The network for 'mrna polyadenylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mrna polyadenylation

The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
PTA1 Pta1p 1.000
RNA14 Rna14p 0.999
FIP1 Fip1p 0.998
MPE1 Mpe1p 0.997
PAP1 Pap1p 0.997
CFT2 Cft2p 0.997
PFS2 Pfs2p 0.996
CFT1 Cft1p 0.991
PTI1 Pti1p 0.980
YSH1 Ysh1p 0.971
PCF11 Pcf11p 0.783
REF2 Ref2p 0.679
CLP1 Clp1p 0.600
SWD2 Swd2p 0.473
RNA15 Rna15p 0.466
SSU72 Ssu72p 0.371
YTH1 Yth1p 0.348
GLC7 Glc7p 0.298
MEX67 Mex67p 0.189
TIF4632 Tif4632p 0.148
NRD1 Nrd1p 0.074
HRP1 Hrp1p 0.052
GBP2 Gbp2p 0.051
SPT5 Spt5p 0.036
MDN1 Mdn1p 0.036
PUB1 Pub1p 0.032
KAP104 Kap104p 0.029
SGN1 Sgn1p 0.027
NUG1 Nug1p 0.022
YLR264C-A hypothetical protein 0.021
SRD1 Srd1p 0.021
MER1 Mer1p 0.018
LEU2 Leu2p 0.018
ARP10 Arp10p 0.017
YOL038C-A hypothetical protein 0.017
NAB3 Nab3p 0.017
YLR162W hypothetical protein 0.016
PBP4 Pbp4p 0.015
ARG8 Arg8p 0.014
YAR068W hypothetical protein 0.014
URA3 Ura3p 0.014
ATP6 Atp6p 0.014
PAN1 Pan1p 0.014
YLR042C hypothetical protein 0.014
YIR035C hypothetical protein 0.013
CPD1 Cpd1p 0.013
HXT3 Hxt3p 0.013
HPF1 Hpf1p 0.013
CFD1 Cfd1p 0.013
ADH2 Adh2p 0.012
SPL2 Spl2p 0.012
YBR013C hypothetical protein 0.012
TFC4 Tfc4p 0.012
ISR1 Isr1p 0.012
YPR157W hypothetical protein 0.012
ZPS1 Zps1p 0.012
HO Hop 0.012
CUP1-1 Cup1-1p 0.012
CRP1 Crp1p 0.012
TIP1 Tip1p 0.011
RPO21 Rpo21p 0.011
YKR075C hypothetical protein 0.011
ICS2 Ics2p 0.011
AUA1 Aua1p 0.011
SRX1 Srx1p 0.011
TYE7 Tye7p 0.011
YNL234W hypothetical protein 0.011
PRP21 Prp21p 0.011
FMT1 Fmt1p 0.010
YOL013W-A hypothetical protein 0.010
SCM4 Scm4p 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
tcf12 transcription factor 12 0.204
eef2b eukaryotic translation elongation factor 2b 0.185
rtn1a reticulon 1a 0.161
thoc5 THO complex 5 0.097
ptprsa protein tyrosine phosphatase, receptor type, s, a 0.088
psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.078
sybu syntabulin (syntaxin-interacting) 0.065
spna2 spectrin alpha 2 0.064
prpf39 PRP39 pre-mRNA processing factor 39 homolog (yeast) 0.057
pabpc1a poly A binding protein, cytoplasmic 1 a 0.053
zgc:86598 zgc:86598 0.046
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.038
gcn1l1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast) 0.037
cfl2l cofilin 2, like 0.037
si:ch211-57k11.10 si:ch211-57k11.10 0.036
nup107 nucleoporin 107 0.035
prnprs3 prion protein, related sequence 3 0.028
taf7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.028
setdb1b SET domain, bifurcated 1b 0.028
sf3b1 splicing factor 3b, subunit 1 0.027
atp1b3b ATPase, Na+/K+ transporting, beta 3b polypeptide 0.026
cct2 chaperonin containing TCP1, subunit 2 (beta) 0.025
zgc:92194 zgc:92194 0.025
tgif1 TGFB-induced factor homeobox 1 0.024
wu:fi04f09 wu:fi04f09 0.024
cct5 chaperonin containing TCP1, subunit 5 (epsilon) 0.023
appa amyloid beta (A4) precursor protein a 0.023
pbx4 pre-B-cell leukemia transcription factor 4 0.022
eif3c eukaryotic translation initiation factor 3, subunit C 0.022
dpysl3 dihydropyrimidinase-like 3 0.022
metrn meteorin, glial cell differentiation regulator 0.021
puf60a poly-U binding splicing factor a 0.021
polr2b polymerase (RNA) II (DNA directed) polypeptide B 0.021
unc45a unc-45 homolog A (C. elegans) 0.021
spred1 sprouty-related, EVH1 domain containing 1 0.020
ptprfb protein tyrosine phosphatase, receptor type, f, b 0.020
cdc23 CDC23 (cell division cycle 23, yeast, homolog) 0.019
pafah1b1a platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a 0.019
cherp calcium homeostasis endoplasmic reticulum protein 0.019
cpsf6 cleavage and polyadenylation specific factor 6 0.019
dip2c DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.018
ppwd1 peptidylprolyl isomerase domain and WD repeat containing 1 0.018
atp6v0cb ATPase, H+ transporting, lysosomal, V0 subunit c, b 0.018
kidins220b kinase D-interacting substrate of 220b 0.018
dpysl5a dihydropyrimidinase-like 5a 0.018
ptpn11a protein tyrosine phosphatase, non-receptor type 11, a 0.017
zgc:193933 zgc:193933 0.017
zgc:136773 zgc:136773 0.017
LOC100536647 disintegrin and metalloproteinase domain-containing protein 10-like 0.017
lingo1b leucine rich repeat and Ig domain containing 1b 0.017
snap25a synaptosome-associated protein 25a 0.017
zgc:123326 zgc:123326 0.016
zgc:66100 zgc:66100 0.016
nup93 nucleoporin 93 0.016
aplp2 amyloid beta (A4) precursor-like protein 2 0.016
robo1 roundabout homolog 1 0.016
phf2 PHD finger protein 2 0.016
rbbp6 retinoblastoma binding protein 6 0.016
buc bucky ball 0.016
yy1b YY1 transcription factor b 0.016
ca15b carbonic anhydrase XV b 0.016
pbrm1l polybromo 1, like 0.016
rnps1 RNA binding protein S1, serine-rich domain 0.016
si:dkey-181m9.9 si:dkey-181m9.9 0.016
timp2a tissue inhibitor of metalloproteinase 2a 0.015
myef2 myelin expression factor 2 0.015
cstf1 cleavage stimulation factor, 3' pre-RNA, subunit 1 0.015
cct8 chaperonin containing TCP1, subunit 8 (theta) 0.015
gkap1 G kinase anchoring protein 1 0.015
lrmp lymphoid-restricted membrane protein 0.015
brca2 breast cancer 2, early onset 0.015
tfip11 tuftelin interacting protein 11 0.015
birc5b baculoviral IAP repeat-containing 5B 0.015
mbnl2 muscleblind-like 2 (Drosophila) 0.015
stau2 staufen, RNA binding protein, homolog 2 (Drosophila) 0.014
LOC100003680 proline-, glutamic acid- and leucine-rich protein 1-like 0.014
hpca hippocalcin 0.014
spock3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 0.014
cdc5l CDC5 cell division cycle 5-like (S. pombe) 0.014
stau1 staufen, RNA binding protein, homolog 1 (Drosophila) 0.014
cstf3 cleavage stimulation factor, 3' pre-RNA, subunit 3 0.014
eif2s2 eukaryotic translation initiation factor 2, subunit 2 beta 0.014
snx30 sorting nexin family member 30 0.014
ddx46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.014
macf1 microtubule-actin crosslinking factor 1 0.013
acsl1 acyl-CoA synthetase long-chain family member 1 0.013
polr2d polymerase (RNA) II (DNA directed) polypeptide D 0.013
huwe1 HECT, UBA and WWE domain containing 1 0.013
dvl2 dishevelled, dsh homolog 2 (Drosophila) 0.013
nfia nuclear factor I/A 0.013
setdb2 SET domain, bifurcated 2 0.013
patl1 protein associated with topoisomerase II homolog 1 (yeast) 0.013
ndrg4 N-myc downstream regulated gene 4 0.013
mettl3 methyltransferase like 3 0.012
her9 hairy-related 9 0.012
eif3d eukaryotic translation initiation factor 3, subunit D 0.012
dbr1 debranching enzyme homolog 1 (S. cerevisiae) 0.012
zgc:113019 zgc:113019 0.012
c20orf14 c20orf14 homolog (H. sapiens) 0.012
cnot3a CCR4-NOT transcription complex, subunit 3a 0.012
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Drosophila melanogaster
Name Description Probability Func Analog Organism
MED6 Mediator complex subunit 6 0.775
Spc105R Spc105-related 0.301
Cpsf160 Cleavage and polyadenylation specificity factor 160 0.187
Sra-1 specifically Rac1-associated protein 1 0.172
MED17 Mediator complex subunit 17 0.159
CG10333 CG10333 gene product from transcript CG10333-RA 0.117
krimp krimper 0.093
Pbp49 PSEA-binding protein 49kD 0.093
Cpsf100 Cleavage and polyadenylation specificity factor 100 0.067
Taf2 TBP-associated factor 2 0.047
MED19 Mediator complex subunit 19 0.045
swa swallow 0.045
Gem3 Gemin3 0.044
aub aubergine 0.043
orb oo18 RNA-binding protein 0.040
Taf8 TBP-associated factor 8 0.040
Nup160 Nucleoporin 160 0.040
Nup75 Nucleoporin 75 0.038
plu plutonium 0.037
dhd deadhead 0.035
Nup107 Nucleoporin 107 0.034
dgt1 dim gamma-tubulin 1 0.033
spn-E spindle E 0.033
fliI flightless I 0.032
fs(1)N female sterile (1) Nasrat 0.032
CG5222 CG5222 gene product from transcript CG5222-RA 0.031
Mnt CG13316 gene product from transcript CG13316-RD 0.030
CG3918 CG3918 gene product from transcript CG3918-RA 0.029
CG31365 CG31365 gene product from transcript CG31365-RA 0.026
CG16941 CG16941 gene product from transcript CG16941-RA 0.026
CG7099 CG7099 gene product from transcript CG7099-RA 0.026
mi minus 0.025
Hsc70Cb CG6603 gene product from transcript CG6603-RG 0.023
Nup358 Nucleoporin 358 0.022
Hrb27C Heterogeneous nuclear ribonucleoprotein at 27C 0.022
yl yolkless 0.020
TppII tripeptidyl-peptidase II 0.020
brat brain tumor 0.019
Tfb1 CG8151 gene product from transcript CG8151-RB 0.019
CG3735 CG3735 gene product from transcript CG3735-RA 0.019
CG8963 CG8963 gene product from transcript CG8963-RB 0.018
fs(1)M3 female sterile (1) M3 0.018
lark CG8597 gene product from transcript CG8597-RD 0.018
RpII215 RNA polymerase II 215kD subunit 0.017
Cp36 Chorion protein 36 0.017
pea peanuts 0.017
Ars2 CG7843 gene product from transcript CG7843-RA 0.016
l(2)NC136 lethal (2) NC136 0.016
cdc16 CG6759 gene product from transcript CG6759-RA 0.016
pasha partner of drosha 0.015
sm smooth 0.015
CG12391 CG12391 gene product from transcript CG12391-RA 0.014
CG32344 CG32344 gene product from transcript CG32344-RA 0.014
CSN3 COP9 complex homolog subunit 3 0.014
snama something that sticks like glue 0.014
eIF-1A Eukaryotic initiation factor 1A 0.014
CG5290 CG5290 gene product from transcript CG5290-RA 0.014
Xpd Xeroderma pigmentosum D 0.014
chm chameau 0.013
CG34415 CG34415 gene product from transcript CG34415-RC 0.013
CG8460 CG8460 gene product from transcript CG8460-RA 0.013
chif chiffon 0.013
CG5859 CG5859 gene product from transcript CG5859-RA 0.012
CG6962 CG6962 gene product from transcript CG6962-RA 0.012
flr flare 0.012
Gen XPG-like endonuclease 0.012
Rpn2 CG11888 gene product from transcript CG11888-RA 0.012
CG7597 CG7597 gene product from transcript CG7597-RB 0.012
Upf2 CG2253 gene product from transcript CG2253-RA 0.012
CG9339 CG9339 gene product from transcript CG9339-RG 0.012
armi armitage 0.011
Tif-IA CG3278 gene product from transcript CG3278-RA 0.011
Fer2LCH Ferritin 2 light chain homologue 0.011
CG8034 CG8034 gene product from transcript CG8034-RA 0.011
l(2)37Cb lethal (2) 37Cb 0.011
Rcd1 Reduction in Cnn dots 1 0.011
Cks30A Cyclin-dependent kinase subunit 30A 0.011
Cpsf73 Cleavage and polyadenylation specificity factor 73 0.011
ttm50 tiny tim 50 0.011
spn-F CG12114 gene product from transcript CG12114-RA 0.011
CG8414 CG8414 gene product from transcript CG8414-RA 0.011
snRNP-U1-70K small ribonucleoprotein particle U1 subunit 70K 0.011
sced scrambled 0.011
CG11596 CG11596 gene product from transcript CG11596-RC 0.010
rhi rhino 0.010
CG4880 CG4880 gene product from transcript CG4880-RA 0.010
CG8545 CG8545 gene product from transcript CG8545-RA 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.681
WWOX WW domain containing oxidoreductase 0.351
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.135
WDR61 WD repeat domain 61 0.056
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa 0.036
CTR9 Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.034
PRRC2A proline-rich coiled-coil 2A 0.020
STAG2 stromal antigen 2 0.020
TCEA1 transcription elongation factor A (SII), 1 0.020
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.017
TOB1 transducer of ERBB2, 1 0.016
KLHL12 kelch-like 12 (Drosophila) 0.015
C7orf64 chromosome 7 open reading frame 64 0.011
CLK2 CDC-like kinase 2 0.011
UBAP2L ubiquitin associated protein 2-like 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Prnp prion protein 1.000
App amyloid beta (A4) precursor protein 0.973
Aplp2 amyloid beta (A4) precursor-like protein 2 0.719
Clstn1 calsyntenin 1 0.175
Neurl1a neuralized homolog 1A (Drosophila) 0.070
Itm2b integral membrane protein 2B 0.060
Usp9x ubiquitin specific peptidase 9, X chromosome 0.044
Zfp830 zinc finger protein 830 0.042
Sparcl1 SPARC-like 1 0.027
Tex11 testis expressed gene 11 0.024
Numb numb gene homolog (Drosophila) 0.022
Apbb1 amyloid beta (A4) precursor protein-binding, family B, member 1 0.021
Cpeb1 cytoplasmic polyadenylation element binding protein 1 0.018
Nbl1 neuroblastoma, suppression of tumorigenicity 1 0.018
Otud4 OTU domain containing 4 0.017
Parp2 poly (ADP-ribose) polymerase family, member 2 0.017
Dab1 disabled homolog 1 (Drosophila) 0.013
Rac1 RAS-related C3 botulinum substrate 1 0.012
Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.012
Eea1 early endosome antigen 1 0.011
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.011
Lsamp limbic system-associated membrane protein 0.010
Clu clusterin 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism