The network for 'negative regulation of membrane potential' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of membrane potential

Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.

Danio rerio
Name Description Probability Func Analog Organism
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.746
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.282
DLG4 discs, large homolog 4 (Drosophila) 0.046
IL1R1 interleukin 1 receptor, type I 0.020
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.010
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.480
Pecam1 platelet/endothelial cell adhesion molecule 1 0.215
Src Rous sarcoma oncogene 0.205
Mcl1 myeloid cell leukemia sequence 1 0.163
Grxcr1 glutaredoxin, cysteine rich 1 0.151
Srrm4 serine/arginine repetitive matrix 4 0.111
Apoe apolipoprotein E 0.105
S1pr2 sphingosine-1-phosphate receptor 2 0.105
Irak4 interleukin-1 receptor-associated kinase 4 0.097
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.086
Kit kit oncogene 0.081
Pou4f3 POU domain, class 4, transcription factor 3 0.080
Esr1 estrogen receptor 1 (alpha) 0.079
Ednrb endothelin receptor type B 0.078
Myo6 myosin VI 0.072
Fbxw7 F-box and WD-40 domain protein 7 0.070
Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 0.067
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.062
Gfi1 growth factor independent 1 0.062
Ctnnb1 catenin (cadherin associated protein), beta 1 0.052
Vim vimentin 0.049
Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 0.047
Ldb3 LIM domain binding 3 0.046
Espn espin 0.043
Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit 0.043
Mapk14 mitogen-activated protein kinase 14 0.041
Trf transferrin 0.040
Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) 0.038
Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 0.037
Prkcc protein kinase C, gamma 0.036
Ina internexin neuronal intermediate filament protein, alpha 0.036
Thrb thyroid hormone receptor beta 0.036
S1pr3 sphingosine-1-phosphate receptor 3 0.035
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.034
Gad1 glutamic acid decarboxylase 1 0.034
Fas Fas (TNF receptor superfamily member 6) 0.032
Cd22 CD22 antigen 0.032
Cxcl2 chemokine (C-X-C motif) ligand 2 0.032
Sult4a1 sulfotransferase family 4A, member 1 0.031
F7 coagulation factor VII 0.031
Cadps Ca2+-dependent secretion activator 0.031
Ctnnd2 catenin (cadherin associated protein), delta 2 0.030
Cx3cr1 chemokine (C-X3-C) receptor 1 0.030
Slc26a4 solute carrier family 26, member 4 0.030
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.029
Gad2 glutamic acid decarboxylase 2 0.029
Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 0.028
Syt1 synaptotagmin I 0.028
Myt1l myelin transcription factor 1-like 0.027
Cplx2 complexin 2 0.027
Syn2 synapsin II 0.027
Ush1g Usher syndrome 1G homolog (human) 0.026
Spock1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 0.026
Spib Spi-B transcription factor (Spi-1/PU.1 related) 0.025
Cntn3 contactin 3 0.025
Mef2c myocyte enhancer factor 2C 0.025
Rgs17 regulator of G-protein signaling 17 0.025
Actb actin, beta 0.025
Rit2 Ras-like without CAAX 2 0.024
Plcb1 phospholipase C, beta 1 0.023
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 0.023
Prkca protein kinase C, alpha 0.023
Elavl3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C) 0.023
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.023
Rgs4 regulator of G-protein signaling 4 0.023
Stmn4 stathmin-like 4 0.022
Nap1l2 nucleosome assembly protein 1-like 2 0.022
Mab21l2 mab-21-like 2 (C. elegans) 0.022
Cplx1 complexin 1 0.022
Hcn1 hyperpolarization-activated, cyclic nucleotide-gated K+ 1 0.021
Gpr37l1 G protein-coupled receptor 37-like 1 0.021
Npc1 Niemann Pick type C1 0.021
Elavl4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) 0.021
Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) 0.021
Rgs14 regulator of G-protein signaling 14 0.021
Btbd17 BTB (POZ) domain containing 17 0.021
Asprv1 aspartic peptidase, retroviral-like 1 0.021
Epha10 Eph receptor A10 0.020
Nptx1 neuronal pentraxin 1 0.020
Nell2 NEL-like 2 (chicken) 0.020
Sstr2 somatostatin receptor 2 0.020
Cntn1 contactin 1 0.020
Tmem198 transmembrane protein 198 0.020
Rgs8 regulator of G-protein signaling 8 0.020
Gal galanin 0.020
Ptprn protein tyrosine phosphatase, receptor type, N 0.020
Fbxo41 F-box protein 41 0.019
Vgf VGF nerve growth factor inducible 0.019
Ifngr1 interferon gamma receptor 1 0.019
Hs3st2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 0.019
Klf12 Kruppel-like factor 12 0.019
Fus fusion, derived from t(12;16) malignant liposarcoma (human) 0.019
Myo7a myosin VIIA 0.019
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.019
Snrk SNF related kinase 0.018
Rimbp2 RIMS binding protein 2 0.018
Prkcb protein kinase C, beta 0.018
Il6st interleukin 6 signal transducer 0.018
Srms src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 0.018
Gng3 guanine nucleotide binding protein (G protein), gamma 3 0.018
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Rattus norvegicus
Name Description Probability Func Analog Organism
Olr287 olfactory receptor 287 0.079
Gjb4 gap junction protein, beta 4 0.032
Opn1mw opsin 1 (cone pigments), medium-wave-sensitive 0.031
Olr442 olfactory receptor 442 0.031
Insrr insulin receptor-related receptor 0.030
Uts2r urotensin 2 receptor 0.027
Mettl7b methyltransferase like 7B 0.026
Pyy peptide YY (mapped) 0.023
Htr3a 5-hydroxytryptamine (serotonin) receptor 3a 0.022
Pth parathyroid hormone 0.021
Car5a carbonic anhydrase 5a, mitochondrial 0.020
Adam18 ADAM metallopeptidase domain 18 0.020
Tff3 trefoil factor 3, intestinal 0.019
Abcc6 ATP-binding cassette, subfamily C (CFTR/MRP), member 6 0.019
Olr1500 olfactory receptor 1500 0.017
Smr3a submaxillary gland androgen regulated protein 3A 0.016
Aqp2 aquaporin 2 (collecting duct) 0.015
Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 0.015
Spam1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 0.014
Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.014
Adora3 adenosine A3 receptor 0.014
Hal histidine ammonia lyase 0.014
Il1rn interleukin 1 receptor antagonist 0.013
Crhr2 corticotropin releasing hormone receptor 2 0.012
Dlg4 discs, large homolog 4 (Drosophila) 0.011
Olr1226 olfactory receptor 1226 0.011
Dusp4 dual specificity phosphatase 4 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism