The network for 'dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest

A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
XIAP X-linked inhibitor of apoptosis 0.998
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.992
RB1 retinoblastoma 1 0.979
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.979
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.974
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.964
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.900
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.829
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.750
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.729
APAF1 apoptotic peptidase activating factor 1 0.716
FAS Fas (TNF receptor superfamily, member 6) 0.708
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.658
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.636
BCL2 B-cell CLL/lymphoma 2 0.579
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 0.554
POU3F2 POU class 3 homeobox 2 0.533
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.395
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.318
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.299
FADD Fas (TNFRSF6)-associated via death domain 0.276
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.258
CFLAR CASP8 and FADD-like apoptosis regulator 0.228
TP53 tumor protein p53 0.193
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.177
LRDD leucine-rich repeats and death domain containing 0.165
POU5F1 POU class 5 homeobox 1 0.139
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.126
SMAD7 SMAD family member 7 0.124
IER3 immediate early response 3 0.118
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.113
NLRC4 NLR family, CARD domain containing 4 0.110
RIPK2 receptor-interacting serine-threonine kinase 2 0.095
FASLG Fas ligand (TNF superfamily, member 6) 0.094
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.089
CCND1 cyclin D1 0.088
CDK2 cyclin-dependent kinase 2 0.085
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.069
PAX3 paired box 3 0.067
PPP2R5D protein phosphatase 2, regulatory subunit B', delta 0.052
BIRC2 baculoviral IAP repeat containing 2 0.051
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.046
DAXX death-domain associated protein 0.042
CCND3 cyclin D3 0.040
ELF4 E74-like factor 4 (ets domain transcription factor) 0.036
CDK6 cyclin-dependent kinase 6 0.033
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.031
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.030
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.025
RBL2 retinoblastoma-like 2 (p130) 0.023
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.022
MAPK1 mitogen-activated protein kinase 1 0.020
TGIF1 TGFB-induced factor homeobox 1 0.020
FOXD3 forkhead box D3 0.020
CCNE1 cyclin E1 0.020
DZIP1 DAZ interacting protein 1 0.018
HDAC4 histone deacetylase 4 0.017
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.017
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.017
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.017
IFI16 interferon, gamma-inducible protein 16 0.016
NUCB2 nucleobindin 2 0.014
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.012
MARCKSL1 MARCKS-like 1 0.012
NOTCH1 notch 1 0.012
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.010
PLSCR1 phospholipid scramblase 1 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Trp63 transformation related protein 63 0.940
Ctnnb1 catenin (cadherin associated protein), beta 1 0.925
Mdm2 transformed mouse 3T3 cell double minute 2 0.910
Mdm4 transformed mouse 3T3 cell double minute 4 0.907
Apc adenomatosis polyposis coli 0.881
Rb1 retinoblastoma 1 0.867
Pten phosphatase and tensin homolog 0.845
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.775
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.597
Kit kit oncogene 0.528
Trp73 transformation related protein 73 0.479
Col1a1 collagen, type I, alpha 1 0.436
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.410
Rara retinoic acid receptor, alpha 0.402
Brca1 breast cancer 1 0.383
Daxx Fas death domain-associated protein 0.321
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.317
Sox9 SRY-box containing gene 9 0.296
Thbs1 thrombospondin 1 0.288
Fgfr2 fibroblast growth factor receptor 2 0.265
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.261
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.241
Braf Braf transforming gene 0.224
Meox2 mesenchyme homeobox 2 0.182
Vhl von Hippel-Lindau tumor suppressor 0.169
Sfn stratifin 0.135
Rxra retinoid X receptor alpha 0.132
Skil SKI-like 0.130
Esr2 estrogen receptor 2 (beta) 0.118
Runx1 runt related transcription factor 1 0.107
Nf1 neurofibromatosis 1 0.096
Hif1a hypoxia inducible factor 1, alpha subunit 0.088
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.075
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.075
Brca2 breast cancer 2 0.075
Ptch1 patched homolog 1 0.073
Rag1 recombination activating gene 1 0.072
Psen1 presenilin 1 0.072
Esr1 estrogen receptor 1 (alpha) 0.060
E2f1 E2F transcription factor 1 0.053
Nf2 neurofibromatosis 2 0.051
Stk11 serine/threonine kinase 11 0.047
Ahr aryl-hydrocarbon receptor 0.045
Ccnd1 cyclin D1 0.043
Shh sonic hedgehog 0.043
Gadd45a growth arrest and DNA-damage-inducible 45 alpha 0.040
Dsc3 desmocollin 3 0.038
Emx2 empty spiracles homolog 2 (Drosophila) 0.034
Krt14 keratin 14 0.034
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.034
Hipk1 homeodomain interacting protein kinase 1 0.033
Smn1 survival motor neuron 1 0.031
Smad3 MAD homolog 3 (Drosophila) 0.031
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.030
Rbl1 retinoblastoma-like 1 (p107) 0.027
Vegfa vascular endothelial growth factor A 0.027
Atm ataxia telangiectasia mutated homolog (human) 0.026
Irf6 interferon regulatory factor 6 0.026
Mybl2 myeloblastosis oncogene-like 2 0.026
Hr hairless 0.025
Gli3 GLI-Kruppel family member GLI3 0.025
Tsc1 tuberous sclerosis 1 0.025
Yap1 yes-associated protein 1 0.024
Xpa xeroderma pigmentosum, complementation group A 0.020
Hhat hedgehog acyltransferase 0.019
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.019
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.018
Msh2 mutS homolog 2 (E. coli) 0.017
Lef1 lymphoid enhancer binding factor 1 0.017
Hprt hypoxanthine guanine phosphoribosyl transferase 0.017
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.017
Tcf3 transcription factor 3 0.016
Nfya nuclear transcription factor-Y alpha 0.016
Rarb retinoic acid receptor, beta 0.016
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.016
Bcl2 B-cell leukemia/lymphoma 2 0.015
Mta2 metastasis-associated gene family, member 2 0.014
Notch2 Notch gene homolog 2 (Drosophila) 0.014
Sin3a transcriptional regulator, SIN3A (yeast) 0.013
Gata3 GATA binding protein 3 0.013
Cdk2 cyclin-dependent kinase 2 0.013
Kitl kit ligand 0.013
Cdx2 caudal type homeobox 2 0.012
Men1 multiple endocrine neoplasia 1 0.012
Isl1 ISL1 transcription factor, LIM/homeodomain 0.012
Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 0.011
Tgfb1 transforming growth factor, beta 1 0.011
Rnf111 ring finger 111 0.011
Egfr epidermal growth factor receptor 0.011
Krt19 keratin 19 0.011
Cxcr4 chemokine (C-X-C motif) receptor 4 0.011
Ar androgen receptor 0.011
Bard1 BRCA1 associated RING domain 1 0.011
Bcl2l1 BCL2-like 1 0.011
Lrp6 low density lipoprotein receptor-related protein 6 0.011
Adam17 a disintegrin and metallopeptidase domain 17 0.010
Gtse1 G two S phase expressed protein 1 0.010
Lrdd leucine-rich and death domain containing 0.010
Wrn Werner syndrome homolog (human) 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism