The network for 'response to nitrosative stress' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to nitrosative stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
MIG2 Mig2p 0.196
CSR2 Csr2p 0.109
HAL5 Hal5p 0.096
YKR075C hypothetical protein 0.089
MIG1 Mig1p 0.076
MIG3 Mig3p 0.075
DAL81 Dal81p 0.074
VHS1 Vhs1p 0.063
ROX1 Rox1p 0.056
GLN3 Gln3p 0.055
LYS5 Lys5p 0.054
YPL014W hypothetical protein 0.052
MOT3 Mot3p 0.052
RTG3 Rtg3p 0.051
VID24 Vid24p 0.049
RGS2 Rgs2p 0.047
NUP157 Nup157p 0.040
GIP2 Gip2p 0.039
GAT2 Gat2p 0.039
CAT8 Cat8p 0.039
HXT3 Hxt3p 0.038
SKS1 Sks1p 0.038
TYE7 Tye7p 0.038
CUP9 Cup9p 0.038
YPR157W hypothetical protein 0.038
SAK1 Sak1p 0.037
TPO2 Tpo2p 0.036
ERV2 Erv2p 0.034
FAA2 Faa2p 0.033
RPN4 Rpn4p 0.033
MGA1 Mga1p 0.032
YKL187C hypothetical protein 0.032
SMP1 Smp1p 0.032
HSF1 Hsf1p 0.032
YIR035C hypothetical protein 0.031
NTO1 Nto1p 0.029
OPY2 Opy2p 0.029
ZAP1 Zap1p 0.029
POG1 Pog1p 0.028
SRD1 Srd1p 0.028
PCT1 Pct1p 0.027
TBS1 Tbs1p 0.027
HOR2 Hor2p 0.027
PHO12 Pho12p 0.027
LEU2 Leu2p 0.027
IRC8 Irc8p 0.027
RPI1 Rpi1p 0.026
YLR264C-A hypothetical protein 0.026
NRG2 Nrg2p 0.026
KIC1 Kic1p 0.026
CBK1 Cbk1p 0.026
ICS2 Ics2p 0.026
YOL038C-A hypothetical protein 0.025
TOS3 Tos3p 0.025
FMP48 Fmp48p 0.025
SWC7 Swc7p 0.025
FOL2 Fol2p 0.024
CUP1-1 Cup1-1p 0.024
HAL1 Hal1p 0.024
YPR013C hypothetical protein 0.024
ARP10 Arp10p 0.024
YPL216W hypothetical protein 0.024
YJL218W hypothetical protein 0.024
IRC23 Irc23p 0.024
ACE2 Ace2p 0.023
YLR162W hypothetical protein 0.023
YAR068W hypothetical protein 0.023
MER1 Mer1p 0.023
YNR014W hypothetical protein 0.023
HPF1 Hpf1p 0.023
YMR317W hypothetical protein 0.023
TIP1 Tip1p 0.023
CHA1 Cha1p 0.023
PCL2 Pcl2p 0.023
YIR042C hypothetical protein 0.023
AGP2 Agp2p 0.023
ECM22 Ecm22p 0.022
MDM1 Mdm1p 0.022
ARE2 Are2p 0.022
SOR2 Sor2p 0.022
ARG8 Arg8p 0.022
FMT1 Fmt1p 0.022
ATP6 Atp6p 0.022
SFL1 Sfl1p 0.022
NRG1 Nrg1p 0.022
STL1 Stl1p 0.022
YOR385W hypothetical protein 0.021
YAR066W hypothetical protein 0.021
AUA1 Aua1p 0.021
DSE3 Dse3p 0.021
ICY1 Icy1p 0.021
SPL2 Spl2p 0.021
VAC7 Vac7p 0.021
YMR295C hypothetical protein 0.021
PMD1 Pmd1p 0.021
BRE4 Bre4p 0.021
DCS2 Dcs2p 0.021
SWI1 Swi1p 0.021
YBR013C hypothetical protein 0.021
IES1 Ies1p 0.021
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
MAPK1 mitogen-activated protein kinase 1 1.000
GSTM1 glutathione S-transferase mu 1 1.000
MAPK14 mitogen-activated protein kinase 14 1.000
GSTM2 glutathione S-transferase mu 2 (muscle) 1.000
GSTM4 glutathione S-transferase mu 4 1.000
MAP2K1 mitogen-activated protein kinase kinase 1 1.000
MAPK3 mitogen-activated protein kinase 3 1.000
DUSP3 dual specificity phosphatase 3 0.997
DUSP1 dual specificity phosphatase 1 0.990
PTPRR protein tyrosine phosphatase, receptor type, R 0.983
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.965
PEA15 phosphoprotein enriched in astrocytes 15 0.959
DUSP5 dual specificity phosphatase 5 0.909
PTPN7 protein tyrosine phosphatase, non-receptor type 7 0.831
DUSP6 dual specificity phosphatase 6 0.814
DUSP7 dual specificity phosphatase 7 0.812
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.789
GSTM3 glutathione S-transferase mu 3 (brain) 0.713
MAP2K4 mitogen-activated protein kinase kinase 4 0.618
PTPRJ protein tyrosine phosphatase, receptor type, J 0.576
ARHGAP9 Rho GTPase activating protein 9 0.507
MBP myelin basic protein 0.416
ATF3 activating transcription factor 3 0.412
IER3 immediate early response 3 0.378
ZFP36L1 zinc finger protein 36, C3H type-like 1 0.374
FOS FBJ murine osteosarcoma viral oncogene homolog 0.337
MAPK8 mitogen-activated protein kinase 8 0.308
ATF2 activating transcription factor 2 0.305
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.298
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.261
MTPN myotrophin 0.255
BHLHE40 basic helix-loop-helix family, member e40 0.237
KLF6 Kruppel-like factor 6 0.172
MAP2K3 mitogen-activated protein kinase kinase 3 0.161
MAP2K6 mitogen-activated protein kinase kinase 6 0.131
TRIB1 tribbles homolog 1 (Drosophila) 0.128
DUSP4 dual specificity phosphatase 4 0.127
IER5 immediate early response 5 0.117
CSDA cold shock domain protein A 0.093
BCL2 B-cell CLL/lymphoma 2 0.092
MAFF v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) 0.084
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.080
IQGAP1 IQ motif containing GTPase activating protein 1 0.070
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.066
EGR1 early growth response 1 0.064
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.056
HADH hydroxyacyl-CoA dehydrogenase 0.056
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.044
RB1 retinoblastoma 1 0.044
ELK1 ELK1, member of ETS oncogene family 0.043
MKNK1 MAP kinase interacting serine/threonine kinase 1 0.042
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.039
MAPK11 mitogen-activated protein kinase 11 0.039
JUN jun proto-oncogene 0.032
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.030
LCK lymphocyte-specific protein tyrosine kinase 0.029
IER2 immediate early response 2 0.026
FAM48A family with sequence similarity 48, member A 0.026
HBEGF heparin-binding EGF-like growth factor 0.025
DUSP16 dual specificity phosphatase 16 0.024
TNIP1 TNFAIP3 interacting protein 1 0.024
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 0.022
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.020
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 0.019
DUSP9 dual specificity phosphatase 9 0.019
CRYZ crystallin, zeta (quinone reductase) 0.016
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 0.013
GHR growth hormone receptor 0.013
PDCD6IP programmed cell death 6 interacting protein 0.012
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.012
RHOB ras homolog gene family, member B 0.011
NFIL3 nuclear factor, interleukin 3 regulated 0.011
AHR aryl hydrocarbon receptor 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Gstm1 glutathione S-transferase, mu 1 1.000
Adh1 alcohol dehydrogenase 1 (class I) 0.985
Gstm2 glutathione S-transferase, mu 2 0.980
Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 0.876
Gsta3 glutathione S-transferase, alpha 3 0.868
Gstm6 glutathione S-transferase, mu 6 0.679
Cyp2f2 cytochrome P450, family 2, subfamily f, polypeptide 2 0.617
Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 0.573
Gstm3 glutathione S-transferase, mu 3 0.545
Inmt indolethylamine N-methyltransferase 0.459
Gstt1 glutathione S-transferase, theta 1 0.382
Ces1d carboxylesterase 1D 0.294
Gsta2 glutathione S-transferase, alpha 2 (Yc2) 0.193
Fmo1 flavin containing monooxygenase 1 0.165
Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 0.116
Ephx1 epoxide hydrolase 1, microsomal 0.116
Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 0.111
Fxyd1 FXYD domain-containing ion transport regulator 1 0.108
Gsta4 glutathione S-transferase, alpha 4 0.100
Gstm4 glutathione S-transferase, mu 4 0.100
Gstk1 glutathione S-transferase kappa 1 0.068
Mapk1 mitogen-activated protein kinase 1 0.067
Sult1a1 sulfotransferase family 1A, phenol-preferring, member 1 0.064
Ttr transthyretin 0.056
Tst thiosulfate sulfurtransferase, mitochondrial 0.055
Pon1 paraoxonase 1 0.052
Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 0.052
Slc22a18 solute carrier family 22 (organic cation transporter), member 18 0.051
Sult1d1 sulfotransferase family 1D, member 1 0.048
Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 0.041
Pxmp2 peroxisomal membrane protein 2 0.040
Iyd iodotyrosine deiodinase 0.039
Gstp1 glutathione S-transferase, pi 1 0.038
Aldh2 aldehyde dehydrogenase 2, mitochondrial 0.037
Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 0.036
Selenbp1 selenium binding protein 1 0.035
Rarres2 retinoic acid receptor responder (tazarotene induced) 2 0.033
Fmo5 flavin containing monooxygenase 5 0.031
Rbp4 retinol binding protein 4, plasma 0.031
Hpgd hydroxyprostaglandin dehydrogenase 15 (NAD) 0.030
Cd59a CD59a antigen 0.029
Fmo2 flavin containing monooxygenase 2 0.028
Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 0.028
Grb7 growth factor receptor bound protein 7 0.027
Tmem205 transmembrane protein 205 0.026
Nqo1 NAD(P)H dehydrogenase, quinone 1 0.026
Cyp2a12 cytochrome P450, family 2, subfamily a, polypeptide 12 0.026
Sord sorbitol dehydrogenase 0.025
Fmo3 flavin containing monooxygenase 3 0.023
Aox1 aldehyde oxidase 1 0.022
Cmbl carboxymethylenebutenolidase-like (Pseudomonas) 0.022
Ier2 immediate early response 2 0.020
Thnsl2 threonine synthase-like 2 (bacterial) 0.019
Acy3 aspartoacylase (aminoacylase) 3 0.018
Ces2g carboxylesterase 2G 0.018
Abhd14b abhydrolase domain containing 14b 0.018
Echdc3 enoyl Coenzyme A hydratase domain containing 3 0.018
Copz2 coatomer protein complex, subunit zeta 2 0.017
Khk ketohexokinase 0.017
Bcl10 B-cell leukemia/lymphoma 10 0.017
Slc22a1 solute carrier family 22 (organic cation transporter), member 1 0.017
Cyb5 cytochrome b-5 0.017
Galm galactose mutarotase 0.017
Aass aminoadipate-semialdehyde synthase 0.016
Itih2 inter-alpha trypsin inhibitor, heavy chain 2 0.016
Cbr2 carbonyl reductase 2 0.016
Bphl biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen) 0.016
Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 0.015
Ephx2 epoxide hydrolase 2, cytoplasmic 0.015
Omd osteomodulin 0.015
Adhfe1 alcohol dehydrogenase, iron containing, 1 0.014
Mettl7a1 methyltransferase like 7A1 0.014
Upb1 ureidopropionase, beta 0.013
Apoc1 apolipoprotein C-I 0.013
Cmtm8 CKLF-like MARVEL transmembrane domain containing 8 0.013
Dpyd dihydropyrimidine dehydrogenase 0.012
Gstm7 glutathione S-transferase, mu 7 0.012
Tcea3 transcription elongation factor A (SII), 3 0.012
Hint2 histidine triad nucleotide binding protein 2 0.012
Pcbd1 pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1 0.012
Acox2 acyl-Coenzyme A oxidase 2, branched chain 0.011
Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 0.011
Gnmt glycine N-methyltransferase 0.011
Bbox1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase) 0.011
Ppara peroxisome proliferator activated receptor alpha 0.011
Ndrg2 N-myc downstream regulated gene 2 0.011
Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 0.011
Ces1e carboxylesterase 1E 0.011
Gm3776 predicted gene 3776 0.011
Gstt3 glutathione S-transferase, theta 3 0.010
Gpld1 glycosylphosphatidylinositol specific phospholipase D1 0.010
Thrsp thyroid hormone responsive SPOT14 homolog (Rattus) 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Gstm1 glutathione S-transferase mu 1 1.000
Ephx1 epoxide hydrolase 1, microsomal 0.871
Gstm2 glutathione S-transferase mu 2 0.754
Gsta3 glutathione S-transferase A3 0.551
Txnrd1 thioredoxin reductase 1 0.293
Selenbp1 selenium binding protein 1 0.189
Serp1 stress-associated endoplasmic reticulum protein 1 0.141
Gstm7 glutathione S-transferase, mu 7 0.117
Hibadh 3-hydroxyisobutyrate dehydrogenase 0.094
Gstm5 glutathione S-transferase, mu 5 0.070
Cyb5r3 cytochrome b5 reductase 3 0.066
Gsr glutathione reductase 0.061
Rab11a RAB11a, member RAS oncogene family 0.046
Egr1 early growth response 1 0.043
Gclm glutamate cysteine ligase, modifier subunit 0.041
Cyb5a cytochrome b5 type A (microsomal) 0.033
Prdx6 peroxiredoxin 6 0.031
Pdk2 pyruvate dehydrogenase kinase, isozyme 2 0.028
Nqo1 NAD(P)H dehydrogenase, quinone 1 0.027
Gstp1 glutathione S-transferase pi 1 0.027
Fahd2a fumarylacetoacetate hydrolase domain containing 2A 0.025
Gsta4 glutathione S-transferase alpha 4 0.025
Gclc glutamate-cysteine ligase, catalytic subunit 0.024
Coq3 coenzyme Q3 homolog, methyltransferase (S. cerevisiae) 0.024
Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 0.023
Mgst1 microsomal glutathione S-transferase 1 0.022
Paics phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 0.022
Tmem218 transmembrane protein 218 0.021
Nenf neuron derived neurotrophic factor 0.020
Wdr61 WD repeat domain 61 0.018
Pgrmc1 progesterone receptor membrane component 1 0.017
Slc40a1 solute carrier family 39 (iron-regulated transporter), member 1 0.017
S100a1 S100 calcium binding protein A1 0.017
Aadac arylacetamide deacetylase (esterase) 0.016
Ugt2b36 UDP glucuronosyltransferase 2 family, polypeptide B36 0.016
Ctdsp1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 0.016
Pecr peroxisomal trans-2-enoyl-CoA reductase 0.016
Dusp1 dual specificity phosphatase 1 0.015
Acot12 acyl-CoA thioesterase 12 0.014
Cat catalase 0.013
RGD1564114 similar to FLJ46082 protein 0.013
Exosc7 exosome component 7 0.012
UST4r integral membrane transport protein UST4r 0.012
Pxmp2 peroxisomal membrane protein 2 0.012
Pde6d phosphodiesterase 6D, cGMP-specific, rod, delta 0.011
Hao2 hydroxyacid oxidase 2 (long chain) 0.011
Pir pirin (iron-binding nuclear protein) 0.011
Slc23a1 solute carrier family 23 (nucleobase transporters), member 1 0.011
Cetn2 centrin, EF-hand protein, 2 0.011
Fxyd1 FXYD domain-containing ion transport regulator 1 0.011
Aldoc aldolase C, fructose-bisphosphate 0.011
Aldh2 aldehyde dehydrogenase 2 family (mitochondrial) 0.010
Mrpl36 mitochondrial ribosomal protein L36 0.010
Rdh10 retinol dehydrogenase 10 (all-trans) 0.010