The network for 'sphingolipid biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

sphingolipid biosynthetic process

The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
LCB2 Lcb2p 0.897
TOR2 Tor2p 0.875
LAG1 Lag1p 0.874
TOR1 Tor1p 0.787
LCB1 Lcb1p 0.510
MDS3 Mds3p 0.446
BMH1 Bmh1p 0.400
SCS7 Scs7p 0.320
PTK2 Ptk2p 0.304
YPK1 Ypk1p 0.286
TSC3 Tsc3p 0.244
CMK2 Cmk2p 0.235
SLM1 Slm1p 0.232
GSF2 Gsf2p 0.208
LAC1 Lac1p 0.207
VMA11 Vma11p 0.203
CSG2 Csg2p 0.193
IFA38 Ifa38p 0.184
FPK1 Fpk1p 0.157
LCB3 Lcb3p 0.152
ELO1 Elo1p 0.141
RIM101 Rim101p 0.128
SVP26 Svp26p 0.110
TCO89 Tco89p 0.109
SIA1 Sia1p 0.100
SUR2 Sur2p 0.098
LIP1 Lip1p 0.096
KSP1 Ksp1p 0.092
GCS1 Gcs1p 0.085
IPT1 Ipt1p 0.080
YJL193W hypothetical protein 0.080
SAK1 Sak1p 0.080
NPR1 Npr1p 0.079
YPL260W hypothetical protein 0.077
YLR257W hypothetical protein 0.076
TAX4 Tax4p 0.075
SUR1 Sur1p 0.072
IZH3 Izh3p 0.072
PPQ1 Ppq1p 0.071
NUR1 Nur1p 0.070
AVT1 Avt1p 0.069
SSK1 Ssk1p 0.069
ISC1 Isc1p 0.066
RTS1 Rts1p 0.064
YLR177W hypothetical protein 0.063
PLB2 Plb2p 0.062
FMP48 Fmp48p 0.060
CTR2 Ctr2p 0.060
ERG11 Erg11p 0.059
OSH3 Osh3p 0.058
TOS1 Tos1p 0.058
MBF1 Mbf1p 0.055
LST4 Lst4p 0.052
YLR162W hypothetical protein 0.050
YPL014W hypothetical protein 0.050
FKS1 Fks1p 0.049
MRS3 Mrs3p 0.049
AGP1 Agp1p 0.046
YGR016W hypothetical protein 0.043
PAM1 Pam1p 0.043
GPI2 Gpi2p 0.043
YNL144C hypothetical protein 0.043
SRD1 Srd1p 0.042
YAR028W hypothetical protein 0.042
YLR264C-A hypothetical protein 0.041
SKS1 Sks1p 0.041
OST1 Ost1p 0.041
PMC1 Pmc1p 0.041
ATO3 Ato3p 0.041
PMT6 Pmt6p 0.040
AZF1 Azf1p 0.040
VMA16 Vma16p 0.039
ATF2 Atf2p 0.039
LEU2 Leu2p 0.038
CSH1 Csh1p 0.038
PRR2 Prr2p 0.038
PSD1 Psd1p 0.037
PHD1 Phd1p 0.037
SHR3 Shr3p 0.037
YOL038C-A hypothetical protein 0.037
ERD2 Erd2p 0.037
YMR102C hypothetical protein 0.036
VHR1 Vhr1p 0.035
VHS1 Vhs1p 0.035
HAL5 Hal5p 0.035
KIN82 Kin82p 0.034
YOR390W hypothetical protein 0.034
YPS1 Yps1p 0.034
OPY1 Opy1p 0.033
SEF1 Sef1p 0.033
MF(ALPHA)2 Mf(alpha)2p 0.033
CHS1 Chs1p 0.033
LDB16 Ldb16p 0.032
YPR063C hypothetical protein 0.032
HRK1 Hrk1p 0.032
SPL2 Spl2p 0.031
YAR068W hypothetical protein 0.031
RPS14B Rps14bp 0.031
ARP10 Arp10p 0.031
SPC25 Spc25p 0.031
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
T22D1.3 Protein T22D1.3 0.038
elo-2 Protein ELO-2 0.022
pmp-1 Protein PMP-1 0.019
tbc-3 Protein TBC-3 0.017
F53E4.1 Protein F53E4.1 0.016
sur-5 Protein SUR-5 0.016
aagr-2 Protein AAGR-2 0.015
mlc-4 Protein MLC-4 0.014
cdc-37 Protein CDC-37 0.014
CELE_C27A7.1 Protein C27A7.1 0.014
abts-3 Protein ABTS-3 0.014
cki-2 Protein CKI-2 0.012
fln-1 Protein FLN-1 0.012
gob-1 Protein GOB-1 0.011
hmgs-1 Protein HMGS-1 0.011
mrp-5 Protein MRP-5 0.011
tre-3 Protein TRE-3 0.011
sptl-1 Protein SPTL-1 0.011
gspd-1 Protein GSPD-1 0.011
dph-2 Protein DPH-2 0.011
best-7 Protein BEST-7 0.011
T10B5.7 Protein T10B5.7 0.011
elt-2 Protein ELT-2 0.010
hpo-19 Protein HPO-19 0.010
mboa-3 Protein MBOA-3 0.010
pcyt-1 Protein PCYT-1 0.010
Y25C1A.7 Protein Y25C1A.7 0.010
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Danio rerio
Name Description Probability Func Analog Organism
st8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 0.306
st8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.256
st8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.252
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.249
slc9a3r1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.233
lpp LIM domain containing preferred translocation partner in lipoma 0.232
vtg7 vitellogenin 7 0.201
pitpna phosphatidylinositol transfer protein, alpha 0.134
fa2h fatty acid 2-hydroxylase 0.118
lass5 LAG1 homolog, ceramide synthase 5 (S. cerevisiae) 0.118
vtg6 vitellogenin 6 0.118
LOC564867 novel protein similar to LAG1 homolog, ceramide synthase family 0.113
rnf128a ring finger protein 128a 0.108
cyp19a1b cytochrome P450, family 19, subfamily A, polypeptide 1b 0.093
elovl7b ELOVL family member 7, elongation of long chain fatty acids (yeast) b 0.091
rplp1 ribosomal protein, large, P1 0.090
ren renin 0.084
ucp2 uncoupling protein 2 0.083
atp6v0d1 ATPase, H+ transporting, V0 subunit D isoform 1 0.083
lndc1 ly6/neurotoxin domain containing 1 0.080
stk10 serine/threonine kinase 10 0.076
cotl1 coactosin-like 1 (Dictyostelium) 0.076
vtg1 vitellogenin 1 0.067
gper G protein-coupled estrogen receptor 1 0.063
mapk1 mitogen-activated protein kinase 1 0.061
fkbp10 FK506 binding protein 10 0.058
pfn1 profilin 1 0.055
csnk1db casein kinase 1, delta b 0.054
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.052
sass6 spindle assembly 6 homolog (C. elegans) 0.048
fam49ba family with sequence similarity 49, member Ba 0.046
eomesa eomesodermin homolog a 0.043
st8sia5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 0.043
c1galt1b core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1b 0.042
anxa3b annexin A3b 0.042
lrmp lymphoid-restricted membrane protein 0.041
spg11 spastic paraplegia 11 0.041
zgc:56419 zgc:56419 0.040
grhl3 grainyhead-like 3 0.040
tob1a transducer of ERBB2, 1a 0.038
sh3gl1a SH3-domain GRB2-like 1a 0.038
si:ch211-284e13.2 si:ch211-284e13.2 0.037
ugp2b UDP-glucose pyrophosphorylase 2b 0.037
slc39a7 solute carrier family 39 (zinc transporter), member 7 0.035
atp6v1h ATPase, H+ transporting, lysosomal, V1 subunit H 0.035
ppp1r14aa protein phosphatase 1, regulatory (inhibitor) subunit 14Aa 0.034
foxo3a forkhead box O3A 0.034
arpc1b actin related protein 2/3 complex, subunit 1B 0.034
fzd5 frizzled homolog 5 0.034
ckmt2 creatine kinase, mitochondrial 2 (sarcomeric) 0.033
dusp1 dual specificity phosphatase 1 0.033
si:dkey-49m19.7 si:dkey-49m19.7 0.032
ctsz cathepsin Z 0.031
si:ch73-178d14.1 si:ch73-178d14.1 0.031
zgc:56280 zgc:56280 0.030
btg2 B-cell translocation gene 2 0.030
ehd2 EH-domain containing 2 0.029
cldn15a claudin 15a 0.029
gulp1 GULP, engulfment adaptor PTB domain containing 1 0.029
aqp7 aquaporin 7 0.029
manf mesencephalic astrocyte-derived neurotrophic factor 0.029
rock2b rho-associated, coiled-coil containing protein kinase 2b 0.029
pgr progesterone receptor 0.028
trpc6 transient receptor potential cation channel, subfamily C, member 6 0.028
pomt1 protein-O-mannosyltransferase 1 0.027
ctsd cathepsin D 0.027
mllt10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.027
etv5a ets variant 5a 0.027
baiap2l1a BAI1-associated protein 2-like 1a 0.027
clica chloride intracellular channel a 0.027
plxnb2b plexin b2b 0.026
gna12 guanine nucleotide binding protein (G protein) alpha 12 0.026
zgc:64098 zgc:64098 0.026
rtn4a reticulon 4a 0.025
junb jun B proto-oncogene 0.025
anxa5b annexin A5b 0.025
pglyrp2 peptidoglycan recognition protein 2 0.024
pafah1b1a platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a 0.024
alas1 aminolevulinate, delta-, synthetase 1 0.023
mmp15a matrix metallopeptidase 15a 0.023
igfbp1a insulin-like growth factor binding protein 1a 0.023
lass2 LAG1 homolog, ceramide synthase 2 (S. cerevisiae) 0.023
rab13 RAB13, member RAS oncogene family 0.023
sgta small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 0.023
gria1b glutamate receptor, ionotropic, AMPA 1b 0.023
cldn2 claudin 2 0.022
cyp2y3 cytochrome P450, family 2, subfamily Y, polypeptide 3 0.022
plk3 polo-like kinase 3 (Drosophila) 0.022
ndel1b nudE nuclear distribution gene E homolog like 1 (A. nidulans) B 0.022
hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 0.021
srpx sushi-repeat-containing protein 0.021
sult3st2 sulfotransferase family 3, cytosolic sulfotransferase 2 0.021
homez homeodomain leucine zipper gene 0.021
trim71 tripartite motif-containing 71 0.021
LOC569642 hypothetical protein LOC569642 0.021
ca8 carbonic anhydrase VIII 0.021
gpx7 glutathione peroxidase 7 0.021
slc25a14 solute carrier family 25 (mitochondrial carrier, brain), member 14 0.020
far1 fatty acyl CoA reductase 1 0.020
th2 tyrosine hydroxylase 2 0.020
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
CG16904 CG16904 gene product from transcript CG16904-RA 0.028
CG30008 CG30008 gene product from transcript CG30008-RA 0.022
CG33129 CG33129 gene product from transcript CG33129-RE 0.011
CG9459 CG9459 gene product from transcript CG9459-RA 0.010
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.379
PDPK1 3-phosphoinositide dependent protein kinase-1 0.092
LAMP1 lysosomal-associated membrane protein 1 0.075
NOXA1 NADPH oxidase activator 1 0.065
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.050
SURF4 surfeit 4 0.039
ANXA4 annexin A4 0.039
NUMB numb homolog (Drosophila) 0.038
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.034
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.033
PICK1 protein interacting with PRKCA 1 0.033
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.031
SH3RF1 SH3 domain containing ring finger 1 0.029
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.027
CDC37 cell division cycle 37 homolog (S. cerevisiae) 0.027
MAPT microtubule-associated protein tau 0.026
RICTOR RPTOR independent companion of MTOR, complex 2 0.025
RARA retinoic acid receptor, alpha 0.025
CTGF connective tissue growth factor 0.024
SLC39A1 solute carrier family 39 (zinc transporter), member 1 0.024
DUSP23 dual specificity phosphatase 23 0.023
PARD6G par-6 partitioning defective 6 homolog gamma (C. elegans) 0.023
LRRK2 leucine-rich repeat kinase 2 0.022
ZNF71 zinc finger protein 71 0.021
CCDC115 coiled-coil domain containing 115 0.018
DCTN1 dynactin 1 0.017
CDCP1 CUB domain containing protein 1 0.017
BRF2 BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like 0.016
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 0.016
RPTOR regulatory associated protein of MTOR, complex 1 0.016
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.015
LASS2 LAG1 homolog, ceramide synthase 2 0.014
TWF2 twinfilin, actin-binding protein, homolog 2 (Drosophila) 0.013
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.013
FYN FYN oncogene related to SRC, FGR, YES 0.012
NR1H2 nuclear receptor subfamily 1, group H, member 2 0.012
RHEB Ras homolog enriched in brain 0.012
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.011
DEPTOR DEP domain containing MTOR-interacting protein 0.011
PDK1 pyruvate dehydrogenase kinase, isozyme 1 0.010
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.010
NPTN neuroplastin 0.010
NMT2 N-myristoyltransferase 2 0.010
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Elovl1 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1 0.976
Mapkap1 mitogen-activated protein kinase associated protein 1 0.863
Ctgf connective tissue growth factor 0.704
Sptlc2 serine palmitoyltransferase, long chain base subunit 2 0.685
Rptor regulatory associated protein of MTOR, complex 1 0.583
Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 0.581
Ebp phenylalkylamine Ca2+ antagonist (emopamil) binding protein 0.570
Mlst8 MTOR associated protein, LST8 homolog (S. cerevisiae) 0.537
Rictor RPTOR independent companion of MTOR, complex 2 0.495
Thbs1 thrombospondin 1 0.494
Fos FBJ osteosarcoma oncogene 0.488
Bcap31 B-cell receptor-associated protein 31 0.458
Spcs2 signal peptidase complex subunit 2 homolog (S. cerevisiae) 0.450
Cyr61 cysteine rich protein 61 0.420
Ptges prostaglandin E synthase 0.376
Mfsd1 major facilitator superfamily domain containing 1 0.357
Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) 0.289
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.271
Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 0.259
Asah1 N-acylsphingosine amidohydrolase 1 0.227
Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 0.220
Mybph myosin binding protein H 0.219
Gaa glucosidase, alpha, acid 0.198
Scarb2 scavenger receptor class B, member 2 0.188
Tmem9b TMEM9 domain family, member B 0.185
Igh immunoglobulin heavy chain complex 0.180
Pttg1ip pituitary tumor-transforming 1 interacting protein 0.179
Errfi1 ERBB receptor feedback inhibitor 1 0.177
Inpp5j inositol polyphosphate 5-phosphatase J 0.170
Tmem33 transmembrane protein 33 0.161
0610007P14Rik RIKEN cDNA 0610007P14 gene 0.157
P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 0.147
Acsl5 acyl-CoA synthetase long-chain family member 5 0.141
Tnc tenascin C 0.138
Dpp7 dipeptidylpeptidase 7 0.133
Rnh1 ribonuclease/angiogenin inhibitor 1 0.132
Orai1 ORAI calcium release-activated calcium modulator 1 0.131
Derl2 Der1-like domain family, member 2 0.128
Acly ATP citrate lyase 0.126
P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 0.126
Cd9 CD9 antigen 0.120
Capn2 calpain 2 0.116
Syt3 synaptotagmin III 0.115
Scamp2 secretory carrier membrane protein 2 0.111
Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 0.111
Txndc12 thioredoxin domain containing 12 (endoplasmic reticulum) 0.110
Ptgir prostaglandin I receptor (IP) 0.108
Atp6ap1 ATPase, H+ transporting, lysosomal accessory protein 1 0.106
Anxa4 annexin A4 0.104
Pthlh parathyroid hormone-like peptide 0.104
Rpa3 replication protein A3 0.103
Soat1 sterol O-acyltransferase 1 0.101
Btk Bruton agammaglobulinemia tyrosine kinase 0.100
Rab25 RAB25, member RAS oncogene family 0.098
Mgat2 mannoside acetylglucosaminyltransferase 2 0.098
Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 0.094
Hrh1 histamine receptor H1 0.090
Rragc Ras-related GTP binding C 0.088
Blnk B-cell linker 0.088
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.085
Nrcam neuron-glia-CAM-related cell adhesion molecule 0.084
F3 coagulation factor III 0.081
D15Ertd621e DNA segment, Chr 15, ERATO Doi 621, expressed 0.080
Sc4mol sterol-C4-methyl oxidase-like 0.078
Tll1 tolloid-like 0.078
Zfp36 zinc finger protein 36 0.077
Cstb cystatin B 0.076
Anxa5 annexin A5 0.076
Serp1 stress-associated endoplasmic reticulum protein 1 0.076
Sft2d1 SFT2 domain containing 1 0.076
Mag myelin-associated glycoprotein 0.075
Hr hairless 0.072
Cln5 ceroid-lipofuscinosis, neuronal 5 0.072
Cd40 CD40 antigen 0.072
Dusp1 dual specificity phosphatase 1 0.072
Pdcd6 programmed cell death 6 0.071
Col8a1 collagen, type VIII, alpha 1 0.067
Rnase1 ribonuclease, RNase A family, 1 (pancreatic) 0.065
Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a 0.063
Slc31a1 solute carrier family 31, member 1 0.063
Cdh13 cadherin 13 0.062
Tpp1 tripeptidyl peptidase I 0.062
Fgf7 fibroblast growth factor 7 0.061
Litaf LPS-induced TN factor 0.061
Tspan31 tetraspanin 31 0.061
Lgmn legumain 0.058
Plekhg6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 0.057
Klf6 Kruppel-like factor 6 0.057
Man2a1 mannosidase 2, alpha 1 0.056
Degs1 degenerative spermatocyte homolog 1 (Drosophila) 0.054
Adam9 a disintegrin and metallopeptidase domain 9 (meltrin gamma) 0.053
Pla2g10 phospholipase A2, group X 0.053
Slc2a5 solute carrier family 2 (facilitated glucose transporter), member 5 0.053
1600012H06Rik RIKEN cDNA 1600012H06 gene 0.052
Lgals2 lectin, galactose-binding, soluble 2 0.052
Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b 0.051
Syt5 synaptotagmin V 0.050
Lox lysyl oxidase 0.049
Tmem19 transmembrane protein 19 0.049
Msln mesothelin 0.049
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Tspan31 tetraspanin 31 0.034
RGD1303130 kidney predominant protein NCU-G1 0.024
Errfi1 ERBB receptor feedback inhibitor 1 0.024
Slc25a5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.016
Lass2 LAG1 homolog, ceramide synthase 2 0.015
Gltp glycolipid transfer protein 0.015
Elovl1 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1 0.015
Aga aspartylglucosaminidase 0.014
Fos FBJ osteosarcoma oncogene 0.014
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.013
Sdc1 syndecan 1 0.013
Fgl2 fibrinogen-like 2 0.013
Scamp3 secretory carrier membrane protein 3 0.013
Dio1 deiodinase, iodothyronine, type I 0.012
Khk ketohexokinase 0.012
Rpn1 ribophorin I 0.012
Efhd2 EF-hand domain family, member D2 0.012
Slc48a1 solute carrier family 48 (heme transporter), member 1 0.012
Upb1 ureidopropionase, beta 0.012
Tmbim1 transmembrane BAX inhibitor motif containing 1 0.012
Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.012
Bpnt1 3'(2'), 5'-bisphosphate nucleotidase 1 0.011
Egr1 early growth response 1 0.011
RGD1311307 similar to 1300014I06Rik protein 0.011
Hyal3 hyaluronoglucosaminidase 3 0.011
Zfp36 zinc finger protein 36 0.010
Acat3 acetyl-Coenzyme A acetyltransferase 3 0.010
Rassf4 Ras association (RalGDS/AF-6) domain family member 4 0.010