IMP
Process View
The network for '4 hydroxyproline metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
4 hydroxyproline metabolic process
The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls.
| Name | Description | Probability | Func Analog Organism |
|---|
Loading network...
Caenorhabditis elegans
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| hsp-3 | Protein HSP-3 | 0.035 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 1.000 | |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.981 | |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.970 | |
| ERO1L | ERO1-like (S. cerevisiae) | 0.799 | |
| CALR | calreticulin | 0.632 | |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | 0.585 | |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.513 | |
| EPAS1 | endothelial PAS domain protein 1 | 0.194 | |
| EGLN1 | egl nine homolog 1 (C. elegans) | 0.189 | |
| DUSP23 | dual specificity phosphatase 23 | 0.180 | |
| EGLN3 | egl nine homolog 3 (C. elegans) | 0.144 | |
| GANAB | glucosidase, alpha; neutral AB | 0.064 | |
| VHL | von Hippel-Lindau tumor suppressor | 0.057 | |
| PLOD1 | procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 | 0.035 | |
| HM13 | histocompatibility (minor) 13 | 0.031 | |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.024 | |
| ARNT | aryl hydrocarbon receptor nuclear translocator | 0.016 | |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.015 | |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.014 | |
| HIF1AN | hypoxia inducible factor 1, alpha subunit inhibitor | 0.012 | |
| ERO1LB | ERO1-like beta (S. cerevisiae) | 0.011 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Epas1 | endothelial PAS domain protein 1 | 0.948 | |
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.852 | |
| Vegfa | vascular endothelial growth factor A | 0.642 | |
| Surf4 | surfeit gene 4 | 0.558 | |
| P4ha1 | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide | 0.512 | |
| Sdhd | succinate dehydrogenase complex, subunit D, integral membrane protein | 0.471 | |
| Fam96a | family with sequence similarity 96, member A | 0.449 | |
| P4ha2 | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide | 0.202 | |
| Vhl | von Hippel-Lindau tumor suppressor | 0.189 | |
| Adam17 | a disintegrin and metallopeptidase domain 17 | 0.177 | |
| Atp5b | ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit | 0.176 | |
| Tmed10 | transmembrane emp24-like trafficking protein 10 (yeast) | 0.145 | |
| Pgk1 | phosphoglycerate kinase 1 | 0.136 | |
| Fh1 | fumarate hydratase 1 | 0.074 | |
| P4htm | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 0.068 | |
| Calr | calreticulin | 0.064 | |
| Rpn2 | ribophorin II | 0.060 | |
| Lama4 | laminin, alpha 4 | 0.058 | |
| Hsp90b1 | heat shock protein 90, beta (Grp94), member 1 | 0.057 | |
| Dbi | diazepam binding inhibitor | 0.055 | |
| Hbb-b1 | hemoglobin, beta adult major chain | 0.054 | |
| Serpinh1 | serine (or cysteine) peptidase inhibitor, clade H, member 1 | 0.050 | |
| Gm3150 | predicted gene 3150 | 0.050 | |
| Pkm2 | pyruvate kinase, muscle | 0.047 | |
| Hbb-b2 | hemoglobin, beta adult minor chain | 0.045 | |
| 1110008F13Rik | RIKEN cDNA 1110008F13 gene | 0.043 | |
| Sel1l | sel-1 suppressor of lin-12-like (C. elegans) | 0.042 | |
| Nphp4 | nephronophthisis 4 (juvenile) homolog (human) | 0.040 | |
| Ssr3 | signal sequence receptor, gamma | 0.038 | |
| Bhlhe40 | basic helix-loop-helix family, member e40 | 0.038 | |
| Hmgn1 | high mobility group nucleosomal binding domain 1 | 0.038 | |
| Kdelr2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | 0.037 | |
| Psma5 | proteasome (prosome, macropain) subunit, alpha type 5 | 0.029 | |
| Gapdh | glyceraldehyde-3-phosphate dehydrogenase | 0.027 | |
| Bag3 | BCL2-associated athanogene 3 | 0.025 | |
| Rps27a | ribosomal protein S27A | 0.025 | |
| Hspa5 | heat shock protein 5 | 0.024 | |
| Calu | calumenin | 0.024 | |
| Slc2a1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.024 | |
| Oaz1 | ornithine decarboxylase antizyme 1 | 0.023 | |
| Vkorc1 | vitamin K epoxide reductase complex, subunit 1 | 0.023 | |
| Tmed2 | transmembrane emp24 domain trafficking protein 2 | 0.023 | |
| Adh5 | alcohol dehydrogenase 5 (class III), chi polypeptide | 0.021 | |
| Rps12 | ribosomal protein S12 | 0.021 | |
| Egln1 | EGL nine homolog 1 (C. elegans) | 0.021 | |
| Shfm1 | split hand/foot malformation (ectrodactyly) type 1 | 0.020 | |
| Aldoa | aldolase A, fructose-bisphosphate | 0.020 | |
| Rps23 | ribosomal protein S23 | 0.019 | |
| Atp2a2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.018 | |
| Ppia | peptidylprolyl isomerase A | 0.018 | |
| Spp1 | secreted phosphoprotein 1 | 0.017 | |
| Gcsh | glycine cleavage system protein H (aminomethyl carrier) | 0.017 | |
| Txndc5 | thioredoxin domain containing 5 | 0.016 | |
| Esd | esterase D/formylglutathione hydrolase | 0.016 | |
| Kdelr3 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 | 0.016 | |
| Cycs | cytochrome c, somatic | 0.016 | |
| Pgam1 | phosphoglycerate mutase 1 | 0.015 | |
| Ldha | lactate dehydrogenase A | 0.015 | |
| Xbp1 | X-box binding protein 1 | 0.014 | |
| Egln3 | EGL nine homolog 3 (C. elegans) | 0.014 | |
| Pdha1 | pyruvate dehydrogenase E1 alpha 1 | 0.014 | |
| Mrpl13 | mitochondrial ribosomal protein L13 | 0.014 | |
| Tbca | tubulin cofactor A | 0.013 | |
| Atp5a1 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 | 0.013 | |
| Ero1l | ERO1-like (S. cerevisiae) | 0.013 | |
| Sar1b | SAR1 gene homolog B (S. cerevisiae) | 0.013 | |
| Sec24d | Sec24 related gene family, member D (S. cerevisiae) | 0.013 | |
| Cyb5 | cytochrome b-5 | 0.013 | |
| Nr3c1 | nuclear receptor subfamily 3, group C, member 1 | 0.012 | |
| Hint1 | histidine triad nucleotide binding protein 1 | 0.012 | |
| Ndufa4 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4 | 0.012 | |
| Lman1 | lectin, mannose-binding, 1 | 0.012 | |
| Lemd2 | LEM domain containing 2 | 0.012 | |
| LOC100503815 | 60S ribosomal protein L39-like | 0.012 | |
| Hspa1a | heat shock protein 1A | 0.012 | |
| Tmem14c | transmembrane protein 14C | 0.012 | |
| Ddit4 | DNA-damage-inducible transcript 4 | 0.012 | |
| Tmco1 | transmembrane and coiled-coil domains 1 | 0.011 | |
| Tfrc | transferrin receptor | 0.011 | |
| Cnpy2 | canopy 2 homolog (zebrafish) | 0.011 | |
| Pfkp | phosphofructokinase, platelet | 0.011 | |
| Pfkl | phosphofructokinase, liver, B-type | 0.011 | |
| Fam136a | family with sequence similarity 136, member A | 0.011 | |
| Map2k1 | mitogen-activated protein kinase kinase 1 | 0.010 | |
| Ndrg1 | N-myc downstream regulated gene 1 | 0.010 | |
| Mcfd2 | multiple coagulation factor deficiency 2 | 0.010 | |
| Hspb8 | heat shock protein 8 | 0.010 | |
| Ran | RAN, member RAS oncogene family | 0.010 |