IMP
Process View
The network for 'negative regulation of b cell proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
negative regulation of b cell proliferation
Any process that stops, prevents or reduces the rate or extent of B cell proliferation.
| Name | Description | Probability | Func Analog Organism |
|---|
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Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| CD80 | CD80 molecule | 0.241 | |
| SYK | spleen tyrosine kinase | 0.149 | |
| MDC1 | mediator of DNA-damage checkpoint 1 | 0.043 | |
| CASP9 | caspase 9, apoptosis-related cysteine peptidase | 0.040 | |
| IL10RA | interleukin 10 receptor, alpha | 0.022 | |
| SLAMF1 | signaling lymphocytic activation molecule family member 1 | 0.020 | |
| APAF1 | apoptotic peptidase activating factor 1 | 0.019 | |
| FANCD2 | Fanconi anemia, complementation group D2 | 0.017 | |
| TFF1 | trefoil factor 1 | 0.017 | |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | 0.014 | |
| ATMIN | ATM interactor | 0.013 | |
| XIAP | X-linked inhibitor of apoptosis | 0.013 | |
| CD86 | CD86 molecule | 0.012 | |
| GRAP2 | GRB2-related adaptor protein 2 | 0.011 | |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.010 |
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Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Igh | immunoglobulin heavy chain complex | 1.000 | |
| Cd40 | CD40 antigen | 0.995 | |
| Cd19 | CD19 antigen | 0.977 | |
| Ptprc | protein tyrosine phosphatase, receptor type, C | 0.914 | |
| Tnf | tumor necrosis factor | 0.893 | |
| Inpp5d | inositol polyphosphate-5-phosphatase D | 0.840 | |
| Pik3cd | phosphatidylinositol 3-kinase catalytic delta polypeptide | 0.726 | |
| Fas | Fas (TNF receptor superfamily member 6) | 0.724 | |
| Rc3h1 | RING CCCH (C3H) domains 1 | 0.719 | |
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.637 | |
| Prkcd | protein kinase C, delta | 0.586 | |
| Btk | Bruton agammaglobulinemia tyrosine kinase | 0.491 | |
| Blnk | B-cell linker | 0.413 | |
| Rb1 | retinoblastoma 1 | 0.397 | |
| Was | Wiskott-Aldrich syndrome homolog (human) | 0.311 | |
| Il2rg | interleukin 2 receptor, gamma chain | 0.299 | |
| Ccr6 | chemokine (C-C motif) receptor 6 | 0.276 | |
| Plcg2 | phospholipase C, gamma 2 | 0.276 | |
| Cd4 | CD4 antigen | 0.237 | |
| Ifng | interferon gamma | 0.235 | |
| Cd28 | CD28 antigen | 0.229 | |
| Il1r1 | interleukin 1 receptor, type I | 0.226 | |
| Tnip1 | TNFAIP3 interacting protein 1 | 0.224 | |
| S1pr2 | sphingosine-1-phosphate receptor 2 | 0.217 | |
| Lta | lymphotoxin A | 0.215 | |
| Ccr7 | chemokine (C-C motif) receptor 7 | 0.211 | |
| Bcl6 | B-cell leukemia/lymphoma 6 | 0.208 | |
| Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 0.206 | |
| Lyn | Yamaguchi sarcoma viral (v-yes-1) oncogene homolog | 0.201 | |
| Pou2af1 | POU domain, class 2, associating factor 1 | 0.185 | |
| Il6 | interleukin 6 | 0.175 | |
| Csf1 | colony stimulating factor 1 (macrophage) | 0.161 | |
| Fcgr2b | Fc receptor, IgG, low affinity IIb | 0.161 | |
| Ptpn22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | 0.158 | |
| Birc3 | baculoviral IAP repeat-containing 3 | 0.149 | |
| Tlr4 | toll-like receptor 4 | 0.148 | |
| Prdm1 | PR domain containing 1, with ZNF domain | 0.133 | |
| Fyn | Fyn proto-oncogene | 0.133 | |
| Lyz2 | lysozyme 2 | 0.132 | |
| Aim2 | absent in melanoma 2 | 0.128 | |
| Hck | hemopoietic cell kinase | 0.128 | |
| Il1b | interleukin 1 beta | 0.124 | |
| Map3k14 | mitogen-activated protein kinase kinase kinase 14 | 0.123 | |
| Tnfsf11 | tumor necrosis factor (ligand) superfamily, member 11 | 0.116 | |
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.112 | |
| Ikzf1 | IKAROS family zinc finger 1 | 0.095 | |
| Pycard | PYD and CARD domain containing | 0.095 | |
| Gbp5 | guanylate binding protein 5 | 0.095 | |
| Cxcr4 | chemokine (C-X-C motif) receptor 4 | 0.088 | |
| Fasl | Fas ligand (TNF superfamily, member 6) | 0.087 | |
| Pten | phosphatase and tensin homolog | 0.087 | |
| Cbl | Casitas B-lineage lymphoma | 0.085 | |
| Icos | inducible T-cell co-stimulator | 0.077 | |
| Cd22 | CD22 antigen | 0.075 | |
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.074 | |
| Bcl3 | B-cell leukemia/lymphoma 3 | 0.072 | |
| Tnfrsf9 | tumor necrosis factor receptor superfamily, member 9 | 0.071 | |
| Map3k7 | mitogen-activated protein kinase kinase kinase 7 | 0.068 | |
| Il27ra | interleukin 27 receptor, alpha | 0.067 | |
| Nos2 | nitric oxide synthase 2, inducible | 0.066 | |
| Mefv | Mediterranean fever | 0.065 | |
| Lck | lymphocyte protein tyrosine kinase | 0.063 | |
| Socs1 | suppressor of cytokine signaling 1 | 0.063 | |
| Il18 | interleukin 18 | 0.061 | |
| Grb2 | growth factor receptor bound protein 2 | 0.060 | |
| Fadd | Fas (TNFRSF6)-associated via death domain | 0.059 | |
| Cd180 | CD180 antigen | 0.058 | |
| Cd72 | CD72 antigen | 0.056 | |
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.053 | |
| Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 0.052 | |
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.052 | |
| Myd88 | myeloid differentiation primary response gene 88 | 0.052 | |
| Ptk2 | PTK2 protein tyrosine kinase 2 | 0.051 | |
| Ccr1 | chemokine (C-C motif) receptor 1 | 0.048 | |
| Cd38 | CD38 antigen | 0.046 | |
| Cd14 | CD14 antigen | 0.045 | |
| Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 | 0.044 | |
| Spib | Spi-B transcription factor (Spi-1/PU.1 related) | 0.043 | |
| Dok1 | docking protein 1 | 0.043 | |
| Cdkn2c | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 0.042 | |
| Il2rb | interleukin 2 receptor, beta chain | 0.042 | |
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.042 | |
| Itsn1 | intersectin 1 (SH3 domain protein 1A) | 0.041 | |
| Cr2 | complement receptor 2 | 0.040 | |
| Il10 | interleukin 10 | 0.040 | |
| C3ar1 | complement component 3a receptor 1 | 0.040 | |
| Prkdc | protein kinase, DNA activated, catalytic polypeptide | 0.040 | |
| Fcgr1 | Fc receptor, IgG, high affinity I | 0.040 | |
| Ch25h | cholesterol 25-hydroxylase | 0.039 | |
| Trp53 | transformation related protein 53 | 0.038 | |
| Cd68 | CD68 antigen | 0.038 | |
| Prf1 | perforin 1 (pore forming protein) | 0.037 | |
| Cd40lg | CD40 ligand | 0.037 | |
| Il4 | interleukin 4 | 0.036 | |
| Pla2g4a | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 0.035 | |
| Cxcl13 | chemokine (C-X-C motif) ligand 13 | 0.035 | |
| Ptpre | protein tyrosine phosphatase, receptor type, E | 0.035 | |
| Traf2 | TNF receptor-associated factor 2 | 0.034 | |
| Tnfrsf13c | tumor necrosis factor receptor superfamily, member 13c | 0.034 | |
| Eif2ak2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.034 |