The network for 'dorsal ventral axon guidance' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dorsal ventral axon guidance

The process in which the migration of an axon growth cone is directed to a specific target site along the dorsal-ventral body axis in response to a combination of attractive and repulsive cues. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.

Danio rerio
Name Description Probability Func Analog Organism
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
unc-73 Protein UNC-73 0.881
mig-2 Protein MIG-2 0.487
ced-10 Protein CED-10 0.449
unc-6 Protein UNC-6 0.412
rig-6 Protein RIG-6 0.412
syg-1 Protein SYG-1 0.362
ceh-20 Protein CEH-20 0.352
unc-9 Protein UNC-9 0.301
ina-1 Protein INA-1 0.294
unc-5 Protein UNC-5 0.232
sdn-1 Protein SDN-1 0.177
ncam-1 Protein NCAM-1 0.176
gap-2 Protein GAP-2 0.161
lin-17 Protein LIN-17 0.134
pqe-1 Protein PQE-1 0.133
ptp-3 Protein PTP-3 0.129
F21C10.7 Protein F21C10.7 0.123
cwn-1 Protein CWN-1 0.115
jmjc-1 Protein JMJC-1 0.113
trim-9 Protein TRIM-9 0.113
tag-241 Protein TAG-241 0.098
nud-2 Protein NUD-2 0.094
zoo-1 Protein ZOO-1 0.088
sax-3 Protein SAX-3 0.083
gmeb-1 Protein GMEB-1 0.082
T28F4.1 Protein T28F4.1 0.082
mab-5 Protein MAB-5 0.082
sem-5 Protein SEM-5 0.069
unc-41 Protein UNC-41 0.068
kin-32 Protein KIN-32 0.066
T24B8.3 Protein T24B8.3 0.065
kal-1 Protein KAL-1 0.064
F36A2.13 Protein F36A2.13 0.063
syd-9 Protein SYD-9 0.062
ten-1 Protein TEN-1 0.057
ttyh-1 Protein TTYH-1 0.057
C11E4.6 Protein C11E4.6 0.046
gck-2 Protein GCK-2 0.044
F22D3.2 Protein F22D3.2 0.042
atat-2 Protein ATAT-2 0.041
tir-1 Protein TIR-1 0.041
unc-53 Protein UNC-53 0.041
cst-1 Protein CST-1 0.039
F09A5.4 Protein F09A5.4 0.039
max-1 Protein MAX-1 0.039
F53B3.5 Protein F53B3.5 0.038
set-18 Protein SET-18 0.038
F19C7.8 Protein F19C7.8 0.038
daf-19 Protein DAF-19 0.036
CELE_C33A12.3 Protein C33A12.3 0.034
unc-112 Protein UNC-112 0.034
T12E12.3 Protein T12E12.3 0.033
sad-1 Protein SAD-1 0.033
somi-1 Protein SOMI-1 0.032
let-19 Protein LET-19 0.032
set-25 Protein SET-25 0.032
T02E9.5 Protein T02E9.5 0.031
unc-120 Protein UNC-120 0.031
unc-108 Protein UNC-108 0.030
etr-1 Protein ETR-1 0.030
lam-2 Protein LAM-2 0.030
hmg-11 Protein HMG-11 0.029
unc-68 Protein UNC-68 0.029
rig-3 Protein RIG-3 0.029
slo-1 Protein SLO-1 0.028
R90.1 Protein R90.1 0.028
afd-1 Protein AFD-1 0.026
sel-7 Protein SEL-7 0.026
nlr-1 Protein NLR-1 0.026
efn-2 Protein EFN-2 0.026
pat-3 Protein PAT-3 0.026
rnp-7 Protein RNP-7 0.026
klp-11 Protein KLP-11 0.025
ugt-57 Protein UGT-57 0.025
let-60 Protein LET-60 0.025
plx-2 Protein PLX-2 0.025
CELE_T13H5.1 Protein T13H5.1 0.025
ctn-1 Protein CTN-1 0.025
ddr-2 Protein DDR-2 0.024
epi-1 Protein EPI-1 0.024
ast-1 Protein AST-1 0.024
kpc-1 Protein KPC-1 0.024
stn-1 Protein STN-1 0.024
pqn-42 Protein PQN-42 0.024
F57F4.4 Protein F57F4.4 0.023
F29A7.4 Protein F29A7.4 0.023
C32E8.3 Protein C32E8.3 0.023
CELE_B0285.3 Protein B0285.3 0.022
F11D5.1 Protein F11D5.1 0.022
T25B9.3 Protein T25B9.3 0.022
fmi-1 Protein FMI-1 0.021
R04B3.2 Protein R04B3.2 0.021
CELE_C01B10.9 Protein C01B10.9 0.021
F54D8.6 Protein F54D8.6 0.021
F58H1.5 Protein F58H1.5 0.021
mig-10 Protein MIG-10 0.021
F32D8.3 Protein F32D8.3 0.020
unc-36 Protein UNC-36 0.020
arl-3 Protein ARL-3 0.020
rap-1 Protein RAP-1 0.020
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Drosophila melanogaster
Name Description Probability Func Analog Organism
robo roundabout 0.998
trio CG18214 gene product from transcript CG18214-RA 0.997
lea leak 0.991
ena enabled 0.979
dock dreadlocks 0.964
Sema-1a CG18405 gene product from transcript CG18405-RD 0.933
comm commissureless 0.923
lola longitudinals lacking 0.819
Abl Abl tyrosine kinase 0.793
fra frazzled 0.750
tutl turtle 0.719
RhoGAPp190 CG32555 gene product from transcript CG32555-RB 0.715
Dscam Down syndrome cell adhesion molecule 0.595
sli slit 0.587
CadN Cadherin-N 0.460
pros prospero 0.413
Rac1 CG2248 gene product from transcript CG2248-RA 0.409
SoxN SoxNeuro 0.390
pod1 CG4532 gene product from transcript CG4532-RF 0.386
Trim9 CG31721 gene product from transcript CG31721-RB 0.379
drl derailed 0.376
RhoGAP93B CG3421 gene product from transcript CG3421-RA 0.312
stan starry night 0.296
plexB plexin B 0.288
elav embryonic lethal abnormal vision 0.274
kuz kuzbanian 0.273
repo reversed polarity 0.255
Sdc Syndecan 0.242
rictor rapamycin-insensitive companion of Tor 0.239
Ptp69D Protein tyrosine phosphatase 69D 0.236
Cdc42 CG12530 gene product from transcript CG12530-RA 0.233
mbc myoblast city 0.222
spen split ends 0.220
Wnt5 Wnt oncogene analog 5 0.216
plexA plexin A 0.187
otk off-track 0.174
mew multiple edematous wings 0.165
Hem HEM-protein 0.164
Rho1 CG8416 gene product from transcript CG8416-RB 0.151
LIMK1 LIM-kinase1 0.150
mid midline 0.148
stumps CG31317 gene product from transcript CG31317-RC 0.143
sim single-minded 0.140
sqz squeeze 0.140
babo baboon 0.135
retn retained 0.132
vnd ventral nervous system defective 0.132
Caps Calcium activated protein for secretion 0.132
unc-5 CG8166 gene product from transcript CG8166-RA 0.131
nerfin-1 nervous fingers 1 0.128
NetB Netrin-B 0.125
shot short stop 0.122
Nrg Neuroglian 0.119
chic chickadee 0.115
Fas2 Fasciclin 2 0.099
Ten-m Tenascin major 0.098
ttk tramtrack 0.097
rok Rho-kinase 0.097
gcm glial cells missing 0.096
robo3 CG5423 gene product from transcript CG5423-RA 0.095
jing CG9397 gene product from transcript CG9397-RI 0.087
ems empty spiracles 0.078
l(2)k16918 lethal (2) k16918 0.067
tup tailup 0.062
pnt pointed 0.061
Nrx-IV Neurexin IV 0.059
mira miranda 0.058
nvy nervy 0.058
Pak PAK-kinase 0.058
Sema-2a CG4700 gene product from transcript CG4700-RC 0.057
Smox Smad on X 0.053
Mical Molecule interacting with CasL 0.049
side sidestep 0.047
Ephrin CG1862 gene product from transcript CG1862-RA 0.046
hkb huckebein 0.045
G-oalpha47A G protein oalpha 47A 0.044
wb wing blister 0.042
LanA Laminin A 0.042
exex extra-extra 0.042
zfh1 Zn finger homeodomain 1 0.039
fog folded gastrulation 0.039
Nrt Neurotactin 0.038
oc ocelliless 0.038
aop anterior open 0.037
Fas3 Fasciclin 3 0.037
Eph Eph receptor tyrosine kinase 0.037
par-1 CG8201 gene product from transcript CG8201-RA 0.036
CG9650 CG9650 gene product from transcript CG9650-RG 0.034
CG12424 CG12424 gene product from transcript CG12424-RC 0.034
fas faint sausage 0.033
jeb jelly belly 0.033
NetA Netrin-A 0.032
argos CG4531 gene product from transcript CG4531-RA 0.030
Ptp52F CG18243 gene product from transcript CG18243-RB 0.030
InR Insulin-like receptor 0.030
hipk homeodomain interacting protein kinase 0.030
Nedd4 CG42279 gene product from transcript CG42279-RJ 0.029
Arf79F ADP ribosylation factor 79F 0.029
form3 formin 3 0.028
tai taiman 0.026
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Robo1 roundabout homolog 1 (Drosophila) 1.000
Slit3 slit homolog 3 (Drosophila) 1.000
Slit2 slit homolog 2 (Drosophila) 1.000
Robo2 roundabout homolog 2 (Drosophila) 1.000
Gli2 GLI-Kruppel family member GLI2 0.973
Dcc deleted in colorectal carcinoma 0.972
Vasp vasodilator-stimulated phosphoprotein 0.970
Gli3 GLI-Kruppel family member GLI3 0.968
Unc5c unc-5 homolog C (C. elegans) 0.959
Slit1 slit homolog 1 (Drosophila) 0.935
Enah enabled homolog (Drosophila) 0.902
Tbx4 T-box 4 0.900
Bhlhe22 basic helix-loop-helix family, member e22 0.853
Shh sonic hedgehog 0.847
Ntn1 netrin 1 0.809
Evl Ena-vasodilator stimulated phosphoprotein 0.800
Pitx1 paired-like homeodomain transcription factor 1 0.791
Fgf8 fibroblast growth factor 8 0.739
Lmx1b LIM homeobox transcription factor 1 beta 0.696
Isl1 ISL1 transcription factor, LIM/homeodomain 0.692
Tbx3 T-box 3 0.590
Zfpm2 zinc finger protein, multitype 2 0.464
Msx2 homeobox, msh-like 2 0.458
Pitx2 paired-like homeodomain transcription factor 2 0.456
Fgfr2 fibroblast growth factor receptor 2 0.436
En1 engrailed 1 0.401
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.394
Otx2 orthodenticle homolog 2 (Drosophila) 0.387
Sox11 SRY-box containing gene 11 0.367
Lhx3 LIM homeobox protein 3 0.355
Ephb2 Eph receptor B2 0.342
Foxc1 forkhead box C1 0.334
Pax6 paired box gene 6 0.328
Twist2 twist homolog 2 (Drosophila) 0.319
Mark1 MAP/microtubule affinity-regulating kinase 1 0.318
Mmp16 matrix metallopeptidase 16 0.294
Mesp1 mesoderm posterior 1 0.279
Hoxa13 homeobox A13 0.275
Apbb1ip amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.267
Fgf10 fibroblast growth factor 10 0.267
Smpd3 sphingomyelin phosphodiesterase 3, neutral 0.255
Wdr1 WD repeat domain 1 0.254
Bmpr1a bone morphogenetic protein receptor, type 1A 0.245
Grb10 growth factor receptor bound protein 10 0.233
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.227
Pax3 paired box gene 3 0.225
Sox9 SRY-box containing gene 9 0.215
Gata4 GATA binding protein 4 0.210
Auts2 autism susceptibility candidate 2 0.204
Emx1 empty spiracles homolog 1 (Drosophila) 0.198
Msn moesin 0.194
Nfatc4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 0.193
Hand1 heart and neural crest derivatives expressed transcript 1 0.192
Ctnnb1 catenin (cadherin associated protein), beta 1 0.190
Fbn2 fibrillin 2 0.189
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.185
Tbx1 T-box 1 0.179
Foxh1 forkhead box H1 0.167
Cdh4 cadherin 4 0.162
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.162
Tead3 TEA domain family member 3 0.159
Drd2 dopamine receptor D2 0.159
Sall4 sal-like 4 (Drosophila) 0.156
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.154
Rhog ras homolog gene family, member G 0.151
Ebf3 early B-cell factor 3 0.149
Ptk7 PTK7 protein tyrosine kinase 7 0.148
Foxc2 forkhead box C2 0.147
Nog noggin 0.145
Zic3 zinc finger protein of the cerebellum 3 0.141
Efs embryonal Fyn-associated substrate 0.138
Dlk1 delta-like 1 homolog (Drosophila) 0.136
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.134
Efna2 ephrin A2 0.132
Tcfap2c transcription factor AP-2, gamma 0.130
Myo10 myosin X 0.128
Cbln1 cerebellin 1 precursor protein 0.128
Gli1 GLI-Kruppel family member GLI1 0.125
Capn6 calpain 6 0.124
Lef1 lymphoid enhancer binding factor 1 0.119
Shox2 short stature homeobox 2 0.119
Tgfb2 transforming growth factor, beta 2 0.118
Col22a1 collagen, type XXII, alpha 1 0.115
Myf5 myogenic factor 5 0.113
Ncam1 neural cell adhesion molecule 1 0.111
Obsl1 obscurin-like 1 0.110
Arhgap1 Rho GTPase activating protein 1 0.108
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.107
Cotl1 coactosin-like 1 (Dictyostelium) 0.106
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.105
Srgap1 SLIT-ROBO Rho GTPase activating protein 1 0.103
Tcfap2a transcription factor AP-2, alpha 0.103
Hoxd13 homeobox D13 0.100
Dbx1 developing brain homeobox 1 0.100
Ednra endothelin receptor type A 0.099
Gpc6 glypican 6 0.098
Vegfa vascular endothelial growth factor A 0.097
Runx1t1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.096
Nodal nodal 0.092
Gbx2 gastrulation brain homeobox 2 0.091
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Rattus norvegicus
Name Description Probability Func Analog Organism
Camk2n2 calcium/calmodulin-dependent protein kinase II inhibitor 2 0.735
Foxd4 forkhead box D4 0.266
Chrnb2 cholinergic receptor, nicotinic, beta 2 (neuronal) 0.182
Robo1 roundabout homolog 1 (Drosophila) 0.182
Foxe3 forkhead box E3 0.181
Hpcal4 hippocalcin-like 4 0.175
Barhl2 BarH-like homeobox 2 0.166
Mip major intrinsic protein of lens fiber 0.133
Hmga2 high mobility group AT-hook 2 0.128
Mpp3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) 0.085
Galr3 galanin receptor 3 0.072
Crybb2 crystallin, beta B2 0.069
Slc2a13 solute carrier family 2 (facilitated glucose transporter), member 13 0.068
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.066
Gjb4 gap junction protein, beta 4 0.063
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.063
Chrm1 cholinergic receptor, muscarinic 1 0.062
Cntfr ciliary neurotrophic factor receptor 0.061
Runx3 runt-related transcription factor 3 0.060
Lim2 lens intrinsic membrane protein 2 0.060
Hes3 hairy and enhancer of split 3 (Drosophila) 0.054
Dcc deleted in colorectal carcinoma 0.048
Epha8 Eph receptor A8 0.046
Begain brain-enriched guanylate kinase-associated 0.046
Unc5a unc-5 homolog A (C. elegans) 0.045
Pgc progastricsin (pepsinogen C) 0.044
Crybb3 crystallin, beta B3 0.043
Gpr182 G protein-coupled receptor 182 0.040
Gcm1 glial cells missing homolog 1 (Drosophila) 0.039
Sdc3 syndecan 3 0.038
Foxi2 forkhead box I2 0.037
Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.037
Pou6f1 POU class 6 homeobox 1 0.036
Grm5 glutamate receptor, metabotropic 5 0.036
Scarf2 scavenger receptor class F, member 2 0.036
Cnn1 calponin 1, basic, smooth muscle 0.035
Syn1 synapsin I 0.035
Sgp158 proline-rich glycoprotein (sgp158) 0.035
Sema6c sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C 0.035
Gdf11 growth differentiation factor 11 0.033
B3gat1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) 0.033
Prlh prolactin releasing hormone 0.033
Lin7b lin-7 homolog b (C. elegans) 0.032
Nr0b2 nuclear receptor subfamily 0, group B, member 2 0.031
Pyy peptide YY (mapped) 0.030
LOC679931 hypothetical protein LOC679931 0.030
Thpo thrombopoietin 0.030
Gna11 guanine nucleotide binding protein, alpha 11 0.030
Gria1 glutamate receptor, ionotropic, AMPA 1 0.029
Aanat arylalkylamine N-acetyltransferase 0.028
Nxph3 neurexophilin 3 0.028
Mgat5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.026
Ttn titin 0.026
Mpp2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.025
Bhlha15 basic helix-loop-helix family, member a15 0.025
Cryba2 crystallin, beta A2 0.024
F2rl3 coagulation factor II (thrombin) receptor-like 3 0.023
Nxph4 neurexophilin 4 0.023
Grk4 G protein-coupled receptor kinase 4 0.023
Ppp1r9a protein phosphatase 1, regulatory (inhibitor) subunit 9A 0.023
Fgf22 fibroblast growth factor 22 0.023
Atp2c1 ATPase, Ca++ transporting, type 2C, member 1 0.022
RGD1305627 hypothetical LOC314467 0.022
Dlg4 discs, large homolog 4 (Drosophila) 0.021
Ghsr growth hormone secretagogue receptor 0.021
Matk megakaryocyte-associated tyrosine kinase 0.021
Tgfb3 transforming growth factor, beta 3 0.021
Aqp5 aquaporin 5 0.021
Myh1 myosin, heavy polypeptide 1, skeletal muscle, adult 0.021
Pgr progesterone receptor 0.021
Pdc phosducin 0.020
Foxd1 forkhead box D1 0.020
Myh13 myosin, heavy chain 13, skeletal muscle 0.020
Acr acrosin 0.020
Zcchc3 zinc finger, CCHC domain containing 3 0.020
Mgat3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase 0.020
Sema6b sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 0.020
Mapk15 mitogen-activated protein kinase 15 0.019
Hapln1 hyaluronan and proteoglycan link protein 1 0.019
Clec11a C-type lectin domain family 11, member a 0.019
Mapk4 mitogen-activated protein kinase 4 0.019
Lmod1 leiomodin 1 (smooth muscle) 0.019
Nlgn3 neuroligin 3 0.019
Aard alanine and arginine rich domain containing protein 0.019
Bves blood vessel epicardial substance 0.018
Galntl1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1 0.018
Nlgn2 neuroligin 2 0.018
Abcc6 ATP-binding cassette, subfamily C (CFTR/MRP), member 6 0.018
Dpp6 dipeptidylpeptidase 6 0.018
Fabp6 fatty acid binding protein 6, ileal 0.018
Sox17 SRY (sex determining region Y)-box 17 0.018
Aqp2 aquaporin 2 (collecting duct) 0.018
Megf6 multiple EGF-like-domains 6 0.018
Rbp2 retinol binding protein 2, cellular 0.018
Crhbp corticotropin releasing hormone binding protein 0.018
Prx periaxin 0.017
Esr2 estrogen receptor 2 (ER beta) 0.017
Amh anti-Mullerian hormone 0.017
Crybb1 crystallin, beta B1 0.017
Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 0.017
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism