IMP
Process View
The network for 'calcitriol biosynthetic process from calciol' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
calcitriol biosynthetic process from calciol
Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol.
| Name | Description | Probability | Func Analog Organism |
|---|
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Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| CYP3A7 | cytochrome P450, family 3, subfamily A, polypeptide 7 | 0.952 | |
| CYP3A4 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 0.422 | |
| CYP2C9 | cytochrome P450, family 2, subfamily C, polypeptide 9 | 0.170 | |
| MASP2 | mannan-binding lectin serine peptidase 2 | 0.118 | |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.071 | |
| CYP3A43 | cytochrome P450, family 3, subfamily A, polypeptide 43 | 0.023 | |
| F9 | coagulation factor IX | 0.017 | |
| C8A | complement component 8, alpha polypeptide | 0.011 | |
| AADAC | arylacetamide deacetylase (esterase) | 0.010 |
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Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Cyp3a11 | cytochrome P450, family 3, subfamily a, polypeptide 11 | 0.999 | |
| Cyp2c29 | cytochrome P450, family 2, subfamily c, polypeptide 29 | 0.997 | |
| Cps1 | carbamoyl-phosphate synthetase 1 | 0.993 | |
| Otc | ornithine transcarbamylase | 0.990 | |
| Cyp2b9 | cytochrome P450, family 2, subfamily b, polypeptide 9 | 0.987 | |
| Cyp2c38 | cytochrome P450, family 2, subfamily c, polypeptide 38 | 0.982 | |
| Crp | C-reactive protein, pentraxin-related | 0.965 | |
| Cyp2a12 | cytochrome P450, family 2, subfamily a, polypeptide 12 | 0.954 | |
| Cyp4a14 | cytochrome P450, family 4, subfamily a, polypeptide 14 | 0.953 | |
| Ugt2b1 | UDP glucuronosyltransferase 2 family, polypeptide B1 | 0.952 | |
| Nr1i2 | nuclear receptor subfamily 1, group I, member 2 | 0.915 | |
| Cyp3a25 | cytochrome P450, family 3, subfamily a, polypeptide 25 | 0.887 | |
| Sult1d1 | sulfotransferase family 1D, member 1 | 0.875 | |
| Cyp2c50 | cytochrome P450, family 2, subfamily c, polypeptide 50 | 0.806 | |
| Cyp2c54 | cytochrome P450, family 2, subfamily c, polypeptide 54 | 0.793 | |
| Cyp2c39 | cytochrome P450, family 2, subfamily c, polypeptide 39 | 0.740 | |
| Slco1b2 | solute carrier organic anion transporter family, member 1b2 | 0.706 | |
| G6pc | glucose-6-phosphatase, catalytic | 0.693 | |
| Ces2a | carboxylesterase 2A | 0.624 | |
| Ugt2a3 | UDP glucuronosyltransferase 2 family, polypeptide A3 | 0.623 | |
| Cyp2c68 | cytochrome P450, family 2, subfamily c, polypeptide 68 | 0.612 | |
| Slc2a2 | solute carrier family 2 (facilitated glucose transporter), member 2 | 0.610 | |
| Cyp2g1 | cytochrome P450, family 2, subfamily g, polypeptide 1 | 0.582 | |
| Akr1d1 | aldo-keto reductase family 1, member D1 | 0.554 | |
| Cyp2b10 | cytochrome P450, family 2, subfamily b, polypeptide 10 | 0.552 | |
| Cml2 | camello-like 2 | 0.548 | |
| Bche | butyrylcholinesterase | 0.506 | |
| Cyp3a13 | cytochrome P450, family 3, subfamily a, polypeptide 13 | 0.501 | |
| Inmt | indolethylamine N-methyltransferase | 0.495 | |
| Ugt2b34 | UDP glucuronosyltransferase 2 family, polypeptide B34 | 0.480 | |
| Cyp2c55 | cytochrome P450, family 2, subfamily c, polypeptide 55 | 0.478 | |
| Hsd3b2 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 | 0.475 | |
| Gsta2 | glutathione S-transferase, alpha 2 (Yc2) | 0.465 | |
| Rdh7 | retinol dehydrogenase 7 | 0.458 | |
| Mbl2 | mannose-binding lectin (protein C) 2 | 0.433 | |
| Defb1 | defensin beta 1 | 0.414 | |
| Abcc2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 0.414 | |
| Pik3c2g | phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide | 0.407 | |
| Krtap6-1 | keratin associated protein 6-1 | 0.399 | |
| Cyp2e1 | cytochrome P450, family 2, subfamily e, polypeptide 1 | 0.392 | |
| Sult1b1 | sulfotransferase family 1B, member 1 | 0.384 | |
| Timd2 | T-cell immunoglobulin and mucin domain containing 2 | 0.380 | |
| Upp2 | uridine phosphorylase 2 | 0.374 | |
| Baat | bile acid-Coenzyme A: amino acid N-acyltransferase | 0.361 | |
| Cfhr1 | complement factor H-related 1 | 0.357 | |
| Adh7 | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide | 0.352 | |
| Hsd3b3 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 | 0.349 | |
| Pck1 | phosphoenolpyruvate carboxykinase 1, cytosolic | 0.335 | |
| Cyp7a1 | cytochrome P450, family 7, subfamily a, polypeptide 1 | 0.325 | |
| Hpd | 4-hydroxyphenylpyruvic acid dioxygenase | 0.317 | |
| Azgp1 | alpha-2-glycoprotein 1, zinc | 0.317 | |
| Nr5a2 | nuclear receptor subfamily 5, group A, member 2 | 0.305 | |
| Cyp3a44 | cytochrome P450, family 3, subfamily a, polypeptide 44 | 0.284 | |
| Slc22a1 | solute carrier family 22 (organic cation transporter), member 1 | 0.278 | |
| Hrg | histidine-rich glycoprotein | 0.266 | |
| Cyp2c37 | cytochrome P450, family 2. subfamily c, polypeptide 37 | 0.264 | |
| Gstm3 | glutathione S-transferase, mu 3 | 0.254 | |
| Ces1g | carboxylesterase 1G | 0.250 | |
| Cyp2d10 | cytochrome P450, family 2, subfamily d, polypeptide 10 | 0.250 | |
| Mup5 | major urinary protein 5 | 0.249 | |
| Fmo5 | flavin containing monooxygenase 5 | 0.246 | |
| Prlr | prolactin receptor | 0.239 | |
| Tdo2 | tryptophan 2,3-dioxygenase | 0.236 | |
| Cyp2d9 | cytochrome P450, family 2, subfamily d, polypeptide 9 | 0.223 | |
| Cyp4a31 | cytochrome P450, family 4, subfamily a, polypeptide 31 | 0.222 | |
| F9 | coagulation factor IX | 0.218 | |
| Cyp2b13 | cytochrome P450, family 2, subfamily b, polypeptide 13 | 0.218 | |
| Pigr | polymeric immunoglobulin receptor | 0.213 | |
| Sult2a2 | sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2 | 0.211 | |
| Lce1c | late cornified envelope 1C | 0.208 | |
| Keg1 | kidney expressed gene 1 | 0.204 | |
| Tmprss15 | transmembrane protease, serine 15 | 0.198 | |
| Fmo3 | flavin containing monooxygenase 3 | 0.198 | |
| Fmo4 | flavin containing monooxygenase 4 | 0.196 | |
| Cyp2c69 | cytochrome P450, family 2, subfamily c, polypeptide 69 | 0.194 | |
| Acot12 | acyl-CoA thioesterase 12 | 0.193 | |
| Fmo1 | flavin containing monooxygenase 1 | 0.191 | |
| Serpina1c | serine (or cysteine) peptidase inhibitor, clade A, member 1C | 0.185 | |
| Slc12a1 | solute carrier family 12, member 1 | 0.184 | |
| Slc10a1 | solute carrier family 10 (sodium/bile acid cotransporter family), member 1 | 0.182 | |
| Slc27a5 | solute carrier family 27 (fatty acid transporter), member 5 | 0.182 | |
| Aadac | arylacetamide deacetylase (esterase) | 0.176 | |
| D630002G06Rik | RIKEN cDNA D630002G06 gene | 0.176 | |
| Cfhr2 | complement factor H-related 2 | 0.168 | |
| Cyp4b1 | cytochrome P450, family 4, subfamily b, polypeptide 1 | 0.163 | |
| Ugt3a1 | UDP glycosyltransferases 3 family, polypeptide A1 | 0.155 | |
| Agmat | agmatine ureohydrolase (agmatinase) | 0.153 | |
| Cyp1a2 | cytochrome P450, family 1, subfamily a, polypeptide 2 | 0.149 | |
| Gsta3 | glutathione S-transferase, alpha 3 | 0.149 | |
| Adamdec1 | ADAM-like, decysin 1 | 0.149 | |
| Glyat | glycine-N-acyltransferase | 0.144 | |
| Adh1 | alcohol dehydrogenase 1 (class I) | 0.141 | |
| Akr1c6 | aldo-keto reductase family 1, member C6 | 0.141 | |
| Aldob | aldolase B, fructose-bisphosphate | 0.140 | |
| Speer4f | spermatogenesis associated glutamate (E)-rich protein 4f | 0.140 | |
| BC089597 | cDNA sequence BC089597 | 0.138 | |
| Ces2e | carboxylesterase 2E | 0.138 | |
| Cyp2d26 | cytochrome P450, family 2, subfamily d, polypeptide 26 | 0.133 | |
| Acox2 | acyl-Coenzyme A oxidase 2, branched chain | 0.131 | |
| Dpyd | dihydropyrimidine dehydrogenase | 0.131 |
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Rattus norvegicus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Cyp3a18 | cytochrome P450, family 3, subfamily a, polypeptide 18 | 0.958 | |
| LOC293989 | cytochrome P450-like | 0.957 | |
| Ugt2b | UDP glycosyltransferase 2 family, polypeptide B | 0.742 | |
| Sult1c3 | sulfotransferase family, cytosolic, 1C, member 3 | 0.585 | |
| Sult1b1 | sulfotransferase family, cytosolic, 1B, member 1 | 0.562 | |
| Abcb11 | ATP-binding cassette, subfamily B (MDR/TAP), member 11 | 0.558 | |
| Cyp2c13 | cytochrome P450, family 2, subfamily c, polypeptide 13 | 0.531 | |
| Cyp1a1 | cytochrome P450, family 1, subfamily a, polypeptide 1 | 0.479 | |
| Cyp2a2 | cytochrome P450, family 2, subfamily a, polypeptide 2 | 0.455 | |
| Akr1c18 | aldo-keto reductase family 1, member C18 | 0.441 | |
| Cyp3a2 | cytochrome P450, family 3, subfamily a, polypeptide 2 | 0.425 | |
| Ugt2b5 | UDP glucuronosyltransferase 2 family, polypeptide B5 | 0.409 | |
| Ugt2b1 | UDP glucuronosyltransferase 2 family, polypeptide B1 | 0.394 | |
| Sult1c2 | sulfotransferase family, cytosolic, 1C, member 2 | 0.332 | |
| Cyp2c11 | cytochrome P450, subfamily 2, polypeptide 11 | 0.330 | |
| Cyp2b1 | cytochrome P450, family 2, subfamily b, polypeptide 1 | 0.263 | |
| Cyp2a1 | cytochrome P450, family 2, subfamily a, polypeptide 1 | 0.246 | |
| Apob | apolipoprotein B | 0.245 | |
| Omd | osteomodulin | 0.241 | |
| Sult1e1 | sulfotransferase family 1E, estrogen-preferring, member 1 | 0.230 | |
| Sult2a1 | sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 | 0.228 | |
| Cyp3a23/3a1 | cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 | 0.163 | |
| Spink1 | serine peptidase inhibitor, Kazal type 1 | 0.133 | |
| Si | sucrase-isomaltase (alpha-glucosidase) | 0.132 | |
| Slco1a1 | solute carrier organic anion transporter family, member 1a1 | 0.123 | |
| Rup2 | urinary protein 2 | 0.117 | |
| Pfkfb1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 0.117 | |
| Cyp2d3 | cytochrome P450, family 2, subfamily d, polypeptide 3 | 0.108 | |
| Kl | Klotho | 0.106 | |
| Hsd3b5 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 | 0.103 | |
| Ugt2b37 | UDP-glucuronosyltransferase 2 family, member 37 | 0.103 | |
| Cyp2b3 | cytochrome P450, family 2, subfamily b, polypeptide 3 | 0.090 | |
| Clcn5 | chloride channel 5 | 0.084 | |
| LOC100361547 | Cytochrome P450, family 2, subfamily c, polypeptide 7-like | 0.079 | |
| Nmu | neuromedin U | 0.071 | |
| Ccl11 | chemokine (C-C motif) ligand 11 | 0.066 | |
| Cdcp1 | CUB domain containing protein 1 | 0.065 | |
| Cyp2d2 | cytochrome P450, family 2, subfamily d, polypeptide 2 | 0.062 | |
| Cyp2c12 | cytochrome P450, family 2, subfamily c, polypeptide 12 | 0.062 | |
| Cyp4a10 | cytochrome P450, family 4, subfamily a, polypeptide 10 | 0.061 | |
| LOC494499 | LOC494499 protein | 0.061 | |
| Ces1c | carboxylesterase 1C | 0.060 | |
| Cyp3a9 | cytochrome P450, family 3, subfamily a, polypeptide 9 | 0.059 | |
| Sult2al1 | sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring-like 1 | 0.056 | |
| Cyp2e1 | cytochrome P450, family 2, subfamily e, polypeptide 1 | 0.052 | |
| Selp | selectin P | 0.050 | |
| Ces1f | carboxylesterase 1F | 0.050 | |
| Nr0b2 | nuclear receptor subfamily 0, group B, member 2 | 0.049 | |
| Cyp2c22 | cytochrome P450, family 2, subfamily c, polypeptide 22 | 0.048 | |
| Il17f | interleukin 17F | 0.047 | |
| Kynu | kynureninase (L-kynurenine hydrolase) | 0.047 | |
| Cyp7a1 | cytochrome P450, family 7, subfamily a, polypeptide 1 | 0.046 | |
| Dpyd | dihydropyrimidine dehydrogenase | 0.045 | |
| Clca4 | chloride channel accessory 4 | 0.045 | |
| Tdo2 | tryptophan 2,3-dioxygenase | 0.044 | |
| Cyp2b21 | cytochrome P450, family 2, subfamily b, polypeptide 21 | 0.041 | |
| Slc9a3 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 | 0.040 | |
| Cyp2d4 | cytochrome P450, family 2, subfamily d, polypeptide 4 | 0.038 | |
| Fut1 | fucosyltransferase 1 | 0.034 | |
| Cyp4f4 | cytochrome P450, family 4, subfamily f, polypeptide 4 | 0.034 | |
| G6pc | glucose-6-phosphatase, catalytic subunit | 0.034 | |
| Hoxb8 | homeo box B8 | 0.033 | |
| Fut9 | fucosyltransferase 9 (alpha (1,3) fucosyltransferase) | 0.032 | |
| Ugt1a5 | UDP glucuronosyltransferase 1 family, polypeptide A5 | 0.032 | |
| Akp3 | alkaline phosphatase 3, intestine, not Mn requiring | 0.032 | |
| Slco1a4 | solute carrier organic anion transporter family, member 1a4 | 0.029 | |
| Tg | thyroglobulin | 0.029 | |
| Cyp2c23 | cytochrome P450, family 2, subfamily c, polypeptide 23 | 0.029 | |
| Hes2 | hairy and enhancer of split 2 (Drosophila) | 0.028 | |
| Slco1b3 | solute carrier organic anion transporter family, member 1b3 | 0.027 | |
| Fat2 | FAT tumor suppressor homolog 2 (Drosophila) | 0.027 | |
| Vcsa2 | variable coding sequence A2 | 0.027 | |
| Klrh1 | killer cell lectin-like receptor subfamily H, member 1 | 0.027 | |
| Cox6a2 | cytochrome c oxidase, subunit VIa, polypeptide 2 | 0.027 | |
| Slc2a4 | solute carrier family 2 (facilitated glucose transporter), member 4 | 0.026 | |
| Vom1r105 | vomeronasal 1 receptor 105 | 0.026 | |
| LOC299282 | Serine protease inhibitor | 0.026 | |
| Slc9a2 | solute carrier family 9 (sodium/hydrogen exchanger), member 2 | 0.026 | |
| Sycp1 | synaptonemal complex protein 1 | 0.025 | |
| Hsd3b1 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | 0.024 | |
| Adhfe1 | alcohol dehydrogenase, iron containing, 1 | 0.023 | |
| Olr416 | olfactory receptor 416 | 0.023 | |
| Cyp2b12 | cytochrome P450, family 2, subfamily b, polypeptide 12 | 0.023 | |
| Adh4 | alcohol dehydrogenase 4 (class II), pi polypeptide | 0.023 | |
| Olr59 | olfactory receptor 59 | 0.023 | |
| Obp1f | odorant binding protein I f | 0.022 | |
| Gfi1 | growth factor independent 1 transcription repressor | 0.022 | |
| Prl8a9 | prolactin family 8, subfamily a, member 9 | 0.021 | |
| Tas2r118 | taste receptor, type 2, member 118 | 0.021 | |
| Adh1 | alcohol dehydrogenase 1 (class I) | 0.021 | |
| Mc5r | melanocortin 5 receptor | 0.021 | |
| Svs3a | seminal vesicle secretory protein 3A | 0.021 | |
| Chrna9 | cholinergic receptor, nicotinic, alpha 9 | 0.021 | |
| Slc34a1 | solute carrier family 34 (sodium phosphate), member 1 | 0.020 | |
| Cyp1a2 | cytochrome P450, family 1, subfamily a, polypeptide 2 | 0.020 | |
| Pon1 | paraoxonase 1 | 0.020 | |
| Olr1082 | olfactory receptor 1082 | 0.020 | |
| Dmgdh | dimethylglycine dehydrogenase | 0.020 | |
| Mgst2 | microsomal glutathione S-transferase 2 | 0.020 | |
| Glp2r | glucagon-like peptide 2 receptor | 0.019 |