The network for 'tube development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

tube development

The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.

Caenorhabditis elegans
Name Description Probability Func Analog Organism
pha-4 Protein PHA-4 0.999
his-31 Protein HIS-31 0.989
his-45 Protein HIS-45 0.984
his-5 Protein HIS-5 0.974
his-48 Protein HIS-48 0.951
his-64 Protein HIS-64 0.950
egl-18 Protein EGL-18 0.913
his-61 Protein HIS-61 0.909
hlh-1 Protein HLH-1 0.904
elt-6 Protein ELT-6 0.886
his-62 Protein HIS-62 0.865
his-47 Protein HIS-47 0.863
his-1 Protein HIS-1 0.861
his-46 Protein HIS-46 0.828
his-30 Protein HIS-30 0.816
atn-1 Protein ATN-1 0.815
his-59 Protein HIS-59 0.801
his-29 Protein HIS-29 0.795
his-16 Protein HIS-16 0.775
egl-46 Protein EGL-46 0.768
zip-7 Protein ZIP-7 0.766
his-9 Protein HIS-9 0.763
his-42 Protein HIS-42 0.761
his-2 Protein HIS-2 0.752
cam-1 Protein CAM-1 0.749
hlh-2 Protein HLH-2 0.740
his-52 Protein HIS-52 0.717
bar-1 Protein BAR-1 0.671
act-4 Protein ACT-4 0.634
his-50 Protein HIS-50 0.634
hnd-1 Protein HND-1 0.624
fkh-2 Protein FKH-2 0.613
mig-5 Protein MIG-5 0.579
his-4 Protein HIS-4 0.497
soc-2 Protein SOC-2 0.484
his-32 Protein HIS-32 0.483
his-39 Protein HIS-39 0.465
hda-1 Protein HDA-1 0.463
lag-1 Protein LAG-1 0.456
F36D4.5 Protein F36D4.5 0.456
pal-1 Protein PAL-1 0.451
sax-3 Protein SAX-3 0.444
pop-1 Protein POP-1 0.419
his-38 Protein HIS-38 0.416
his-14 Protein HIS-14 0.400
his-3 Protein HIS-3 0.399
crt-1 Protein CRT-1 0.398
egl-27 Protein EGL-27 0.398
unc-62 Protein UNC-62 0.398
sma-6 Protein SMA-6 0.391
unc-98 Protein UNC-98 0.390
che-13 Protein CHE-13 0.385
his-63 Protein HIS-63 0.378
nhr-67 Protein NHR-67 0.375
mls-2 Protein MLS-2 0.372
sem-4 Protein SEM-4 0.370
mab-5 Protein MAB-5 0.361
mep-1 Protein MEP-1 0.360
unc-5 Protein UNC-5 0.354
hmg-1.2 Protein HMG-1.2 0.353
unc-42 Protein UNC-42 0.347
syg-2 Protein SYG-2 0.343
lin-12 Protein LIN-12 0.333
Y44E3A.6 Protein Y44E3A.6 0.327
nhr-25 Protein NHR-25 0.319
deb-1 Protein DEB-1 0.313
irx-1 Protein IRX-1 0.301
flh-2 Protein FLH-2 0.300
emb-9 Protein EMB-9 0.290
nrde-2 Protein NRDE-2 0.287
tbx-9 Protein TBX-9 0.276
rig-6 Protein RIG-6 0.270
sem-5 Protein SEM-5 0.270
ldb-1 Protein LDB-1 0.266
C35D10.7 Protein C35D10.7 0.263
pes-1 Protein PES-1 0.261
unc-37 Protein UNC-37 0.256
his-6 Protein HIS-6 0.250
patr-1 Protein PATR-1 0.246
CELE_F54D5.5 Protein F54D5.5 0.242
hbl-1 Protein HBL-1 0.240
his-49 Protein HIS-49 0.233
vab-3 Protein VAB-3 0.233
R10E12.2 Protein R10E12.2 0.228
ncam-1 Protein NCAM-1 0.228
ncx-3 Protein NCX-3 0.220
vab-1 Protein VAB-1 0.217
zyg-8 Protein ZYG-8 0.217
ceh-20 Protein CEH-20 0.213
his-43 Protein HIS-43 0.213
osm-5 Protein OSM-5 0.212
rsp-1 Protein RSP-1 0.206
epi-1 Protein EPI-1 0.203
pry-1 Protein PRY-1 0.203
lin-3 Protein LIN-3 0.203
ifb-2 Protein IFB-2 0.200
xpo-1 Protein XPO-1 0.198
syd-2 Protein SYD-2 0.195
wrm-1 Protein WRM-1 0.193
osm-3 Protein OSM-3 0.193
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
arm armadillo 1.000
Egfr Epidermal growth factor receptor 1.000
shn schnurri 0.999
tkv thickveins 0.999
ci cubitus interruptus 0.998
Mad Mothers against dpp 0.998
brk brinker 0.997
emc extra macrochaetae 0.997
ato atonal 0.997
Rac1 CG2248 gene product from transcript CG2248-RA 0.996
stumps CG31317 gene product from transcript CG31317-RC 0.993
mew multiple edematous wings 0.992
mys myospheroid 0.992
l(2)gl lethal (2) giant larvae 0.990
LanB1 CG7123 gene product from transcript CG7123-RA 0.990
ed echinoid 0.989
sna snail 0.989
ttv tout-velu 0.988
zfh1 Zn finger homeodomain 1 0.988
Ras85D Ras oncogene at 85D 0.987
msn misshapen 0.987
Akt1 CG4006 gene product from transcript CG4006-RA 0.986
puc puckered 0.986
crb crumbs 0.986
pnt pointed 0.985
tgo tango 0.985
slp1 sloppy paired 1 0.984
LanB2 Laminin B2 0.982
EcR Ecdysone receptor 0.981
retn retained 0.981
N Notch 0.980
rib ribbon 0.980
wg wingless 0.977
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.976
wb wing blister 0.976
G-oalpha47A G protein oalpha 47A 0.974
srp serpent 0.973
shg shotgun 0.972
htl heartless 0.971
twi twist 0.971
da daughterless 0.969
btl breathless 0.969
ftz-f1 ftz transcription factor 1 0.966
fz2 frizzled 2 0.964
argos CG4531 gene product from transcript CG4531-RA 0.960
Doc2 Dorsocross2 0.960
cora coracle 0.959
kni knirps 0.959
hep hemipterous 0.956
CycA Cyclin A 0.954
lin lines 0.952
E(spl) Enhancer of split 0.952
CtBP C-terminal Binding Protein 0.952
nej nejire 0.951
Src42A Src oncogene at 42A 0.950
Mrtf Myocardin-related transcription factor 0.950
slmb supernumerary limbs 0.950
frc fringe connection 0.947
Gap1 GTPase-activating protein 1 0.946
if inflated 0.945
tin tinman 0.944
rl rolled 0.942
hkb huckebein 0.941
baz bazooka 0.941
raw CG12437 gene product from transcript CG12437-RB 0.936
drk downstream of receptor kinase 0.932
drpr draper 0.929
LanA Laminin A 0.928
sns sticks and stones 0.923
scb scab 0.922
pan pangolin 0.916
fas faint sausage 0.915
vvl ventral veins lacking 0.914
eya eyes absent 0.906
ush u-shaped 0.905
Six4 CG3871 gene product from transcript CG3871-RA 0.897
mam mastermind 0.888
Pkn Protein kinase related to protein kinase N 0.886
robo roundabout 0.879
rols rolling pebbles 0.876
gbb glass bottom boat 0.875
rap retina aberrant in pattern 0.872
lola longitudinals lacking 0.867
TSG101 tumor suppressor protein 101 0.867
ftz fushi tarazu 0.863
opa odd paired 0.860
14-3-3zeta CG17870 gene product from transcript CG17870-RB 0.853
jing CG9397 gene product from transcript CG9397-RI 0.852
mid midline 0.849
TBPH CG10327 gene product from transcript CG10327-RC 0.847
how held out wings 0.844
pyr pyramus 0.838
luna CG33473 gene product from transcript CG33473-RB 0.838
Syx1A Syntaxin 1A 0.837
zip zipper 0.835
bib big brain 0.834
ptc patched 0.826
Khc Kinesin heavy chain 0.826
HLHmdelta E(spl) region transcript mdelta 0.822
csw corkscrew 0.820
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Homo sapiens
Name Description Probability Func Analog Organism
RB1 retinoblastoma 1 1.000
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.000
EGFR epidermal growth factor receptor 1.000
ESR1 estrogen receptor 1 0.999
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.999
TP53 tumor protein p53 0.996
VEGFA vascular endothelial growth factor A 0.995
FLNA filamin A, alpha 0.995
CAV1 caveolin 1, caveolae protein, 22kDa 0.993
YAP1 Yes-associated protein 1 0.992
CREBBP CREB binding protein 0.986
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.986
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.984
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.984
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.983
SP1 Sp1 transcription factor 0.983
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.980
MYH9 myosin, heavy chain 9, non-muscle 0.979
RXRA retinoid X receptor, alpha 0.979
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.978
NRP1 neuropilin 1 0.974
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.974
SMAD2 SMAD family member 2 0.970
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.970
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.969
THBS1 thrombospondin 1 0.966
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.964
SMAD3 SMAD family member 3 0.962
GSK3B glycogen synthase kinase 3 beta 0.962
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.961
FN1 fibronectin 1 0.957
ZNF512B zinc finger protein 512B 0.955
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.947
JAG1 jagged 1 0.946
PRKCZ protein kinase C, zeta 0.938
BCL2 B-cell CLL/lymphoma 2 0.936
MAPK8 mitogen-activated protein kinase 8 0.936
FGFR1 fibroblast growth factor receptor 1 0.924
NCOR2 nuclear receptor corepressor 2 0.923
PAX3 paired box 3 0.920
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.914
COL1A1 collagen, type I, alpha 1 0.910
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.905
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.904
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.902
RUNX1 runt-related transcription factor 1 0.902
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.892
RARA retinoic acid receptor, alpha 0.887
SMAD7 SMAD family member 7 0.887
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.880
SOX2 SRY (sex determining region Y)-box 2 0.875
FGFR2 fibroblast growth factor receptor 2 0.870
FOXA2 forkhead box A2 0.864
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.863
BECN1 beclin 1, autophagy related 0.859
FHL2 four and a half LIM domains 2 0.855
FGF1 fibroblast growth factor 1 (acidic) 0.854
PLEC plectin 0.851
APC adenomatous polyposis coli 0.848
EP300 E1A binding protein p300 0.847
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.843
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.840
MET met proto-oncogene (hepatocyte growth factor receptor) 0.839
YY1 YY1 transcription factor 0.832
COL2A1 collagen, type II, alpha 1 0.819
IQGAP1 IQ motif containing GTPase activating protein 1 0.818
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.817
PKM2 pyruvate kinase, muscle 0.815
STK3 serine/threonine kinase 3 0.814
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.814
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.811
COL6A1 collagen, type VI, alpha 1 0.799
NCOA1 nuclear receptor coactivator 1 0.796
KRT8 keratin 8 0.782
EGR1 early growth response 1 0.764
ACTN1 actinin, alpha 1 0.749
PXN paxillin 0.743
MAPK14 mitogen-activated protein kinase 14 0.743
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.733
COL4A1 collagen, type IV, alpha 1 0.721
ATF2 activating transcription factor 2 0.717
NCOA3 nuclear receptor coactivator 3 0.712
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.704
COL5A1 collagen, type V, alpha 1 0.700
NCOR1 nuclear receptor corepressor 1 0.698
MYOD1 myogenic differentiation 1 0.698
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.696
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.693
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.691
TNC tenascin C 0.682
CDC37 cell division cycle 37 homolog (S. cerevisiae) 0.680
SOX1 SRY (sex determining region Y)-box 1 0.676
RAD21 RAD21 homolog (S. pombe) 0.674
FOXF1 forkhead box F1 0.673
TBX2 T-box 2 0.669
AXIN1 axin 1 0.666
NOTCH3 notch 3 0.664
INSR insulin receptor 0.662
DDX3X DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked 0.651
COL3A1 collagen, type III, alpha 1 0.650
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Fkbp1a FK506 binding protein 1a 0.565
Fgfr1 Fibroblast growth factor receptor 1 0.463
Ednra endothelin receptor type A 0.458
Pdcl phosducin-like 0.392
Cmklr1 chemokine-like receptor 1 0.392
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.365
Fstl1 follistatin-like 1 0.340
Jak1 Janus kinase 1 0.320
Atf3 activating transcription factor 3 0.311
Tgfbr2 transforming growth factor, beta receptor II 0.307
Col12a1 collagen, type XII, alpha 1 0.306
Rara retinoic acid receptor, alpha 0.294
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.293
Unc5b unc-5 homolog B (C. elegans) 0.291
Loxl1 lysyl oxidase-like 1 0.282
Postn periostin, osteoblast specific factor 0.279
Slit3 slit homolog 3 (Drosophila) 0.257
Ncr1 natural cytotoxicity triggering receptor 1 0.217
Smcp sperm mitochondria-associated cysteine-rich protein 0.213
Lgals7 lectin, galactoside-binding, soluble, 7 0.208
Col1a1 collagen, type I, alpha 1 0.206
Bgn biglycan 0.201
Cyp51 cytochrome P450, family 51 0.195
Foxd3 forkhead box D3 0.194
Hand2 heart and neural crest derivatives expressed 2 0.193
Dchs1 dachsous 1 (Drosophila) 0.190
Fdps farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) 0.186
Jun Jun oncogene 0.184
Phox2a paired-like homeobox 2a 0.182
Sc4mol sterol-C4-methyl oxidase-like 0.182
Prrx1 paired related homeobox 1 0.179
Smad7 SMAD family member 7 0.177
Oxtr oxytocin receptor 0.177
Casp2 caspase 2 0.177
Ube2d4 ubiquitin-conjugating enzyme E2D 4 0.175
Hoxb7 homeo box B7 0.172
Sparc secreted protein, acidic, cysteine-rich (osteonectin) 0.171
Nfia nuclear factor I/A 0.168
Id1 inhibitor of DNA binding 1 0.168
Ier2 immediate early response 2 0.167
Plagl1 pleiomorphic adenoma gene-like 1 0.163
Sox17 SRY (sex determining region Y)-box 17 0.162
Pip prolactin induced protein 0.162
Gja5 gap junction protein, alpha 5 0.162
Pfn1 profilin 1 0.157
Rhoa ras homolog gene family, member A 0.156
Manea mannosidase, endo-alpha 0.156
Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase 0.154
Foxe1 forkhead box E1 (thyroid transcription factor 2) 0.151
Vcan versican 0.149
Stxbp2 syntaxin binding protein 2 0.148
Klf2 Kruppel-like factor 2 (lung) 0.146
Csn1s2a casein alpha s2-like A 0.145
Lepr leptin receptor 0.144
Col8a1 collagen, type VIII, alpha 1 0.144
Arnt aryl hydrocarbon receptor nuclear translocator 0.144
Efnb1 ephrin B1 0.141
Sirpa signal-regulatory protein alpha 0.137
Cux1 cut-like homeobox 1 0.136
Ephx1 epoxide hydrolase 1, microsomal 0.135
Sval1 seminal vesicle antigen-like 1 0.134
Adam17 ADAM metallopeptidase domain 17 0.134
Kcns1 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 0.133
Acta2 smooth muscle alpha-actin 0.133
Il1r1 interleukin 1 receptor, type I 0.133
Igfbp5 insulin-like growth factor binding protein 5 0.133
Sqle squalene epoxidase 0.132
Akt2 v-akt murine thymoma viral oncogene homolog 2 0.132
Bcl2 B-cell CLL/lymphoma 2 0.130
Agtr1a angiotensin II receptor, type 1a 0.127
Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 0.125
Il8rb interleukin 8 receptor, beta 0.124
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.122
Ctsj cathepsin J 0.121
Anxa4 annexin A4 0.121
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.121
Twist2 twist homolog 2 (Drosophila) 0.120
Casp1 caspase 1 0.119
Fgfr2 fibroblast growth factor receptor 2 0.117
Dusp1 dual specificity phosphatase 1 0.116
Idi1 isopentenyl-diphosphate delta isomerase 1 0.115
Boc biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein 0.115
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.112
Kl Klotho 0.110
Fdft1 farnesyl diphosphate farnesyl transferase 1 0.109
Tcfe2a transcription factor E2a 0.109
Grin2a glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.108
Sdc3 syndecan 3 0.108
Agtr1b angiotensin II receptor, type 1b 0.107
Gdf10 growth differentiation factor 10 0.107
Nr1h4 nuclear receptor subfamily 1, group H, member 4 0.106
Svs1 seminal vesicle secretory protein 1 0.104
Dab2 disabled homolog 2 (Drosophila) 0.104
Bmp3 bone morphogenetic protein 3 0.104
Foxm1 forkhead box M1 0.103
Hoxc4 homeo box C4 0.103
Pax8 paired box 8 0.103
Selenbp1 selenium binding protein 1 0.102
Rps6ka1 ribosomal protein S6 kinase polypeptide 1 0.102
Obp2b odorant binding protein 2B 0.101
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism