The network for 'regulation of protein secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of protein secretion

Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
p24-1 p24-related-1 0.627
bai baiser 0.372
sbb scribbler 0.367
p24-2 p24-related-2 0.322
cup CG11181 gene product from transcript CG11181-RB 0.216
Cg25C Collagen type IV 0.210
Pvf1 PDGF- and VEGF-related factor 1 0.202
Drep-2 DNA fragmentation factor-related protein 2 0.182
trio CG18214 gene product from transcript CG18214-RA 0.141
sog short gastrulation 0.121
BG4 CG12297 gene product from transcript CG12297-RA 0.119
mew multiple edematous wings 0.107
Hrs Hepatocyte growth factor regulated tyrosine kinase substrate 0.085
fng fringe 0.082
CHOp24 CG3564 gene product from transcript CG3564-RA 0.071
Rel Relish 0.070
fs(1)K10 female sterile (1) K10 0.069
eca eclair 0.062
imd immune deficiency 0.060
Atg13 Autophagy-specific gene 13 0.051
wun wunen 0.049
Dcp-1 Death caspase-1 0.045
EloA Elongin A 0.044
Krn Keren 0.041
myoglianin CG1838 gene product from transcript CG1838-RD 0.040
Myo10A unconventional myosin class XV 0.038
pnt pointed 0.037
Sema-1a CG18405 gene product from transcript CG18405-RD 0.032
egh egghead 0.032
Osbp Oxysterol binding protein 0.031
byn brachyenteron 0.029
G-oalpha47A G protein oalpha 47A 0.028
CG9536 CG9536 gene product from transcript CG9536-RB 0.028
NetB Netrin-B 0.027
zfh1 Zn finger homeodomain 1 0.027
vkg viking 0.027
RhoGAP92B CG4755 gene product from transcript CG4755-RA 0.027
stc shuttle craft 0.026
tin tinman 0.025
Manf Mesencephalic astrocyte-derived neurotrophic factor 0.024
if inflated 0.024
CG9053 CG9053 gene product from transcript CG9053-RA 0.024
Fs Follistatin 0.024
Pvr PDGF- and VEGF-receptor related 0.024
deltaCOP delta-coatomer protein 0.023
Wnt2 Wnt oncogene analog 2 0.023
SdhA Succinate dehydrogenase A 0.023
CG12187 CG12187 gene product from transcript CG12187-RA 0.022
gcm glial cells missing 0.022
loj logjam 0.022
Atg4 Autophagy-specific gene 4 0.022
Ppn Papilin 0.022
Itp-r83A Inositol 1,4,5,-tris-phosphate receptor 0.021
CG5382 CG5382 gene product from transcript CG5382-RB 0.021
gt giant 0.020
pll pelle 0.019
mun munin 0.019
Octbeta2R CG33976 gene product from transcript CG33976-RA 0.019
Gef26 CG9491 gene product from transcript CG9491-RB 0.019
Eip74EF Ecdysone-induced protein 74EF 0.019
fkh fork head 0.019
Smg5 CG8954 gene product from transcript CG8954-RA 0.019
Hip14 Huntingtin-interacting protein 14 0.018
scb scab 0.018
Tfb5 CG42373 gene product from transcript CG42373-RB 0.018
fas faint sausage 0.018
pex16 peroxin 16 0.018
snk snake 0.016
trpml transient receptor potential mucolipin 0.016
repo reversed polarity 0.015
GlcAT-P CG6207 gene product from transcript CG6207-RC 0.015
CG5027 CG5027 gene product from transcript CG5027-RA 0.014
Tig Tiggrin 0.014
RpS20 Ribosomal protein S20 0.014
Ark Apaf-1-related-killer 0.014
mdy midway 0.014
scf supercoiling factor 0.014
Drep-1 DNA fragmentation factor-related protein 1 0.014
betaCop beta-coatomer protein 0.014
btl breathless 0.013
ome omega 0.013
CG9063 CG9063 gene product from transcript CG9063-RA 0.013
Tbh Tyramine beta hydroxylase 0.013
spi spitz 0.012
form3 formin 3 0.012
prtp pretaporter 0.012
CG9904 CG9904 gene product from transcript CG9904-RA 0.012
LanA Laminin A 0.012
SrpRbeta Signal recognition particle receptor beta 0.011
capu cappuccino 0.011
Atg9 Autophagy-specific gene 9 0.011
HLH54F CG5005 gene product from transcript CG5005-RA 0.011
NPFR1 neuropeptide F receptor 0.011
piwi CG6122 gene product from transcript CG6122-RA 0.011
P58IPK CG8286 gene product from transcript CG8286-RA 0.011
TRAM CG11642 gene product from transcript CG11642-RB 0.011
ro rough 0.011
OdsH Ods-site homeobox 0.010
oa2 octopamine receptor 2 0.010
brn brainiac 0.010
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 0.994
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.977
ANXA1 annexin A1 0.968
TEK TEK tyrosine kinase, endothelial 0.953
TAL1 T-cell acute lymphocytic leukemia 1 0.920
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.908
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.899
BTN3A2 butyrophilin, subfamily 3, member A2 0.897
BTN3A3 butyrophilin, subfamily 3, member A3 0.803
CD80 CD80 molecule 0.749
SMN1 survival of motor neuron 1, telomeric 0.744
LAT linker for activation of T cells 0.741
ENO1 enolase 1, (alpha) 0.738
IL1R1 interleukin 1 receptor, type I 0.736
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.732
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.729
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.721
CAV1 caveolin 1, caveolae protein, 22kDa 0.719
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.701
TRAF1 TNF receptor-associated factor 1 0.677
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.665
ALB albumin 0.663
FGA fibrinogen alpha chain 0.652
PILRA paired immunoglobin-like type 2 receptor alpha 0.649
APOE apolipoprotein E 0.622
NLRC4 NLR family, CARD domain containing 4 0.619
ANG angiogenin, ribonuclease, RNase A family, 5 0.619
CCL4 chemokine (C-C motif) ligand 4 0.615
LRP1 low density lipoprotein receptor-related protein 1 0.605
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.593
FGB fibrinogen beta chain 0.580
A2M alpha-2-macroglobulin 0.578
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.569
APP amyloid beta (A4) precursor protein 0.564
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.563
BTN3A1 butyrophilin, subfamily 3, member A1 0.563
ABI2 abl-interactor 2 0.543
AXL AXL receptor tyrosine kinase 0.538
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.526
IL1RN interleukin 1 receptor antagonist 0.484
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.481
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.463
HP haptoglobin 0.460
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.446
FAS Fas (TNF receptor superfamily, member 6) 0.431
MPDZ multiple PDZ domain protein 0.400
ITK IL2-inducible T-cell kinase 0.399
ANGPT2 angiopoietin 2 0.396
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.379
RNASE4 ribonuclease, RNase A family, 4 0.378
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.367
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.350
IFI16 interferon, gamma-inducible protein 16 0.344
FSTL1 follistatin-like 1 0.344
CCR2 chemokine (C-C motif) receptor 2 0.339
CDH5 cadherin 5, type 2 (vascular endothelium) 0.337
TRIM22 tripartite motif containing 22 0.326
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.323
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.322
NLRP3 NLR family, pyrin domain containing 3 0.319
IL10RA interleukin 10 receptor, alpha 0.312
CRP C-reactive protein, pentraxin-related 0.306
NRP1 neuropilin 1 0.305
S100A10 S100 calcium binding protein A10 0.287
IL10 interleukin 10 0.285
CCL2 chemokine (C-C motif) ligand 2 0.282
IDE insulin-degrading enzyme 0.282
DRD2 dopamine receptor D2 0.277
TLR2 toll-like receptor 2 0.261
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.261
CCR1 chemokine (C-C motif) receptor 1 0.258
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.256
HCK hemopoietic cell kinase 0.253
IL1B interleukin 1, beta 0.240
FGG fibrinogen gamma chain 0.238
ADORA2A adenosine A2a receptor 0.237
ANXA2 annexin A2 0.234
C19orf50 chromosome 19 open reading frame 50 0.233
HLA-DMA major histocompatibility complex, class II, DM alpha 0.221
TRIM39 tripartite motif containing 39 0.218
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.218
COL4A1 collagen, type IV, alpha 1 0.215
HK3 hexokinase 3 (white cell) 0.214
HLA-DMB major histocompatibility complex, class II, DM beta 0.209
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) 0.206
HLA-G major histocompatibility complex, class I, G 0.205
CD86 CD86 molecule 0.203
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.203
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.202
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.200
SIGLEC7 sialic acid binding Ig-like lectin 7 0.187
SOS1 son of sevenless homolog 1 (Drosophila) 0.186
IL4 interleukin 4 0.183
SP100 SP100 nuclear antigen 0.180
TTR transthyretin 0.178
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 0.177
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.173
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.167
BTN2A2 butyrophilin, subfamily 2, member A2 0.164
SP110 SP110 nuclear body protein 0.163
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Tnf tumor necrosis factor 0.934
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.918
Ccr2 chemokine (C-C motif) receptor 2 0.834
Cd40 CD40 antigen 0.829
Il1b interleukin 1 beta 0.826
C3ar1 complement component 3a receptor 1 0.825
Cd28 CD28 antigen 0.822
Pax8 paired box gene 8 0.794
Tlr4 toll-like receptor 4 0.767
Lepr leptin receptor 0.754
Ccl2 chemokine (C-C motif) ligand 2 0.729
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.702
Pdcd1 programmed cell death 1 0.678
Csf1r colony stimulating factor 1 receptor 0.653
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.653
Msr1 macrophage scavenger receptor 1 0.637
Ccr1 chemokine (C-C motif) receptor 1 0.613
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.608
Gpr33 G protein-coupled receptor 33 0.596
Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.593
Ifng interferon gamma 0.574
Kl klotho 0.537
Il10 interleukin 10 0.533
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.521
Lta lymphotoxin A 0.519
Csf1 colony stimulating factor 1 (macrophage) 0.509
Ccl22 chemokine (C-C motif) ligand 22 0.502
Ccl6 chemokine (C-C motif) ligand 6 0.500
Mefv Mediterranean fever 0.494
Agtr1a angiotensin II receptor, type 1a 0.488
Socs1 suppressor of cytokine signaling 1 0.484
Clec4n C-type lectin domain family 4, member n 0.480
Ccl9 chemokine (C-C motif) ligand 9 0.470
Itgax integrin alpha X 0.453
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.447
Tlr7 toll-like receptor 7 0.436
Pcdh12 protocadherin 12 0.428
Il1rn interleukin 1 receptor antagonist 0.426
Folr2 folate receptor 2 (fetal) 0.426
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.422
Ren1 renin 1 structural 0.421
Nos2 nitric oxide synthase 2, inducible 0.415
Ccl8 chemokine (C-C motif) ligand 8 0.405
Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 0.399
Cxcr5 chemokine (C-X-C motif) receptor 5 0.393
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.387
Lyz2 lysozyme 2 0.380
Pdcd1lg2 programmed cell death 1 ligand 2 0.377
Cybb cytochrome b-245, beta polypeptide 0.374
Clec7a C-type lectin domain family 7, member a 0.372
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.371
C1qb complement component 1, q subcomponent, beta polypeptide 0.371
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.369
Fgf21 fibroblast growth factor 21 0.369
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.368
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.367
Cd160 CD160 antigen 0.358
Fcgr1 Fc receptor, IgG, high affinity I 0.353
Mmp12 matrix metallopeptidase 12 0.353
Ccr5 chemokine (C-C motif) receptor 5 0.347
Il12rb2 interleukin 12 receptor, beta 2 0.337
Il6st interleukin 6 signal transducer 0.329
Cd86 CD86 antigen 0.325
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.320
Il1rl1 interleukin 1 receptor-like 1 0.316
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.315
Sfpi1 SFFV proviral integration 1 0.315
Trpm1 transient receptor potential cation channel, subfamily M, member 1 0.306
Ptgir prostaglandin I receptor (IP) 0.306
C5ar1 complement component 5a receptor 1 0.304
Fas Fas (TNF receptor superfamily member 6) 0.299
Eln elastin 0.290
Il4 interleukin 4 0.289
Il2rb interleukin 2 receptor, beta chain 0.287
Lair1 leukocyte-associated Ig-like receptor 1 0.287
Cyp2b19 cytochrome P450, family 2, subfamily b, polypeptide 19 0.285
Klk6 kallikrein related-peptidase 6 0.277
Sh2d2a SH2 domain protein 2A 0.277
Ltb lymphotoxin B 0.275
Il18rap interleukin 18 receptor accessory protein 0.275
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.275
AF251705 cDNA sequence AF251705 0.270
Rel reticuloendotheliosis oncogene 0.269
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.267
Cxcl13 chemokine (C-X-C motif) ligand 13 0.267
Has2 hyaluronan synthase 2 0.266
Sfrp4 secreted frizzled-related protein 4 0.265
Fgf7 fibroblast growth factor 7 0.262
Zan zonadhesin 0.261
Cd4 CD4 antigen 0.260
Atp4b ATPase, H+/K+ exchanging, beta polypeptide 0.259
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.257
Cd80 CD80 antigen 0.249
Xcl1 chemokine (C motif) ligand 1 0.247
Ccl7 chemokine (C-C motif) ligand 7 0.247
Ccl24 chemokine (C-C motif) ligand 24 0.245
Nlrp3 NLR family, pyrin domain containing 3 0.241
Itgb2l integrin beta 2-like 0.237
Apoe apolipoprotein E 0.234
Atp7a ATPase, Cu++ transporting, alpha polypeptide 0.233
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Anxa2 annexin A2 0.463
Il1b interleukin 1 beta 0.257
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.257
Cxcl10 chemokine (C-X-C motif) ligand 10 0.137
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.136
S1pr2 sphingosine-1-phosphate receptor 2 0.124
Adora2a adenosine A2a receptor 0.122
Alb albumin 0.109
Ccr2 chemokine (C-C motif) receptor 2 0.085
Cd247 Cd247 molecule 0.079
Arl11 ADP-ribosylation factor-like 11 0.077
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.077
Arpc1b actin related protein 2/3 complex, subunit 1B 0.076
Plau plasminogen activator, urokinase 0.070
Tlr4 toll-like receptor 4 0.066
Stat6 signal transducer and activator of transcription 6 0.065
Ubb ubiquitin B 0.065
Ptprc protein tyrosine phosphatase, receptor type, C 0.064
Cd44 Cd44 molecule 0.063
Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 0.060
Ccl3 chemokine (C-C motif) ligand 3 0.060
Ccl4 chemokine (C-C motif) ligand 4 0.059
Bdkrb2 bradykinin receptor B2 0.059
Egfr epidermal growth factor receptor 0.058
Cast calpastatin 0.058
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.057
Ccl2 chemokine (C-C motif) ligand 2 0.056
Il1r1 interleukin 1 receptor, type I 0.055
Il4 interleukin 4 0.054
S100a10 S100 calcium binding protein A10 0.054
Mc5r melanocortin 5 receptor 0.054
Prrx1 paired related homeobox 1 0.047
Olr1082 olfactory receptor 1082 0.047
Msx2 msh homeobox 2 0.046
Casp1 caspase 1 0.046
Olr1500 olfactory receptor 1500 0.044
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.043
Mca32 mast cell antigen 32 0.043
Ltbp2 latent transforming growth factor beta binding protein 2 0.043
Rnf4 ring finger protein 4 0.042
Gfi1 growth factor independent 1 transcription repressor 0.041
Ctsc cathepsin C 0.041
Htr2b 5-hydroxytryptamine (serotonin) receptor 2B 0.041
Ceacam10 carcinoembryonic antigen-related cell adhesion molecule 10 0.040
Rab1b RAB1B, member RAS oncogene family 0.040
Pdcl phosducin-like 0.039
Cmklr1 chemokine-like receptor 1 0.039
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.038
Sec61a1 Sec61 alpha 1 subunit (S. cerevisiae) 0.038
Gzmk granzyme K 0.037
siat7D alpha-2,6-sialyltransferase ST6GalNAc IV 0.037
Iapp islet amyloid polypeptide 0.037
Il8rb interleukin 8 receptor, beta 0.036
Dnah1 dynein, axonemal, heavy chain 1 0.036
Has2 hyaluronan synthase 2 0.036
Hpca hippocalcin 0.035
Slc34a1 solute carrier family 34 (sodium phosphate), member 1 0.035
Olfml2b olfactomedin-like 2B 0.035
Gabrp gamma-aminobutyric acid (GABA-A) receptor, pi 0.035
Matk megakaryocyte-associated tyrosine kinase 0.034
Sec24d SEC24 family, member D (S. cerevisiae) 0.034
Ocln occludin 0.034
Sirpa signal-regulatory protein alpha 0.034
Il2rb interleukin 2 receptor, beta 0.034
Insrr insulin receptor-related receptor 0.034
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.033
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.033
Ceacam3 carcinoembryonic antigen-related cell adhesion molecule 3 0.033
Ctse cathepsin E 0.032
Nat1 N-acetyltransferase 1 0.032
Ptafr platelet-activating factor receptor 0.031
Reg3a regenerating islet-derived 3 alpha 0.031
Kcnh7 potassium voltage-gated channel, subfamily H (eag-related), member 7 0.030
Adam17 ADAM metallopeptidase domain 17 0.030
Csk c-src tyrosine kinase 0.029
Icam1 intercellular adhesion molecule 1 0.029
Svs1 seminal vesicle secretory protein 1 0.029
Ripk3 receptor-interacting serine-threonine kinase 3 0.029
Fgfr1 Fibroblast growth factor receptor 1 0.029
Cxcl2 chemokine (C-X-C motif) ligand 2 0.029
LOC24906 RoBo-1 0.029
Anpep alanyl (membrane) aminopeptidase 0.028
Klrb1a killer cell lectin-like receptor subfamily B, member 1A 0.028
Aqp5 aquaporin 5 0.028
Casp3 caspase 3 0.028
Cxcr3 chemokine (C-X-C motif) receptor 3 0.028
Il2rg interleukin 2 receptor, gamma 0.027
Slc25a5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.027
LOC619574 hypothetical protein LOC619574 0.027
Dock8 dedicator of cytokinesis 8 0.027
Cd38 CD38 molecule 0.027
Gfap glial fibrillary acidic protein 0.027
Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b 0.026
Anxa4 annexin A4 0.026
Csn1s1 casein alpha s1 0.026
Itgam integrin, alpha M 0.026
Csrnp2 cysteine-serine-rich nuclear protein 2 0.026
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.025
Glt25d1 glycosyltransferase 25 domain containing 1 0.025
Hck hemopoietic cell kinase 0.025