IMP
Process View
The network for 'positive regulation of keratinocyte proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
positive regulation of keratinocyte proliferation
Any process that increases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.
| Name | Description | Probability | Func Analog Organism |
|---|
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Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| FGFR2 | fibroblast growth factor receptor 2 | 1.000 | |
| FGF1 | fibroblast growth factor 1 (acidic) | 1.000 | |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 1.000 | |
| FGFR1 | fibroblast growth factor receptor 1 | 1.000 | |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | 0.999 | |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.999 | |
| DSG2 | desmoglein 2 | 0.999 | |
| JUP | junction plakoglobin | 0.992 | |
| FGF10 | fibroblast growth factor 10 | 0.989 | |
| PSEN1 | presenilin 1 | 0.971 | |
| KRT5 | keratin 5 | 0.941 | |
| CDH3 | cadherin 3, type 1, P-cadherin (placental) | 0.930 | |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4 | 0.843 | |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.802 | |
| FGFR3 | fibroblast growth factor receptor 3 | 0.788 | |
| FGF2 | fibroblast growth factor 2 (basic) | 0.731 | |
| FGF7 | fibroblast growth factor 7 | 0.653 | |
| SATB2 | SATB homeobox 2 | 0.595 | |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.534 | |
| GLIS2 | GLIS family zinc finger 2 | 0.486 | |
| APC | adenomatous polyposis coli | 0.474 | |
| DSP | desmoplakin | 0.462 | |
| PLCG1 | phospholipase C, gamma 1 | 0.455 | |
| TCF4 | transcription factor 4 | 0.421 | |
| BTRC | beta-transducin repeat containing | 0.411 | |
| FGF8 | fibroblast growth factor 8 (androgen-induced) | 0.392 | |
| KRT6C | keratin 6C | 0.382 | |
| FRS2 | fibroblast growth factor receptor substrate 2 | 0.295 | |
| EMD | emerin | 0.287 | |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.272 | |
| CTNNBIP1 | catenin, beta interacting protein 1 | 0.235 | |
| PKP1 | plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) | 0.233 | |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.230 | |
| KRT14 | keratin 14 | 0.229 | |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.215 | |
| PKP2 | plakophilin 2 | 0.165 | |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.145 | |
| HNRNPCL1 | heterogeneous nuclear ribonucleoprotein C-like 1 | 0.141 | |
| FGFBP1 | fibroblast growth factor binding protein 1 | 0.136 | |
| PKP3 | plakophilin 3 | 0.121 | |
| CTGF | connective tissue growth factor | 0.119 | |
| CREBBP | CREB binding protein | 0.103 | |
| S1PR5 | sphingosine-1-phosphate receptor 5 | 0.102 | |
| CFTR | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | 0.093 | |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.091 | |
| EGFR | epidermal growth factor receptor | 0.089 | |
| GPR87 | G protein-coupled receptor 87 | 0.085 | |
| DSC3 | desmocollin 3 | 0.080 | |
| NOSTRIN | nitric oxide synthase trafficker | 0.072 | |
| CRYAB | crystallin, alpha B | 0.071 | |
| ERBB3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 0.069 | |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.069 | |
| FERMT2 | fermitin family member 2 | 0.069 | |
| DSG3 | desmoglein 3 | 0.068 | |
| PTHLH | parathyroid hormone-like hormone | 0.067 | |
| AR | androgen receptor | 0.063 | |
| GSK3B | glycogen synthase kinase 3 beta | 0.063 | |
| TGFA | transforming growth factor, alpha | 0.060 | |
| KRT34 | keratin 34 | 0.058 | |
| YAP1 | Yes-associated protein 1 | 0.057 | |
| BNC1 | basonuclin 1 | 0.055 | |
| FOXC2 | forkhead box C2 (MFH-1, mesenchyme forkhead 1) | 0.054 | |
| PLEKHA7 | pleckstrin homology domain containing, family A member 7 | 0.054 | |
| FGF3 | fibroblast growth factor 3 | 0.048 | |
| WNT1 | wingless-type MMTV integration site family, member 1 | 0.046 | |
| INHBA | inhibin, beta A | 0.046 | |
| AXIN1 | axin 1 | 0.043 | |
| FGF4 | fibroblast growth factor 4 | 0.043 | |
| KRT6A | keratin 6A | 0.042 | |
| DSG1 | desmoglein 1 | 0.042 | |
| KRT1 | keratin 1 | 0.041 | |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | 0.040 | |
| NIPSNAP3A | nipsnap homolog 3A (C. elegans) | 0.038 | |
| PKP4 | plakophilin 4 | 0.037 | |
| CDKN2A | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 0.037 | |
| CLCA2 | chloride channel accessory 2 | 0.036 | |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 0.035 | |
| IRF6 | interferon regulatory factor 6 | 0.034 | |
| G6PC | glucose-6-phosphatase, catalytic subunit | 0.033 | |
| PVR | poliovirus receptor | 0.033 | |
| PTK7 | PTK7 protein tyrosine kinase 7 | 0.032 | |
| PCDH7 | protocadherin 7 | 0.032 | |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.032 | |
| PTH | parathyroid hormone | 0.032 | |
| CNTN1 | contactin 1 | 0.031 | |
| ARVCF | armadillo repeat gene deleted in velocardiofacial syndrome | 0.031 | |
| MPZL2 | myelin protein zero-like 2 | 0.030 | |
| FGF19 | fibroblast growth factor 19 | 0.029 | |
| SLIT1 | slit homolog 1 (Drosophila) | 0.029 | |
| PRKCA | protein kinase C, alpha | 0.028 | |
| PARD3 | par-3 partitioning defective 3 homolog (C. elegans) | 0.028 | |
| PAX8 | paired box 8 | 0.028 | |
| ITGB6 | integrin, beta 6 | 0.027 | |
| FRMD5 | FERM domain containing 5 | 0.027 | |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.027 | |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.026 | |
| COL17A1 | collagen, type XVII, alpha 1 | 0.026 | |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.026 | |
| RGS4 | regulator of G-protein signaling 4 | 0.026 | |
| KRT6B | keratin 6B | 0.025 |
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Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Otx2 | orthodenticle homolog 2 (Drosophila) | 1.000 | |
| Neurod1 | neurogenic differentiation 1 | 0.999 | |
| Shh | sonic hedgehog | 0.996 | |
| Ptf1a | pancreas specific transcription factor, 1a | 0.993 | |
| Pax6 | paired box gene 6 | 0.986 | |
| Ascl1 | achaete-scute complex homolog 1 (Drosophila) | 0.977 | |
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.944 | |
| Nhlh1 | nescient helix loop helix 1 | 0.927 | |
| Pten | phosphatase and tensin homolog | 0.879 | |
| Neurod4 | neurogenic differentiation 4 | 0.859 | |
| Pax3 | paired box gene 3 | 0.822 | |
| Tcfap2a | transcription factor AP-2, alpha | 0.816 | |
| Trp53 | transformation related protein 53 | 0.799 | |
| Neurog2 | neurogenin 2 | 0.793 | |
| Prrx2 | paired related homeobox 2 | 0.785 | |
| Sox9 | SRY-box containing gene 9 | 0.777 | |
| Foxc2 | forkhead box C2 | 0.741 | |
| Emx1 | empty spiracles homolog 1 (Drosophila) | 0.702 | |
| Gli2 | GLI-Kruppel family member GLI2 | 0.694 | |
| Mecom | MDS1 and EVI1 complex locus | 0.690 | |
| Gli3 | GLI-Kruppel family member GLI3 | 0.685 | |
| Gnrhr | gonadotropin releasing hormone receptor | 0.667 | |
| Igdcc3 | immunoglobulin superfamily, DCC subclass, member 3 | 0.632 | |
| En1 | engrailed 1 | 0.589 | |
| Pdx1 | pancreatic and duodenal homeobox 1 | 0.550 | |
| 2210010C04Rik | RIKEN cDNA 2210010C04 gene | 0.526 | |
| Etv4 | ets variant gene 4 (E1A enhancer binding protein, E1AF) | 0.500 | |
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.493 | |
| Nkx2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.488 | |
| Onecut1 | one cut domain, family member 1 | 0.482 | |
| Neurog3 | neurogenin 3 | 0.479 | |
| Hoxd13 | homeobox D13 | 0.465 | |
| Tlx3 | T-cell leukemia, homeobox 3 | 0.460 | |
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.457 | |
| Insm1 | insulinoma-associated 1 | 0.452 | |
| Hoxd1 | homeobox D1 | 0.411 | |
| Lhx3 | LIM homeobox protein 3 | 0.407 | |
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.395 | |
| Cdkn2a | cyclin-dependent kinase inhibitor 2A | 0.386 | |
| Gata1 | GATA binding protein 1 | 0.382 | |
| Cdx2 | caudal type homeobox 2 | 0.381 | |
| Hoxd11 | homeobox D11 | 0.379 | |
| Hoxa13 | homeobox A13 | 0.375 | |
| Pitx1 | paired-like homeodomain transcription factor 1 | 0.372 | |
| Sox2 | SRY-box containing gene 2 | 0.366 | |
| Msx1 | homeobox, msh-like 1 | 0.360 | |
| Col22a1 | collagen, type XXII, alpha 1 | 0.344 | |
| Pitx2 | paired-like homeodomain transcription factor 2 | 0.343 | |
| Prrx1 | paired related homeobox 1 | 0.342 | |
| Reg2 | regenerating islet-derived 2 | 0.321 | |
| Gata4 | GATA binding protein 4 | 0.315 | |
| Dlx2 | distal-less homeobox 2 | 0.312 | |
| Reg3a | regenerating islet-derived 3 alpha | 0.309 | |
| Cyp19a1 | cytochrome P450, family 19, subfamily a, polypeptide 1 | 0.298 | |
| Gsc | goosecoid homeobox | 0.284 | |
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.284 | |
| Rb1 | retinoblastoma 1 | 0.271 | |
| Ebf2 | early B-cell factor 2 | 0.262 | |
| Gpr50 | G-protein-coupled receptor 50 | 0.261 | |
| Sox11 | SRY-box containing gene 11 | 0.256 | |
| Rspo2 | R-spondin 2 homolog (Xenopus laevis) | 0.254 | |
| Lhx9 | LIM homeobox protein 9 | 0.254 | |
| T | brachyury | 0.251 | |
| Krt14 | keratin 14 | 0.248 | |
| Muc13 | mucin 13, epithelial transmembrane | 0.246 | |
| Pax9 | paired box gene 9 | 0.243 | |
| Ebf3 | early B-cell factor 3 | 0.236 | |
| Fgf8 | fibroblast growth factor 8 | 0.236 | |
| Nr5a1 | nuclear receptor subfamily 5, group A, member 1 | 0.235 | |
| Six6 | sine oculis-related homeobox 6 homolog (Drosophila) | 0.235 | |
| Reg3d | regenerating islet-derived 3 delta | 0.234 | |
| Fgf15 | fibroblast growth factor 15 | 0.231 | |
| Igfbpl1 | insulin-like growth factor binding protein-like 1 | 0.231 | |
| Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.228 | |
| Hoxd12 | homeobox D12 | 0.224 | |
| Hoxd3 | homeobox D3 | 0.223 | |
| Hba-x | hemoglobin X, alpha-like embryonic chain in Hba complex | 0.220 | |
| Lhx5 | LIM homeobox protein 5 | 0.219 | |
| Nkx1-2 | NK1 transcription factor related, locus 2 (Drosophila) | 0.216 | |
| Snai1 | snail homolog 1 (Drosophila) | 0.214 | |
| Nkx3-2 | NK3 homeobox 2 | 0.208 | |
| Mdm4 | transformed mouse 3T3 cell double minute 4 | 0.206 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 0.202 | |
| Foxc1 | forkhead box C1 | 0.202 | |
| Msx2 | homeobox, msh-like 2 | 0.197 | |
| Dlx5 | distal-less homeobox 5 | 0.190 | |
| Hoxa1 | homeobox A1 | 0.187 | |
| Cel | carboxyl ester lipase | 0.186 | |
| Gbx2 | gastrulation brain homeobox 2 | 0.185 | |
| Cbfa2t3 | core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) | 0.185 | |
| Evx1 | even skipped homeotic gene 1 homolog | 0.183 | |
| Foxd3 | forkhead box D3 | 0.172 | |
| Eya1 | eyes absent 1 homolog (Drosophila) | 0.170 | |
| Cryba1 | crystallin, beta A1 | 0.163 | |
| Tbx15 | T-box 15 | 0.163 | |
| Hoxc6 | homeobox C6 | 0.159 | |
| Dkk1 | dickkopf homolog 1 (Xenopus laevis) | 0.158 | |
| Trim10 | tripartite motif-containing 10 | 0.158 | |
| Cpa1 | carboxypeptidase A1 | 0.157 | |
| Clps | colipase, pancreatic | 0.156 |