The network for 'ribosomal large subunit biogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

ribosomal large subunit biogenesis

A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
TIF6 Tif6p 1.000
SSF1 Ssf1p 0.999
CIC1 Cic1p 0.998
MAK21 Mak21p 0.997
DBP10 Dbp10p 0.996
NOG1 Nog1p 0.996
RLP7 Rlp7p 0.996
NOP7 Nop7p 0.993
NIP7 Nip7p 0.988
DRS1 Drs1p 0.987
NOP4 Nop4p 0.985
PUF6 Puf6p 0.983
NOC2 Noc2p 0.983
RIX1 Rix1p 0.981
NOP12 Nop12p 0.977
RPF2 Rpf2p 0.972
ARX1 Arx1p 0.971
BRX1 Brx1p 0.953
NSA1 Nsa1p 0.950
NOP2 Nop2p 0.945
NOC3 Noc3p 0.925
RPF1 Rpf1p 0.923
RPL8B Rpl8bp 0.922
HAS1 Has1p 0.920
RPL5 Rpl5p 0.882
YTM1 Ytm1p 0.876
RRP5 Rrp5p 0.874
MRT4 Mrt4p 0.874
BUD20 Bud20p 0.872
RRP15 Rrp15p 0.862
NOP15 Nop15p 0.841
NSA2 Nsa2p 0.836
RPL3 Rpl3p 0.834
MDN1 Mdn1p 0.820
SPB4 Spb4p 0.810
SPB1 Spb1p 0.808
ERB1 Erb1p 0.802
RPL36B Rpl36bp 0.787
RLP24 Rlp24p 0.751
MAK11 Mak11p 0.744
IPI3 Ipi3p 0.741
DBP3 Dbp3p 0.737
RIX7 Rix7p 0.732
EBP2 Ebp2p 0.730
SDA1 Sda1p 0.724
NUG1 Nug1p 0.710
NOG2 Nog2p 0.697
NOP13 Nop13p 0.692
RPL20A Rpl20ap 0.655
RPL8A Rpl8ap 0.655
RSA4 Rsa4p 0.618
RPL25 Rpl25p 0.610
DBP9 Dbp9p 0.565
RPL1B Rpl1bp 0.530
CBF5 Cbf5p 0.527
LTV1 Ltv1p 0.508
RPL28 Rpl28p 0.463
YNL260C hypothetical protein 0.457
MAK5 Mak5p 0.432
URB2 Urb2p 0.430
NOP16 Nop16p 0.427
RPL7A Rpl7ap 0.425
PWP1 Pwp1p 0.411
RRP17 Rrp17p 0.408
NMD3 Nmd3p 0.379
LAS1 Las1p 0.359
RPL13A Rpl13ap 0.352
RNT1 Rnt1p 0.350
RRS1 Rrs1p 0.349
RPL19A Rpl19ap 0.348
RPL16A Rpl16ap 0.348
RRP1 Rrp1p 0.347
NOP8 Nop8p 0.337
RRP14 Rrp14p 0.320
URB1 Urb1p 0.306
RPL30 Rpl30p 0.282
RSA1 Rsa1p 0.279
ALB1 Alb1p 0.275
GAR1 Gar1p 0.270
RPL31A Rpl31ap 0.266
FYV7 Fyv7p 0.241
FPR4 Fpr4p 0.235
GUS1 Gus1p 0.222
PRS3 Prs3p 0.219
RPL10 Rpl10p 0.216
RPL17A Rpl17ap 0.215
YEF3 Yef3p 0.206
ARB1 Arb1p 0.206
FUN12 Fun12p 0.203
GDS1 Gds1p 0.195
RPS14B Rps14bp 0.192
RPL1A Rpl1ap 0.191
LOC1 Loc1p 0.189
RMT2 Rmt2p 0.178
DBP2 Dbp2p 0.177
ATC1 Atc1p 0.175
RRP36 Rrp36p 0.173
SLX9 Slx9p 0.168
TEF1 Tef1p 0.166
BUD22 Bud22p 0.166
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
CG8939 CG8939 gene product from transcript CG8939-RA 0.964
CG1785 CG1785 gene product from transcript CG1785-RA 0.899
eIF-3p40 Eukaryotic initiation factor 3 p40 subunit 0.882
CG30349 CG30349 gene product from transcript CG30349-RA 0.819
Int6 Int6 homologue 0.777
Nap1 Nucleosome assembly protein 1 0.765
RpL35A Ribosomal protein L35A 0.744
CG4364 CG4364 gene product from transcript CG4364-RA 0.673
Ip259 Intronic Protein 259 0.613
RpL17 Ribosomal protein L17 0.609
rept reptin 0.608
bys by S6 0.599
RpL3 Ribosomal protein L3 0.577
Rs1 CG2173 gene product from transcript CG2173-RA 0.555
RpS4 Ribosomal protein S4 0.549
RpI135 RNA polymerase I 135kD subunit 0.525
Ef2b Elongation factor 2b 0.525
RpL23A Ribosomal protein L23A 0.504
CG9253 CG9253 gene product from transcript CG9253-RA 0.471
CG9246 CG9246 gene product from transcript CG9246-RA 0.458
CG8801 CG8801 gene product from transcript CG8801-RA 0.444
CG1542 CG1542 gene product from transcript CG1542-RA 0.432
CG7686 CG7686 gene product from transcript CG7686-RA 0.430
RpL26 Ribosomal protein L26 0.430
RpL7 Ribosomal protein L7 0.419
Sas10 CG4202 gene product from transcript CG4202-RA 0.406
pit pitchoune 0.406
CG10286 CG10286 gene product from transcript CG10286-RA 0.399
RpS8 Ribosomal protein S8 0.387
l(1)G0020 lethal (1) G0020 0.375
Art3 Arginine methyltransferase 3 0.370
RpS26 Ribosomal protein S26 0.349
sop string of pearls 0.342
CG6724 CG6724 gene product from transcript CG6724-RA 0.329
CG2691 CG2691 gene product from transcript CG2691-RA 0.329
l(2)k09022 lethal (2) k09022 0.327
RpL37a Ribosomal protein L37a 0.321
RpL11 Ribosomal protein L11 0.308
CG11583 CG11583 gene product from transcript CG11583-RA 0.307
nop5 CG10206 gene product from transcript CG10206-RA 0.287
CG3335 CG3335 gene product from transcript CG3335-RA 0.287
CG1234 CG1234 gene product from transcript CG1234-RA 0.283
CG12301 CG12301 gene product from transcript CG12301-RA 0.282
CG7993 CG7993 gene product from transcript CG7993-RA 0.281
RpS5a Ribosomal protein S5a 0.278
CG12325 CG12325 gene product from transcript CG12325-RA 0.277
l(3)07882 lethal (3) 07882 0.268
RpL13A Ribosomal protein L13A 0.267
l(2)09851 lethal (2) 09851 0.263
CG1671 CG1671 gene product from transcript CG1671-RA 0.249
sta stubarista 0.249
CG18178 CG18178 gene product from transcript CG18178-RA 0.248
Mat89Ba Maternal transcript 89Ba 0.242
Csl4 CG6249 gene product from transcript CG6249-RA 0.240
Nop56 CG13849 gene product from transcript CG13849-RA 0.239
CG3756 CG3756 gene product from transcript CG3756-RA 0.235
Nmd3 Nonsense-mediated mRNA 3 0.231
Tango7 Transport and Golgi organization 7 0.227
CG9630 CG9630 gene product from transcript CG9630-RA 0.227
RpL18 Ribosomal protein L18 0.226
RpL27 Ribosomal protein L27 0.223
CG9769 CG9769 gene product from transcript CG9769-RA 0.212
RpS6 Ribosomal protein S6 0.211
Dis3 CG6413 gene product from transcript CG6413-RA 0.199
RpL18A Ribosomal protein L18A 0.196
Mys45A Mystery 45A 0.194
RpL10Ab Ribosomal protein L10Ab 0.190
CG7845 CG7845 gene product from transcript CG7845-RB 0.189
CG8064 CG8064 gene product from transcript CG8064-RA 0.189
CG6937 CG6937 gene product from transcript CG6937-RA 0.180
CG2875 CG2875 gene product from transcript CG2875-RB 0.178
CG9107 CG9107 gene product from transcript CG9107-RA 0.176
RpS15 Ribosomal protein S15 0.175
Rack1 Receptor of activated protein kinase C 1 0.173
RpL7A Ribosomal protein L7A 0.165
CG5018 CG5018 gene product from transcript CG5018-RA 0.158
CG11180 CG11180 gene product from transcript CG11180-RA 0.150
RpL4 Ribosomal protein L4 0.148
ssp sunspot 0.144
RpS7 Ribosomal protein S7 0.141
AGO1 Argonaute-1 0.141
CG5033 CG5033 gene product from transcript CG5033-RA 0.141
RpS16 Ribosomal protein S16 0.140
RpL22 Ribosomal protein L22 0.137
CG6712 CG6712 gene product from transcript CG6712-RA 0.130
CG9890 CG9890 gene product from transcript CG9890-RA 0.127
ns1 nucleostemin 1 0.126
CG10565 CG10565 gene product from transcript CG10565-RA 0.126
RpLP0 Ribosomal protein LP0 0.125
RpL13 Ribosomal protein L13 0.118
Trip1 CG8882 gene product from transcript CG8882-RA 0.117
CG4554 CG4554 gene product from transcript CG4554-RA 0.113
RpL24-like Ribosomal protein L24-like 0.111
Ef1beta Elongation factor 1 beta 0.111
NHP2 CG5258 gene product from transcript CG5258-RA 0.107
CG2260 CG2260 gene product from transcript CG2260-RA 0.104
CG5642 CG5642 gene product from transcript CG5642-RA 0.104
CG4038 CG4038 gene product from transcript CG4038-RA 0.102
CG9799 CG9799 gene product from transcript CG9799-RA 0.099
RpS13 Ribosomal protein S13 0.095
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Homo sapiens
Name Description Probability Func Analog Organism
LYAR Ly1 antibody reactive homolog (mouse) 0.990
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 0.957
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.893
BOP1 block of proliferation 1 0.694
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 0.685
GTPBP4 GTP binding protein 4 0.669
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 0.665
RPL17 ribosomal protein L17 0.593
PELP1 proline, glutamate and leucine rich protein 1 0.450
MYBBP1A MYB binding protein (P160) 1a 0.369
PUS1 pseudouridylate synthase 1 0.348
RBM28 RNA binding motif protein 28 0.300
PES1 pescadillo homolog 1, containing BRCT domain (zebrafish) 0.296
RPL27A ribosomal protein L27a 0.274
RPL3 ribosomal protein L3 0.263
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.236
NOP56 NOP56 ribonucleoprotein homolog (yeast) 0.195
BTF3 basic transcription factor 3 0.186
RPL4 ribosomal protein L4 0.185
RPL18 ribosomal protein L18 0.180
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 0.178
RPL7A ribosomal protein L7a 0.175
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 0.169
MAGOH mago-nashi homolog, proliferation-associated (Drosophila) 0.169
RPL31 ribosomal protein L31 0.158
DKC1 dyskeratosis congenita 1, dyskerin 0.155
EBNA1BP2 EBNA1 binding protein 2 0.146
ZC3H15 zinc finger CCCH-type containing 15 0.141
DDX21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 0.132
RPL29 ribosomal protein L29 0.128
RPF2 ribosome production factor 2 homolog (S. cerevisiae) 0.127
BRIX1 BRX1, biogenesis of ribosomes, homolog (S. cerevisiae) 0.124
RPL6 ribosomal protein L6 0.119
EEF1B2 eukaryotic translation elongation factor 1 beta 2 0.108
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) 0.103
NOL11 nucleolar protein 11 0.097
RPL36AL ribosomal protein L36a-like 0.097
RPL14 ribosomal protein L14 0.094
RPS6 ribosomal protein S6 0.087
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae) 0.086
MKI67IP MKI67 (FHA domain) interacting nucleolar phosphoprotein 0.086
RPL11 ribosomal protein L11 0.085
BMS1 BMS1 homolog, ribosome assembly protein (yeast) 0.085
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 0.083
WDR12 WD repeat domain 12 0.077
RPL8 ribosomal protein L8 0.075
CCDC59 coiled-coil domain containing 59 0.071
FTSJ3 FtsJ homolog 3 (E. coli) 0.064
RPL19 ribosomal protein L19 0.063
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) 0.060
ATAD3A ATPase family, AAA domain containing 3A 0.056
RPS7 ribosomal protein S7 0.056
C14orf166 chromosome 14 open reading frame 166 0.052
WDR43 WD repeat domain 43 0.049
RPL24 ribosomal protein L24 0.049
RPL5 ribosomal protein L5 0.048
RPL13 ribosomal protein L13 0.045
RPS10 ribosomal protein S10 0.045
RPL22 ribosomal protein L22 0.043
RPL23A ribosomal protein L23a 0.043
RPL10 ribosomal protein L10 0.042
RPL15 ribosomal protein L15 0.042
C8orf33 chromosome 8 open reading frame 33 0.042
PTRH2 peptidyl-tRNA hydrolase 2 0.041
NACA nascent polypeptide-associated complex alpha subunit 0.040
LAS1L LAS1-like (S. cerevisiae) 0.040
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.040
EEF2 eukaryotic translation elongation factor 2 0.036
BCAS2 breast carcinoma amplified sequence 2 0.036
DHX37 DEAH (Asp-Glu-Ala-His) box polypeptide 37 0.036
NAT10 N-acetyltransferase 10 (GCN5-related) 0.035
RPP40 ribonuclease P/MRP 40kDa subunit 0.034
NCL nucleolin 0.034
POLR1C polymerase (RNA) I polypeptide C, 30kDa 0.034
NOP58 NOP58 ribonucleoprotein homolog (yeast) 0.033
RPLP0 ribosomal protein, large, P0 0.032
WDR74 WD repeat domain 74 0.032
NOL7 nucleolar protein 7, 27kDa 0.031
PAK1IP1 PAK1 interacting protein 1 0.031
WDR5 WD repeat domain 5 0.030
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 0.029
POLR1E polymerase (RNA) I polypeptide E, 53kDa 0.028
NOL8 nucleolar protein 8 0.028
RPL10A ribosomal protein L10a 0.027
TRMT1 TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae) 0.027
WDR3 WD repeat domain 3 0.026
TEX10 testis expressed 10 0.026
CIRH1A cirrhosis, autosomal recessive 1A (cirhin) 0.026
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) 0.026
SUGP1 SURP and G patch domain containing 1 0.026
RPL37A ribosomal protein L37a 0.025
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa 0.025
WDR75 WD repeat domain 75 0.024
WDR46 WD repeat domain 46 0.023
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 0.023
RPL21 ribosomal protein L21 0.023
EIF3E eukaryotic translation initiation factor 3, subunit E 0.023
RPL9 ribosomal protein L9 0.022
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) 0.022
OSGEP O-sialoglycoprotein endopeptidase 0.021
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Mus musculus
Name Description Probability Func Analog Organism
Mybbp1a MYB binding protein (P160) 1a 0.506
Nop56 NOP56 ribonucleoprotein homolog (yeast) 0.236
Eed embryonic ectoderm development 0.231
Gnl3 guanine nucleotide binding protein-like 3 (nucleolar) 0.137
Wdr74 WD repeat domain 74 0.123
Wdr43 WD repeat domain 43 0.117
Gm10335 predicted gene 10335 0.075
Lsg1 large subunit GTPase 1 homolog (S. cerevisiae) 0.072
Rpl32 ribosomal protein L32 0.062
Rpl4 ribosomal protein L4 0.059
Per1 period homolog 1 (Drosophila) 0.042
Mak16 MAK16 homolog (S. cerevisiae) 0.039
Rpl23 ribosomal protein L23 0.037
Ltv1 LTV1 homolog (S. cerevisiae) 0.035
Naca nascent polypeptide-associated complex alpha polypeptide 0.032
Mki67ip Mki67 (FHA domain) interacting nucleolar phosphoprotein 0.032
Ftsj3 FtsJ homolog 3 (E. coli) 0.031
Rars arginyl-tRNA synthetase 0.026
D19Bwg1357e DNA segment, Chr 19, Brigham & Women's Genetics 1357 expressed 0.026
Rpl3 ribosomal protein L3 0.026
Nolc1 nucleolar and coiled-body phosphoprotein 1 0.024
Rpl7 ribosomal protein L7 0.023
Rrp12 ribosomal RNA processing 12 homolog (S. cerevisiae) 0.023
Utp20 UTP20, small subunit (SSU) processome component, homolog (yeast) 0.023
Ddx21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 0.022
Ppan peter pan homolog (Drosophila) 0.022
Gm10119 predicted gene 10119 0.022
LOC100044627 60S ribosomal protein L23-like 0.020
Grwd1 glutamate-rich WD repeat containing 1 0.020
Nop2 NOP2 nucleolar protein homolog (yeast) 0.020
Nop58 NOP58 ribonucleoprotein homolog (yeast) 0.020
Cct2 chaperonin containing Tcp1, subunit 2 (beta) 0.019
Rrp1b ribosomal RNA processing 1 homolog B (S. cerevisiae) 0.019
Ccdc86 coiled-coil domain containing 86 0.018
Gnl2 guanine nucleotide binding protein-like 2 (nucleolar) 0.018
Rpl36a ribosomal protein L36A 0.018
Rsl1d1 ribosomal L1 domain containing 1 0.016
Npm1 nucleophosmin 1 0.016
Rpl35 ribosomal protein L35 0.015
Rps24 ribosomal protein S24 0.015
Ddx10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 0.015
Farsb phenylalanyl-tRNA synthetase, beta subunit 0.015
Rpl26 ribosomal protein L26 0.015
Tsr1 TSR1, 20S rRNA accumulation, homolog (yeast) 0.015
Pwp1 PWP1 homolog (S. cerevisiae) 0.015
Rrp15 ribosomal RNA processing 15 homolog (S. cerevisiae) 0.013
Pwp2 PWP2 periodic tryptophan protein homolog (yeast) 0.013
Nol11 nucleolar protein 11 0.013
Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha 0.013
Rnaseh1 ribonuclease H1 0.013
Dimt1 DIM1 dimethyladenosine transferase 1-like (S. cerevisiae) 0.013
Polr1e polymerase (RNA) I polypeptide E 0.013
Tars threonyl-tRNA synthetase 0.013
Wdr46 WD repeat domain 46 0.012
Rpl5 ribosomal protein L5 0.012
Per2 period homolog 2 (Drosophila) 0.011
Eif3d eukaryotic translation initiation factor 3, subunit D 0.011
Nop14 NOP14 nucleolar protein homolog (yeast) 0.011
Aatf apoptosis antagonizing transcription factor 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism