The network for 'negative regulation of steroid metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of steroid metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
MIG2 Mig2p 0.155
VHS1 Vhs1p 0.131
YKR075C hypothetical protein 0.130
CSR2 Csr2p 0.072
MIG1 Mig1p 0.069
SWI1 Swi1p 0.068
ROX1 Rox1p 0.068
MIG3 Mig3p 0.067
TRA1 Tra1p 0.066
RGS2 Rgs2p 0.058
YPL014W hypothetical protein 0.057
GIP2 Gip2p 0.056
DAL81 Dal81p 0.054
TPO2 Tpo2p 0.052
NRG1 Nrg1p 0.052
SSK2 Ssk2p 0.050
MOT3 Mot3p 0.049
WAR1 War1p 0.046
RTG3 Rtg3p 0.046
CAT8 Cat8p 0.044
LYS5 Lys5p 0.044
FAA2 Faa2p 0.040
TOS3 Tos3p 0.038
CBK1 Cbk1p 0.038
GAL4 Gal4p 0.037
HXT3 Hxt3p 0.036
NUP157 Nup157p 0.036
SMP1 Smp1p 0.035
ZAP1 Zap1p 0.035
SAK1 Sak1p 0.034
GAT2 Gat2p 0.034
SRD1 Srd1p 0.033
RLM1 Rlm1p 0.033
FMP48 Fmp48p 0.032
HSF1 Hsf1p 0.031
HAL5 Hal5p 0.031
LEU2 Leu2p 0.031
YLR162W hypothetical protein 0.030
YLR264C-A hypothetical protein 0.029
YPR013C hypothetical protein 0.029
PHO12 Pho12p 0.029
YOL038C-A hypothetical protein 0.029
CAR2 Car2p 0.029
NDD1 Ndd1p 0.029
YNL234W hypothetical protein 0.028
GIS3 Gis3p 0.028
RMA1 Rma1p 0.028
MSN4 Msn4p 0.028
BSD2 Bsd2p 0.028
STP1 Stp1p 0.028
ARP10 Arp10p 0.028
HXT1 Hxt1p 0.028
IRC23 Irc23p 0.028
MER1 Mer1p 0.027
GUT2 Gut2p 0.027
VAC7 Vac7p 0.026
PSR2 Psr2p 0.026
BSC1 Bsc1p 0.026
TIP1 Tip1p 0.026
HPF1 Hpf1p 0.026
YIR035C hypothetical protein 0.026
STR3 Str3p 0.026
ICS2 Ics2p 0.026
SPL2 Spl2p 0.026
FAR3 Far3p 0.026
KIC1 Kic1p 0.025
SKS1 Sks1p 0.025
ATP6 Atp6p 0.025
YMR317W hypothetical protein 0.025
RIB2 Rib2p 0.024
ARG8 Arg8p 0.024
YAR068W hypothetical protein 0.024
YOL013W-A hypothetical protein 0.024
KRE29 Kre29p 0.024
PCT1 Pct1p 0.024
AUA1 Aua1p 0.024
PSR1 Psr1p 0.024
YAR066W hypothetical protein 0.024
NRG2 Nrg2p 0.024
RPT4 Rpt4p 0.024
ATF1 Atf1p 0.024
SNF3 Snf3p 0.024
YAP5 Yap5p 0.023
RPI1 Rpi1p 0.023
TOS8 Tos8p 0.023
FRK1 Frk1p 0.023
ZPS1 Zps1p 0.023
HRK1 Hrk1p 0.023
CUP1-1 Cup1-1p 0.023
AAD6 Aad6p 0.023
CHA1 Cha1p 0.023
FMT1 Fmt1p 0.023
YBR013C hypothetical protein 0.023
ALT2 Alt2p 0.023
YOR385W hypothetical protein 0.023
EAR1 Ear1p 0.022
YPL216W hypothetical protein 0.022
DOT6 Dot6p 0.022
STL1 Stl1p 0.022
SFC1 Sfc1p 0.022
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.661
BMPR1A bone morphogenetic protein receptor, type IA 0.392
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.369
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.267
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.217
BCL3 B-cell CLL/lymphoma 3 0.199
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.155
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.134
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.110
NCOR2 nuclear receptor corepressor 2 0.103
HNF4A hepatocyte nuclear factor 4, alpha 0.086
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.076
HP haptoglobin 0.035
RARA retinoic acid receptor, alpha 0.032
RXRA retinoid X receptor, alpha 0.032
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.031
JUB jub, ajuba homolog (Xenopus laevis) 0.026
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.021
APOC1 apolipoprotein C-I 0.021
NOG noggin 0.020
FSTL1 follistatin-like 1 0.019
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.016
TNIP2 TNFAIP3 interacting protein 2 0.016
RCOR1 REST corepressor 1 0.016
PPARA peroxisome proliferator-activated receptor alpha 0.015
LOXL4 lysyl oxidase-like 4 0.015
KLB klotho beta 0.014
NCOA1 nuclear receptor coactivator 1 0.012
HDAC3 histone deacetylase 3 0.012
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Mus musculus
Name Description Probability Func Analog Organism
Kl klotho 0.374
Phex phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) 0.327
Wnt4 wingless-related MMTV integration site 4 0.294
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.266
Bmp7 bone morphogenetic protein 7 0.241
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.205
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.150
Emid2 EMI domain containing 2 0.145
Wnt3a wingless-related MMTV integration site 3A 0.135
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.127
Prrx2 paired related homeobox 2 0.114
Pax2 paired box gene 2 0.103
Pax8 paired box gene 8 0.094
Casr calcium-sensing receptor 0.090
Tbx1 T-box 1 0.084
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.078
Lhx1 LIM homeobox protein 1 0.077
Fgf8 fibroblast growth factor 8 0.075
Wnt9a wingless-type MMTV integration site 9A 0.071
Hbb-b1 hemoglobin, beta adult major chain 0.068
Gdnf glial cell line derived neurotrophic factor 0.061
Porcn porcupine homolog (Drosophila) 0.060
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.052
Fgfr4 fibroblast growth factor receptor 4 0.049
Pou3f1 POU domain, class 3, transcription factor 1 0.047
Acvr1 activin A receptor, type 1 0.047
Insr insulin receptor 0.043
Cdx1 caudal type homeobox 1 0.043
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.042
Wnt10b wingless related MMTV integration site 10b 0.039
Htt huntingtin 0.039
Hoxa2 homeobox A2 0.038
Wnt1 wingless-related MMTV integration site 1 0.036
Wnt6 wingless-related MMTV integration site 6 0.036
Lepr leptin receptor 0.033
Snai1 snail homolog 1 (Drosophila) 0.032
Fzd10 frizzled homolog 10 (Drosophila) 0.031
Emx1 empty spiracles homolog 1 (Drosophila) 0.030
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.030
Dlx6 distal-less homeobox 6 0.030
Col13a1 collagen, type XIII, alpha 1 0.029
Pcsk4 proprotein convertase subtilisin/kexin type 4 0.029
Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 0.028
Npas1 neuronal PAS domain protein 1 0.028
Pou3f3 POU domain, class 3, transcription factor 3 0.027
Amhr2 anti-Mullerian hormone type 2 receptor 0.025
Fgf18 fibroblast growth factor 18 0.024
Foxi1 forkhead box I1 0.023
Vax1 ventral anterior homeobox containing gene 1 0.023
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.022
Tmem146 transmembrane protein 146 0.022
Ror1 receptor tyrosine kinase-like orphan receptor 1 0.021
Clic3 chloride intracellular channel 3 0.020
Socs1 suppressor of cytokine signaling 1 0.020
Fgfr1 fibroblast growth factor receptor 1 0.019
Tnfrsf8 tumor necrosis factor receptor superfamily, member 8 0.019
Gli1 GLI-Kruppel family member GLI1 0.018
Hoxd11 homeobox D11 0.018
Irx4 Iroquois related homeobox 4 (Drosophila) 0.018
Csf1 colony stimulating factor 1 (macrophage) 0.018
Adra2b adrenergic receptor, alpha 2b 0.018
Fzd1 frizzled homolog 1 (Drosophila) 0.017
Maf avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog 0.017
Bhlhe23 basic helix-loop-helix family, member e23 0.017
3110079O15Rik RIKEN cDNA 3110079O15 gene 0.017
Fgf2 fibroblast growth factor 2 0.016
Lmx1a LIM homeobox transcription factor 1 alpha 0.016
Gja3 gap junction protein, alpha 3 0.015
Artn artemin 0.015
Fzd8 frizzled homolog 8 (Drosophila) 0.015
Six6 sine oculis-related homeobox 6 homolog (Drosophila) 0.014
Hmx3 H6 homeobox 3 0.014
Fut7 fucosyltransferase 7 0.014
Nanog Nanog homeobox 0.014
Fbn2 fibrillin 2 0.013
Hoxc9 homeobox C9 0.013
Btbd17 BTB (POZ) domain containing 17 0.013
Galnt3 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 0.013
Chrdl2 chordin-like 2 0.013
Kcnma1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 0.013
Fgf3 fibroblast growth factor 3 0.013
Rarg retinoic acid receptor, gamma 0.012
Barx1 BarH-like homeobox 1 0.012
Tbx2 T-box 2 0.012
Fzd2 frizzled homolog 2 (Drosophila) 0.012
Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) 0.012
Wnt2 wingless-related MMTV integration site 2 0.012
Hand2 heart and neural crest derivatives expressed transcript 2 0.012
Pnpla2 patatin-like phospholipase domain containing 2 0.012
Atoh8 atonal homolog 8 (Drosophila) 0.012
Des desmin 0.012
Snai2 snail homolog 2 (Drosophila) 0.012
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.012
Fgfr3 fibroblast growth factor receptor 3 0.012
Epha1 Eph receptor A1 0.011
Tcfap2c transcription factor AP-2, gamma 0.011
Foxn1 forkhead box N1 0.011
Nkx6-3 NK6 homeobox 3 0.011
Pparg peroxisome proliferator activated receptor gamma 0.011
Hs6st3 heparan sulfate 6-O-sulfotransferase 3 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism