The network for 'protein deacetylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein deacetylation

The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
SIN3 Sin3p 0.999
SNT1 Snt1p 0.986
HDA2 Hda2p 0.971
RCO1 Rco1p 0.955
HOS2 Hos2p 0.932
HOS4 Hos4p 0.910
SET3 Set3p 0.906
HDA1 Hda1p 0.845
HDA3 Hda3p 0.722
SIF2 Sif2p 0.618
HST1 Hst1p 0.603
CTI6 Cti6p 0.595
CPR1 Cpr1p 0.295
RPD3 Rpd3p 0.268
ZDS1 Zds1p 0.262
SDS3 Sds3p 0.205
WWM1 Wwm1p 0.191
PHO80 Pho80p 0.184
UME6 Ume6p 0.182
IRC8 Irc8p 0.170
CDC4 Cdc4p 0.146
YCL021W-A hypothetical protein 0.102
MMS1 Mms1p 0.101
PHO23 Pho23p 0.101
ECM30 Ecm30p 0.097
UME1 Ume1p 0.088
BDF1 Bdf1p 0.088
SET1 Set1p 0.085
SUM1 Sum1p 0.084
ARP4 Arp4p 0.070
ACP1 Acp1p 0.063
GZF3 Gzf3p 0.056
HHO1 Hho1p 0.055
YLR143W hypothetical protein 0.054
IZH4 Izh4p 0.051
CAM1 Cam1p 0.050
SET2 Set2p 0.050
DOT6 Dot6p 0.042
MSH3 Msh3p 0.042
PCL9 Pcl9p 0.038
AAT1 Aat1p 0.038
SRP54 Srp54p 0.037
ASH1 Ash1p 0.037
YBR138C hypothetical protein 0.034
SRD1 Srd1p 0.034
YLR264C-A hypothetical protein 0.033
SSK1 Ssk1p 0.033
YLR162W hypothetical protein 0.030
YJL181W hypothetical protein 0.030
YPL014W hypothetical protein 0.029
LEU2 Leu2p 0.028
UTP18 Utp18p 0.027
OPT2 Opt2p 0.026
RRN5 Rrn5p 0.026
YBL029W hypothetical protein 0.026
YOL038C-A hypothetical protein 0.026
YMR259C hypothetical protein 0.026
MMR1 Mmr1p 0.026
EST2 Est2p 0.026
AMD1 Amd1p 0.025
YAR068W hypothetical protein 0.025
AHP1 Ahp1p 0.025
FPK1 Fpk1p 0.025
SWM2 Swm2p 0.025
CRP1 Crp1p 0.024
MER1 Mer1p 0.024
SRP68 Srp68p 0.024
FMT1 Fmt1p 0.024
EPL1 Epl1p 0.023
RNR2 Rnr2p 0.023
CPR5 Cpr5p 0.023
IZH3 Izh3p 0.022
ARP10 Arp10p 0.022
RAM2 Ram2p 0.022
TAX4 Tax4p 0.022
YMR295C hypothetical protein 0.021
URA3 Ura3p 0.021
GAL7 Gal7p 0.021
YCL042W hypothetical protein 0.021
PZF1 Pzf1p 0.020
LAT1 Lat1p 0.020
UFD2 Ufd2p 0.020
BRO1 Bro1p 0.019
ZPS1 Zps1p 0.019
SAP30 Sap30p 0.019
ARE2 Are2p 0.019
HHT1 Hht1p 0.019
ARG8 Arg8p 0.019
YLR042C hypothetical protein 0.019
YIR035C hypothetical protein 0.019
YBR013C hypothetical protein 0.018
PRI1 Pri1p 0.018
YAR066W hypothetical protein 0.018
CAK1 Cak1p 0.018
MSI1 Msi1p 0.018
ADH2 Adh2p 0.018
MF(ALPHA)2 Mf(alpha)2p 0.017
YBR096W hypothetical protein 0.017
MDS3 Mds3p 0.017
CWP1 Cwp1p 0.017
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
rarga retinoic acid receptor gamma a 0.055
pbx4 pre-B-cell leukemia transcription factor 4 0.049
axin2 axin 2 (conductin, axil) 0.031
nphs1l nephrosis 1, congenital, Finnish type (nephrin)-like 0.030
cry1a cryptochrome 1a 0.029
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.028
lamc1 laminin, gamma 1 0.027
znf703 zinc finger protein 703 0.027
skia nuclear oncoprotein skia 0.024
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.024
tcf12 transcription factor 12 0.024
gnl2 guanine nucleotide binding protein-like 2 (nucleolar) 0.023
si:dkey-11e23.5 si:dkey-11e23.5 0.023
brd4 bromodomain containing 4 0.023
hsp47 heat shock protein 47 0.022
rbfox2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.022
crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.022
ahctf1 AT hook containing transcription factor 1 0.021
mef2d myocyte enhancer factor 2d 0.020
mib mind bomb 0.020
tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.020
lmo4a LIM domain only 4a 0.019
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.018
LOC100536021 spectrin beta chain, brain 1-like 0.018
zgc:77155 zgc:77155 0.017
wu:fv91b12 wu:fv91b12 0.017
dzip1 DAZ interacting protein 1 0.017
sox9a SRY-box containing gene 9a 0.016
cart1 cartilage paired-class homeoprotein 1 0.016
zgc:85746 zgc:85746 0.016
sephs1 selenophosphate synthetase 1 0.016
tagln2 transgelin 2 0.015
dab2ip DAB2 interacting protein 0.015
ctnnb1 catenin (cadherin-associated protein), beta 1 0.015
ppil4 peptidylprolyl isomerase (cyclophilin)-like 4 0.015
tfe3a transcription factor binding to IGHM enhancer 3a 0.015
ptprsa protein tyrosine phosphatase, receptor type, s, a 0.015
tcf7l1a transcription factor 7-like 1a (T-cell specific, HMG-box) 0.015
mapk1 mitogen-activated protein kinase 1 0.015
med25 mediator of RNA polymerase II transcription, subunit 25 homolog (yeast) 0.014
slit2 slit (Drosophila) homolog 2 0.014
hcfc1b host cell factor C1b 0.014
hoxb1a homeo box B1a 0.014
zeb2a zinc finger E-box binding homeobox 2a 0.014
myh11a myosin, heavy polypeptide 11, smooth muscle a 0.014
ier5l immediate early response 5-like 0.014
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.013
ptpra protein tyrosine phosphatase, receptor type, A 0.013
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.013
smc3 structural maintenance of chromosomes 3 0.013
eya2 eyes absent homolog 2 (Drosophila) 0.013
midn midnolin 0.013
snx6 sorting nexin 6 0.013
sumo3a SMT3 suppressor of mif two 3 homolog 3a 0.013
spry4 sprouty (Drosophila) homolog 4 0.012
im:6907121 im:6907121 0.012
mknk2b MAP kinase-interacting serine/threonine kinase 2b 0.012
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.012
ssbp3b single stranded DNA binding protein 3b 0.012
atp1b2a ATPase, Na+/K+ transporting, beta 2a polypeptide 0.012
gata6 GATA-binding protein 6 0.012
setd7 SET domain containing (lysine methyltransferase) 7 0.012
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.012
npepps aminopeptidase puromycin sensitive 0.012
foxi2 forkhead box I2 0.012
pknox1.2 pbx/knotted 1 homeobox 1.2 0.012
nrg2a neuregulin 2a 0.012
dram2 DNA-damage regulated autophagy modulator 2 0.012
stxbp3 syntaxin binding protein 3 0.012
bsg basigin 0.012
sema3aa semaphorin 3aa 0.012
fzd2 frizzled homolog 2 0.012
snx12 sorting nexin 12 0.012
zgc:162630 zgc:162630 0.012
si:dkey-261h15.1 si:dkey-261h15.1 0.011
cdh2 cadherin 2, neuronal 0.011
mlst8 MTOR associated protein, LST8 homolog (S. cerevisiae) 0.011
gsk3b glycogen synthase kinase 3 beta 0.011
sfrs3b splicing factor, arginine/serine-rich 3b 0.011
ext1a exostoses (multiple) 1a 0.011
znf503 zinc finger protein 503 0.011
dedd1 death effector domain-containing 1 0.011
ppp4ca protein phosphatase 4 (formerly X), catalytic subunit a 0.011
dip2c DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.011
btg1 B-cell translocation gene 1 0.011
si:dkey-20n3.1 si:dkey-20n3.1 0.011
hdac9b histone deacetylase 9b 0.011
zfyve1 zinc finger, FYVE domain containing 1 0.011
notch3 notch homolog 3 0.011
stau2 staufen, RNA binding protein, homolog 2 (Drosophila) 0.011
ash2l ash2 (absent, small, or homeotic)-like (Drosophila) 0.011
rcc2 regulator of chromosome condensation 2 0.011
smad3a MAD homolog 3a (Drosophila) 0.011
zgc:114140 zgc:114140 0.010
usp5 ubiquitin specific protease 5 0.010
zgc:63587 zgc:63587 0.010
zgc:153061 zgc:153061 0.010
wls wntless homolog (Drosophila) 0.010
twist1a twist1a 0.010
ren renin 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
CtBP C-terminal Binding Protein 0.048
wapl wings apart-like 0.044
CG14478 CG14478 gene product from transcript CG14478-RA 0.020
Caki Calcium/calmodulin-dependent protein kinase 0.018
ed echinoid 0.018
sty sprouty 0.017
ara araucan 0.015
pxb CG33207 gene product from transcript CG33207-RB 0.014
morgue modifier of rpr and grim, ubiquitously expressed 0.013
Appl beta amyloid protein precursor-like 0.011
gcm glial cells missing 0.011
ex expanded 0.011
14-3-3zeta CG17870 gene product from transcript CG17870-RB 0.010
nej nejire 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
HDAC1 histone deacetylase 1 1.000
HDAC2 histone deacetylase 2 0.998
NCOR2 nuclear receptor corepressor 2 0.996
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.996
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.992
HDAC7 histone deacetylase 7 0.955
HDAC3 histone deacetylase 3 0.946
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.876
BCL6 B-cell CLL/lymphoma 6 0.852
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.843
EP300 E1A binding protein p300 0.799
MAPK14 mitogen-activated protein kinase 14 0.780
RB1 retinoblastoma 1 0.764
TGIF1 TGFB-induced factor homeobox 1 0.651
NRP1 neuropilin 1 0.625
PPARA peroxisome proliferator-activated receptor alpha 0.579
JUN jun proto-oncogene 0.499
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.480
NCOR1 nuclear receptor corepressor 1 0.465
IRF2BP1 interferon regulatory factor 2 binding protein 1 0.442
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.437
HDAC4 histone deacetylase 4 0.426
MRFAP1 Morf4 family associated protein 1 0.396
SNTA1 syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) 0.360
MAP2K4 mitogen-activated protein kinase kinase 4 0.324
CREBBP CREB binding protein 0.314
KDM1A lysine (K)-specific demethylase 1A 0.306
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0.275
ATF2 activating transcription factor 2 0.245
ZMYM2 zinc finger, MYM-type 2 0.234
MEF2C myocyte enhancer factor 2C 0.230
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.228
BRMS1 breast cancer metastasis suppressor 1 0.221
SMAD2 SMAD family member 2 0.211
SMAD4 SMAD family member 4 0.199
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.184
PGR progesterone receptor 0.175
CEP70 centrosomal protein 70kDa 0.172
CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae) 0.172
HDAC5 histone deacetylase 5 0.170
CTBP1 C-terminal binding protein 1 0.167
RUNX1 runt-related transcription factor 1 0.158
MED15 mediator complex subunit 15 0.157
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.152
MAPK8 mitogen-activated protein kinase 8 0.149
HIPK2 homeodomain interacting protein kinase 2 0.145
MORF4L1 mortality factor 4 like 1 0.130
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.127
SMAD3 SMAD family member 3 0.119
HDAC9 histone deacetylase 9 0.118
SP1 Sp1 transcription factor 0.118
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 0.118
SIRT3 sirtuin 3 0.116
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.116
KDM2A lysine (K)-specific demethylase 2A 0.113
ESR1 estrogen receptor 1 0.110
PML promyelocytic leukemia 0.109
DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 0.109
ARRB1 arrestin, beta 1 0.107
BCL3 B-cell CLL/lymphoma 3 0.102
SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.102
CDC5L CDC5 cell division cycle 5-like (S. pombe) 0.099
KAT2B K(lysine) acetyltransferase 2B 0.085
PRKD2 protein kinase D2 0.085
MTA3 metastasis associated 1 family, member 3 0.078
SKIL SKI-like oncogene 0.077
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.070
TBL1X transducin (beta)-like 1X-linked 0.070
IKZF3 IKAROS family zinc finger 3 (Aiolos) 0.067
C16orf70 chromosome 16 open reading frame 70 0.064
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.063
SIRT1 sirtuin 1 0.061
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.060
MORF4L2 mortality factor 4 like 2 0.057
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.055
RARA retinoic acid receptor, alpha 0.055
MAPK3 mitogen-activated protein kinase 3 0.055
SKI v-ski sarcoma viral oncogene homolog (avian) 0.054
NCOA2 nuclear receptor coactivator 2 0.054
PDGFC platelet derived growth factor C 0.053
CUX1 cut-like homeobox 1 0.052
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.052
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.051
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.051
KIAA0182 KIAA0182 0.050
PDGFA platelet-derived growth factor alpha polypeptide 0.050
SETD7 SET domain containing (lysine methyltransferase) 7 0.049
TP53 tumor protein p53 0.049
ZBTB16 zinc finger and BTB domain containing 16 0.048
HSPA1L heat shock 70kDa protein 1-like 0.048
RBBP4 retinoblastoma binding protein 4 0.047
STAG1 stromal antigen 1 0.046
ADRBK1 adrenergic, beta, receptor kinase 1 0.046
YY1 YY1 transcription factor 0.045
ATF3 activating transcription factor 3 0.043
MTA1 metastasis associated 1 0.042
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.042
MECP2 methyl CpG binding protein 2 (Rett syndrome) 0.042
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.042
COL5A1 collagen, type V, alpha 1 0.042
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Mus musculus
Name Description Probability Func Analog Organism
Sin3a transcriptional regulator, SIN3A (yeast) 1.000
Nanog Nanog homeobox 1.000
Hdac1 histone deacetylase 1 0.998
Arid1a AT rich interactive domain 1A (SWI-like) 0.991
Mef2d myocyte enhancer factor 2D 0.989
Per2 period homolog 2 (Drosophila) 0.977
Trp53 transformation related protein 53 0.977
Kdm5b lysine (K)-specific demethylase 5B 0.973
Hdac2 histone deacetylase 2 0.950
Skil SKI-like 0.921
Jun Jun oncogene 0.917
Cry2 cryptochrome 2 (photolyase-like) 0.912
Mta1 metastasis associated 1 0.885
Sox2 SRY-box containing gene 2 0.813
Pten phosphatase and tensin homolog 0.780
Suds3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.775
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.753
Ncor1 nuclear receptor co-repressor 1 0.705
Clock circadian locomotor output cycles kaput 0.701
Ncor2 nuclear receptor co-repressor 2 0.688
Pou5f1 POU domain, class 5, transcription factor 1 0.622
Nacc1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 0.572
Chd4 chromodomain helicase DNA binding protein 4 0.542
Mta2 metastasis-associated gene family, member 2 0.514
Per1 period homolog 1 (Drosophila) 0.514
Evl Ena-vasodilator stimulated phosphoprotein 0.479
Sp1 trans-acting transcription factor 1 0.429
Sall4 sal-like 4 (Drosophila) 0.409
Yy1 YY1 transcription factor 0.402
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.395
Vasp vasodilator-stimulated phosphoprotein 0.378
Fos FBJ osteosarcoma oncogene 0.338
Cry1 cryptochrome 1 (photolyase-like) 0.329
Plin1 perilipin 1 0.254
Zeb1 zinc finger E-box binding homeobox 1 0.240
Yeats2 YEATS domain containing 2 0.231
Kat2a K(lysine) acetyltransferase 2A 0.219
Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.209
Dusp1 dual specificity phosphatase 1 0.187
Hdac5 histone deacetylase 5 0.180
Cyld cylindromatosis (turban tumor syndrome) 0.172
Hdac7 histone deacetylase 7 0.167
Csrp2bp cysteine and glycine-rich protein 2 binding protein 0.167
Smarcd1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.145
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.130
Nr0b1 nuclear receptor subfamily 0, group B, member 1 0.129
Sin3b transcriptional regulator, SIN3B (yeast) 0.127
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.127
Wdr5 WD repeat domain 5 0.126
Daxx Fas death domain-associated protein 0.121
Sall1 sal-like 1 (Drosophila) 0.120
Fst follistatin 0.114
Csnk1e casein kinase 1, epsilon 0.112
Usp2 ubiquitin specific peptidase 2 0.111
5430411K18Rik RIKEN cDNA 5430411K18 gene 0.110
Arid1b AT rich interactive domain 1B (SWI-like) 0.105
Cyr61 cysteine rich protein 61 0.104
Ctbp2 C-terminal binding protein 2 0.103
Rnf44 ring finger protein 44 0.103
Tet1 tet oncogene 1 0.099
Wiz widely-interspaced zinc finger motifs 0.098
Sfn stratifin 0.098
Srf serum response factor 0.096
Esrrb estrogen related receptor, beta 0.095
Egr1 early growth response 1 0.095
Hdac4 histone deacetylase 4 0.095
Hcfc1 host cell factor C1 0.093
Rara retinoic acid receptor, alpha 0.091
Jarid2 jumonji, AT rich interactive domain 2 0.090
Tada3 transcriptional adaptor 3 0.087
Trappc2l trafficking protein particle complex 2-like 0.087
Grhl2 grainyhead-like 2 (Drosophila) 0.084
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.084
Itch itchy, E3 ubiquitin protein ligase 0.082
Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.082
Ilf3 interleukin enhancer binding factor 3 0.081
Ewsr1 Ewing sarcoma breakpoint region 1 0.078
Actn1 actinin, alpha 1 0.076
Brd1 bromodomain containing 1 0.075
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.075
Gatad2a GATA zinc finger domain containing 2A 0.073
Exoc7 exocyst complex component 7 0.073
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.071
Crebbp CREB binding protein 0.070
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.068
Ctcf CCCTC-binding factor 0.067
Enah enabled homolog (Drosophila) 0.066
Rnf220 ring finger protein 220 0.065
Ncoa1 nuclear receptor coactivator 1 0.064
Irs2 insulin receptor substrate 2 0.063
Cic capicua homolog (Drosophila) 0.061
Wwox WW domain-containing oxidoreductase 0.061
Tbl1xr1 transducin (beta)-like 1X-linked receptor 1 0.061
Arid2 AT rich interactive domain 2 (ARID, RFX-like) 0.060
Thra thyroid hormone receptor alpha 0.060
Kdm1a lysine (K)-specific demethylase 1A 0.058
Runx1 runt related transcription factor 1 0.057
Kdr kinase insert domain protein receptor 0.055
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.055
Spry4 sprouty homolog 4 (Drosophila) 0.055
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Rattus norvegicus
Name Description Probability Func Analog Organism