Homo sapiens

66 known processes

IDE

insulin-degrading enzyme

(Aliases: INSULYSIN,FLJ35968)

IDE biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of natural killer cell chemotaxis GO:2000502 1 0.987
regulation of c c chemokine binding GO:2001263 1 0.985
cd8 positive alpha beta t cell activation GO:0036037 3 0.957
positive regulation of cell cell adhesion mediated by integrin GO:0033634 3 0.946
negative regulation of t cell cytokine production GO:0002725 4 0.944
mature natural killer cell chemotaxis GO:0035782 1 0.924
granzyme a production GO:0035746 1 0.910
regulation of cd4 positive alpha beta t cell proliferation GO:2000561 2 0.903
response to nitric oxide GO:0071731 4 0.899
regulation of granzyme a production GO:2000511 1 0.893
positive regulation of cd8 positive alpha beta t cell proliferation GO:2000566 1 0.887
negative regulation of lymphocyte chemotaxis GO:1901624 2 0.876
granzyme b production GO:0071613 1 0.872
eosinophil mediated immunity GO:0002447 2 0.858
eosinophil degranulation GO:0043308 2 0.858
establishment of t cell polarity GO:0001768 2 0.858
nucleoside catabolic process GO:0009164 408 0.856
Rat
t helper 1 cell activation GO:0035711 1 0.855
negative regulation of lymphocyte migration GO:2000402 4 0.817
positive regulation of t cell apoptotic process GO:0070234 4 0.813
negative regulation of alpha beta t cell proliferation GO:0046642 1 0.812
regulation of sensory perception of pain GO:0051930 3 0.793
positive regulation of macrophage chemotaxis GO:0010759 3 0.789
positive regulation of granzyme b production GO:0071663 1 0.761
cd4 positive alpha beta t cell proliferation GO:0035739 2 0.760
negative regulation of t helper 1 cell activation GO:2000518 1 0.760
establishment of lymphocyte polarity GO:0001767 2 0.754
regulation of granzyme b production GO:0071661 1 0.708
positive regulation of cd8 positive alpha beta t cell activation GO:2001187 1 0.701
regulation of t helper 1 cell activation GO:2000517 1 0.699
eosinophil migration GO:0072677 10 0.689
negative regulation of cd4 positive alpha beta t cell proliferation GO:2000562 1 0.687
regulation of cd8 positive alpha beta t cell activation GO:2001185 2 0.669
eosinophil activation involved in immune response GO:0002278 2 0.662
negative regulation of c c chemokine binding GO:2001264 1 0.639
natural killer cell chemotaxis GO:0035747 6 0.639
regulation of sensory perception GO:0051931 3 0.628
nucleotide catabolic process GO:0009166 408 0.601
Rat
regulation of cellular amine metabolic process GO:0033238 11 0.601
eosinophil activation GO:0043307 3 0.589
ribonucleoside catabolic process GO:0042454 406 0.575
Rat
organophosphate catabolic process GO:0046434 430 0.568
Rat
regulation of cd8 positive alpha beta t cell proliferation GO:2000564 1 0.565
cellular amino acid metabolic process GO:0006520 116 0.547
cellular response to fibroblast growth factor stimulus GO:0044344 39 0.524
negative regulation of chemokine mediated signaling pathway GO:0070100 5 0.522
positive regulation of interleukin 1 beta secretion GO:0050718 11 0.504
purine nucleoside triphosphate catabolic process GO:0009146 392 0.493
Rat
nucleoside phosphate catabolic process GO:1901292 412 0.491
Rat
eosinophil chemotaxis GO:0048245 8 0.489
myeloid dendritic cell chemotaxis GO:0002408 3 0.483
protein localization to organelle GO:0033365 280 0.472
positive regulation of cytoplasmic transport GO:1903651 82 0.458
regulation of chemokine mediated signaling pathway GO:0070099 6 0.449
glial cell migration GO:0008347 4 0.443
intracellular protein transport GO:0006886 270 0.440
ribonucleoside triphosphate metabolic process GO:0009199 412 0.440
Rat
sensory perception of pain GO:0019233 4 0.431
astrocyte cell migration GO:0043615 1 0.431
positive regulation of granzyme a production GO:2000513 1 0.428
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.426
cd8 positive alpha beta t cell proliferation GO:0035740 1 0.424
ribonucleotide catabolic process GO:0009261 405 0.424
Rat
regulation of establishment of protein localization GO:0070201 242 0.410
regulation of cellular ketone metabolic process GO:0010565 50 0.394
cellular amine metabolic process GO:0044106 41 0.391
negative regulation of cd4 positive alpha beta t cell activation GO:2000515 1 0.382
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.368
glycosyl compound catabolic process GO:1901658 413 0.364
Rat
regulation of lymphocyte chemotaxis GO:1901623 12 0.363
purine containing compound catabolic process GO:0072523 411 0.361
Rat
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 22 0.353
positive regulation of natural killer cell chemotaxis GO:2000503 5 0.344
gtp metabolic process GO:0046039 239 0.344
amine metabolic process GO:0009308 44 0.333
purine ribonucleoside catabolic process GO:0046130 398 0.331
Rat
establishment of protein localization to organelle GO:0072594 172 0.331
negative regulation of t cell apoptotic process GO:0070233 4 0.320
regulation of natural killer cell chemotaxis GO:2000501 6 0.319
regulation of protein transport GO:0051223 213 0.312
activation of phospholipase d activity GO:0031584 3 0.311
nucleoside triphosphate metabolic process GO:0009141 422 0.305
Rat
response to oxidative stress GO:0006979 121 0.304
ion transmembrane transport GO:0034220 338 0.299
sequestering of calcium ion GO:0051208 17 0.292
regulation of nucleocytoplasmic transport GO:0046822 98 0.287
positive regulation of cellular amine metabolic process GO:0033240 7 0.287
nuclear transport GO:0051169 179 0.284
cellular ketone metabolic process GO:0042180 80 0.283
regulation of protein secretion GO:0050708 86 0.282
viral life cycle GO:0019058 132 0.274
regulation of cellular amino acid metabolic process GO:0006521 6 0.273
positive regulation of homotypic cell cell adhesion GO:0034112 4 0.271
t cell chemotaxis GO:0010818 10 0.264
purine ribonucleoside metabolic process GO:0046128 437 0.260
Rat
purine nucleoside triphosphate metabolic process GO:0009144 412 0.255
Rat
cytoplasmic transport GO:0016482 379 0.250
ribonucleoside triphosphate catabolic process GO:0009203 391 0.250
Rat
positive regulation of hydrolase activity GO:0051345 331 0.250
single organism cellular localization GO:1902580 332 0.245
innate immune response GO:0045087 178 0.243
Fly
protein oligomerization GO:0051259 173 0.243
interleukin 1 beta secretion GO:0050702 15 0.243
tumor necrosis factor superfamily cytokine production GO:0071706 45 0.240
negative regulation of cytokine production involved in immune response GO:0002719 13 0.237
muscle cell migration GO:0014812 19 0.228
positive regulation of tumor necrosis factor production GO:0032760 21 0.227
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 44 0.224
transmembrane transport GO:0055085 399 0.219
positive regulation of intracellular protein transport GO:0090316 76 0.219
regulation of interleukin 1 beta secretion GO:0050706 12 0.216
t cell activation GO:0042110 99 0.213
guanosine containing compound metabolic process GO:1901068 244 0.209
protein tetramerization GO:0051262 47 0.207
Rat
regulation of immune response GO:0050776 201 0.207
Fly
regulation of defense response GO:0031347 154 0.200
Fly
peptidyl tyrosine phosphorylation GO:0018108 170 0.199
protein import into nucleus GO:0006606 104 0.198
ras protein signal transduction GO:0007265 73 0.197
nitrogen compound transport GO:0071705 191 0.197
osteoblast differentiation GO:0001649 92 0.197
negative regulation of cytokine mediated signaling pathway GO:0001960 22 0.195
cellular divalent inorganic cation homeostasis GO:0072503 128 0.195
regulation of intracellular protein transport GO:0033157 123 0.191
regulation of viral genome replication GO:0045069 48 0.190
positive regulation of t cell proliferation GO:0042102 33 0.189
response to reactive oxygen species GO:0000302 61 0.187
secretion GO:0046903 254 0.185
positive regulation of nucleotide catabolic process GO:0030813 185 0.184
protein import GO:0017038 130 0.182
viral genome replication GO:0019079 50 0.182
regulation of protein targeting GO:1903533 91 0.179
positive regulation of cellular catabolic process GO:0031331 284 0.179
guanosine containing compound catabolic process GO:1901069 239 0.176
positive regulation of immune response GO:0050778 159 0.175
Fly
cellular response to growth factor stimulus GO:0071363 197 0.174
regulation of protein import into nucleus GO:0042306 78 0.174
positive regulation of lipase activity GO:0060193 28 0.173
positive regulation of defense response GO:0031349 87 0.172
Fly
cellular response to interleukin 1 GO:0071347 35 0.171
transforming growth factor beta production GO:0071604 14 0.171
positive regulation of interleukin 1 production GO:0032732 14 0.170
positive regulation of nucleoside metabolic process GO:0045979 186 0.169
regulation of secretion GO:0051046 194 0.165
regulation of protein localization to nucleus GO:1900180 85 0.164
protein targeting GO:0006605 187 0.163
rna interference GO:0016246 4 0.159
positive regulation of lymphocyte migration GO:2000403 16 0.158
negative regulation of immune system process GO:0002683 136 0.156
tumor necrosis factor production GO:0032640 43 0.155
positive regulation of catabolic process GO:0009896 310 0.152
nucleocytoplasmic transport GO:0006913 176 0.150
regulation of lymphocyte migration GO:2000401 22 0.146
protein targeting to nucleus GO:0044744 104 0.146
response to growth factor GO:0070848 205 0.145
lymphocyte proliferation GO:0046651 70 0.144
viral process GO:0016032 146 0.144
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 28 0.144
lipid metabolic process GO:0006629 381 0.143
response to fibroblast growth factor GO:0071774 39 0.142
rho protein signal transduction GO:0007266 26 0.141
regulation of multi organism process GO:0043900 157 0.140
Fly
positive regulation of stress activated mapk cascade GO:0032874 60 0.140
positive regulation of cell death GO:0010942 263 0.140
regulation of neutrophil migration GO:1902622 10 0.138
cell type specific apoptotic process GO:0097285 125 0.138
peptide hormone secretion GO:0030072 50 0.138
interspecies interaction between organisms GO:0044419 156 0.136
cellular lipid metabolic process GO:0044255 303 0.136
regulation of cytokine production GO:0001817 232 0.136
positive regulation of transport GO:0051050 336 0.136
positive regulation of protein import into nucleus GO:0042307 46 0.134
nucleoside triphosphate catabolic process GO:0009143 394 0.134
Rat
response to interferon gamma GO:0034341 39 0.133
regulation of nucleotide catabolic process GO:0030811 205 0.132
defense response GO:0006952 315 0.130
Fly
regulation of leukocyte differentiation GO:1902105 61 0.130
positive regulation of protein complex assembly GO:0031334 86 0.129
oxidation reduction process GO:0055114 396 0.129
positive regulation of cell activation GO:0050867 81 0.128
calcium ion import GO:0070509 23 0.128
positive regulation of protein localization to nucleus GO:1900182 48 0.127
regulation of tyrosine phosphorylation of stat protein GO:0042509 30 0.126
t cell cytokine production GO:0002369 12 0.126
regulation of nucleoside metabolic process GO:0009118 209 0.126
regulation of alpha beta t cell activation GO:0046634 13 0.125
cellular response to interferon gamma GO:0071346 24 0.124
negative regulation of binding GO:0051100 57 0.123
negative regulation of viral genome replication GO:0045071 35 0.123
phospholipid metabolic process GO:0006644 99 0.123
regulation of t cell activation GO:0050863 77 0.122
secretion by cell GO:0032940 226 0.122
positive regulation of cytokine production GO:0001819 167 0.121
lymphocyte mediated immunity GO:0002449 48 0.120
response to interleukin 1 GO:0070555 47 0.120
positive regulation of response to external stimulus GO:0032103 88 0.120
lymphocyte chemotaxis GO:0048247 17 0.118
myeloid cell differentiation GO:0030099 117 0.118
small gtpase mediated signal transduction GO:0007264 78 0.118
mitochondrion organization GO:0007005 156 0.118
regulation of tumor necrosis factor production GO:0032680 43 0.116
regulation of cytoplasmic transport GO:1903649 149 0.116
regulation of kinase activity GO:0043549 314 0.116
cellular response to tumor necrosis factor GO:0071356 63 0.116
regulation of gtp catabolic process GO:0033124 180 0.115
peptidyl tyrosine modification GO:0018212 170 0.115
negative regulation of leukocyte migration GO:0002686 14 0.115
protein localization to nucleus GO:0034504 136 0.114
positive regulation of protein transport GO:0051222 135 0.113
positive regulation of phospholipase activity GO:0010518 22 0.113
regulation of t cell chemotaxis GO:0010819 7 0.111
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.111
interleukin 1 beta production GO:0032611 22 0.109
muscle cell proliferation GO:0033002 35 0.108
regulation of lipid metabolic process GO:0019216 96 0.108
positive regulation of programmed cell death GO:0043068 249 0.108
positive regulation of phosphorylation GO:0042327 394 0.108
regulation of ras protein signal transduction GO:0046578 155 0.107
regulation of hormone levels GO:0010817 125 0.107
Rat
single organism nuclear import GO:1902593 104 0.104
cellular macromolecular complex assembly GO:0034622 324 0.104
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 35 0.103
Fly
bone mineralization GO:0030282 34 0.103
negative regulation of leukocyte chemotaxis GO:0002689 5 0.103
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.102
regulation of cell adhesion mediated by integrin GO:0033628 22 0.101
purine nucleoside catabolic process GO:0006152 398 0.101
Rat
leukocyte mediated immunity GO:0002443 59 0.099
cellular cation homeostasis GO:0030003 163 0.098
positive regulation of transcription factor import into nucleus GO:0042993 25 0.098
regulation of intracellular transport GO:0032386 195 0.098
macrophage chemotaxis GO:0048246 10 0.097
positive regulation of myeloid leukocyte differentiation GO:0002763 24 0.097
multi organism cellular process GO:0044764 156 0.097
negative regulation of immune response GO:0050777 40 0.096
positive regulation of t cell activation GO:0050870 54 0.096
negative regulation of cell motility GO:2000146 104 0.096
cellular response to endogenous stimulus GO:0071495 336 0.096
regulation of smooth muscle cell proliferation GO:0048660 28 0.095
positive regulation of intracellular transport GO:0032388 104 0.095
regulation of purine nucleotide catabolic process GO:0033121 205 0.095
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.094
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 28 0.094
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.094
cation homeostasis GO:0055080 189 0.094
positive regulation of lipid metabolic process GO:0045834 50 0.094
positive regulation of protein phosphorylation GO:0001934 313 0.094
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.092
response to wounding GO:0009611 168 0.092
positive regulation of ras gtpase activity GO:0032320 117 0.092
vesicle mediated transport GO:0016192 371 0.092
regulation of t cell cytokine production GO:0002724 10 0.091
regulation of transcription factor import into nucleus GO:0042990 39 0.091
negative regulation of programmed cell death GO:0043069 321 0.090
regulation of cell morphogenesis GO:0022604 153 0.090
cellular response to oxygen containing compound GO:1901701 276 0.090
positive regulation of apoptotic process GO:0043065 246 0.089
regulation of interleukin 1 secretion GO:0050704 14 0.088
cellular ion homeostasis GO:0006873 168 0.088
leukocyte apoptotic process GO:0071887 31 0.088
regulation of viral process GO:0050792 103 0.087
purine ribonucleotide catabolic process GO:0009154 404 0.087
Rat
regulation of gtpase activity GO:0043087 180 0.087
cation transport GO:0006812 331 0.086
positive regulation of organelle organization GO:0010638 195 0.086
positive regulation of leukocyte activation GO:0002696 80 0.086
positive regulation of alpha beta t cell activation GO:0046635 10 0.085
sequestering of metal ion GO:0051238 24 0.085
positive regulation of protein kinase b signaling GO:0051897 42 0.085
regulation of biomineral tissue development GO:0070167 31 0.085
cellular response to cytokine stimulus GO:0071345 181 0.085
regulation of interleukin 1 production GO:0032652 21 0.085
leukocyte cell cell adhesion GO:0007159 37 0.084
cytokine secretion GO:0050663 64 0.084
phosphatidylinositol mediated signaling GO:0048015 55 0.084
Fly
t cell migration GO:0072678 16 0.084
positive regulation of t cell migration GO:2000406 13 0.084
regulation of cytokine mediated signaling pathway GO:0001959 41 0.084
immune system development GO:0002520 195 0.084
positive regulation of cell cell adhesion GO:0022409 22 0.083
regulation of actin filament based process GO:0032970 141 0.083
regulation of lipid kinase activity GO:0043550 19 0.083
tyrosine phosphorylation of stat protein GO:0007260 33 0.083
i kappab kinase nf kappab signaling GO:0007249 166 0.083
regulation of t cell migration GO:2000404 14 0.083
regulation of leukocyte chemotaxis GO:0002688 46 0.082
mononuclear cell proliferation GO:0032943 71 0.082
dicarboxylic acid metabolic process GO:0043648 29 0.082
amide transport GO:0042886 76 0.082
modulation of transcription in other organism involved in symbiotic interaction GO:0052312 20 0.081
positive regulation of immune system process GO:0002684 283 0.081
Fly
negative regulation of interferon gamma production GO:0032689 9 0.081
negative regulation of protein metabolic process GO:0051248 391 0.081
Rat
cellular response to molecule of bacterial origin GO:0071219 62 0.080
osteoclast differentiation GO:0030316 21 0.080
positive regulation of secretion GO:0051047 116 0.080
protein secretion GO:0009306 98 0.080
metal ion homeostasis GO:0055065 169 0.079
negative regulation by host of viral transcription GO:0043922 12 0.079
positive regulation of t cell chemotaxis GO:0010820 7 0.079
regulation of response to external stimulus GO:0032101 222 0.079
regulation of leukocyte mediated cytotoxicity GO:0001910 19 0.079
nuclear import GO:0051170 106 0.078
response to virus GO:0009615 126 0.078
calcium ion transport GO:0006816 147 0.078
negative regulation of chemotaxis GO:0050922 13 0.077
peptide secretion GO:0002790 51 0.077
regulation of cytoskeleton organization GO:0051493 177 0.077
response to inorganic substance GO:0010035 127 0.077
interleukin 1 secretion GO:0050701 18 0.077
regulation of system process GO:0044057 101 0.076
regulation of ion transport GO:0043269 189 0.076
regulation of leukocyte activation GO:0002694 115 0.076
regulation of nucleotide metabolic process GO:0006140 269 0.076
negative regulation of myeloid cell differentiation GO:0045638 42 0.076
positive regulation of gtpase activity GO:0043547 166 0.075
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.075
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.075
positive regulation of cell proliferation GO:0008284 301 0.074
regulation of lymphocyte apoptotic process GO:0070228 15 0.074
positive regulation of ion transmembrane transport GO:0034767 40 0.074
negative regulation of response to external stimulus GO:0032102 83 0.074
negative regulation of lymphocyte mediated immunity GO:0002707 12 0.073
response to tumor necrosis factor GO:0034612 76 0.073
immune effector process GO:0002252 159 0.073
regulation of cell cell adhesion mediated by integrin GO:0033632 6 0.073
regulation of calcium ion import GO:0090279 11 0.073
divalent inorganic cation transport GO:0072511 158 0.072
lipopolysaccharide mediated signaling pathway GO:0031663 26 0.072
regulation of inflammatory response GO:0050727 46 0.072
positive regulation of protein tyrosine kinase activity GO:0061098 24 0.072
positive regulation of nucleotide metabolic process GO:0045981 230 0.071
positive regulation of granulocyte chemotaxis GO:0071624 9 0.071
regulation of response to wounding GO:1903034 101 0.071
positive regulation of leukocyte differentiation GO:1902107 37 0.071
cellular calcium ion homeostasis GO:0006874 117 0.070
regulation of protein localization GO:0032880 296 0.070
regulation of lymphocyte activation GO:0051249 103 0.069
cellular response to biotic stimulus GO:0071216 71 0.069
negative regulation of t cell mediated immunity GO:0002710 5 0.069
negative regulation of cell differentiation GO:0045596 171 0.068
negative regulation of glial cell apoptotic process GO:0034351 6 0.068
chemokine mediated signaling pathway GO:0070098 16 0.068
response to oxygen containing compound GO:1901700 369 0.068
negative regulation of viral process GO:0048525 66 0.068
cytokine production GO:0001816 247 0.068
positive regulation of cellular component organization GO:0051130 376 0.068
regulation of small gtpase mediated signal transduction GO:0051056 156 0.068
positive regulation of osteoclast differentiation GO:0045672 9 0.068
regulation of transferase activity GO:0051338 355 0.068
positive regulation of cell adhesion mediated by integrin GO:0033630 9 0.067
positive regulation of gtp catabolic process GO:0033126 166 0.067
regulation of ion homeostasis GO:2000021 73 0.067
response to fatty acid GO:0070542 13 0.067
divalent inorganic cation homeostasis GO:0072507 136 0.066
positive regulation of lymphocyte activation GO:0051251 73 0.066
positive regulation of developmental process GO:0051094 314 0.066
regulation of binding GO:0051098 111 0.065
regulation of immune effector process GO:0002697 91 0.065
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.065
cellular response to organic cyclic compound GO:0071407 127 0.064
positive regulation of alpha beta t cell proliferation GO:0046641 5 0.064
cytokine production involved in immune response GO:0002367 27 0.064
positive regulation of interleukin 1 beta production GO:0032731 13 0.064
regulation of neuron apoptotic process GO:0043523 35 0.063
regulation of behavior GO:0050795 82 0.063
Fly
immune response GO:0006955 307 0.062
Fly
regulation of interleukin 2 production GO:0032663 19 0.062
regulation of t cell proliferation GO:0042129 42 0.062
regulation of ion transmembrane transport GO:0034765 132 0.061
regulation of protein kinase activity GO:0045859 289 0.061
regulation of leukocyte mediated immunity GO:0002703 38 0.061
positive regulation of secretion by cell GO:1903532 108 0.061
cellular macromolecule catabolic process GO:0044265 380 0.061
regulation of myeloid cell differentiation GO:0045637 81 0.060
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.060
Rat
regulation of cytokine production involved in immune response GO:0002718 22 0.060
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.060
cellular homeostasis GO:0019725 196 0.060
single organismal cell cell adhesion GO:0016337 148 0.060
purine nucleoside monophosphate metabolic process GO:0009126 186 0.060
Rat
ion homeostasis GO:0050801 230 0.059
regulation of cell differentiation GO:0045595 393 0.059
positive regulation of calcium ion transport into cytosol GO:0010524 20 0.059
posttranscriptional regulation of gene expression GO:0010608 213 0.059
regulation of calcium ion transport GO:0051924 79 0.059
biological adhesion GO:0022610 331 0.059
cell activation GO:0001775 213 0.058
posttranscriptional gene silencing by rna GO:0035194 25 0.058
regulation of insulin secretion GO:0050796 33 0.058
response to lipid GO:0033993 206 0.058
regulation of lymphocyte mediated immunity GO:0002706 33 0.058
cytokine mediated signaling pathway GO:0019221 109 0.058
regulation of purine nucleotide metabolic process GO:1900542 264 0.058
t cell proliferation GO:0042098 45 0.058
positive regulation of jak stat cascade GO:0046427 35 0.058
regulation of peptide secretion GO:0002791 42 0.058
regulation of lipase activity GO:0060191 37 0.058
positive regulation of endothelial cell proliferation GO:0001938 37 0.058
negative regulation of response to cytokine stimulus GO:0060761 25 0.057
cellular chemical homeostasis GO:0055082 180 0.057
cellular metal ion homeostasis GO:0006875 146 0.057
negative regulation of production of molecular mediator of immune response GO:0002701 13 0.057
positive regulation of smooth muscle cell migration GO:0014911 6 0.057
positive regulation of cell adhesion GO:0045785 84 0.057
positive regulation of cytokine secretion GO:0050715 42 0.057
cellular protein complex assembly GO:0043623 188 0.057
modification by host of symbiont morphology or physiology GO:0051851 26 0.057
t cell apoptotic process GO:0070231 12 0.057
negative regulation of myeloid leukocyte differentiation GO:0002762 16 0.056
regulation of cell adhesion GO:0030155 166 0.056
positive regulation of cellular component biogenesis GO:0044089 158 0.056
negative regulation of neuron apoptotic process GO:0043524 23 0.056
positive regulation of adaptive immune response GO:0002821 21 0.055
negative regulation of locomotion GO:0040013 118 0.055
endoplasmic reticulum to cytosol transport GO:1903513 13 0.055
regulation of leukocyte apoptotic process GO:2000106 25 0.055
alpha beta t cell proliferation GO:0046633 5 0.055
regulation of anatomical structure morphogenesis GO:0022603 286 0.055
regulation of calcium ion transport into cytosol GO:0010522 33 0.055
calcium ion homeostasis GO:0055074 122 0.055
regulation of mononuclear cell proliferation GO:0032944 65 0.054
interleukin 1 production GO:0032612 26 0.054
leukocyte activation involved in immune response GO:0002366 30 0.054
regulation of lymphocyte proliferation GO:0050670 64 0.054
actin filament based process GO:0030029 224 0.053
regulation of cellular component movement GO:0051270 334 0.053
lymphocyte migration GO:0072676 28 0.053
leukocyte activation GO:0045321 164 0.053
erk1 and erk2 cascade GO:0070371 104 0.053
negative regulation of cell migration GO:0030336 102 0.053
hematopoietic or lymphoid organ development GO:0048534 186 0.053
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.053
regulation of leukocyte proliferation GO:0070663 67 0.053
negative regulation of t cell proliferation GO:0042130 8 0.053
stress activated protein kinase signaling cascade GO:0031098 94 0.053
regulation of ras gtpase activity GO:0032318 128 0.052
regulation of transmembrane transport GO:0034762 139 0.052
response to biotic stimulus GO:0009607 276 0.052
Fly
leukocyte migration GO:0050900 107 0.052
negative regulation of behavior GO:0048521 15 0.052
sensory perception GO:0007600 103 0.052
interleukin 2 production GO:0032623 20 0.051
regulation of chemotaxis GO:0050920 74 0.051
protein complex localization GO:0031503 31 0.051
response to drug GO:0042493 81 0.051
protein kinase b signaling GO:0043491 69 0.051
hemopoiesis GO:0030097 180 0.050
positive regulation of protein kinase activity GO:0045860 190 0.050
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.049
Rat
regulation of endopeptidase activity GO:0052548 170 0.049
lymphocyte activation GO:0046649 133 0.049
g protein coupled receptor signaling pathway GO:0007186 207 0.048
maintenance of location GO:0051235 112 0.048
negative regulation of cellular component movement GO:0051271 106 0.048
modification of morphology or physiology of other organism GO:0035821 43 0.048
sarcoplasmic reticulum calcium ion transport GO:0070296 13 0.048
granulocyte migration GO:0097530 40 0.047
negative regulation of cellular protein metabolic process GO:0032269 353 0.047
Rat
positive regulation of ion transport GO:0043270 87 0.047
negative regulation of bone mineralization GO:0030502 7 0.047
positive regulation of production of molecular mediator of immune response GO:0002702 11 0.047
adaptive immune response GO:0002250 49 0.046
positive regulation of leukocyte mediated immunity GO:0002705 24 0.046
response to lipopolysaccharide GO:0032496 70 0.046
regulation of leukocyte migration GO:0002685 63 0.046
negative regulation of multi organism process GO:0043901 92 0.046
signal transduction by phosphorylation GO:0023014 297 0.046
regulation of g protein coupled receptor protein signaling pathway GO:0008277 35 0.046
cell morphogenesis GO:0000902 296 0.046
negative regulation of apoptotic process GO:0043066 316 0.046
positive regulation of transmembrane transport GO:0034764 41 0.046
jak stat cascade GO:0007259 46 0.046
negative regulation of developmental process GO:0051093 247 0.046
divalent metal ion transport GO:0070838 152 0.045
mitochondrial transport GO:0006839 60 0.044
lymphocyte apoptotic process GO:0070227 20 0.044
establishment of cell polarity GO:0030010 22 0.044
positive regulation of response to wounding GO:1903036 28 0.044
regulation of peptidase activity GO:0052547 180 0.044
response to other organism GO:0051707 261 0.044
Fly
regulation of proteolysis GO:0030162 293 0.044
Rat
smooth muscle cell proliferation GO:0048659 28 0.043
positive regulation of jnk cascade GO:0046330 52 0.043
regulation of metal ion transport GO:0010959 120 0.043
negative regulation of cytokine production GO:0001818 82 0.043
negative regulation of cell death GO:0060548 345 0.043
positive regulation of smooth muscle cell proliferation GO:0048661 14 0.043
ossification GO:0001503 121 0.042
regulation of cellular component biogenesis GO:0044087 281 0.042
response to cytokine GO:0034097 232 0.042
regulation of response to cytokine stimulus GO:0060759 46 0.042

IDE disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.059
amino acid metabolic disorder DOID:9252 50 0.059
inherited metabolic disorder DOID:655 242 0.059