The network for 'posttranslational protein targeting to membrane' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

posttranslational protein targeting to membrane

The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
SEC62 Sec62p 0.997
SBH1 Sbh1p 0.992
SEC63 Sec63p 0.991
SSS1 Sss1p 0.955
GET3 Get3p 0.938
SGT2 Sgt2p 0.887
MDY2 Mdy2p 0.834
SEC72 Sec72p 0.656
KAR2 Kar2p 0.488
SEC66 Sec66p 0.449
SEC61 Sec61p 0.425
ERP2 Erp2p 0.204
GET4 Get4p 0.144
WBP1 Wbp1p 0.118
OST4 Ost4p 0.098
GET1 Get1p 0.090
RPN14 Rpn14p 0.090
SBH2 Sbh2p 0.078
SIL1 Sil1p 0.073
CAF130 Caf130p 0.054
PRP45 Prp45p 0.046
SPC2 Spc2p 0.046
YLR264C-A hypothetical protein 0.043
SRD1 Srd1p 0.043
CUE4 Cue4p 0.042
OST2 Ost2p 0.040
RPL15B Rpl15bp 0.039
SWC7 Swc7p 0.038
SCJ1 Scj1p 0.037
LEU2 Leu2p 0.035
ARP10 Arp10p 0.032
YOL038C-A hypothetical protein 0.032
CUP1-1 Cup1-1p 0.031
SRP14 Srp14p 0.030
YLR042C hypothetical protein 0.030
UBC4 Ubc4p 0.029
TSC3 Tsc3p 0.028
SPC1 Spc1p 0.027
YLR162W hypothetical protein 0.027
MER1 Mer1p 0.027
ERO1 Ero1p 0.026
HXT3 Hxt3p 0.026
SAR1 Sar1p 0.026
YLR126C hypothetical protein 0.024
ATP6 Atp6p 0.022
EGD1 Egd1p 0.021
SPL2 Spl2p 0.021
LCL2 Lcl2p 0.021
YSY6 Ysy6p 0.021
ERD2 Erd2p 0.021
YAR068W hypothetical protein 0.021
YBR013C hypothetical protein 0.021
REE1 Ree1p 0.021
YPR157W hypothetical protein 0.020
ARG8 Arg8p 0.020
ZPS1 Zps1p 0.020
URA3 Ura3p 0.019
ARO10 Aro10p 0.019
UPS3 Ups3p 0.019
CPD1 Cpd1p 0.019
TYE7 Tye7p 0.019
HPF1 Hpf1p 0.019
NOP10 Nop10p 0.018
ERJ5 Erj5p 0.018
AUA1 Aua1p 0.018
BSC1 Bsc1p 0.018
FMT1 Fmt1p 0.018
YCH1 Ych1p 0.018
PMT1 Pmt1p 0.017
MF(ALPHA)2 Mf(alpha)2p 0.017
SEC20 Sec20p 0.017
YOL013W-A hypothetical protein 0.017
YDL085C-A hypothetical protein 0.017
YLR040C hypothetical protein 0.017
YDL012C hypothetical protein 0.017
YPL067C hypothetical protein 0.016
CRP1 Crp1p 0.016
FMN1 Fmn1p 0.016
RPL41A Rpl41ap 0.015
OPT2 Opt2p 0.015
YJL107C hypothetical protein 0.015
PTR2 Ptr2p 0.015
ALT2 Alt2p 0.015
GYL1 Gyl1p 0.014
LIF1 Lif1p 0.014
YER134C hypothetical protein 0.014
YPR159C-A hypothetical protein 0.014
YKR075C hypothetical protein 0.014
APA1 Apa1p 0.014
YIR035C hypothetical protein 0.014
DIC1 Dic1p 0.014
NRG2 Nrg2p 0.014
JEM1 Jem1p 0.014
YPR096C hypothetical protein 0.013
YAL064W hypothetical protein 0.013
PRS2 Prs2p 0.013
YAL037C-A hypothetical protein 0.013
YAR066W hypothetical protein 0.013
YOL014W hypothetical protein 0.013
SRP54 Srp54p 0.013
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
PTPN23 protein tyrosine phosphatase, non-receptor type 23 0.534
NACA nascent polypeptide-associated complex alpha subunit 0.134
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.106
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) 0.060
CANX calnexin 0.055
SURF4 surfeit 4 0.045
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.033
ATF7IP activating transcription factor 7 interacting protein 0.028
USP54 ubiquitin specific peptidase 54 0.022
CRELD2 cysteine-rich with EGF-like domains 2 0.015
SELS selenoprotein S 0.015
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.014
MANF mesencephalic astrocyte-derived neurotrophic factor 0.014
BAG6 BCL2-associated athanogene 6 0.014
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.012
TMEM173 transmembrane protein 173 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Hsp90b1 heat shock protein 90, beta (Grp94), member 1 0.355
P4hb prolyl 4-hydroxylase, beta polypeptide 0.181
Pdia3 protein disulfide isomerase associated 3 0.150
Surf4 surfeit gene 4 0.097
Bdnf brain derived neurotrophic factor 0.097
Dnajb11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.096
Prkcsh protein kinase C substrate 80K-H 0.094
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.076
Pdia6 protein disulfide isomerase associated 6 0.074
Canx calnexin 0.071
Tram1 translocating chain-associating membrane protein 1 0.068
Magt1 magnesium transporter 1 0.063
Mll5 myeloid/lymphoid or mixed-lineage leukemia 5 0.061
Gorasp2 golgi reassembly stacking protein 2 0.053
Nphp4 nephronophthisis 4 (juvenile) homolog (human) 0.048
Mll1 myeloid/lymphoid or mixed-lineage leukemia 1 0.046
Dnajc3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.045
Clasp1 CLIP associating protein 1 0.041
Spna2 spectrin alpha 2 0.036
Dnajc5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.036
Ssr3 signal sequence receptor, gamma 0.036
Arcn1 archain 1 0.036
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.035
Spnb2 spectrin beta 2 0.034
Uso1 USO1 homolog, vesicle docking protein (yeast) 0.034
Slc35b1 solute carrier family 35, member B1 0.031
Ssr1 signal sequence receptor, alpha 0.031
Lrrc59 leucine rich repeat containing 59 0.029
Creld2 cysteine-rich with EGF-like domains 2 0.028
Rrbp1 ribosome binding protein 1 0.028
Slc39a7 solute carrier family 39 (zinc transporter), member 7 0.027
Hspa5 heat shock protein 5 0.027
Sel1l sel-1 suppressor of lin-12-like (C. elegans) 0.027
Sec31a Sec31 homolog A (S. cerevisiae) 0.027
Sec63 SEC63-like (S. cerevisiae) 0.026
Ntf3 neurotrophin 3 0.023
Fastk Fas-activated serine/threonine kinase 0.023
D730040F13Rik RIKEN cDNA D730040F13 gene 0.022
Sec23b SEC23B (S. cerevisiae) 0.022
Hspa13 heat shock protein 70 family, member 13 0.022
Dync1h1 dynein cytoplasmic 1 heavy chain 1 0.022
Nrg1 neuregulin 1 0.022
Xbp1 X-box binding protein 1 0.020
Usp9x ubiquitin specific peptidase 9, X chromosome 0.019
Nomo1 nodal modulator 1 0.019
Txndc5 thioredoxin domain containing 5 0.019
Ttc3 tetratricopeptide repeat domain 3 0.019
Copg coatomer protein complex, subunit gamma 0.019
Kif1b kinesin family member 1B 0.019
Dctn1 dynactin 1 0.019
Invs inversin 0.018
Uba5 ubiquitin-like modifier activating enzyme 5 0.018
Lmna lamin A 0.018
Kpna3 karyopherin (importin) alpha 3 0.017
Calu calumenin 0.017
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.016
Usp48 ubiquitin specific peptidase 48 0.015
Ddost dolichyl-di-phosphooligosaccharide-protein glycotransferase 0.015
Rock2 Rho-associated coiled-coil containing protein kinase 2 0.015
Rpn2 ribophorin II 0.015
Tnrc6a trinucleotide repeat containing 6a 0.014
Hgs HGF-regulated tyrosine kinase substrate 0.014
Gnl1 guanine nucleotide binding protein-like 1 0.014
Cdc42bpa CDC42 binding protein kinase alpha 0.014
Dag1 dystroglycan 1 0.013
Dlg1 discs, large homolog 1 (Drosophila) 0.013
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.013
Ncln nicalin homolog (zebrafish) 0.013
Clasp2 CLIP associating protein 2 0.013
Epn1 epsin 1 0.013
Clptm1 cleft lip and palate associated transmembrane protein 1 0.012
Lamc1 laminin, gamma 1 0.012
Mapk8 mitogen-activated protein kinase 8 0.012
Git1 G protein-coupled receptor kinase-interactor 1 0.012
Glg1 golgi apparatus protein 1 0.012
Copb2 coatomer protein complex, subunit beta 2 (beta prime) 0.012
Cask calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.012
Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.012
Rpn1 ribophorin I 0.012
Lman1 lectin, mannose-binding, 1 0.012
Hyou1 hypoxia up-regulated 1 0.011
Hdlbp high density lipoprotein (HDL) binding protein 0.011
Mlec malectin 0.011
Ahi1 Abelson helper integration site 1 0.011
Dscaml1 Down syndrome cell adhesion molecule-like 1 0.011
ORF61 open reading frame 61 0.011
Spcs3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 0.011
Ubr4 ubiquitin protein ligase E3 component n-recognin 4 0.011
Sdf2l1 stromal cell-derived factor 2-like 1 0.011
Pex14 peroxisomal biogenesis factor 14 0.011
Atp9a ATPase, class II, type 9A 0.011
Lpp LIM domain containing preferred translocation partner in lipoma 0.011
Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase) 0.011
Csnk1g2 casein kinase 1, gamma 2 0.011
Erp44 endoplasmic reticulum protein 44 0.010
Mtap4 microtubule-associated protein 4 0.010
Pdia4 protein disulfide isomerase associated 4 0.010
Slc27a4 solute carrier family 27 (fatty acid transporter), member 4 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism