The network for 'negative regulation of steroid biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of steroid biosynthetic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
VID24 Vid24p 0.076
TRA1 Tra1p 0.066
GLN3 Gln3p 0.056
YKR075C hypothetical protein 0.054
MIG2 Mig2p 0.054
HXT3 Hxt3p 0.048
HAL5 Hal5p 0.045
TPO2 Tpo2p 0.044
GAT2 Gat2p 0.044
MIG3 Mig3p 0.041
YPR157W hypothetical protein 0.039
BSD2 Bsd2p 0.038
LYS5 Lys5p 0.036
ROX1 Rox1p 0.036
VHS1 Vhs1p 0.036
ARP8 Arp8p 0.032
VAC7 Vac7p 0.030
RLM1 Rlm1p 0.030
ZAP1 Zap1p 0.030
CSR2 Csr2p 0.030
YLR297W hypothetical protein 0.029
EAR1 Ear1p 0.029
WAR1 War1p 0.029
OPY2 Opy2p 0.027
FAA2 Faa2p 0.027
RGS2 Rgs2p 0.027
TOS3 Tos3p 0.027
GIP2 Gip2p 0.026
NUM1 Num1p 0.026
SRD1 Srd1p 0.025
TYE7 Tye7p 0.025
MSN2 Msn2p 0.025
GDH3 Gdh3p 0.025
TBS1 Tbs1p 0.025
YNR014W hypothetical protein 0.025
KIC1 Kic1p 0.025
RPI1 Rpi1p 0.025
HST3 Hst3p 0.025
YPL014W hypothetical protein 0.024
MIG1 Mig1p 0.024
ACE2 Ace2p 0.024
DAL81 Dal81p 0.024
RMA1 Rma1p 0.024
YKL187C hypothetical protein 0.024
YNL234W hypothetical protein 0.023
SSK2 Ssk2p 0.023
SFL1 Sfl1p 0.023
GAL4 Gal4p 0.023
NRG1 Nrg1p 0.023
ICS2 Ics2p 0.023
YLR264C-A hypothetical protein 0.022
LEU2 Leu2p 0.022
MOT3 Mot3p 0.022
YLR162W hypothetical protein 0.022
YOL038C-A hypothetical protein 0.022
YOL036W hypothetical protein 0.022
GIS3 Gis3p 0.022
SSU1 Ssu1p 0.022
NUP157 Nup157p 0.022
PUT4 Put4p 0.022
CHS2 Chs2p 0.021
SAK1 Sak1p 0.021
MF(ALPHA)2 Mf(alpha)2p 0.021
POG1 Pog1p 0.021
CUP1-1 Cup1-1p 0.021
SPL2 Spl2p 0.021
MOB1 Mob1p 0.021
ARP10 Arp10p 0.021
YIR035C hypothetical protein 0.020
KRE29 Kre29p 0.020
ADH2 Adh2p 0.020
PHM8 Phm8p 0.020
MF(ALPHA)1 Mf(alpha)1p 0.020
YNL058C hypothetical protein 0.020
HPF1 Hpf1p 0.020
ATP6 Atp6p 0.020
YAR066W hypothetical protein 0.020
RDS2 Rds2p 0.020
VPS27 Vps27p 0.020
TIP1 Tip1p 0.020
AUA1 Aua1p 0.019
NHA1 Nha1p 0.019
YJL107C hypothetical protein 0.019
HOR2 Hor2p 0.019
MER1 Mer1p 0.019
YPR013C hypothetical protein 0.019
YDR506C hypothetical protein 0.019
AAD6 Aad6p 0.019
SMP1 Smp1p 0.019
STL1 Stl1p 0.019
CHA1 Cha1p 0.019
CAT8 Cat8p 0.019
IRC23 Irc23p 0.019
YMR317W hypothetical protein 0.019
SCM4 Scm4p 0.019
BSC2 Bsc2p 0.019
FMP48 Fmp48p 0.019
ADY2 Ady2p 0.019
RAD28 Rad28p 0.019
NDD1 Ndd1p 0.019
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.834
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.617
BMPR1A bone morphogenetic protein receptor, type IA 0.396
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.325
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.276
BCL3 B-cell CLL/lymphoma 3 0.173
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.134
HNF4A hepatocyte nuclear factor 4, alpha 0.126
NCOR2 nuclear receptor corepressor 2 0.120
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.114
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.096
BMPR1B bone morphogenetic protein receptor, type IB 0.075
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.071
HP haptoglobin 0.070
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.064
NOG noggin 0.039
PRDX1 peroxiredoxin 1 0.030
TNIP2 TNFAIP3 interacting protein 2 0.026
KDM1A lysine (K)-specific demethylase 1A 0.024
APOC1 apolipoprotein C-I 0.022
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.022
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.020
A2M alpha-2-macroglobulin 0.019
HR hairless homolog (mouse) 0.017
RXRA retinoid X receptor, alpha 0.017
IDI1 isopentenyl-diphosphate delta isomerase 1 0.017
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.016
CHD9 chromodomain helicase DNA binding protein 9 0.016
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.015
LCAT lecithin-cholesterol acyltransferase 0.014
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 0.014
KLB klotho beta 0.014
RCOR1 REST corepressor 1 0.013
ZFYVE9 zinc finger, FYVE domain containing 9 0.013
FGF4 fibroblast growth factor 4 0.012
RARA retinoic acid receptor, alpha 0.011
ALB albumin 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Bmp7 bone morphogenetic protein 7 0.299
Kl klotho 0.291
T brachyury 0.234
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.160
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.131
Casr calcium-sensing receptor 0.059
Pax8 paired box gene 8 0.058
Pcsk4 proprotein convertase subtilisin/kexin type 4 0.055
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.053
Lepr leptin receptor 0.051
Insr insulin receptor 0.044
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.044
Esr1 estrogen receptor 1 (alpha) 0.043
Wnt4 wingless-related MMTV integration site 4 0.042
Hoxa2 homeobox A2 0.038
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.038
Acvr1 activin A receptor, type 1 0.036
Fgfr4 fibroblast growth factor receptor 4 0.032
Gli1 GLI-Kruppel family member GLI1 0.031
Shh sonic hedgehog 0.031
Wnt3a wingless-related MMTV integration site 3A 0.029
Sox9 SRY-box containing gene 9 0.027
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.027
Prrx2 paired related homeobox 2 0.026
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.025
Lhx1 LIM homeobox protein 1 0.024
Porcn porcupine homolog (Drosophila) 0.023
Phex phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) 0.022
Pou3f3 POU domain, class 3, transcription factor 3 0.019
Fgfr3 fibroblast growth factor receptor 3 0.019
Fgfr1 fibroblast growth factor receptor 1 0.018
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.018
Fzd1 frizzled homolog 1 (Drosophila) 0.017
Pax2 paired box gene 2 0.017
Htt huntingtin 0.016
Lep leptin 0.016
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.016
Wnt1 wingless-related MMTV integration site 1 0.016
Barx1 BarH-like homeobox 1 0.015
Fgfr2 fibroblast growth factor receptor 2 0.015
Fgf8 fibroblast growth factor 8 0.015
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.014
Vdr vitamin D receptor 0.014
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.013
Gdnf glial cell line derived neurotrophic factor 0.013
Pparg peroxisome proliferator activated receptor gamma 0.013
Hoxd11 homeobox D11 0.013
Cdx1 caudal type homeobox 1 0.013
Vax1 ventral anterior homeobox containing gene 1 0.012
Tmem146 transmembrane protein 146 0.012
Ror1 receptor tyrosine kinase-like orphan receptor 1 0.012
Lrp6 low density lipoprotein receptor-related protein 6 0.011
Fgf2 fibroblast growth factor 2 0.011
Fgf18 fibroblast growth factor 18 0.011
Wnt9a wingless-type MMTV integration site 9A 0.011
Fzd8 frizzled homolog 8 (Drosophila) 0.011
Hoxc9 homeobox C9 0.010
Nos3 nitric oxide synthase 3, endothelial cell 0.010
Hoxa13 homeobox A13 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism