 2 0.252
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.252
Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.250
LOC100360501 ribonuclease inhibitor-like 0.250
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.249
Taok1 TAO kinase 1 0.248
Mrgprf MAS-related GPR, member F 0.247
Serpinb1a serine (or cysteine) proteinase inhibitor, clade B, member 1a 0.247
Cast calpastatin 0.245
Creb1 cAMP responsive element binding protein 1 0.245
S100a6 S100 calcium binding protein A6 0.245
Vim vimentin 0.245
Psmb2 proteasome (prosome, macropain) subunit, beta type 2 0.242
Hoxa2 homeo box A2 0.242
Syngr2 synaptogyrin 2 0.239
Phb prohibitin 0.238
Errfi1 ERBB receptor feedback inhibitor 1 0.238
March5 membrane-associated ring finger (C3HC4) 5 0.238
Gria1 glutamate receptor, ionotropic, AMPA 1 0.234
Tcf12 transcription factor 12 0.234
Cdkn1a cyclin-dependent kinase inhibitor 1A 0.234
Npffr2 neuropeptide FF receptor 2 0.232
S1pr2 sphingosine-1-phosphate receptor 2 0.232
Psmb4 proteasome (prosome, macropain) subunit, beta type 4 0.231
Ednrb endothelin receptor type B 0.231
Cxcl2 chemokine (C-X-C motif) ligand 2 0.230
Ugt8 UDP glycosyltransferase 8 0.229
Ppara peroxisome proliferator activated receptor alpha 0.228
Psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.227
Cryab crystallin, alpha B 0.227
PVR poliovirus receptor 0.226
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.226
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.226
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism