The network for 'hypotonic response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

hypotonic response

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
HXT3 Hxt3p 0.033
GLN3 Gln3p 0.031
YKR075C hypothetical protein 0.026
MIG1 Mig1p 0.026
HAL5 Hal5p 0.026
GAT2 Gat2p 0.022
ROX1 Rox1p 0.021
RGS2 Rgs2p 0.019
MOT3 Mot3p 0.018
WAR1 War1p 0.018
TRA1 Tra1p 0.018
PHM8 Phm8p 0.018
YPL014W hypothetical protein 0.018
POG1 Pog1p 0.017
TYE7 Tye7p 0.017
LYS5 Lys5p 0.017
YLR297W hypothetical protein 0.017
IRC8 Irc8p 0.016
VAC7 Vac7p 0.016
SBE22 Sbe22p 0.016
HXT1 Hxt1p 0.015
RTG3 Rtg3p 0.015
HXT2 Hxt2p 0.015
PMD1 Pmd1p 0.015
PCL2 Pcl2p 0.015
YAR066W hypothetical protein 0.015
YAR068W hypothetical protein 0.015
NTO1 Nto1p 0.015
YPR157W hypothetical protein 0.015
NUP157 Nup157p 0.015
FAA2 Faa2p 0.015
TKL2 Tkl2p 0.015
GIP2 Gip2p 0.015
SMP1 Smp1p 0.015
CUP1-1 Cup1-1p 0.014
STP4 Stp4p 0.014
ZAP1 Zap1p 0.014
YNR014W hypothetical protein 0.014
GIS4 Gis4p 0.014
YPR013C hypothetical protein 0.014
YLR264C-A hypothetical protein 0.014
RLM1 Rlm1p 0.014
DAL81 Dal81p 0.014
SRD1 Srd1p 0.014
HAL1 Hal1p 0.014
CAT8 Cat8p 0.014
SSK2 Ssk2p 0.014
MGA1 Mga1p 0.014
ICY1 Icy1p 0.014
IRC23 Irc23p 0.014
LEU2 Leu2p 0.014
VHS1 Vhs1p 0.014
GIS3 Gis3p 0.014
YOL038C-A hypothetical protein 0.014
GDH3 Gdh3p 0.013
SWI1 Swi1p 0.013
PST1 Pst1p 0.013
MET4 Met4p 0.013
ARP10 Arp10p 0.013
TIP1 Tip1p 0.013
CTS1 Cts1p 0.013
YIR035C hypothetical protein 0.013
PHO12 Pho12p 0.013
CSR2 Csr2p 0.013
HOR2 Hor2p 0.013
YLR162W hypothetical protein 0.013
MER1 Mer1p 0.013
SPL2 Spl2p 0.013
SPI1 Spi1p 0.013
AUA1 Aua1p 0.013
ICS2 Ics2p 0.013
YAP5 Yap5p 0.013
EAR1 Ear1p 0.013
YMR317W hypothetical protein 0.013
ATP6 Atp6p 0.013
ARG8 Arg8p 0.013
YNL194C hypothetical protein 0.013
VHS2 Vhs2p 0.012
CAB3 Cab3p 0.012
VID24 Vid24p 0.012
RIM13 Rim13p 0.012
HST3 Hst3p 0.012
YBR013C hypothetical protein 0.012
YIL151C hypothetical protein 0.012
BSC1 Bsc1p 0.012
ZPS1 Zps1p 0.012
YOR385W hypothetical protein 0.012
FPK1 Fpk1p 0.012
RPI1 Rpi1p 0.012
YER130C hypothetical protein 0.012
YOL013W-A hypothetical protein 0.012
YNL234W hypothetical protein 0.012
HPF1 Hpf1p 0.012
YPL216W hypothetical protein 0.012
DFG16 Dfg16p 0.012
ADH2 Adh2p 0.012
YML003W hypothetical protein 0.012
FMT1 Fmt1p 0.012
ICL1 Icl1p 0.012
YAT1 Yat1p 0.012
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
ca2 carbonic anhydrase II 0.906
ca15a carbonic anhydrase XV a 0.423
slc9a3.2 solute carrier family 9 (sodium/hydrogen exchanger), member 3.2 0.119
slc4a1b solute carrier family 4, anion exchanger, member 1b 0.107
cfl2l cofilin 2, like 0.085
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.074
gcm2 glial cells missing homolog 2 (Drosophila) 0.073
foxh1 forkhead box H1 0.054
fabp11a fatty acid binding protein 11a 0.042
rhcgb Rhesus blood group, C glycoprotein b 0.040
cx27.5 connexin 27.5 0.034
aqp1a.1 aquaporin 1a, tandem duplicate 1 0.031
slc4a1a solute carrier family 4, anion exchanger, member 1a 0.024
si:ch211-284e13.2 si:ch211-284e13.2 0.024
slc4a4b solute carrier family 4, sodium bicarbonate cotransporter, member 4b 0.018
buc bucky ball 0.017
rgs4 regulator of G-protein signalling 4 0.017
tfe3b transcription factor binding to IGHM enhancer 3b 0.015
slc26a3 solute carrier family 26, member 3 0.014
cx30.3 connexin 30.3 0.014
slc12a10.2 solute carrier family 12 (sodium/potassium/chloride transporters), member 10.2 0.013
a2ml alpha-2-macroglobulin-like 0.013
acsl3a acyl-CoA synthetase long-chain family member 3a 0.012
zgc:153063 zgc:153063 0.012
rhag Rhesus blood group-associated glycoprotein 0.012
slc3a2 solute carrier family 3, member 2 0.012
zgc:193933 zgc:193933 0.012
cacnb2a calcium channel, voltage-dependent, beta 2a 0.011
znf536 zinc finger protein 536 0.011
fam20b family with sequence similarity 20, member B (H. sapiens) 0.011
nrg1 neuregulin 1 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CAB39 calcium binding protein 39 1.000
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.841
WNK4 WNK lysine deficient protein kinase 4 0.545
TRIP12 thyroid hormone receptor interactor 12 0.326
ITGA6 integrin, alpha 6 0.308
CTTN cortactin 0.257
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporters), member 2 0.157
PDIA3 protein disulfide isomerase family A, member 3 0.081
MMP1 matrix metallopeptidase 1 (interstitial collagenase) 0.073
CALD1 caldesmon 1 0.071
FN1 fibronectin 1 0.055
FHL2 four and a half LIM domains 2 0.055
MYL9 myosin, light chain 9, regulatory 0.053
STK39 serine threonine kinase 39 0.044
CNN1 calponin 1, basic, smooth muscle 0.031
OXSR1 oxidative-stress responsive 1 0.029
WDR26 WD repeat domain 26 0.029
CD63 CD63 molecule 0.025
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.024
UBA6 ubiquitin-like modifier activating enzyme 6 0.022
TPM1 tropomyosin 1 (alpha) 0.022
TNS1 tensin 1 0.021
SHARPIN SHANK-associated RH domain interactor 0.020
LTBP1 latent transforming growth factor beta binding protein 1 0.020
MAP2K1 mitogen-activated protein kinase kinase 1 0.017
CD9 CD9 molecule 0.016
ENG endoglin 0.016
WASL Wiskott-Aldrich syndrome-like 0.014
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.014
MAP2K4 mitogen-activated protein kinase kinase 4 0.014
CSRP1 cysteine and glycine-rich protein 1 0.012
LAMB3 laminin, beta 3 0.011
ING2 inhibitor of growth family, member 2 0.011
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 0.011
JAM3 junctional adhesion molecule 3 0.010
MXD1 MAX dimerization protein 1 0.010
EFTUD1 elongation factor Tu GTP binding domain containing 1 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Wnk4 WNK lysine deficient protein kinase 4 0.998
Cldn16 claudin 16 0.978
Slc12a2 solute carrier family 12, member 2 0.977
Mb myoglobin 0.936
Slc4a7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.850
Adora3 adenosine A3 receptor 0.823
Tgfb1 transforming growth factor, beta 1 0.738
Atp7a ATPase, Cu++ transporting, alpha polypeptide 0.614
Slc26a4 solute carrier family 26, member 4 0.475
Slc5a2 solute carrier family 5 (sodium/glucose cotransporter), member 2 0.336
Stk39 serine/threonine kinase 39, STE20/SPS1 homolog (yeast) 0.222
Kl klotho 0.211
Slc9a3 solute carrier family 9 (sodium/hydrogen exchanger), member 3 0.184
Scarb2 scavenger receptor class B, member 2 0.157
Ano1 anoctamin 1, calcium activated chloride channel 0.143
Coro1a coronin, actin binding protein 1A 0.108
Adipoq adiponectin, C1Q and collagen domain containing 0.102
Scnn1g sodium channel, nonvoltage-gated 1 gamma 0.072
Lgals12 lectin, galactose binding, soluble 12 0.069
Cfd complement factor D (adipsin) 0.050
Scnn1b sodium channel, nonvoltage-gated 1 beta 0.049
Cdh23 cadherin 23 (otocadherin) 0.038
Paqr5 progestin and adipoQ receptor family member V 0.037
Hmx2 H6 homeobox 2 0.034
Slc12a6 solute carrier family 12, member 6 0.033
Akr1b3 aldo-keto reductase family 1, member B3 (aldose reductase) 0.031
Cox8b cytochrome c oxidase, subunit VIIIb 0.030
Calml3 calmodulin-like 3 0.029
Gpr81 G protein-coupled receptor 81 0.029
Fxyd4 FXYD domain-containing ion transport regulator 4 0.028
Tmem45b transmembrane protein 45b 0.027
Cytl1 cytokine-like 1 0.027
Thrsp thyroid hormone responsive SPOT14 homolog (Rattus) 0.026
Ces1d carboxylesterase 1D 0.026
Arhgdib Rho, GDP dissociation inhibitor (GDI) beta 0.026
Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 0.025
Prr15l proline rich 15-like 0.024
Timp4 tissue inhibitor of metalloproteinase 4 0.024
Mapk15 mitogen-activated protein kinase 15 0.023
Prom2 prominin 2 0.023
Cnn1 calponin 1 0.022
Erp44 endoplasmic reticulum protein 44 0.022
Edn1 endothelin 1 0.022
Mapk14 mitogen-activated protein kinase 14 0.022
Anxa8 annexin A8 0.020
Myom3 myomesin family, member 3 0.020
Bsnd Bartter syndrome, infantile, with sensorineural deafness (Barttin) 0.020
Clec3b C-type lectin domain family 3, member b 0.020
Itgb6 integrin beta 6 0.020
Dpt dermatopontin 0.020
Tspan1 tetraspanin 1 0.019
Nr2e1 nuclear receptor subfamily 2, group E, member 1 0.018
Clcn3 chloride channel 3 0.018
Ckmt2 creatine kinase, mitochondrial 2 0.018
Cidec cell death-inducing DFFA-like effector c 0.018
Atox1 ATX1 (antioxidant protein 1) homolog 1 (yeast) 0.017
Cdkn2d cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.017
Umod uromodulin 0.017
Atp6v1c2 ATPase, H+ transporting, lysosomal V1 subunit C2 0.017
Slc44a3 solute carrier family 44, member 3 0.017
Myo6 myosin VI 0.016
Pabpn1l poly(A)binding protein nuclear 1-like 0.016
Ces1f carboxylesterase 1F 0.016
Sla src-like adaptor 0.015
Jag1 jagged 1 0.015
Itgb4 integrin beta 4 0.015
Epn3 epsin 3 0.015
Tmprss4 transmembrane protease, serine 4 0.015
Tmc5 transmembrane channel-like gene family 5 0.015
Sema3b sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.014
Panx3 pannexin 3 0.014
Clic3 chloride intracellular channel 3 0.014
Il17re interleukin 17 receptor E 0.014
Kremen2 kringle containing transmembrane protein 2 0.014
Dmrt2 doublesex and mab-3 related transcription factor 2 0.014
Inmt indolethylamine N-methyltransferase 0.014
Igsf5 immunoglobulin superfamily, member 5 0.014
Tusc5 tumor suppressor candidate 5 0.014
Cyp51 cytochrome P450, family 51 0.014
Trpv5 transient receptor potential cation channel, subfamily V, member 5 0.013
Sec23b SEC23B (S. cerevisiae) 0.013
Duox1 dual oxidase 1 0.013
Trim54 tripartite motif-containing 54 0.013
Plin4 perilipin 4 0.013
Tmprss13 transmembrane protease, serine 13 0.012
Art3 ADP-ribosyltransferase 3 0.012
Aqp1 aquaporin 1 0.012
Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 0.012
Sytl1 synaptotagmin-like 1 0.012
Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 0.012
Rnf128 ring finger protein 128 0.012
Fkbp1b FK506 binding protein 1b 0.012
Atp2c2 ATPase, Ca++ transporting, type 2C, member 2 0.012
Cd24a CD24a antigen 0.012
Scara5 scavenger receptor class A, member 5 (putative) 0.012
Ddo D-aspartate oxidase 0.012
Atp6v0a4 ATPase, H+ transporting, lysosomal V0 subunit A4 0.012
Acsl1 acyl-CoA synthetase long-chain family member 1 0.012
Arhgap9 Rho GTPase activating protein 9 0.012
Lrrc26 leucine rich repeat containing 26 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism