The network for 'drug transmembrane transport' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

drug transmembrane transport

The process in which a drug is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
PDR5 Pdr5p 0.218
TPO1 Tpo1p 0.215
NCR1 Ncr1p 0.135
SNQ2 Snq2p 0.108
PDR12 Pdr12p 0.082
HER1 Her1p 0.040
TMS1 Tms1p 0.023
ASI3 Asi3p 0.023
AVT3 Avt3p 0.020
DAP2 Dap2p 0.019
QDR2 Qdr2p 0.019
IRA1 Ira1p 0.019
SDS23 Sds23p 0.018
YHR140W hypothetical protein 0.018
TCB1 Tcb1p 0.017
HXT2 Hxt2p 0.015
ARG8 Arg8p 0.015
DIP5 Dip5p 0.015
ZPS1 Zps1p 0.015
STE2 Ste2p 0.015
ATR1 Atr1p 0.015
TMN2 Tmn2p 0.014
SRD1 Srd1p 0.014
HXT3 Hxt3p 0.013
NAR1 Nar1p 0.013
MFA2 Mfa2p 0.013
YAR028W hypothetical protein 0.012
YLR164W hypothetical protein 0.012
ZRT1 Zrt1p 0.012
YLR264C-A hypothetical protein 0.011
ADH2 Adh2p 0.011
MCH5 Mch5p 0.011
RAD28 Rad28p 0.011
BAP2 Bap2p 0.011
YOL038C-A hypothetical protein 0.011
CUP1-1 Cup1-1p 0.011
IML1 Iml1p 0.011
YLR162W hypothetical protein 0.011
YAR068W hypothetical protein 0.011
LEU2 Leu2p 0.011
YRR1 Yrr1p 0.011
FMO1 Fmo1p 0.011
YPL216W hypothetical protein 0.010
MER1 Mer1p 0.010
PTR2 Ptr2p 0.010
ARP10 Arp10p 0.010
YOR338W hypothetical protein 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
CG11897 CG11897 gene product from transcript CG11897-RA 0.056
eIF4G eukaryotic translation initiation factor 4G 0.054
Mpcp Mitochondrial phosphate carrier protein 0.054
CG6659 CG6659 gene product from transcript CG6659-RA 0.031
CG12020 CG12020 gene product from transcript CG12020-RA 0.020
Karybeta3 Karyopherin beta 3 0.018
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Homo sapiens
Name Description Probability Func Analog Organism
CD164 CD164 molecule, sialomucin 0.213
YIPF5 Yip1 domain family, member 5 0.158
FBXW12 F-box and WD repeat domain containing 12 0.150
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 0.098
TMEM30B transmembrane protein 30B 0.097
PJA2 praja ring finger 2 0.081
GNS glucosamine (N-acetyl)-6-sulfatase 0.080
SLC28A1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 0.063
SLC6A12 solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 0.062
SCARB2 scavenger receptor class B, member 2 0.061
NPTN neuroplastin 0.059
SERINC1 serine incorporator 1 0.052
TRAF3 TNF receptor-associated factor 3 0.050
TMEM173 transmembrane protein 173 0.049
ATP8B4 ATPase, class I, type 8B, member 4 0.045
TM9SF2 transmembrane 9 superfamily member 2 0.041
SGPP1 sphingosine-1-phosphate phosphatase 1 0.033
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.028
CTNS cystinosis, nephropathic 0.027
TMED7 transmembrane emp24 protein transport domain containing 7 0.026
OSTM1 osteopetrosis associated transmembrane protein 1 0.025
ATP11B ATPase, class VI, type 11B 0.023
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.023
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.021
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 0.020
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 0.019
TMEM30A transmembrane protein 30A 0.019
CD46 CD46 molecule, complement regulatory protein 0.017
ADAM10 ADAM metallopeptidase domain 10 0.017
CLCN7 chloride channel 7 0.016
ZNF721 zinc finger protein 721 0.015
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 0.014
ADAM9 ADAM metallopeptidase domain 9 0.014
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase 0.014
C8A complement component 8, alpha polypeptide 0.012
RDH16 retinol dehydrogenase 16 (all-trans) 0.012
ADH6 alcohol dehydrogenase 6 (class V) 0.011
PICALM phosphatidylinositol binding clathrin assembly protein 0.011
APCS amyloid P component, serum 0.011
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A 0.155
Aldh8a1 aldehyde dehydrogenase 8 family, member A1 0.066
Keg1 kidney expressed gene 1 0.063
1300017J02Rik RIKEN cDNA 1300017J02 gene 0.061
Abcg8 ATP-binding cassette, sub-family G (WHITE), member 8 0.053
Cyp4f15 cytochrome P450, family 4, subfamily f, polypeptide 15 0.053
Slc22a7 solute carrier family 22 (organic anion transporter), member 7 0.046
Iyd iodotyrosine deiodinase 0.046
Ttc36 tetratricopeptide repeat domain 36 0.042
Cyp2j5 cytochrome P450, family 2, subfamily j, polypeptide 5 0.041
Aadac arylacetamide deacetylase (esterase) 0.035
Dpys dihydropyrimidinase 0.033
Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 0.031
Ugt2a3 UDP glucuronosyltransferase 2 family, polypeptide A3 0.031
Hao1 hydroxyacid oxidase 1, liver 0.030
Cml2 camello-like 2 0.029
G6pc glucose-6-phosphatase, catalytic 0.027
Gulo gulonolactone (L-) oxidase 0.025
Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 0.025
Slc22a2 solute carrier family 22 (organic cation transporter), member 2 0.023
Afm afamin 0.022
Abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 0.022
Glyat glycine-N-acyltransferase 0.021
Pla2g12b phospholipase A2, group XIIB 0.020
AI317395 expressed sequence AI317395 0.020
Serpind1 serine (or cysteine) peptidase inhibitor, clade D, member 1 0.019
Abcg5 ATP-binding cassette, sub-family G (WHITE), member 5 0.019
Ugt2b36 UDP glucuronosyltransferase 2 family, polypeptide B36 0.018
Mlxipl MLX interacting protein-like 0.018
Akr1c20 aldo-keto reductase family 1, member C20 0.017
Slc17a2 solute carrier family 17 (sodium phosphate), member 2 0.016
Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 0.015
Spp2 secreted phosphoprotein 2 0.015
Ugt3a2 UDP glycosyltransferases 3 family, polypeptide A2 0.015
D730039F16Rik RIKEN cDNA D730039F16 gene 0.015
2810459M11Rik RIKEN cDNA 2810459M11 gene 0.015
Agmat agmatine ureohydrolase (agmatinase) 0.014
Ido2 indoleamine 2,3-dioxygenase 2 0.014
Sgk2 serum/glucocorticoid regulated kinase 2 0.014
Cyp2c54 cytochrome P450, family 2, subfamily c, polypeptide 54 0.013
Fpgs folylpolyglutamyl synthetase 0.012
Cpn2 carboxypeptidase N, polypeptide 2 0.012
Mettl7b methyltransferase like 7B 0.012
Akr1c6 aldo-keto reductase family 1, member C6 0.012
Cideb cell death-inducing DNA fragmentation factor, alpha subunit-like effector B 0.012
Acsm1 acyl-CoA synthetase medium-chain family member 1 0.012
Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 0.012
Pbld1 phenazine biosynthesis-like protein domain containing 1 0.011
Creb3l3 cAMP responsive element binding protein 3-like 3 0.011
Vwce von Willebrand factor C and EGF domains 0.011
Slco1a1 solute carrier organic anion transporter family, member 1a1 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ust5r integral membrane transport protein UST5r 0.428
Slc6a13 solute carrier family 6 (neurotransmitter transporter, GABA), member 13 0.388
Acot12 acyl-CoA thioesterase 12 0.294
Slc22a7 solute carrier family 22 (organic anion transporter), member 7 0.270
Slc23a1 solute carrier family 23 (nucleobase transporters), member 1 0.262
Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 0.257
Sult1b1 sulfotransferase family, cytosolic, 1B, member 1 0.244
Abcb11 ATP-binding cassette, subfamily B (MDR/TAP), member 11 0.244
Keg1 kidney expressed gene 1 0.217
Kynu kynureninase (L-kynurenine hydrolase) 0.206
Gulo gulonolactone (L-) oxidase 0.202
Aspg asparaginase homolog (S. cerevisiae) 0.195
Cpn1 carboxypeptidase N, polypeptide 1 0.182
Abcc6 ATP-binding cassette, subfamily C (CFTR/MRP), member 6 0.171
Mep1a meprin 1 alpha 0.155
Slc13a3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 0.154
Nr1i3 nuclear receptor subfamily 1, group I, member 3 0.148
Cldn2 claudin 2 0.136
Dao D-amino-acid oxidase 0.130
Slco1a4 solute carrier organic anion transporter family, member 1a4 0.114
Mosc1 MOCO sulphurase C-terminal domain containing 1 0.102
Mbl1 mannose-binding lectin (protein A) 1 0.091
Nat8 N-acetyltransferase 8 0.091
Slc22a1 solute carrier family 22 (organic cation transporter), member 1 0.086
Asgr2 asialoglycoprotein receptor 2 0.080
Slco1a1 solute carrier organic anion transporter family, member 1a1 0.079
Ugt1a6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.073
Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide 0.073
Cldn1 claudin 1 0.072
Sult1c2 sulfotransferase family, cytosolic, 1C, member 2 0.071
Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 0.062
Pdzk1 PDZ domain containing 1 0.058
Gpr182 G protein-coupled receptor 182 0.056
Masp2 mannan-binding lectin serine peptidase 2 0.052
Ncr3 natural cytotoxicity triggering receptor 3 0.049
Acox2 acyl-Coenzyme A oxidase 2, branched chain 0.044
G6pc glucose-6-phosphatase, catalytic subunit 0.043
Anks4b ankyrin repeat and sterile alpha motif domain containing 4B 0.043
Xpnpep2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 0.042
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.042
Cbs cystathionine beta synthase 0.042
Ces1c carboxylesterase 1C 0.039
Lrrc10 leucine-rich repeat-containing 10 0.039
Ces2c carboxylesterase 2C 0.037
Lect1 leukocyte cell derived chemotaxin 1 0.037
Mettl7b methyltransferase like 7B 0.035
Acsm2 acyl-CoA synthetase medium-chain family member 2 0.035
Masp1 mannan-binding lectin serine peptidase 1 0.034
Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 0.033
Inhbc inhibin beta C 0.032
Hnmt histamine N-methyltransferase 0.031
Akr7a3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 0.031
Ocln occludin 0.030
Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 0.029
Hao2 hydroxyacid oxidase 2 (long chain) 0.029
Gjb2 gap junction protein, beta 2 0.028
Slc17a1 solute carrier family 17 (sodium phosphate), member 1 0.026
Ceacam9 carcinoembryonic antigen-related cell adhesion molecule 9 0.026
Hnf4a hepatocyte nuclear factor 4, alpha 0.025
Hhip Hedgehog-interacting protein 0.025
Crp C-reactive protein, pentraxin-related 0.025
Akr1c14 aldo-keto reductase family 1, member C14 0.025
Prl7a3 prolactin family 7, subfamily a, member 3 0.025
Tmem82 transmembrane protein 82 0.025
Hnf1b HNF1 homeobox B 0.024
Mug1 murinoglobulin 1 0.023
Sec14l2 SEC14-like 2 (S. cerevisiae) 0.023
Slc26a1 solute carrier family 26 (sulfate transporter), member 1 0.021
Ephx1 epoxide hydrolase 1, microsomal 0.021
Crisp1 cysteine-rich secretory protein 1 0.020
Akr1d1 aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) 0.020
Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 0.019
Crygn crystallin, gamma N 0.019
Tmed2 transmembrane emp24 domain trafficking protein 2 0.019
Abcg8 ATP-binding cassette, subfamily G (WHITE), member 8 0.018
Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 0.017
Anpep alanyl (membrane) aminopeptidase 0.017
Slc7a9 solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 0.017
Fam38b family with sequence similarity 38, member B 0.017
Dpp4 dipeptidylpeptidase 4 0.017
Treh trehalase (brush-border membrane glycoprotein) 0.017
Upb1 ureidopropionase, beta 0.016
Adra1b adrenergic, alpha-1B-, receptor 0.016
Mpeg1 macrophage expressed 1 0.016
Dio1 deiodinase, iodothyronine, type I 0.016
Serpina5 serine (or cysteine) peptidase inhibitor, clade A, member 5 0.016
Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 0.016
Igfbpl1 insulin-like growth factor binding protein-like 1 0.016
Akr1c12 aldo-keto reductase family 1, member C12 0.015
Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 0.015
Gcm1 glial cells missing homolog 1 (Drosophila) 0.015
Slc27a2 solute carrier family 27 (fatty acid transporter), member 2 0.014
Obp1f odorant binding protein I f 0.014
Tat tyrosine aminotransferase 0.014
Gcgr glucagon receptor 0.014
St6gal1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.013
Azgp1 alpha-2-glycoprotein 1, zinc-binding 0.013
Asgr1 asialoglycoprotein receptor 1 0.013
RGD1310495 similar to KIAA1919 protein 0.013
Slc2a5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 0.013