The network for 'negative regulation of actin filament depolymerization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of actin filament depolymerization

Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
MYO5 Myo5p 0.753
CAP2 Cap2p 0.425
ABP1 Abp1p 0.331
SRV2 Srv2p 0.141
ARC15 Arc15p 0.135
LAS17 Las17p 0.092
ARC40 Arc40p 0.062
AIP1 Aip1p 0.043
SLA2 Sla2p 0.037
ARC19 Arc19p 0.035
CAP1 Cap1p 0.034
SAC6 Sac6p 0.028
ARC35 Arc35p 0.027
ARP2 Arp2p 0.027
BBC1 Bbc1p 0.022
ARP3 Arp3p 0.021
LSB1 Lsb1p 0.019
SRD1 Srd1p 0.016
ARP10 Arp10p 0.015
BEM3 Bem3p 0.014
YOL038C-A hypothetical protein 0.014
YIL151C hypothetical protein 0.014
SCP1 Scp1p 0.013
LEU2 Leu2p 0.013
PAN1 Pan1p 0.012
YLR162W hypothetical protein 0.012
YFR016C hypothetical protein 0.012
YLR264C-A hypothetical protein 0.012
MER1 Mer1p 0.012
HXT3 Hxt3p 0.011
GYL1 Gyl1p 0.011
YPR1 Ypr1p 0.011
YBR013C hypothetical protein 0.010
YAR068W hypothetical protein 0.010
ATP6 Atp6p 0.010
CDC24 Cdc24p 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
up upheld 0.557
Arp66B Actin-related protein 66B 0.433
Cortactin CG3637 gene product from transcript CG3637-RA 0.392
cpb capping protein beta 0.362
cpa capping protein alpha 0.282
flr flare 0.277
Sop2 Suppressor of profilin 2 0.198
wupA wings up A 0.188
sqh spaghetti squash 0.152
sls sallimus 0.131
Prm Paramyosin 0.115
Zasp66 Z band alternatively spliced PDZ-motif protein 66 0.114
Act5C Actin 5C 0.099
Mlc2 Myosin light chain 2 0.091
Arp14D Actin-related protein 14D 0.072
CG8578 CG8578 gene product from transcript CG8578-RA 0.072
Act88F Actin 88F 0.061
Mlp84B Muscle LIM protein at 84B 0.058
nct nicastrin 0.057
CG11299 CG11299 gene product from transcript CG11299-RA 0.056
sec5 CG8843 gene product from transcript CG8843-RA 0.047
tmod tropomodulin 0.041
TER94 CG2331 gene product from transcript CG2331-RA 0.041
CanB2 Calcineurin B2 0.038
CG12007 CG12007 gene product from transcript CG12007-RA 0.037
Mlc1 Myosin alkali light chain 1 0.035
SH3PX1 CG6757 gene product from transcript CG6757-RA 0.033
CG8443 CG8443 gene product from transcript CG8443-RA 0.033
Lasp CG3849 gene product from transcript CG3849-RB 0.031
Tom34 Translocase of outer membrane 34 0.030
c11.1 CG12132 gene product from transcript CG12132-RA 0.027
CG6194 CG6194 gene product from transcript CG6194-RA 0.026
Gpo-1 Glycerophosphate oxidase-1 0.025
Stim Stromal interaction molecule 0.025
yata CG1973 gene product from transcript CG1973-RA 0.024
CG11210 CG11210 gene product from transcript CG11210-RA 0.020
sec6 CG5341 gene product from transcript CG5341-RA 0.020
Syb Synaptobrevin 0.020
Cf2 Chorion factor 2 0.019
Khc Kinesin heavy chain 0.019
Ilk Integrin linked kinase 0.018
Act57B Actin 57B 0.018
Mhc Myosin heavy chain 0.018
Marf Mitochondrial assembly regulatory factor 0.018
Vrp1 Verprolin 1 0.017
capt capulet 0.017
Zasp52 Z band alternatively spliced PDZ-motif protein 52 0.017
GstS1 Glutathione S transferase S1 0.016
fln flightin 0.015
par-6 CG5884 gene product from transcript CG5884-RA 0.015
Letm1 CG4589 gene product from transcript CG4589-RB 0.015
yki yorkie 0.014
pgant3 polypeptide GalNAc transferase 3 0.014
cindr CIN85 and CD2AP orthologue 0.014
sals sarcomere length short 0.014
CG5262 CG5262 gene product from transcript CG5262-RA 0.013
sds22 CG5851 gene product from transcript CG5851-RA 0.013
betaggt-I beta subunit of type I geranylgeranyl transferase 0.013
Rbsn-5 Rabenosyn-5 0.012
Actn alpha actinin 0.012
sima similar 0.012
aret arrest 0.012
Gpdh Glycerol 3 phosphate dehydrogenase 0.012
trc tricornered 0.012
flw flapwing 0.011
how held out wings 0.011
cher cheerio 0.011
Rab6 Rab-protein 6 0.011
CG3573 CG3573 gene product from transcript CG3573-RA 0.010
cib ciboulot 0.010
katanin-60 katanin 60 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
MYH9 myosin, heavy chain 9, non-muscle 0.471
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.331
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.313
CORO1C coronin, actin binding protein, 1C 0.308
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.249
ACTN1 actinin, alpha 1 0.124
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 0.123
FLNA filamin A, alpha 0.116
MYPN myopalladin 0.113
ZYX zyxin 0.083
TTN titin 0.081
TPM4 tropomyosin 4 0.074
SOS1 son of sevenless homolog 1 (Drosophila) 0.053
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.052
PDLIM7 PDZ and LIM domain 7 (enigma) 0.037
CAPZB capping protein (actin filament) muscle Z-line, beta 0.027
RIPK3 receptor-interacting serine-threonine kinase 3 0.026
ABI1 abl-interactor 1 0.025
CNN2 calponin 2 0.024
RFX1 regulatory factor X, 1 (influences HLA class II expression) 0.023
BAIAP2 BAI1-associated protein 2 0.019
GLIS2 GLIS family zinc finger 2 0.019
TRIM63 tripartite motif containing 63 0.017
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 0.014
MYL9 myosin, light chain 9, regulatory 0.012
WDR1 WD repeat domain 1 0.011
ARRB1 arrestin, beta 1 0.011
LASP1 LIM and SH3 protein 1 0.011
IQGAP1 IQ motif containing GTPase activating protein 1 0.011
SVIL supervillin 0.010
ACTA1 actin, alpha 1, skeletal muscle 0.010
GRB2 growth factor receptor-bound protein 2 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 1.000
Actr3 ARP3 actin-related protein 3 homolog (yeast) 0.999
Rac1 RAS-related C3 botulinum substrate 1 0.984
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.968
Wdr1 WD repeat domain 1 0.968
Capzb capping protein (actin filament) muscle Z-line, beta 0.920
Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.856
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.788
Cltc clathrin, heavy polypeptide (Hc) 0.749
Msn moesin 0.730
Rap1b RAS related protein 1b 0.688
Arpc4 actin related protein 2/3 complex, subunit 4 0.687
Csrp1 cysteine and glycine-rich protein 1 0.624
Rhoa ras homolog gene family, member A 0.614
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.609
Arhgap1 Rho GTPase activating protein 1 0.538
Gnb1 guanine nucleotide binding protein (G protein), beta 1 0.513
Mobkl1b MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.444
Lrrk2 leucine-rich repeat kinase 2 0.386
Stx7 syntaxin 7 0.384
Actr2 ARP2 actin-related protein 2 homolog (yeast) 0.360
Capza2 capping protein (actin filament) muscle Z-line, alpha 2 0.339
Sept7 septin 7 0.258
Ilk integrin linked kinase 0.256
Akt1 thymoma viral proto-oncogene 1 0.232
Slc25a24 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24 0.224
Tmod3 tropomodulin 3 0.219
Rod1 ROD1 regulator of differentiation 1 (S. pombe) 0.215
Pdlim5 PDZ and LIM domain 5 0.205
Arf1 ADP-ribosylation factor 1 0.188
Actg1 actin, gamma, cytoplasmic 1 0.187
Cttn cortactin 0.174
Tpm4 tropomyosin 4 0.164
Actb actin, beta 0.159
Capza1 capping protein (actin filament) muscle Z-line, alpha 1 0.149
Calm1 calmodulin 1 0.142
Tagln transgelin 0.136
Cnn2 calponin 2 0.119
Abi1 abl-interactor 1 0.119
Snx2 sorting nexin 2 0.115
Myl9 myosin, light polypeptide 9, regulatory 0.113
Bzw1 basic leucine zipper and W2 domains 1 0.110
Fam49b family with sequence similarity 49, member B 0.106
Bcl10 B-cell leukemia/lymphoma 10 0.106
Ugdh UDP-glucose dehydrogenase 0.100
Sdcbp syndecan binding protein 0.099
Arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.093
Lims1 LIM and senescent cell antigen-like domains 1 0.092
Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A 0.092
Vasp vasodilator-stimulated phosphoprotein 0.085
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.082
Cfl1 cofilin 1, non-muscle 0.080
Mtpn myotrophin 0.075
Actg2 actin, gamma 2, smooth muscle, enteric 0.066
Pfn1 profilin 1 0.062
Coro1c coronin, actin binding protein 1C 0.061
Dbnl drebrin-like 0.060
Actn4 actinin alpha 4 0.059
Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha 0.057
Vcl vinculin 0.051
Adam10 a disintegrin and metallopeptidase domain 10 0.049
Sri sorcin 0.048
Cdc42se1 CDC42 small effector 1 0.048
Actn1 actinin, alpha 1 0.048
Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.048
Cyfip1 cytoplasmic FMR1 interacting protein 1 0.045
Tpm1 tropomyosin 1, alpha 0.044
Arpc2 actin related protein 2/3 complex, subunit 2 0.041
Gnb2 guanine nucleotide binding protein (G protein), beta 2 0.040
Sept2 septin 2 0.038
Ap2a2 adaptor protein complex AP-2, alpha 2 subunit 0.035
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.034
Nsf N-ethylmaleimide sensitive fusion protein 0.033
Pitpna phosphatidylinositol transfer protein, alpha 0.032
Ptp4a2 protein tyrosine phosphatase 4a2 0.031
Flna filamin, alpha 0.031
Myh9 myosin, heavy polypeptide 9, non-muscle 0.031
Ugcg UDP-glucose ceramide glucosyltransferase 0.030
Rtn4 reticulon 4 0.030
Krt7 keratin 7 0.029
Hif1a hypoxia inducible factor 1, alpha subunit 0.029
Snx6 sorting nexin 6 0.028
Efnb2 ephrin B2 0.026
Rab18 RAB18, member RAS oncogene family 0.026
Ctnnd1 catenin (cadherin associated protein), delta 1 0.025
Spna2 spectrin alpha 2 0.024
Acot9 acyl-CoA thioesterase 9 0.024
Arf4 ADP-ribosylation factor 4 0.023
Kctd10 potassium channel tetramerisation domain containing 10 0.023
Epb4.1l2 erythrocyte protein band 4.1-like 2 0.023
Pgm1 phosphoglucomutase 1 0.023
Arl6ip5 ADP-ribosylation factor-like 6 interacting protein 5 0.022
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.022
Nptn neuroplastin 0.021
Cab39 calcium binding protein 39 0.020
Nipa2 non imprinted in Prader-Willi/Angelman syndrome 2 homolog (human) 0.020
Ppp1ca protein phosphatase 1, catalytic subunit, alpha isoform 0.020
Tmem167 transmembrane protein 167 0.020
Actc1 actin, alpha, cardiac muscle 1 0.020
Wsb2 WD repeat and SOCS box-containing 2 0.019
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.458
Tpm4 tropomyosin 4 0.452
Gnai3 guanine nucleotide binding protein (G protein), alpha inhibiting 3 0.136
Tagln transgelin 0.087
Efhd2 EF-hand domain family, member D2 0.060
Actr3 ARP3 actin-related protein 3 homolog (yeast) 0.058
Acta2 smooth muscle alpha-actin 0.054
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.053
Actg2 actin, gamma 2, smooth muscle, enteric 0.045
Arpc2 actin related protein 2/3 complex, subunit 2 0.042
Actg1 actin, gamma 1 0.041
Myl9 myosin, light chain 9, regulatory 0.033
Txnrd1 thioredoxin reductase 1 0.032
Rhoa ras homolog gene family, member A 0.028
Myo1c myosin IC 0.027
Iqgap1 IQ motif containing GTPase activating protein 1 0.026
Stk17b serine/threonine kinase 17b 0.026
Emp1 epithelial membrane protein 1 0.025
Myh11 myosin, heavy chain 11, smooth muscle 0.025
Rac1 ras-related C3 botulinum toxin substrate 1 0.021
Cd82 Cd82 molecule 0.019
Cast calpastatin 0.017
Arf6 ADP-ribosylation factor 6 0.016
Actb actin, beta 0.016
Cd44 Cd44 molecule 0.016
Msn moesin 0.015
Itgb1 integrin, beta 1 0.015
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.014
Sept11 septin 11 0.014
Sept2 septin 2 0.014
Lbr lamin B receptor 0.013
Clic4 chloride intracellular channel 4 0.013
Elovl5 ELOVL family member 5, elongation of long chain fatty acids (yeast) 0.013
Tuba1c tubulin, alpha 1C 0.013
Acta1 actin, alpha 1, skeletal muscle 0.012
Actn1 actinin, alpha 1 0.012
Fam129b family with sequence similarity 129, member B 0.012
Bnip2 BCL2/adenovirus E1B interacting protein 2 0.012
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.012
Capza1 capping protein (actin filament) muscle Z-line, alpha 1 0.011
Lman1 lectin, mannose-binding, 1 0.011
Myh9 myosin, heavy chain 9, non-muscle 0.011