IMP

Process View

Homo sapiens

2 genes annotated in human

disruption by host of symbiont cells

Any process in which an organism has a negative effect on the functioning of the symbiont's cells. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "disruption by host of symbiont cells"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "disruption by host of symbiont cells" (in gray)

Name	Description	Probability	Func Analog Organism
CXCL3	chemokine (C-X-C motif) ligand 3	1.000	Mouse
IL8	interleukin 8	1.000
CXCL2	chemokine (C-X-C motif) ligand 2	0.992	Mouse
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.971	Mouse
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.953
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.770
IL6	interleukin 6 (interferon, beta 2)	0.720
CCL20	chemokine (C-C motif) ligand 20	0.527
IL1B	interleukin 1, beta	0.379
NCF2	neutrophil cytosolic factor 2	0.225
CYBA	cytochrome b-245, alpha polypeptide	0.187
INADL	InaD-like (Drosophila)	0.112
NCF4	neutrophil cytosolic factor 4, 40kDa	0.099
IER3	immediate early response 3	0.092
SETD7	SET domain containing (lysine methyltransferase) 7	0.075
CXCL5	chemokine (C-X-C motif) ligand 5	0.072	Mouse
TRIM9	tripartite motif containing 9	0.066
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.061
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.059
PI3	peptidase inhibitor 3, skin-derived	0.056
SOD2	superoxide dismutase 2, mitochondrial	0.054
RNASE3	ribonuclease, RNase A family, 3	0.049
MMP10	matrix metallopeptidase 10 (stromelysin 2)	0.041
BPI	bactericidal/permeability-increasing protein	0.039
ELANE	elastase, neutrophil expressed	0.038	Mouse
DEFA4	defensin, alpha 4, corticostatin	0.038
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.038
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.037
AZU1	azurocidin 1	0.036
LCN2	lipocalin 2	0.032
MPO	myeloperoxidase	0.031
CCL7	chemokine (C-C motif) ligand 7	0.030
FPR1	formyl peptide receptor 1	0.030
PRKCB	protein kinase C, beta	0.029
PRKCD	protein kinase C, delta	0.028
PGLYRP1	peptidoglycan recognition protein 1	0.028
CDCP1	CUB domain containing protein 1	0.027
PASK	PAS domain containing serine/threonine kinase	0.027
CCL2	chemokine (C-C motif) ligand 2	0.026
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.026
PRTN3	proteinase 3	0.025
GPR97	G protein-coupled receptor 97	0.025
MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	0.025
CAMP	cathelicidin antimicrobial peptide	0.024
TFPI2	tissue factor pathway inhibitor 2	0.024
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.023
DPP4	dipeptidyl-peptidase 4	0.023
PROCR	protein C receptor, endothelial	0.022
CEACAM4	carcinoembryonic antigen-related cell adhesion molecule 4	0.021
MPZL2	myelin protein zero-like 2	0.021
CXCR2	chemokine (C-X-C motif) receptor 2	0.021
ORM1	orosomucoid 1	0.021
CAV2	caveolin 2	0.021
CSF3	colony stimulating factor 3 (granulocyte)	0.020
NFE2	nuclear factor (erythroid-derived 2), 45kDa	0.019
SELE	selectin E	0.019
S100A12	S100 calcium binding protein A12	0.018
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.018
PF4	platelet factor 4	0.017
LRP1	low density lipoprotein receptor-related protein 1	0.017
PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	0.016
EREG	epiregulin	0.016
PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	0.016
ACTG1	actin, gamma 1	0.016
CFL2	cofilin 2 (muscle)	0.016
LAMB3	laminin, beta 3	0.015
IL1R2	interleukin 1 receptor, type II	0.015
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.015
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.015
ZC3H12A	zinc finger CCCH-type containing 12A	0.014
FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)	0.014
PTX3	pentraxin 3, long	0.014
G0S2	G0/G1switch 2	0.013
TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	0.013
GFI1	growth factor independent 1 transcription repressor	0.013
HBD	hemoglobin, delta	0.013
INHBA	inhibin, beta A	0.013
VNN1	vanin 1	0.013
CMA1	chymase 1, mast cell	0.013
MASP2	mannan-binding lectin serine peptidase 2	0.013
IL1RAP	interleukin 1 receptor accessory protein	0.013
EPHA2	EPH receptor A2	0.013
IL18R1	interleukin 18 receptor 1	0.013
LTF	lactotransferrin	0.013
IL13RA2	interleukin 13 receptor, alpha 2	0.012
CEACAM8	carcinoembryonic antigen-related cell adhesion molecule 8	0.012
CEACAM6	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)	0.012
RETN	resistin	0.012
MYL4	myosin, light chain 4, alkali; atrial, embryonic	0.012
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.012
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.012
SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	0.012
FFAR2	free fatty acid receptor 2	0.011
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.011
LAMC2	laminin, gamma 2	0.011
F3	coagulation factor III (thromboplastin, tissue factor)	0.011
LTC4S	leukotriene C4 synthase	0.011
DEFA1B	defensin, alpha 1B	0.011
IL1RN	interleukin 1 receptor antagonist	0.011
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.011
GP5	glycoprotein V (platelet)	0.011
PLAUR	plasminogen activator, urokinase receptor	0.010
CH25H	cholesterol 25-hydroxylase	0.010
ALAS2	aminolevulinate, delta-, synthase 2	0.010
BMP2	bone morphogenetic protein 2	0.010