IMP
Process View
The network for 'positive regulation of actin nucleation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
positive regulation of actin nucleation
Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament.
| Name | Description | Probability | Func Analog Organism |
|---|
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Drosophila melanogaster
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Sra-1 | specifically Rac1-associated protein 1 | 0.139 | |
| katanin-60 | katanin 60 | 0.031 | |
| Hem | HEM-protein | 0.027 | |
| RhoGAP93B | CG3421 gene product from transcript CG3421-RA | 0.025 | |
| Vrp1 | Verprolin 1 | 0.024 | |
| Rala | Ras-related protein | 0.019 | |
| CG10413 | CG10413 gene product from transcript CG10413-RA | 0.016 | |
| Arp66B | Actin-related protein 66B | 0.015 | |
| bif | bifocal | 0.013 | |
| Liprin-alpha | CG11199 gene product from transcript CG11199-RB | 0.013 | |
| Eps-15 | Epidermal growth factor receptor pathway substrate clone 15 | 0.011 | |
| Cip4 | CG15015 gene product from transcript CG15015-RA | 0.011 | |
| mbc | myoblast city | 0.011 | |
| Letm1 | CG4589 gene product from transcript CG4589-RB | 0.010 | |
| Arp14D | Actin-related protein 14D | 0.010 | |
| MESR4 | Misexpression suppressor of ras 4 | 0.010 |
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Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| GAS7 | growth arrest-specific 7 | 1.000 | |
| ABL1 | c-abl oncogene 1, non-receptor tyrosine kinase | 1.000 | |
| ABI2 | abl-interactor 2 | 0.999 | |
| WASF1 | WAS protein family, member 1 | 0.989 | |
| WASF2 | WAS protein family, member 2 | 0.968 | |
| BAIAP2 | BAI1-associated protein 2 | 0.930 | |
| WAS | Wiskott-Aldrich syndrome (eczema-thrombocytopenia) | 0.922 | |
| PFDN1 | prefoldin subunit 1 | 0.916 | |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.850 | |
| WIPF1 | WAS/WASL interacting protein family, member 1 | 0.826 | |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.786 | |
| SORBS3 | sorbin and SH3 domain containing 3 | 0.686 | |
| CYFIP1 | cytoplasmic FMR1 interacting protein 1 | 0.615 | |
| CDC42 | cell division cycle 42 (GTP binding protein, 25kDa) | 0.533 | |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 | 0.447 | |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.434 | |
| RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 0.423 | |
| TPM4 | tropomyosin 4 | 0.272 | |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | 0.254 | |
| PAK2 | p21 protein (Cdc42/Rac)-activated kinase 2 | 0.193 | |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.184 | |
| FMNL1 | formin-like 1 | 0.179 | |
| NCKAP1 | NCK-associated protein 1 | 0.146 | |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.139 | |
| PFN1 | profilin 1 | 0.134 | |
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.082 | |
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 0.080 | |
| VAV1 | vav 1 guanine nucleotide exchange factor | 0.079 | |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | 0.078 | |
| CDC34 | cell division cycle 34 homolog (S. cerevisiae) | 0.074 | |
| TUBGCP4 | tubulin, gamma complex associated protein 4 | 0.074 | |
| ITSN1 | intersectin 1 (SH3 domain protein) | 0.063 | |
| ANXA2 | annexin A2 | 0.061 | |
| MCOLN1 | mucolipin 1 | 0.060 | |
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.047 | |
| DEF6 | differentially expressed in FDCP 6 homolog (mouse) | 0.047 | |
| CTTN | cortactin | 0.046 | |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | 0.045 | |
| CRK | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.038 | |
| DLG5 | discs, large homolog 5 (Drosophila) | 0.038 | |
| COTL1 | coactosin-like 1 (Dictyostelium) | 0.035 | |
| PSTPIP1 | proline-serine-threonine phosphatase interacting protein 1 | 0.034 | |
| NCK1 | NCK adaptor protein 1 | 0.034 | |
| SPRR2A | small proline-rich protein 2A | 0.031 | |
| DTNBP1 | dystrobrevin binding protein 1 | 0.031 | |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | 0.030 | |
| MAVS | mitochondrial antiviral signaling protein | 0.029 | |
| KIAA0408 | KIAA0408 | 0.024 | |
| DNM2 | dynamin 2 | 0.024 | |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.021 | |
| UBE2Z | ubiquitin-conjugating enzyme E2Z | 0.021 | |
| RIOK3 | RIO kinase 3 (yeast) | 0.017 | |
| GNGT2 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 | 0.017 | |
| NCKAP1L | NCK-associated protein 1-like | 0.015 | |
| PIK3C2B | phosphoinositide-3-kinase, class 2, beta polypeptide | 0.014 | |
| ZDHHC24 | zinc finger, DHHC-type containing 24 | 0.014 | |
| FGR | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | 0.014 | |
| RGS19 | regulator of G-protein signaling 19 | 0.013 | |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.012 | |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | 0.012 | |
| PRKAA1 | protein kinase, AMP-activated, alpha 1 catalytic subunit | 0.012 | |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.011 | |
| DAXX | death-domain associated protein | 0.011 | |
| GRB2 | growth factor receptor-bound protein 2 | 0.011 | |
| RGS14 | regulator of G-protein signaling 14 | 0.010 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Trim30d | tripartite motif-containing 30D | 0.750 | |
| Pfn2 | profilin 2 | 0.626 | |
| Irf9 | interferon regulatory factor 9 | 0.473 | |
| 9430031J16Rik | RIKEN cDNA 9430031J16 gene | 0.460 | |
| Stat1 | signal transducer and activator of transcription 1 | 0.455 | |
| Arpc4 | actin related protein 2/3 complex, subunit 4 | 0.348 | |
| Trim21 | tripartite motif-containing 21 | 0.290 | |
| Oasl2 | 2'-5' oligoadenylate synthetase-like 2 | 0.269 | |
| Parp14 | poly (ADP-ribose) polymerase family, member 14 | 0.234 | |
| Gbp3 | guanylate binding protein 3 | 0.204 | |
| Wipf1 | WAS/WASL interacting protein family, member 1 | 0.184 | |
| Uba7 | ubiquitin-like modifier activating enzyme 7 | 0.164 | |
| Sash3 | SAM and SH3 domain containing 3 | 0.150 | |
| Tuba1a | tubulin, alpha 1A | 0.145 | |
| Cttn | cortactin | 0.141 | |
| Dbnl | drebrin-like | 0.132 | |
| Gbp7 | guanylate binding protein 7 | 0.131 | |
| Ifi203 | interferon activated gene 203 | 0.122 | |
| Trim30a | tripartite motif-containing 30A | 0.118 | |
| Ddx60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.113 | |
| Maged1 | melanoma antigen, family D, 1 | 0.107 | |
| Stat6 | signal transducer and activator of transcription 6 | 0.104 | |
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.100 | |
| Gnb2 | guanine nucleotide binding protein (G protein), beta 2 | 0.098 | |
| Sp100 | nuclear antigen Sp100 | 0.091 | |
| Ptpn6 | protein tyrosine phosphatase, non-receptor type 6 | 0.083 | |
| Ddx58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 0.081 | |
| Ywhab | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | 0.075 | |
| Shisa5 | shisa homolog 5 (Xenopus laevis) | 0.072 | |
| Gnai2 | guanine nucleotide binding protein (G protein), alpha inhibiting 2 | 0.070 | |
| Usp18 | ubiquitin specific peptidase 18 | 0.069 | |
| Fez1 | fasciculation and elongation protein zeta 1 (zygin I) | 0.065 | |
| Ms4a6b | membrane-spanning 4-domains, subfamily A, member 6B | 0.064 | |
| E4f1 | E4F transcription factor 1 | 0.063 | |
| Npas3 | neuronal PAS domain protein 3 | 0.063 | |
| Pcdh10 | protocadherin 10 | 0.062 | |
| Nbea | neurobeachin | 0.057 | |
| Oas1b | 2'-5' oligoadenylate synthetase 1B | 0.056 | |
| Epsti1 | epithelial stromal interaction 1 (breast) | 0.055 | |
| Tjp1 | tight junction protein 1 | 0.053 | |
| Csk | c-src tyrosine kinase | 0.052 | |
| Plcg2 | phospholipase C, gamma 2 | 0.052 | |
| Adrbk1 | adrenergic receptor kinase, beta 1 | 0.052 | |
| Man2b1 | mannosidase 2, alpha B1 | 0.051 | |
| Arpc2 | actin related protein 2/3 complex, subunit 2 | 0.050 | |
| Oas3 | 2'-5' oligoadenylate synthetase 3 | 0.049 | |
| Ifi44 | interferon-induced protein 44 | 0.049 | |
| Adar | adenosine deaminase, RNA-specific | 0.049 | |
| Parp10 | poly (ADP-ribose) polymerase family, member 10 | 0.048 | |
| Dhx58 | DEXH (Asp-Glu-X-His) box polypeptide 58 | 0.048 | |
| Fermt3 | fermitin family homolog 3 (Drosophila) | 0.047 | |
| Arhgef1 | Rho guanine nucleotide exchange factor (GEF) 1 | 0.047 | |
| 0610031J06Rik | RIKEN cDNA 0610031J06 gene | 0.046 | |
| Rab4b | RAB4B, member RAS oncogene family | 0.045 | |
| Rtp4 | receptor transporter protein 4 | 0.040 | |
| Samhd1 | SAM domain and HD domain, 1 | 0.039 | |
| Cdc42se1 | CDC42 small effector 1 | 0.038 | |
| Cotl1 | coactosin-like 1 (Dictyostelium) | 0.038 | |
| Kif3b | kinesin family member 3B | 0.037 | |
| Gmip | Gem-interacting protein | 0.036 | |
| Arhgdia | Rho GDP dissociation inhibitor (GDI) alpha | 0.036 | |
| Lgals9 | lectin, galactose binding, soluble 9 | 0.035 | |
| Rps6ka4 | ribosomal protein S6 kinase, polypeptide 4 | 0.035 | |
| Pitpnm1 | phosphatidylinositol transfer protein, membrane-associated 1 | 0.035 | |
| Cd37 | CD37 antigen | 0.034 | |
| Tnfsf10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.034 | |
| Psmb9 | proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) | 0.034 | |
| Tap2 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | 0.034 | |
| Trim34a | tripartite motif-containing 34A | 0.034 | |
| Herc6 | hect domain and RLD 6 | 0.034 | |
| Hmha1 | histocompatibility (minor) HA-1 | 0.033 | |
| Cherp | calcium homeostasis endoplasmic reticulum protein | 0.033 | |
| Sfi1 | Sfi1 homolog, spindle assembly associated (yeast) | 0.033 | |
| Arhgap9 | Rho GTPase activating protein 9 | 0.032 | |
| Adcy7 | adenylate cyclase 7 | 0.032 | |
| Eid1 | EP300 interacting inhibitor of differentiation 1 | 0.032 | |
| Klraq1 | KLRAQ motif containing 1 | 0.032 | |
| Apbb1ip | amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein | 0.031 | |
| Slc4a1 | solute carrier family 4 (anion exchanger), member 1 | 0.031 | |
| Lxn | latexin | 0.031 | |
| Atp6v1a | ATPase, H+ transporting, lysosomal V1 subunit A | 0.031 | |
| Irgm1 | immunity-related GTPase family M member 1 | 0.031 | |
| D6Wsu116e | DNA segment, Chr 6, Wayne State University 116, expressed | 0.031 | |
| BC006779 | cDNA sequence BC006779 | 0.031 | |
| Rps6ka1 | ribosomal protein S6 kinase polypeptide 1 | 0.030 | |
| Vasp | vasodilator-stimulated phosphoprotein | 0.030 | |
| H2-Q6 | histocompatibility 2, Q region locus 6 | 0.030 | |
| Samd9l | sterile alpha motif domain containing 9-like | 0.030 | |
| H2-M3 | histocompatibility 2, M region locus 3 | 0.029 | |
| Nmi | N-myc (and STAT) interactor | 0.029 | |
| Kcnab2 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | 0.029 | |
| Trim12c | tripartite motif-containing 12C | 0.029 | |
| Pcdh18 | protocadherin 18 | 0.028 | |
| Ctnna1 | catenin (cadherin associated protein), alpha 1 | 0.028 | |
| Ankfy1 | ankyrin repeat and FYVE domain containing 1 | 0.028 | |
| Ifih1 | interferon induced with helicase C domain 1 | 0.028 | |
| Gbp2 | guanylate binding protein 2 | 0.028 | |
| Trim5 | tripartite motif-containing 5 | 0.028 | |
| Kel | Kell blood group | 0.027 | |
| Stxbp2 | syntaxin binding protein 2 | 0.027 |