The network for 'neuroblast fate determination' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

neuroblast fate determination

The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus.

Caenorhabditis elegans
Name Description Probability Func Analog Organism
cnd-1 Protein CND-1 0.940
elt-6 Protein ELT-6 0.918
egl-18 Protein EGL-18 0.812
nhr-2 Protein NHR-2 0.636
nhr-67 Protein NHR-67 0.517
ten-1 Protein TEN-1 0.430
sel-8 Protein SEL-8 0.427
hnd-1 Protein HND-1 0.322
nhr-25 Protein NHR-25 0.277
hbl-1 Protein HBL-1 0.226
ceh-16 Protein CEH-16 0.147
rig-5 Protein RIG-5 0.143
egl-46 Protein EGL-46 0.138
C27B7.5 Protein C27B7.5 0.134
kal-1 Protein KAL-1 0.112
lag-2 Protein LAG-2 0.108
cam-1 Protein CAM-1 0.093
kvs-2 Protein KVS-2 0.091
duo-1 Protein DUO-1 0.091
zoo-1 Protein ZOO-1 0.079
ref-2 Protein REF-2 0.075
mls-2 Protein MLS-2 0.071
CELE_C38D4.4 Protein C38D4.4 0.068
klp-18 Protein KLP-18 0.066
zag-1 Protein ZAG-1 0.064
hlh-14 Protein HLH-14 0.064
cfz-2 Protein CFZ-2 0.063
ceh-34 Protein CEH-34 0.061
C32C4.3 Protein C32C4.3 0.061
nhr-168 Protein NHR-168 0.056
lin-12 Protein LIN-12 0.054
gcy-22 Protein GCY-22 0.052
fkh-2 Protein FKH-2 0.050
unc-86 Protein UNC-86 0.050
ceh-27 Protein CEH-27 0.049
CELE_Y39E4B.2 Protein Y39E4B.2 0.047
ref-1 Protein REF-1 0.045
C37C3.1 Protein C37C3.1 0.043
pha-4 Protein PHA-4 0.042
rnt-1 Protein RNT-1 0.041
ahr-1 Protein AHR-1 0.040
tbx-11 Protein TBX-11 0.039
ceh-36 Protein CEH-36 0.038
dao-5 Protein DAO-5 0.036
hch-1 Protein HCH-1 0.036
sdz-28 Protein SDZ-28 0.034
unc-42 Protein UNC-42 0.034
T24F1.2 Protein T24F1.2 0.034
che-1 Protein CHE-1 0.033
plx-1 Protein PLX-1 0.033
ceh-13 Protein CEH-13 0.032
F43D9.1 Protein F43D9.1 0.030
ace-3 Protein ACE-3 0.029
fbxc-40 Protein FBXC-40 0.029
T25B9.3 Protein T25B9.3 0.029
pes-1 Protein PES-1 0.028
glh-3 Protein GLH-3 0.028
K08E3.4 Protein K08E3.4 0.026
R07B7.2 Protein R07B7.2 0.025
Y7A9D.1 Protein Y7A9D.1 0.025
pag-3 Protein PAG-3 0.024
hlh-2 Protein HLH-2 0.023
C43H6.6 Protein C43H6.6 0.023
lin-32 Protein LIN-32 0.022
lim-4 Protein LIM-4 0.022
lgc-55 Protein LGC-55 0.021
pop-1 Protein POP-1 0.021
tctn-1 Protein TCTN-1 0.021
B0511.12 Protein B0511.12 0.020
F01G4.4 Protein F01G4.4 0.020
pax-1 Protein PAX-1 0.020
unc-130 Protein UNC-130 0.020
aqp-5 Protein AQP-5 0.019
CELE_T26E3.5 Protein T26E3.5 0.019
F09F9.4 Protein F09F9.4 0.018
egl-38 Protein EGL-38 0.017
phat-5 Protein PHAT-5 0.017
egl-36 Protein EGL-36 0.017
nra-3 Protein NRA-3 0.016
ast-1 Protein AST-1 0.016
let-60 Protein LET-60 0.016
zig-10 Protein ZIG-10 0.016
zip-8 Protein ZIP-8 0.015
CELE_Y50E8A.5 Protein Y50E8A.5 0.015
CELE_F21H7.10 Protein F21H7.10 0.015
arrd-4 Protein ARRD-4 0.015
scc-1 Protein SCC-1 0.015
dsl-6 Protein DSL-6 0.014
ins-34 Protein INS-34 0.014
ceh-8 Protein CEH-8 0.014
mec-4 Protein MEC-4 0.013
C11H1.8 Protein C11H1.8 0.013
fbxb-96 Protein FBXB-96 0.013
fbxb-81 Protein FBXB-81 0.013
ceh-53 Protein CEH-53 0.013
CELE_F53C3.5 Protein F53C3.5 0.012
sos-1 Protein SOS-1 0.012
pgl-3 Protein PGL-3 0.012
eya-1 Protein EYA-1 0.012
unc-7 Protein UNC-7 0.012
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Danio rerio
Name Description Probability Func Analog Organism
eng2a engrailed 2a 0.982
ascl1a achaete-scute complex-like 1a (Drosophila) 0.974
eng2b engrailed 2b 0.673
foxn4 forkhead box N4 0.627
pax6a paired box gene 6a 0.600
vsx2 visual system homeobox 2 0.591
gbx2 gastrulation brain homeo box 2 0.564
nkx2.2a NK2 transcription factor related 2a 0.486
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.474
neurod4 neurogenic differentiation 4 0.444
lhx1a LIM homeobox 1a 0.416
dbx1a developing brain homeobox 1a 0.392
dlb deltaB 0.371
ascl1b achaete-scute complex-like 1b (Drosophila) 0.285
otx2 orthodenticle homolog 2 0.268
lhx5 LIM homeobox 5 0.256
plp1a proteolipid protein 1a 0.254
vsx1 visual system homeobox 1 homolog, chx10-like 0.214
lamc1 laminin, gamma 1 0.197
dla deltaA 0.195
sox19a SRY-box containing gene 19a 0.182
pou3f2 POU class 3 homeobox 2 0.170
sox3 SRY-box containing gene 3 0.165
ptf1a pancreas specific transcription factor, 1a 0.160
dlc deltaC 0.159
sox2 SRY-box containing gene 2 0.154
tfap2b transcription factor AP-2 beta 0.149
inab internexin neuronal intermediate filament protein, alpha b 0.147
prl prolactin 0.139
otpb orthopedia homolog b 0.131
pou3f3b POU class 3 homeobox 3b 0.123
barhl2 BarH-like 2 0.121
neurod neurogenic differentiation 0.119
scube2 signal peptide, CUB domain, EGF-like 2 0.106
insm1b insulinoma-associated 1b 0.105
jag1b jagged 1b 0.103
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.099
zic6 zic family member 6 0.099
mab21l2 mab-21-like 2 0.099
pitx3 paired-like homeodomain transcription factor 3 0.098
pou3f1 POU class 3 homeobox 1 0.088
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.086
foxg1a forkhead box G1a 0.085
eya1 eyes absent homolog 1 0.085
notch1a notch homolog 1a 0.083
nr2e3 nuclear receptor subfamily 2, group E, member 3 0.081
nr2f2 nuclear receptor subfamily 2, group F, member 2 0.077
zic4 zic family member 4 0.076
robo3 roundabout homolog 3 0.071
zgc:174506 zgc:174506 0.071
olig3 oligodendrocyte transcription factor 3 0.068
meis3 myeloid ecotropic viral integration site 3 0.068
gata2a GATA-binding protein 2a 0.065
fgf8b fibroblast growth factor 8 b 0.058
dld deltaD 0.055
wnt9a wingless-type MMTV integration site family, member 9A 0.050
cdh2 cadherin 2, neuronal 0.048
ccnd1 cyclin D1 0.048
phox2a paired-like homeobox 2a 0.046
irx1b iroquois homeobox protein 1, b 0.045
her4.2 hairy-related 4.2 0.043
irx4a iroquois homeobox protein 4a 0.043
epha4b eph receptor A4b 0.042
atoh7 atonal homolog 7 0.041
neurog1 neurogenin 1 0.040
fzd7b frizzled homolog 7b 0.039
lama4 laminin, alpha 4 0.039
tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.039
nkx2.2b NK2 transcription factor related 2b 0.038
irx1a iroquois homeobox protein 1, a 0.038
gfap glial fibrillary acidic protein 0.037
olig2 oligodendrocyte lineage transcription factor 2 0.037
hmx3 homeo box (H6 family) 3 0.036
sox10 SRY-box containing gene 10 0.036
prdm5 PR domain containing 5 0.036
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.035
nkx2.1b NK2 homeobox 1b 0.034
bhlhe22 basic helix-loop-helix family, member e22 0.032
gbx1 gastrulation brain homeobox 1 0.032
dbx1b developing brain homeobox 1b 0.031
foxc1a forkhead box C1a 0.031
coe2 coe2 0.030
irx7 iroquois homeobox protein 7 0.030
rag1 recombination activating gene 1 0.030
pax7a paired box gene 7a 0.029
sox1a SRY-box containing gene 1a 0.029
myf5 myogenic factor 5 0.028
jag1a jagged 1a 0.028
zfp36l1a zinc finger protein 36, C3H type-like 1a 0.028
gli2a GLI-Kruppel family member GLI2a 0.028
tp53 tumor protein p53 0.027
gata3 GATA-binding protein 3 0.027
foxb1.1 forkhead box B1.1 0.027
her2 hairy-related 2 0.027
cdc25 cell division cycle 25 homolog 0.026
irx5a iroquois homeobox protein 5a 0.026
eng1a engrailed 1a 0.026
klf2a Kruppel-like factor 2a 0.026
nr2f1b nuclear receptor subfamily 2, group F, member 1b 0.025
lamb2 laminin, beta 2 (laminin S) 0.025
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Drosophila melanogaster
Name Description Probability Func Analog Organism
stg string 0.999
numb CG3779 gene product from transcript CG3779-RB 0.992
mam mastermind 0.989
H Hairless 0.845
Su(H) Suppressor of Hairless 0.839
E(spl) Enhancer of split 0.793
wg wingless 0.680
neur neuralized 0.663
hb hunchback 0.572
bib big brain 0.529
dap dacapo 0.507
kuz kuzbanian 0.404
gcm glial cells missing 0.391
aop anterior open 0.386
N Notch 0.299
Abd-B Abdominal B 0.295
spdo sanpodo 0.295
Ubx Ultrabithorax 0.262
ed echinoid 0.262
hh hedgehog 0.196
mira miranda 0.194
rho rhomboid 0.176
CycA Cyclin A 0.174
al aristaless 0.174
SoxN SoxNeuro 0.169
amos absent MD neurons and olfactory sensilla 0.169
foi fear-of-intimacy 0.165
HLHm7 E(spl) region transcript m7 0.152
Pc Polycomb 0.148
sens senseless 0.139
insc inscuteable 0.130
l(2)gl lethal (2) giant larvae 0.128
brat brain tumor 0.124
zfh1 Zn finger homeodomain 1 0.107
lbe ladybird early 0.106
en engrailed 0.099
Antp Antennapedia 0.096
Tre1 trapped in endoderm-1 0.093
slp1 sloppy paired 1 0.083
HLHmgamma E(spl) region transcript mgamma 0.083
fas faint sausage 0.081
osk oskar 0.081
cic capicua 0.072
pbl pebble 0.072
pnr pannier 0.071
Wnt5 Wnt oncogene analog 5 0.071
eve even skipped 0.065
sktl skittles 0.063
sim single-minded 0.062
pdm2 POU domain protein 2 0.057
HLHmbeta E(spl) region transcript mbeta 0.057
cad caudal 0.056
pros prospero 0.054
HLHm5 E(spl) region transcript m5 0.054
salm spalt major 0.053
slmb supernumerary limbs 0.050
nct nicastrin 0.050
Su(Tpl) CG32217 gene product from transcript CG32217-RB 0.049
gsb gooseberry 0.048
nerfin-1 nervous fingers 1 0.044
sli slit 0.042
grn grain 0.039
CycE Cyclin E 0.038
jumu jumeau 0.037
thr three rows 0.036
tll tailless 0.036
ds dachsous 0.036
mid midline 0.035
loco locomotion defects 0.034
da daughterless 0.034
m2 E(spl) region transcript m2 0.034
CG6954 CG6954 gene product from transcript CG6954-RB 0.032
Kr Kruppel 0.031
SAK Sak kinase 0.031
heph hephaestus 0.030
spo spook 0.029
orb oo18 RNA-binding protein 0.029
ptc patched 0.029
m4 E(spl) region transcript m4 0.028
cdi center divider 0.028
Pcl Polycomblike 0.027
sr stripe 0.027
drm drumstick 0.026
InR Insulin-like receptor 0.026
Ser Serrate 0.025
arr arrow 0.025
brk brinker 0.024
lab labial 0.024
l(2)k16918 lethal (2) k16918 0.023
sub subito 0.023
oaf out at first 0.023
upd3 unpaired 3 0.023
ex expanded 0.022
oc ocelliless 0.022
lbl ladybird late 0.021
ttv tout-velu 0.019
comm commissureless 0.019
Pli Pellino 0.019
ro rough 0.019
unc-5 CG8166 gene product from transcript CG8166-RA 0.019
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Notch1 Notch gene homolog 1 (Drosophila) 1.000
Psen1 presenilin 1 0.999
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.998
Dll1 delta-like 1 (Drosophila) 0.996
Hes1 hairy and enhancer of split 1 (Drosophila) 0.979
Otx2 orthodenticle homolog 2 (Drosophila) 0.978
Pax2 paired box gene 2 0.972
Jag1 jagged 1 0.953
Shh sonic hedgehog 0.951
Fgfr1 fibroblast growth factor receptor 1 0.947
En2 engrailed 2 0.931
Chd7 chromodomain helicase DNA binding protein 7 0.930
Gli3 GLI-Kruppel family member GLI3 0.917
Otx1 orthodenticle homolog 1 (Drosophila) 0.909
Pten phosphatase and tensin homolog 0.905
Msx2 homeobox, msh-like 2 0.881
Trp53 transformation related protein 53 0.850
Gbx2 gastrulation brain homeobox 2 0.814
En1 engrailed 1 0.736
Pax3 paired box gene 3 0.729
Neurod1 neurogenic differentiation 1 0.687
Fgf8 fibroblast growth factor 8 0.687
Psen2 presenilin 2 0.675
Ctnnb1 catenin (cadherin associated protein), beta 1 0.671
Lmx1b LIM homeobox transcription factor 1 beta 0.620
Rxra retinoid X receptor alpha 0.606
Neurog2 neurogenin 2 0.605
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.599
Notch2 Notch gene homolog 2 (Drosophila) 0.572
Rb1 retinoblastoma 1 0.570
Pax6 paired box gene 6 0.570
Pitx2 paired-like homeodomain transcription factor 2 0.566
Foxc1 forkhead box C1 0.550
Ptf1a pancreas specific transcription factor, 1a 0.544
Vangl2 vang-like 2 (van gogh, Drosophila) 0.513
Gata3 GATA binding protein 3 0.473
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.436
Foxp3 forkhead box P3 0.434
Cdk2 cyclin-dependent kinase 2 0.407
Pkd1 polycystic kidney disease 1 homolog 0.385
Lmx1a LIM homeobox transcription factor 1 alpha 0.380
Ikzf1 IKAROS family zinc finger 1 0.368
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.361
Hr hairless 0.295
Braf Braf transforming gene 0.292
Dll4 delta-like 4 (Drosophila) 0.282
Rag1 recombination activating gene 1 0.275
Bcl2 B-cell leukemia/lymphoma 2 0.262
Zfp423 zinc finger protein 423 0.259
Jag2 jagged 2 0.239
Neurod4 neurogenic differentiation 4 0.222
Emx1 empty spiracles homolog 1 (Drosophila) 0.218
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.207
Gli2 GLI-Kruppel family member GLI2 0.201
Sox2 SRY-box containing gene 2 0.199
Rag2 recombination activating gene 2 0.193
Arid1a AT rich interactive domain 1A (SWI-like) 0.189
Fgf17 fibroblast growth factor 17 0.186
Wnt1 wingless-related MMTV integration site 1 0.166
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.164
Lat linker for activation of T cells 0.158
Egfl7 EGF-like domain 7 0.158
Egfr epidermal growth factor receptor 0.147
Ncor2 nuclear receptor co-repressor 2 0.139
Dsg4 desmoglein 4 0.133
Mll1 myeloid/lymphoid or mixed-lineage leukemia 1 0.129
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.127
Foxg1 forkhead box G1 0.126
Lama5 laminin, alpha 5 0.123
Tcra T-cell receptor alpha chain 0.121
Fgfr2 fibroblast growth factor receptor 2 0.120
Ret ret proto-oncogene 0.117
Efnb2 ephrin B2 0.108
Hoxa1 homeobox A1 0.101
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.098
Fgf4 fibroblast growth factor 4 0.094
Nfatc2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.090
Notch3 Notch gene homolog 3 (Drosophila) 0.085
Socs1 suppressor of cytokine signaling 1 0.082
Zfp362 zinc finger protein 362 0.082
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.081
Insm1 insulinoma-associated 1 0.080
Fas Fas (TNF receptor superfamily member 6) 0.080
Ebf3 early B-cell factor 3 0.079
Ptch1 patched homolog 1 0.079
Emx2 empty spiracles homolog 2 (Drosophila) 0.078
Wbp7 WW domain binding protein 7 0.074
Smo smoothened homolog (Drosophila) 0.073
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.071
Cic capicua homolog (Drosophila) 0.069
Nos3 nitric oxide synthase 3, endothelial cell 0.066
Wiz widely-interspaced zinc finger motifs 0.064
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.064
Apoe apolipoprotein E 0.062
Lef1 lymphoid enhancer binding factor 1 0.062
Polr2a polymerase (RNA) II (DNA directed) polypeptide A 0.062
Wnt3 wingless-related MMTV integration site 3 0.062
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.060
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.059
Sema5b sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B 0.057
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism