The network for 'trna aminoacylation for protein translation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

trna aminoacylation for protein translation

The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
CDC60 Cdc60p 0.981
GUS1 Gus1p 0.972
VAS1 Vas1p 0.967
ILS1 Ils1p 0.944
THS1 Ths1p 0.913
SES1 Ses1p 0.903
IFM1 Ifm1p 0.873
MSE1 Mse1p 0.864
DYS1 Dys1p 0.862
DED81 Ded81p 0.814
KRS1 Krs1p 0.791
FRS2 Frs2p 0.699
SLM5 Slm5p 0.657
TYS1 Tys1p 0.643
HTS1 Hts1p 0.611
YHR020W hypothetical protein 0.586
MES1 Mes1p 0.560
MSF1 Msf1p 0.544
ASN2 Asn2p 0.535
GRS1 Grs1p 0.455
ALA1 Ala1p 0.431
GLN4 Gln4p 0.361
AIM10 Aim10p 0.325
YDR341C hypothetical protein 0.318
MRF1 Mrf1p 0.305
FRS1 Frs1p 0.257
GCN20 Gcn20p 0.256
KAP104 Kap104p 0.248
KEL3 Kel3p 0.238
MSD1 Msd1p 0.236
YNL247W hypothetical protein 0.235
MRP20 Mrp20p 0.228
GUA1 Gua1p 0.226
YFH7 Yfh7p 0.197
RSM23 Rsm23p 0.187
COQ1 Coq1p 0.183
SUB2 Sub2p 0.166
TCM62 Tcm62p 0.144
MEF1 Mef1p 0.139
GUF1 Guf1p 0.129
SUP35 Sup35p 0.123
PET112 Pet112p 0.123
ADE6 Ade6p 0.114
GYL1 Gyl1p 0.109
DBP5 Dbp5p 0.106
AGC1 Agc1p 0.099
CTM1 Ctm1p 0.086
ISM1 Ism1p 0.082
CYM1 Cym1p 0.080
DPS1 Dps1p 0.077
MST1 Mst1p 0.071
MAP2 Map2p 0.059
MSY1 Msy1p 0.059
LEU9 Leu9p 0.055
NAM2 Nam2p 0.054
IMD2 Imd2p 0.051
THR4 Thr4p 0.047
ACO2 Aco2p 0.047
OLA1 Ola1p 0.047
LYS21 Lys21p 0.046
YLR264C-A hypothetical protein 0.045
AAP1 Aap1p 0.045
SSZ1 Ssz1p 0.044
ILV3 Ilv3p 0.043
SRD1 Srd1p 0.042
MDN1 Mdn1p 0.041
NMT1 Nmt1p 0.040
RPS20 Rps20p 0.039
YOL038C-A hypothetical protein 0.038
MSR1 Msr1p 0.037
DPH5 Dph5p 0.036
ART10 Art10p 0.036
MAS2 Mas2p 0.036
YNR040W hypothetical protein 0.034
YLR162W hypothetical protein 0.033
FMP25 Fmp25p 0.033
MRPL1 Mrpl1p 0.032
MER1 Mer1p 0.032
CUP1-1 Cup1-1p 0.031
ASN1 Asn1p 0.031
RPG1 Rpg1p 0.031
UBP16 Ubp16p 0.030
YRB1 Yrb1p 0.029
URA3 Ura3p 0.029
EMC1 Emc1p 0.028
HXT3 Hxt3p 0.028
IBA57 Iba57p 0.028
ARP10 Arp10p 0.028
PRO2 Pro2p 0.028
YPR157W hypothetical protein 0.027
FMP30 Fmp30p 0.027
LEU2 Leu2p 0.027
CPD1 Cpd1p 0.026
ATP6 Atp6p 0.026
YAR068W hypothetical protein 0.026
YLR132C hypothetical protein 0.026
COX10 Cox10p 0.026
HO Hop 0.026
SPL2 Spl2p 0.025
YLR363W-A hypothetical protein 0.025
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Aats-tyr Tyrosyl-tRNA synthetase 0.908
Aats-thr Threonyl-tRNA synthetase 0.701
Hsc70-5 Heat shock protein cognate 5 0.666
Aats-trp Tryptophanyl-tRNA synthetase 0.631
Aats-leu Leucyl-tRNA synthetase 0.551
CG17259 CG17259 gene product from transcript CG17259-RA 0.540
Aats-asp Aspartyl-tRNA synthetase 0.454
Aats-gly Glycyl-tRNA synthetase 0.342
Aats-asn Asparaginyl-tRNA synthetase 0.239
Srp54k Signal recognition particle protein 54k 0.200
Srp68 CG5064 gene product from transcript CG5064-RA 0.198
Aats-met Methionyl-tRNA synthetase 0.195
Aats-pro Prolyl-tRNA synthetase 0.168
l(2)k01209 lethal (2) k01209 0.130
Aats-glupro Glutamyl-prolyl-tRNA synthetase 0.112
Trxr-1 Thioredoxin reductase-1 0.102
l(2)37Cc lethal (2) 37Cc 0.088
CG4679 CG4679 gene product from transcript CG4679-RA 0.065
CG1703 CG1703 gene product from transcript CG1703-RA 0.053
Aats-gln Glutaminyl-tRNA synthetase 0.047
CG2076 CG2076 gene product from transcript CG2076-RA 0.045
RFeSP Rieske iron-sulfur protein 0.043
Aats-val Valyl-tRNA synthetase 0.039
Aats-his Histidyl-tRNA synthetase 0.037
Gcn2 CG1609 gene product from transcript CG1609-RA 0.034
CG13393 CG13393 gene product from transcript CG13393-RA 0.032
beta'Cop beta'-coatomer protein 0.031
CG11771 CG11771 gene product from transcript CG11771-RA 0.030
CG2263 CG2263 gene product from transcript CG2263-RA 0.028
EfTuM Elongation factor Tu mitochondrial 0.028
eIF2B-epsilon CG3806 gene product from transcript CG3806-RB 0.028
CG33123 CG33123 gene product from transcript CG33123-RA 0.028
CG42630 CG42630 gene product from transcript CG42630-RA 0.027
ox oxen 0.027
Aats-ala Alanyl-tRNA synthetase 0.025
CG4389 CG4389 gene product from transcript CG4389-RA 0.024
Elp1 Elongator complex protein 1 0.022
Aats-ile Isoleucyl-tRNA synthetase 0.021
Drp1 Dynamin related protein 1 0.019
Dph5 Diphthamide methyltransferase 0.019
nmd no mitochondrial derivative 0.018
CG7791 CG7791 gene product from transcript CG7791-RA 0.017
l(3)02640 lethal (3) 02640 0.017
eRF1 eukaryotic release factor 1 0.017
l(2)03709 lethal (2) 03709 0.017
sec3 CG3885 gene product from transcript CG3885-RA 0.016
eIF-3p66 Eukaryotic initiation factor 3 p66 subunit 0.014
CG8531 CG8531 gene product from transcript CG8531-RA 0.014
Aats-cys Cysteinyl-tRNA synthetase 0.013
CG8728 CG8728 gene product from transcript CG8728-RA 0.013
CG3267 CG3267 gene product from transcript CG3267-RA 0.013
SrpRbeta Signal recognition particle receptor beta 0.013
CG5789 CG5789 gene product from transcript CG5789-RA 0.012
CG5525 CG5525 gene product from transcript CG5525-RA 0.012
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Homo sapiens
Name Description Probability Func Analog Organism
IARS isoleucyl-tRNA synthetase 1.000
GARS glycyl-tRNA synthetase 1.000
EPRS glutamyl-prolyl-tRNA synthetase 1.000
MARS methionyl-tRNA synthetase 1.000
AARS alanyl-tRNA synthetase 1.000
YARS tyrosyl-tRNA synthetase 1.000
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.000
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 1.000
SARS seryl-tRNA synthetase 0.995
RARS arginyl-tRNA synthetase 0.995
CARS cysteinyl-tRNA synthetase 0.992
NARS asparaginyl-tRNA synthetase 0.991
TARS threonyl-tRNA synthetase 0.982
KARS lysyl-tRNA synthetase 0.849
LARS leucyl-tRNA synthetase 0.726
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 0.696
XPOT exportin, tRNA (nuclear export receptor for tRNAs) 0.691
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 0.600
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.452
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.414
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 0.191
DARS aspartyl-tRNA synthetase 0.175
ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) 0.167
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 0.157
LONP1 lon peptidase 1, mitochondrial 0.130
PSAT1 phosphoserine aminotransferase 1 0.078
WARS tryptophanyl-tRNA synthetase 0.068
TRIB3 tribbles homolog 3 (Drosophila) 0.060
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 0.059
METTL13 methyltransferase like 13 0.049
EIF3CL eukaryotic translation initiation factor 3, subunit C-like 0.048
SLC3A2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 0.046
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 0.045
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 0.044
BOP1 block of proliferation 1 0.038
ALG3 asparagine-linked glycosylation 3, alpha-1,3- mannosyltransferase homolog (S. cerevisiae) 0.036
PUF60 poly-U binding splicing factor 60KDa 0.033
C12orf44 chromosome 12 open reading frame 44 0.030
ECSIT ECSIT homolog (Drosophila) 0.029
OTUD5 OTU domain containing 5 0.029
CNO cappuccino homolog (mouse) 0.029
IPO4 importin 4 0.028
XPO5 exportin 5 0.025
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.025
LARS2 leucyl-tRNA synthetase 2, mitochondrial 0.022
SLC7A5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 0.022
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 0.021
PFAS phosphoribosylformylglycinamidine synthase 0.021
TBL3 transducin (beta)-like 3 0.020
RPTOR regulatory associated protein of MTOR, complex 1 0.019
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 0.018
HYOU1 hypoxia up-regulated 1 0.018
WDR46 WD repeat domain 46 0.017
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.015
GOT1 glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) 0.014
C10orf2 chromosome 10 open reading frame 2 0.013
ALG8 asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae) 0.013
AATF apoptosis antagonizing transcription factor 0.013
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.012
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 0.011
HARS2 histidyl-tRNA synthetase 2, mitochondrial (putative) 0.011
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Gars glycyl-tRNA synthetase 0.994
Nars asparaginyl-tRNA synthetase 0.977
Lars leucyl-tRNA synthetase 0.958
Dus1l dihydrouridine synthase 1-like (S. cerevisiae) 0.804
Tars threonyl-tRNA synthetase 0.785
Eif3c eukaryotic translation initiation factor 3, subunit C 0.732
Eprs glutamyl-prolyl-tRNA synthetase 0.722
Mars methionine-tRNA synthetase 0.697
Aars alanyl-tRNA synthetase 0.694
Rars arginyl-tRNA synthetase 0.606
Yars tyrosyl-tRNA synthetase 0.581
Farsb phenylalanyl-tRNA synthetase, beta subunit 0.580
Eif3d eukaryotic translation initiation factor 3, subunit D 0.512
Iars isoleucine-tRNA synthetase 0.476
Ddx1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 0.193
Sars seryl-aminoacyl-tRNA synthetase 0.185
Asns asparagine synthetase 0.149
Cct5 chaperonin containing Tcp1, subunit 5 (epsilon) 0.099
Xpot exportin, tRNA (nuclear export receptor for tRNAs) 0.099
Lrpprc leucine-rich PPR-motif containing 0.067
Fam98a family with sequence similarity 98, member A 0.058
Hspa9 heat shock protein 9 0.054
Cpsf3 cleavage and polyadenylation specificity factor 3 0.053
Tcp1 t-complex protein 1 0.047
Eif3g eukaryotic translation initiation factor 3, subunit G 0.045
Srp68 signal recognition particle 68 0.044
Wdr36 WD repeat domain 36 0.042
Eif2b4 eukaryotic translation initiation factor 2B, subunit 4 delta 0.035
Cct7 chaperonin containing Tcp1, subunit 7 (eta) 0.034
Dohh deoxyhypusine hydroxylase/monooxygenase 0.032
Lonp1 lon peptidase 1, mitochondrial 0.030
Eif2b3 eukaryotic translation initiation factor 2B, subunit 3 0.030
Psmc5 protease (prosome, macropain) 26S subunit, ATPase 5 0.025
Mrps18b mitochondrial ribosomal protein S18B 0.024
Nsun2 NOL1/NOP2/Sun domain family member 2 0.022
Psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.021
Aatf apoptosis antagonizing transcription factor 0.021
Supt5h suppressor of Ty 5 homolog (S. cerevisiae) 0.020
Ruvbl1 RuvB-like protein 1 0.020
Mlh1 mutL homolog 1 (E. coli) 0.019
Eif5a eukaryotic translation initiation factor 5A 0.019
Atad3a ATPase family, AAA domain containing 3A 0.019
Atf4 activating transcription factor 4 0.018
Abce1 ATP-binding cassette, sub-family E (OABP), member 1 0.018
Rrp12 ribosomal RNA processing 12 homolog (S. cerevisiae) 0.018
Cfdp1 craniofacial development protein 1 0.017
Ttc27 tetratricopeptide repeat domain 27 0.017
Cars cysteinyl-tRNA synthetase 0.017
Wdr74 WD repeat domain 74 0.017
Drg2 developmentally regulated GTP binding protein 2 0.016
Polr2b polymerase (RNA) II (DNA directed) polypeptide B 0.016
Exosc9 exosome component 9 0.016
Gtf2f1 general transcription factor IIF, polypeptide 1 0.016
Fastkd2 FAST kinase domains 2 0.015
Ftsj3 FtsJ homolog 3 (E. coli) 0.015
Las1l LAS1-like (S. cerevisiae) 0.015
Bms1 BMS1 homolog, ribosome assembly protein (yeast) 0.015
Cops4 COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana) 0.015
Ppp1r7 protein phosphatase 1, regulatory (inhibitor) subunit 7 0.014
Vcp valosin containing protein 0.014
Mrpl3 mitochondrial ribosomal protein L3 0.014
Xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 0.013
Ncbp1 nuclear cap binding protein subunit 1 0.013
Elac2 elaC homolog 2 (E. coli) 0.013
Nop14 NOP14 nucleolar protein homolog (yeast) 0.013
Orc5 origin recognition complex, subunit 5 0.013
Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 0.013
Bccip BRCA2 and CDKN1A interacting protein 0.013
C1qbp complement component 1, q subcomponent binding protein 0.012
Ddx54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 0.012
Faf1 Fas-associated factor 1 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Yars tyrosyl-tRNA synthetase 0.917
Eif3b eukaryotic translation initiation factor 3, subunit B 0.746
Mars methionine-tRNA synthetase 0.498
Eif3c eukaryotic translation initiation factor 3, subunit C 0.497
Gars glycyl-tRNA synthetase 0.488
Tars threonyl-tRNA synthetase 0.465
Aars alanyl-tRNA synthetase 0.281
Cars cysteinyl-tRNA synthetase 0.253
Cct3 chaperonin containing Tcp1, subunit 3 (gamma) 0.169
Sars seryl-tRNA synthetase 0.085
Psmd2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.050
Ddx1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 0.049
Nmt1 N-myristoyltransferase 1 0.048
Aatf apoptosis antagonizing transcription factor 0.039
Abce1 ATP-binding cassette, subfamily E (OABP), member 1 0.032
Asns asparagine synthetase 0.031
Cpsf3 cleavage and polyadenylation specificity factor 3 0.027
Wars tryptophanyl-tRNA synthetase 0.022
LOC100360406 rCG34104-like 0.021
LOC362855 P55 0.018
Pno1 partner of NOB1 homolog (S. cerevisiae) 0.017
Tmem69 transmembrane protein 69 0.016
Lars leucyl-tRNA synthetase 0.016
Fastkd2 FAST kinase domains 2 0.015
Psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.015
Anapc5 anaphase-promoting complex subunit 5 0.015
Farsb phenylalanyl-tRNA synthetase, beta subunit 0.014
Cirh1a cirrhosis, autosomal recessive 1A (cirhin) 0.014
Ipo4 importin 4 0.013
Eef1g eukaryotic translation elongation factor 1 gamma 0.013
Nsfl1c NSFL1 (p97) cofactor (p47) 0.012
Tcp1 t-complex 1 0.012
Faf1 Fas (TNFRSF6) associated factor 1 0.012
Eif2d eukaryotic translation initiation factor 2D 0.012
Eif2b3 eukaryotic translation initiation factor 2B, subunit 3 0.011
Abcf1 ATP-binding cassette, subfamily F (GCN20), member 1 0.011
Ubxn4 UBX domain protein 4 0.011
Elac2 elaC homolog 2 (E. coli) 0.011
Tmem177 transmembrane protein 177 0.010
Eprs glutamyl-prolyl-tRNA synthetase 0.010
Iars isoleucyl-tRNA synthetase 0.010
Vcp valosin-containing protein 0.010