The network for 'positive regulation of protein kinase b signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of protein kinase b signaling

Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
rag1 recombination activating gene 1 0.645
foxc1a forkhead box C1a 0.337
igf1 insulin-like growth factor 1 0.327
stc1l stanniocalcin 1, like 0.271
ptgs1 prostaglandin-endoperoxide synthase 1 0.228
ptk2.1 protein tyrosine kinase 2a 0.216
LOC557072 caspase recruitment domain-containing protein 11-like 0.210
insrb insulin receptor b 0.207
evx1 even-skipped homeobox 1 0.200
ripk2 receptor-interacting serine-threonine kinase 2 0.176
fabp11a fatty acid binding protein 11a 0.169
dtng dystrobrevin, gamma and dystrobrevin, gamma-like 0.153
slc4a2a solute carrier family 4, anion exchanger, member 2a 0.136
ighm immunoglobulin heavy constant mu and immunoglobulin heavy constant mu 0.134
epas1b endothelial PAS domain protein 1b 0.131
igf2a insulin-like growth factor 2a 0.130
irx3a iroquois homeobox protein 3a 0.125
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.124
efnb2a ephrin B2a 0.123
bmp3 bone morphogenetic protein 3 0.120
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.113
podxl podocalyxin-like 0.112
tbpl2 TATA box binding protein like 2 0.112
ctgf connective tissue growth factor 0.111
vdra vitamin D receptor a 0.105
erbb3a v-erb-b2 erythroblastic leukemia viral oncogene homolog 3a 0.105
si:ch211-235f6.2 si:ch211-235f6.2 0.096
mbtps1 membrane-bound transcription factor protease, site 1 0.094
tgfb1a transforming growth factor, beta 1a 0.090
furinb furin (paired basic amino acid cleaving enzyme) b 0.090
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.090
vegfaa vascular endothelial growth factor Aa 0.089
hoxa4a homeo box A4a 0.085
hlxb9la homeo box HB9 like a 0.084
hoxc9a homeo box C9a 0.078
jag1b jagged 1b 0.074
emp2 epithelial membrane protein 2 0.074
plk2b polo-like kinase 2b (Drosophila) 0.072
pxn paxillin 0.070
hif1ab hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b 0.070
grifin galectin related inter-fiber protein 0.069
met met proto-oncogene (hepatocyte growth factor receptor) 0.069
tp63 tumor protein p63 0.066
ahr2 aryl hydrocarbon receptor 2 0.065
si:dkeyp-34c12.2 si:dkeyp-34c12.2 0.064
ghra growth hormone receptor a 0.062
plcg1 phospholipase C, gamma 1 0.061
card14 caspase recruitment domain family, member 14 0.060
dscam Down syndrome cell adhesion molecule 0.059
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.059
ighz immunoglobulin heavy constant zeta 0.058
masp2 mannan-binding lectin serine peptidase 2 0.057
insra insulin receptor a 0.057
pomt2 protein-O-mannosyltransferase 2 0.056
polm polymerase (DNA directed), mu 0.055
cyp19a1a cytochrome P450, family 19, subfamily A, polypeptide 1a 0.052
notch2 notch homolog 2 0.052
LOC100534970 hypothetical protein LOC100534970 0.052
notch3 notch homolog 3 0.051
cyp1d1 cytochrome P450, family 1, subfamily D, polypeptide 1 0.051
ccbe1 collagen and calcium binding EGF domains 1 0.050
large like-glycosyltransferase 0.050
plekhg4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 0.050
itgb1b integrin, beta 1b 0.050
dmd dystrophin 0.050
col27a1a collagen, type XXVII, alpha 1a 0.049
zgc:77714 zgc:77714 0.048
igf1rb insulin-like growth factor 1b receptor 0.048
pdgfaa platelet-derived growth factor alpha a 0.048
ifnphi1 interferon phi 1 0.048
thbs4b thrombospondin 4b 0.048
bfb complement component bfb 0.048
fn1 fibronectin 1 0.048
appb amyloid beta (A4) precursor protein b 0.046
fgfr2 fibroblast growth factor receptor 2 0.046
fabp11b fatty acid binding protein 11b 0.046
pomt1 protein-O-mannosyltransferase 1 0.046
dll4 delta-like 4 (Drosophila) 0.046
dip2c DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.045
sox7 SRY-box containing gene 7 0.045
copeb core promoter element binding protein 0.044
il1b interleukin 1, beta and interleukin 1, beta 0.044
isl2a islet2a 0.043
mstna myostatin a 0.042
mt2 metallothionein 2 0.042
zgc:85866 zgc:85866 0.042
atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.041
abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.041
si:rp71-39b20.7 si:rp71-39b20.7 0.041
fn1b fibronectin 1b 0.041
igf2b insulin-like growth factor 2b 0.041
zeb1 zinc finger E-box binding homeobox 1 0.040
fgfr3 fibroblast growth factor receptor 3 0.040
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.040
stk11 serine/threonine kinase 11 0.040
ddr2b discoidin domain receptor family, member 2b 0.040
si:ch211-212m21.5 si:ch211-212m21.5 0.039
bmp2a bone morphogenetic protein 2a 0.039
si:ch211-195h23.3 si:ch211-195h23.3 0.038
irf2bp2b interferon regulatory factor 2 binding protein 2b 0.038
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.000
GRB2 growth factor receptor-bound protein 2 1.000
EGFR epidermal growth factor receptor 1.000
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 1.000
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.999
SH3KBP1 SH3-domain kinase binding protein 1 0.997
SYK spleen tyrosine kinase 0.995
TEK TEK tyrosine kinase, endothelial 0.989
LCK lymphocyte-specific protein tyrosine kinase 0.989
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.979
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.978
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.976
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.976
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.969
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.964
LAT linker for activation of T cells 0.961
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.956
PLCG1 phospholipase C, gamma 1 0.940
MET met proto-oncogene (hepatocyte growth factor receptor) 0.923
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.922
AXL AXL receptor tyrosine kinase 0.911
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.903
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.816
GAB1 GRB2-associated binding protein 1 0.812
VEGFA vascular endothelial growth factor A 0.803
IGF1R insulin-like growth factor 1 receptor 0.802
FGFR1 fibroblast growth factor receptor 1 0.685
RXRA retinoid X receptor, alpha 0.608
SH2D4A SH2 domain containing 4A 0.598
FKBP1A FK506 binding protein 1A, 12kDa 0.575
ENG endoglin 0.530
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.525
VAV1 vav 1 guanine nucleotide exchange factor 0.483
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.480
CCR5 chemokine (C-C motif) receptor 5 0.473
NRP1 neuropilin 1 0.457
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.455
SNX9 sorting nexin 9 0.443
GHR growth hormone receptor 0.430
IRS1 insulin receptor substrate 1 0.425
BMP2 bone morphogenetic protein 2 0.405
FGA fibrinogen alpha chain 0.401
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.370
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.362
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.359
STK4 serine/threonine kinase 4 0.311
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.305
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.304
SPRR2A small proline-rich protein 2A 0.299
PDCD6IP programmed cell death 6 interacting protein 0.296
FYN FYN oncogene related to SRC, FGR, YES 0.295
WIPF1 WAS/WASL interacting protein family, member 1 0.287
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.260
SMAD7 SMAD family member 7 0.259
SPRY2 sprouty homolog 2 (Drosophila) 0.252
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.244
IL6 interleukin 6 (interferon, beta 2) 0.243
WASL Wiskott-Aldrich syndrome-like 0.242
SH3BP2 SH3-domain binding protein 2 0.233
TGFB1 transforming growth factor, beta 1 0.209
BCAR1 breast cancer anti-estrogen resistance 1 0.206
BLNK B-cell linker 0.202
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.197
CXCL9 chemokine (C-X-C motif) ligand 9 0.183
ANGPT2 angiopoietin 2 0.173
CDH5 cadherin 5, type 2 (vascular endothelium) 0.161
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.160
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.159
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.156
BBS10 Bardet-Biedl syndrome 10 0.156
CCL2 chemokine (C-C motif) ligand 2 0.148
DPP4 dipeptidyl-peptidase 4 0.143
GRAP2 GRB2-related adaptor protein 2 0.139
TGFB3 transforming growth factor, beta 3 0.138
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 0.127
VAV2 vav 2 guanine nucleotide exchange factor 0.127
CCL19 chemokine (C-C motif) ligand 19 0.122
PTPRB protein tyrosine phosphatase, receptor type, B 0.122
GAS7 growth arrest-specific 7 0.119
GAS6 growth arrest-specific 6 0.118
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.115
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.114
GAB2 GRB2-associated binding protein 2 0.114
PARVA parvin, alpha 0.114
PTK2 PTK2 protein tyrosine kinase 2 0.107
PTPRJ protein tyrosine phosphatase, receptor type, J 0.106
PDGFC platelet derived growth factor C 0.103
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.103
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.097
ARRB1 arrestin, beta 1 0.095
ALB albumin 0.090
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.087
CAV1 caveolin 1, caveolae protein, 22kDa 0.085
IDE insulin-degrading enzyme 0.085
MAPK8 mitogen-activated protein kinase 8 0.080
CSNK1E casein kinase 1, epsilon 0.079
FGG fibrinogen gamma chain 0.078
GDF5 growth differentiation factor 5 0.077
CXCL12 chemokine (C-X-C motif) ligand 12 0.075
MED28 mediator complex subunit 28 0.074
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Mus musculus
Name Description Probability Func Analog Organism
Tnf tumor necrosis factor 0.994
Egfr epidermal growth factor receptor 0.977
Cxcl13 chemokine (C-X-C motif) ligand 13 0.845
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.832
Cbl Casitas B-lineage lymphoma 0.828
C1qa complement component 1, q subcomponent, alpha polypeptide 0.810
LOC100048884 novel member of the major urinary protein (Mup) gene family 0.809
Grb2 growth factor receptor bound protein 2 0.768
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.711
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.679
Arrb2 arrestin, beta 2 0.619
Gab1 growth factor receptor bound protein 2-associated protein 1 0.612
C1qc complement component 1, q subcomponent, C chain 0.598
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.585
Ifng interferon gamma 0.519
Grb10 growth factor receptor bound protein 10 0.512
Arrb1 arrestin, beta 1 0.488
Mup10 major urinary protein 10 0.480
Hoxa9 homeobox A9 0.477
C1qb complement component 1, q subcomponent, beta polypeptide 0.449
Socs1 suppressor of cytokine signaling 1 0.448
Adam17 a disintegrin and metallopeptidase domain 17 0.434
Cd40 CD40 antigen 0.419
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.419
Itsn1 intersectin 1 (SH3 domain protein 1A) 0.379
Bdnf brain derived neurotrophic factor 0.361
Phox2a paired-like homeobox 2a 0.358
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.356
Axl AXL receptor tyrosine kinase 0.340
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.335
Cxcr5 chemokine (C-X-C motif) receptor 5 0.334
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.329
Dab2 disabled homolog 2 (Drosophila) 0.323
Ccr1 chemokine (C-C motif) receptor 1 0.313
Apoe apolipoprotein E 0.310
Mup9 major urinary protein 9 0.307
Mup4 major urinary protein 4 0.305
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.302
Lta lymphotoxin A 0.299
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.277
Il2 interleukin 2 0.269
Pbx1 pre B-cell leukemia transcription factor 1 0.268
Tyro3 TYRO3 protein tyrosine kinase 3 0.266
Ltbp4 latent transforming growth factor beta binding protein 4 0.260
Mup19 major urinary protein 19 0.248
Mertk c-mer proto-oncogene tyrosine kinase 0.248
Fxyd7 FXYD domain-containing ion transport regulator 7 0.240
Icos inducible T-cell co-stimulator 0.240
Kdr kinase insert domain protein receptor 0.236
Ntf3 neurotrophin 3 0.236
Il4 interleukin 4 0.235
Dpt dermatopontin 0.234
Adam4 a disintegrin and metallopeptidase domain 4 0.229
Lepr leptin receptor 0.228
Igf1 insulin-like growth factor 1 0.227
Lmna lamin A 0.226
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.224
Efs embryonal Fyn-associated substrate 0.221
Shc1 src homology 2 domain-containing transforming protein C1 0.221
Pten phosphatase and tensin homolog 0.217
Lrp1 low density lipoprotein receptor-related protein 1 0.212
Tox thymocyte selection-associated high mobility group box 0.212
Eln elastin 0.209
Mup5 major urinary protein 5 0.209
Pax2 paired box gene 2 0.206
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.195
Pkd2 polycystic kidney disease 2 0.195
Foxp3 forkhead box P3 0.191
Pou3f3 POU domain, class 3, transcription factor 3 0.188
Ltb lymphotoxin B 0.181
Atoh7 atonal homolog 7 (Drosophila) 0.178
Ramp2 receptor (calcitonin) activity modifying protein 2 0.176
Csf1r colony stimulating factor 1 receptor 0.173
Mup17 major urinary protein 17 0.172
Slc16a2 solute carrier family 16 (monocarboxylic acid transporters), member 2 0.169
Mup11 major urinary protein 11 0.169
Lhx4 LIM homeobox protein 4 0.167
Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 0.161
Mup12 major urinary protein 12 0.159
Shc3 src homology 2 domain-containing transforming protein C3 0.158
Sh2d1a SH2 domain protein 1A 0.157
Rxra retinoid X receptor alpha 0.155
Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 0.154
Sox2 SRY-box containing gene 2 0.152
Jag1 jagged 1 0.152
Il7 interleukin 7 0.150
Tenc1 tensin like C1 domain-containing phosphatase 0.148
Crhr1 corticotropin releasing hormone receptor 1 0.148
Sox10 SRY-box containing gene 10 0.147
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.147
Ikzf1 IKAROS family zinc finger 1 0.142
Mup14 major urinary protein 14 0.137
Aire autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) 0.136
Lmx1a LIM homeobox transcription factor 1 alpha 0.134
Efnb2 ephrin B2 0.133
Foxn1 forkhead box N1 0.133
Mup8 major urinary protein 8 0.131
Inpp5d inositol polyphosphate-5-phosphatase D 0.129
Mafb v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.129
Ptch2 patched homolog 2 0.127
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Rattus norvegicus
Name Description Probability Func Analog Organism
Dbp D site of albumin promoter (albumin D-box) binding protein 0.082
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.067
Cyfip1 cytoplasmic FMR1 interacting protein 1 0.048
Runx1 runt-related transcription factor 1 0.043
Il6 interleukin 6 0.043
Ddr1 discoidin domain receptor tyrosine kinase 1 0.040
Ptgs2 prostaglandin-endoperoxide synthase 2 0.035
Cyp3a23/3a1 cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 0.035
Scn9a sodium channel, voltage-gated, type IX, alpha 0.032
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.031
Agtr1a angiotensin II receptor, type 1a 0.030
Fosl1 fos-like antigen 1 0.029
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.028
Col8a1 collagen, type VIII, alpha 1 0.028
Cd80 Cd80 molecule 0.025
Gata3 GATA binding protein 3 0.025
Vdr vitamin D (1,25- dihydroxyvitamin D3) receptor 0.025
Calcb calcitonin-related polypeptide, beta 0.023
Ptafr platelet-activating factor receptor 0.022
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.022
Tgfbr2 transforming growth factor, beta receptor II 0.021
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.021
Ccl3 chemokine (C-C motif) ligand 3 0.021
Podxl podocalyxin-like 0.020
Ghr growth hormone receptor 0.019
Tgm1 transglutaminase 1, K polypeptide 0.019
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.019
Gucy2f guanylate cyclase 2F 0.019
Olr1701 olfactory receptor 1701 0.019
Snx18 sorting nexin 18 0.017
Ccl4 chemokine (C-C motif) ligand 4 0.016
Smad7 SMAD family member 7 0.016
Ralgds ral guanine nucleotide dissociation stimulator 0.016
Shc3 SHC (Src homology 2 domain containing) transforming protein 3 0.016
Dmgdh dimethylglycine dehydrogenase 0.015
Mup5 major urinary protein 5 0.015
Pou2f2 POU class 2 homeobox 2 0.015
Rgs1 regulator of G-protein signaling 1 0.014
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.014
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.014
Tfpi2 tissue factor pathway inhibitor 2 0.013
Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.013
Car3 carbonic anhydrase 3 0.012
Il1a interleukin 1 alpha 0.012
Trim17 tripartite motif-containing 17 0.012
Crip2 cysteine-rich protein 2 0.012
Pdc phosducin 0.012
Gata6 GATA binding protein 6 0.012
LOC259246 alpha-2u globulin PGCL1 0.012
Guca1a guanylate cyclase activator 1a (retina) 0.012
Slc5a7 solute carrier family 5 (choline transporter), member 7 0.012
Fgf18 fibroblast growth factor 18 0.012
Pdgfb platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.012
Stat5b signal transducer and activator of transcription 5B 0.011
Itgam integrin, alpha M 0.011
Gdf10 growth differentiation factor 10 0.011
Myo1f myosin IF 0.011
Ccnd3 cyclin D3 0.011
Nox4 NADPH oxidase 4 0.011
Sycn syncollin 0.010
Tbxa2r thromboxane A2 receptor 0.010
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.010