The network for 'regulation of g1 s transition of mitotic cell cycle' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of g1 s transition of mitotic cell cycle

Any cell cycle regulatory process that controls the commitment of a cell from G1 to S phase of the mitotic cell cycle.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
UBI4 Ubi4p 0.047
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
npp-1 Protein NPP-1 0.021
ced-9 Protein CED-9 0.015
lig-1 Protein LIG-1 0.012
sel-8 Protein SEL-8 0.012
let-60 Protein LET-60 0.012
elc-1 Protein ELC-1 0.011
T24B8.2 Protein T24B8.2 0.011
xpo-1 Protein XPO-1 0.011
sel-12 Protein SEL-12 0.011
pha-4 Protein PHA-4 0.011
elt-6 Protein ELT-6 0.010
Y42H9AR.4 Protein Y42H9AR.4 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Mad Mothers against dpp 0.961
dap dacapo 0.905
Akt1 CG4006 gene product from transcript CG4006-RA 0.828
Dp DP transcription factor 0.621
brm brahma 0.532
Rbf Retinoblastoma-family protein 0.498
Cdk4 Cyclin-dependent kinase 4 0.447
CycE Cyclin E 0.421
heph hephaestus 0.337
Mcm2 Minichromosome maintenance 2 0.303
sgg shaggy 0.276
phl pole hole 0.240
emc extra macrochaetae 0.230
tefu telomere fusion 0.200
Ras85D Ras oncogene at 85D 0.196
rap retina aberrant in pattern 0.192
CG15220 CG15220 gene product from transcript CG15220-RA 0.188
imd immune deficiency 0.178
CtBP C-terminal Binding Protein 0.173
ci cubitus interruptus 0.172
osa CG7467 gene product from transcript CG7467-RD 0.159
RASSF8 CG5053 gene product from transcript CG5053-RA 0.154
chico CG5686 gene product from transcript CG5686-RB 0.128
mip120 Myb-interacting protein 120 0.126
nej nejire 0.123
Psf2 CG18013 gene product from transcript CG18013-RA 0.123
myoglianin CG1838 gene product from transcript CG1838-RD 0.108
gbb glass bottom boat 0.106
Cp190 Centrosomal protein 190kD 0.102
Caf1 Chromatin assembly factor 1 subunit 0.101
gro groucho 0.092
CG14614 CG14614 gene product from transcript CG14614-RA 0.092
Mer Merlin 0.091
CG3508 CG3508 gene product from transcript CG3508-RB 0.091
E(z) Enhancer of zeste 0.089
e(y)3 enhancer of yellow 3 0.086
polybromo CG11375 gene product from transcript CG11375-RA 0.084
yki yorkie 0.084
CycA Cyclin A 0.083
Cul-2 Cullin-2 0.081
kn knot 0.081
smo smoothened 0.076
sd scalloped 0.076
Sld5 CG14549 gene product from transcript CG14549-RA 0.074
CycD Cyclin D 0.071
mus205 mutagen-sensitive 205 0.071
Pc Polycomb 0.070
pic piccolo 0.068
babo baboon 0.066
Mcm10 Sensitized chromosome inheritance modifier 19 0.066
RfC3 Replication factor C subunit 3 0.066
JhI-1 Juvenile hormone-inducible protein 1 0.066
Su(z)12 CG8013 gene product from transcript CG8013-RA 0.064
Slip1 CG1783 gene product from transcript CG1783-RA 0.062
asf1 anti-silencing factor 1 0.061
emb embargoed 0.059
cdc2 CG5363 gene product from transcript CG5363-RA 0.059
Snoo Sno oncogene 0.059
hh hedgehog 0.053
kay kayak 0.052
Smg1 CG32743 gene product from transcript CG32743-RA 0.050
RpL39 Ribosomal protein L39 0.049
sax saxophone 0.048
dlt discs lost 0.046
Psf1 CG9187 gene product from transcript CG9187-RA 0.045
stg string 0.043
shn schnurri 0.041
Gnf1 Germ line transcription factor 1 0.041
CG9339 CG9339 gene product from transcript CG9339-RG 0.041
CG11242 CG11242 gene product from transcript CG11242-RA 0.039
Hmr Hybrid male rescue 0.039
EcR Ecdysone receptor 0.039
klu klumpfuss 0.039
WRNexo WRN exonuclease 0.039
dpp decapentaplegic 0.038
neur neuralized 0.036
fu fused 0.036
CG12026 CG12026 gene product from transcript CG12026-RB 0.035
sav salvador 0.035
lgs legless 0.034
mib1 mind bomb 1 0.033
GATAd CG5034 gene product from transcript CG5034-RA 0.033
por porcupine 0.033
CG6843 CG6843 gene product from transcript CG6843-RA 0.032
tld tolloid 0.032
CG14057 CG14057 gene product from transcript CG14057-RA 0.032
HLH54F CG5005 gene product from transcript CG5005-RA 0.032
tkv thickveins 0.031
Cbl CG7037 gene product from transcript CG7037-RB 0.031
Gug Grunge 0.030
H Hairless 0.030
CG3704 CG3704 gene product from transcript CG3704-RA 0.030
CG8486 CG8486 gene product from transcript CG8486-RE 0.030
p53 CG33336 gene product from transcript CG33336-RB 0.029
hpo hippo 0.029
Dref DNA replication-related element factor 0.028
O-fut1 O-fucosyltransferase 1 0.028
18w 18 wheeler 0.027
rols rolling pebbles 0.027
G-oalpha47A G protein oalpha 47A 0.027
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Homo sapiens
Name Description Probability Func Analog Organism
RB1 retinoblastoma 1 0.980
CDK2 cyclin-dependent kinase 2 0.963
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.955
NOTCH1 notch 1 0.949
RBL2 retinoblastoma-like 2 (p130) 0.940
CDK6 cyclin-dependent kinase 6 0.873
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.852
E2F1 E2F transcription factor 1 0.815
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.815
XIAP X-linked inhibitor of apoptosis 0.781
CDC5L CDC5 cell division cycle 5-like (S. pombe) 0.746
CCND1 cyclin D1 0.711
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.684
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.648
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.627
YY1 YY1 transcription factor 0.581
JAG1 jagged 1 0.464
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.455
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.444
RBL1 retinoblastoma-like 1 (p107) 0.411
ARID1A AT rich interactive domain 1A (SWI-like) 0.397
CCND3 cyclin D3 0.331
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.309
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.297
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.294
FAS Fas (TNF receptor superfamily, member 6) 0.272
DDB1 damage-specific DNA binding protein 1, 127kDa 0.225
SKP2 S-phase kinase-associated protein 2 (p45) 0.224
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.223
ACTN2 actinin, alpha 2 0.218
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.214
EP300 E1A binding protein p300 0.212
ESR1 estrogen receptor 1 0.208
TFDP1 transcription factor Dp-1 0.207
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.202
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.192
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.189
PDE4DIP phosphodiesterase 4D interacting protein 0.182
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.178
EGFR epidermal growth factor receptor 0.172
E2F8 E2F transcription factor 8 0.170
HEXIM1 hexamethylene bis-acetamide inducible 1 0.166
VHL von Hippel-Lindau tumor suppressor 0.165
AR androgen receptor 0.162
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.160
CUL1 cullin 1 0.142
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.130
CCNE1 cyclin E1 0.129
CFLAR CASP8 and FADD-like apoptosis regulator 0.128
CDC6 cell division cycle 6 homolog (S. cerevisiae) 0.128
PLCG1 phospholipase C, gamma 1 0.126
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.121
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 0.119
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.116
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.106
CNOT8 CCR4-NOT transcription complex, subunit 8 0.106
E2F3 E2F transcription factor 3 0.103
LRDD leucine-rich repeats and death domain containing 0.102
SMAD3 SMAD family member 3 0.102
SMAD1 SMAD family member 1 0.099
SMAD7 SMAD family member 7 0.097
CNOT1 CCR4-NOT transcription complex, subunit 1 0.093
MCM7 minichromosome maintenance complex component 7 0.090
RBBP8 retinoblastoma binding protein 8 0.089
APAF1 apoptotic peptidase activating factor 1 0.089
FADD Fas (TNFRSF6)-associated via death domain 0.088
DTL denticleless homolog (Drosophila) 0.088
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.087
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.087
BTRC beta-transducin repeat containing 0.086
CUL4A cullin 4A 0.084
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.083
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.083
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.082
IRAK2 interleukin-1 receptor-associated kinase 2 0.082
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.079
MAML1 mastermind-like 1 (Drosophila) 0.079
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.077
IER3 immediate early response 3 0.077
HBP1 HMG-box transcription factor 1 0.075
YAP1 Yes-associated protein 1 0.074
UBE3A ubiquitin protein ligase E3A 0.074
TAL1 T-cell acute lymphocytic leukemia 1 0.073
SKP1 S-phase kinase-associated protein 1 0.073
UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.070
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.065
MCM10 minichromosome maintenance complex component 10 0.064
ARID1B AT rich interactive domain 1B (SWI1-like) 0.063
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.061
CDC7 cell division cycle 7 homolog (S. cerevisiae) 0.060
PBRM1 polybromo 1 0.059
LIN54 lin-54 homolog (C. elegans) 0.059
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.059
CDC25A cell division cycle 25 homolog A (S. pombe) 0.056
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.056
NLRC4 NLR family, CARD domain containing 4 0.055
DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae) 0.055
EPS8 epidermal growth factor receptor pathway substrate 8 0.055
CAV1 caveolin 1, caveolae protein, 22kDa 0.054
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.053
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Rb1 retinoblastoma 1 0.982
Pten phosphatase and tensin homolog 0.906
Notch1 Notch gene homolog 1 (Drosophila) 0.841
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.709
Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.690
Arid1b AT rich interactive domain 1B (SWI-like) 0.642
Nf1 neurofibromatosis 1 0.637
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.589
Ccnd1 cyclin D1 0.573
Mdm2 transformed mouse 3T3 cell double minute 2 0.566
Cdk4 cyclin-dependent kinase 4 0.540
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.534
Ctnnb1 catenin (cadherin associated protein), beta 1 0.500
Grb2 growth factor receptor bound protein 2 0.465
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.435
Cdk6 cyclin-dependent kinase 6 0.431
Bax BCL2-associated X protein 0.387
Shh sonic hedgehog 0.377
Arid1a AT rich interactive domain 1A (SWI-like) 0.346
Psen1 presenilin 1 0.343
Ptch1 patched homolog 1 0.321
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.303
Fgfr2 fibroblast growth factor receptor 2 0.276
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.268
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.262
Cdk2 cyclin-dependent kinase 2 0.256
Bcl2 B-cell leukemia/lymphoma 2 0.256
E2f1 E2F transcription factor 1 0.253
Ccne1 cyclin E1 0.236
Ccnd2 cyclin D2 0.231
Notch2 Notch gene homolog 2 (Drosophila) 0.218
Ptpn13 protein tyrosine phosphatase, non-receptor type 13 0.215
Pkd1 polycystic kidney disease 1 homolog 0.213
Mdm4 transformed mouse 3T3 cell double minute 4 0.207
Tcf3 transcription factor 3 0.198
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.166
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.166
Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.153
Rbl2 retinoblastoma-like 2 0.153
Hdac2 histone deacetylase 2 0.152
Cd80 CD80 antigen 0.146
Smarcd1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.143
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.131
Dysf dysferlin 0.131
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.128
Hes1 hairy and enhancer of split 1 (Drosophila) 0.127
Meox2 mesenchyme homeobox 2 0.123
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.121
Fgfr1 fibroblast growth factor receptor 1 0.119
Daxx Fas death domain-associated protein 0.109
Stk11 serine/threonine kinase 11 0.108
Hif1a hypoxia inducible factor 1, alpha subunit 0.105
Hprt hypoxanthine guanine phosphoribosyl transferase 0.098
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.093
Rbl1 retinoblastoma-like 1 (p107) 0.085
Braf Braf transforming gene 0.081
Bak1 BCL2-antagonist/killer 1 0.080
Msh2 mutS homolog 2 (E. coli) 0.076
Gli2 GLI-Kruppel family member GLI2 0.076
Sfn stratifin 0.074
Mybl2 myeloblastosis oncogene-like 2 0.073
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.071
Thbs1 thrombospondin 1 0.071
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.069
Skil SKI-like 0.064
Hdac1 histone deacetylase 1 0.063
Numa1 nuclear mitotic apparatus protein 1 0.062
Nbn nibrin 0.062
Rxra retinoid X receptor alpha 0.061
Gli3 GLI-Kruppel family member GLI3 0.061
Nrg1 neuregulin 1 0.060
Anxa5 annexin A5 0.058
Trp63 transformation related protein 63 0.058
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.057
Ikzf1 IKAROS family zinc finger 1 0.057
Tgfb2 transforming growth factor, beta 2 0.055
Ccnd3 cyclin D3 0.055
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.054
Rdx radixin 0.053
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.053
Pkdcc protein kinase domain containing, cytoplasmic 0.053
Sin3a transcriptional regulator, SIN3A (yeast) 0.053
Apc adenomatosis polyposis coli 0.053
Plcb3 phospholipase C, beta 3 0.052
Smn1 survival motor neuron 1 0.051
Fstl1 follistatin-like 1 0.050
S100a11 S100 calcium binding protein A11 (calgizzarin) 0.048
Kit kit oncogene 0.046
Dll1 delta-like 1 (Drosophila) 0.046
Pdcd1 programmed cell death 1 0.046
Hdac7 histone deacetylase 7 0.046
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.045
Smad1 MAD homolog 1 (Drosophila) 0.045
Zfp830 zinc finger protein 830 0.045
Lrrc58 leucine rich repeat containing 58 0.044
Sox4 SRY-box containing gene 4 0.043
Gtse1 G two S phase expressed protein 1 0.043
Ncapd2 non-SMC condensin I complex, subunit D2 0.042
Sox9 SRY-box containing gene 9 0.042
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Rattus norvegicus
Name Description Probability Func Analog Organism
Wipf1 WAS/WASL interacting protein family, member 1 0.026
Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 0.025
Cntn3 contactin 3 (plasmacytoma associated) 0.019
Cdk2 cyclin dependent kinase 2 0.019
Mbtps1 membrane-bound transcription factor peptidase, site 1 0.016
Drd1a dopamine receptor D1A 0.015
Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 0.013
Lmnb1 lamin B1 0.013
Haao 3-hydroxyanthranilate 3,4-dioxygenase 0.013
Cdk4 cyclin-dependent kinase 4 0.012
Ptprc protein tyrosine phosphatase, receptor type, C 0.011
Rara retinoic acid receptor, alpha 0.011
Gata4 GATA binding protein 4 0.011
Ubtf upstream binding transcription factor, RNA polymerase I 0.011
Slfn2 schlafen 2 0.010
Tgfbr2 transforming growth factor, beta receptor II 0.010
Pcmtd2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 0.010
Bmp7 bone morphogenetic protein 7 0.010
Casp1 caspase 1 0.010