Homo sapiens

0 known processes

HADHA

hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit

(Aliases: ECHA,LCHAD,HADH,MGC1728,GBP,TP-ALPHA,LCEH,MTPA)

HADHA biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oxidation reduction process GO:0055114 396 0.951
Mouse Fly
carboxylic acid catabolic process GO:0046395 71 0.915
Mouse Fly
lipid oxidation GO:0034440 33 0.838
Mouse Fly
fatty acid metabolic process GO:0006631 115 0.832
Mouse Fly
organic acid catabolic process GO:0016054 71 0.706
Mouse Fly
determination of adult lifespan GO:0008340 2 0.690
Fly
multicellular organismal aging GO:0010259 3 0.669
Fly
monocarboxylic acid catabolic process GO:0072329 37 0.626
Mouse Fly
cellular lipid metabolic process GO:0044255 303 0.617
Mouse Fly
lipid catabolic process GO:0016042 84 0.506
Mouse Fly
rab protein signal transduction GO:0032482 4 0.401
small molecule catabolic process GO:0044282 92 0.381
Mouse Fly
cellular lipid catabolic process GO:0044242 65 0.377
Mouse Fly
fatty acid oxidation GO:0019395 31 0.350
Mouse Fly
nucleoside monophosphate metabolic process GO:0009123 191 0.346
lipid metabolic process GO:0006629 381 0.338
Mouse Fly
monocarboxylic acid metabolic process GO:0032787 185 0.329
Mouse Fly
energy derivation by oxidation of organic compounds GO:0015980 43 0.322
ribonucleoside monophosphate metabolic process GO:0009161 187 0.315
purine nucleoside triphosphate metabolic process GO:0009144 412 0.302
purine nucleoside monophosphate metabolic process GO:0009126 186 0.296
mitochondrion organization GO:0007005 156 0.285
tricarboxylic acid metabolic process GO:0072350 4 0.279
post embryonic development GO:0009791 2 0.241
Worm
lipid modification GO:0030258 84 0.232
Mouse Fly
aerobic respiration GO:0009060 7 0.228
fatty acid catabolic process GO:0009062 29 0.204
Mouse Fly
cellular respiration GO:0045333 21 0.190
protein oligomerization GO:0051259 173 0.187
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.181
nucleoside triphosphate metabolic process GO:0009141 422 0.181
purine ribonucleoside metabolic process GO:0046128 437 0.180
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.150
aging GO:0007568 66 0.134
Fly
atp metabolic process GO:0046034 176 0.115
generation of precursor metabolites and energy GO:0006091 68 0.113
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.106
ribonucleoside triphosphate metabolic process GO:0009199 412 0.097
membrane organization GO:0061024 292 0.089
ribose phosphate biosynthetic process GO:0046390 82 0.080
cellular amino acid metabolic process GO:0006520 116 0.079
purine containing compound catabolic process GO:0072523 411 0.079
purine ribonucleotide biosynthetic process GO:0009152 79 0.076
protein homooligomerization GO:0051260 100 0.075
negative regulation of cell death GO:0060548 345 0.074
locomotory behavior GO:0007626 1 0.073
system process GO:0003008 349 0.072
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.070
regulation of purine nucleotide catabolic process GO:0033121 205 0.068
regulation of purine nucleotide metabolic process GO:1900542 264 0.068
nadh dehydrogenase complex assembly GO:0010257 16 0.068
vesicle mediated transport GO:0016192 371 0.066
Worm
cellular cation homeostasis GO:0030003 163 0.066
organonitrogen compound biosynthetic process GO:1901566 200 0.065
cellular ketone metabolic process GO:0042180 80 0.065
nucleoside phosphate catabolic process GO:1901292 412 0.065
regulation of atpase activity GO:0043462 25 0.064
organophosphate catabolic process GO:0046434 430 0.064
fatty acid beta oxidation GO:0006635 22 0.062
Mouse Fly
cation transmembrane transport GO:0098655 238 0.061
tricarboxylic acid cycle GO:0006099 4 0.060
regulation of cellular ketone metabolic process GO:0010565 50 0.058
dicarboxylic acid biosynthetic process GO:0043650 4 0.057
purine nucleoside monophosphate catabolic process GO:0009128 158 0.056
regulation of cellular amino acid metabolic process GO:0006521 6 0.055
carbohydrate derivative biosynthetic process GO:1901137 207 0.055
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.054
response to external biotic stimulus GO:0043207 261 0.054
Zebrafish
transmembrane transport GO:0055085 399 0.054
nucleoside catabolic process GO:0009164 408 0.053
nitrogen compound transport GO:0071705 191 0.053
negative regulation of transport GO:0051051 176 0.053
female gamete generation GO:0007292 2 0.053
purine ribonucleoside biosynthetic process GO:0046129 23 0.050
organic hydroxy compound metabolic process GO:1901615 147 0.049
ribonucleoside triphosphate catabolic process GO:0009203 391 0.049
regulation of nucleotide catabolic process GO:0030811 205 0.049
purine nucleotide catabolic process GO:0006195 405 0.048
cellular protein complex assembly GO:0043623 188 0.048
guanosine containing compound metabolic process GO:1901068 244 0.048
anion transport GO:0006820 161 0.048
embryo development GO:0009790 123 0.047
Worm
positive regulation of developmental process GO:0051094 314 0.047
negative regulation of apoptotic process GO:0043066 316 0.047
cellular amine metabolic process GO:0044106 41 0.046
purine nucleoside triphosphate catabolic process GO:0009146 392 0.046
cellular ion homeostasis GO:0006873 168 0.042
cellular homeostasis GO:0019725 196 0.042
ion homeostasis GO:0050801 230 0.041
amine metabolic process GO:0009308 44 0.041
purine ribonucleotide catabolic process GO:0009154 404 0.040
ras protein signal transduction GO:0007265 73 0.040
regulation of nucleotide metabolic process GO:0006140 269 0.040
protein processing GO:0016485 226 0.039
ossification GO:0001503 121 0.038
epithelium development GO:0060429 227 0.038
single organism membrane organization GO:0044802 268 0.038
nucleoside triphosphate catabolic process GO:0009143 394 0.037
cell development GO:0048468 328 0.037
positive regulation of apoptotic process GO:0043065 246 0.036
oogenesis GO:0048477 2 0.036
nucleotide catabolic process GO:0009166 408 0.036
growth GO:0040007 202 0.035
regulation of cellular amine metabolic process GO:0033238 11 0.035
secretion by cell GO:0032940 226 0.035
cellular chemical homeostasis GO:0055082 180 0.035
positive regulation of programmed cell death GO:0043068 249 0.035
response to abiotic stimulus GO:0009628 336 0.034
regulation of secretion GO:0051046 194 0.034
cation homeostasis GO:0055080 189 0.034
negative regulation of catalytic activity GO:0043086 335 0.034
protein maturation GO:0051604 233 0.033
ribonucleoside catabolic process GO:0042454 406 0.033
immune response GO:0006955 307 0.033
endosomal transport GO:0016197 129 0.033
dicarboxylic acid metabolic process GO:0043648 29 0.032
citrate metabolic process GO:0006101 2 0.032
organophosphate biosynthetic process GO:0090407 163 0.032
cellular component morphogenesis GO:0032989 314 0.032
protein tetramerization GO:0051262 47 0.032
regulation of nucleoside metabolic process GO:0009118 209 0.032
intracellular protein transport GO:0006886 270 0.031
ribonucleotide catabolic process GO:0009261 405 0.031
single organism membrane fusion GO:0044801 37 0.031
regulation of mitochondrion organization GO:0010821 54 0.031
ribonucleoside monophosphate catabolic process GO:0009158 158 0.031
positive regulation of catabolic process GO:0009896 310 0.030
epithelial cell differentiation GO:0030855 141 0.030
coenzyme metabolic process GO:0006732 65 0.030
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.030
negative regulation of protein metabolic process GO:0051248 391 0.030
inorganic anion transmembrane transport GO:0098661 47 0.030
cellular response to oxidative stress GO:0034599 85 0.030
regulation of atp catabolic process GO:1903289 25 0.029
nucleoside phosphate biosynthetic process GO:1901293 109 0.029
response to oxygen containing compound GO:1901700 369 0.029
Mouse
apoptotic signaling pathway GO:0097190 268 0.029
protein localization to organelle GO:0033365 280 0.029
purine ribonucleoside catabolic process GO:0046130 398 0.029
neuroblast proliferation GO:0007405 4 0.029
carboxylic acid biosynthetic process GO:0046394 97 0.028
regulation of atp metabolic process GO:1903578 29 0.028
ion transmembrane transport GO:0034220 338 0.028
positive regulation of cell differentiation GO:0045597 211 0.028
cytoplasmic transport GO:0016482 379 0.027
primary alcohol metabolic process GO:0034308 17 0.027
excretion GO:0007588 9 0.027
hemoglobin metabolic process GO:0020027 3 0.027
response to inorganic substance GO:0010035 127 0.027
regulation of oxidoreductase activity GO:0051341 43 0.026
regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902108 18 0.026
nucleotide biosynthetic process GO:0009165 109 0.026
negative regulation of cell proliferation GO:0008285 228 0.025
inorganic ion transmembrane transport GO:0098660 231 0.025
mitochondrial transport GO:0006839 60 0.025
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.025
cellular amino acid catabolic process GO:0009063 31 0.025
regulation of rab gtpase activity GO:0032313 39 0.025
negative regulation of cellular component organization GO:0051129 235 0.024
mitochondrial respiratory chain complex i biogenesis GO:0097031 16 0.024
purine nucleotide biosynthetic process GO:0006164 84 0.024
regulation of neural precursor cell proliferation GO:2000177 4 0.024
negative regulation of atpase activity GO:0032780 5 0.024
nucleoside triphosphate biosynthetic process GO:0009142 20 0.023
purine containing compound biosynthetic process GO:0072522 88 0.023
establishment of protein localization to organelle GO:0072594 172 0.023
positive regulation of nucleotide metabolic process GO:0045981 230 0.023
response to metal ion GO:0010038 84 0.023
reactive oxygen species metabolic process GO:0072593 75 0.022
purine nucleoside catabolic process GO:0006152 398 0.022
negative regulation of oxidoreductase activity GO:0051354 17 0.022
defense response to other organism GO:0098542 129 0.022
response to decreased oxygen levels GO:0036293 96 0.022
secretion GO:0046903 254 0.022
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.022
mitochondrial membrane organization GO:0007006 40 0.022
protein localization to membrane GO:0072657 160 0.021
alcohol metabolic process GO:0006066 114 0.021
cellular amide metabolic process GO:0043603 69 0.021
mating GO:0007618 1 0.021
peptide transport GO:0015833 74 0.021
receptor mediated endocytosis GO:0006898 84 0.021
Worm
organic acid biosynthetic process GO:0016053 97 0.021
cell morphogenesis GO:0000902 296 0.021
negative regulation of apoptotic signaling pathway GO:2001234 97 0.021
inorganic anion transport GO:0015698 60 0.020
negative regulation of programmed cell death GO:0043069 321 0.020
establishment of protein localization to membrane GO:0090150 121 0.020
acylglycerol metabolic process GO:0006639 27 0.020
cellular macromolecular complex assembly GO:0034622 324 0.019
response to drug GO:0042493 81 0.019
ribonucleotide biosynthetic process GO:0009260 81 0.019
response to peptide GO:1901652 65 0.019
Mouse
positive regulation of nucleotide catabolic process GO:0030813 185 0.019
regulation of rab protein signal transduction GO:0032483 39 0.018
protein targeting to membrane GO:0006612 42 0.018
negative regulation of secretion by cell GO:1903531 52 0.018
regulation of cell differentiation GO:0045595 393 0.018
cellular response to oxygen containing compound GO:1901701 276 0.018
negative regulation of multicellular organismal process GO:0051241 317 0.018
positive regulation of hydrolase activity GO:0051345 331 0.018
positive regulation of cellular amine metabolic process GO:0033240 7 0.017
positive regulation of secretion by cell GO:1903532 108 0.017
nervous system development GO:0007399 293 0.017
regulation of mitochondrial membrane permeability GO:0046902 25 0.017
negative regulation of cellular catabolic process GO:0031330 83 0.017
isoprenoid metabolic process GO:0006720 39 0.017
neuromuscular junction development GO:0007528 3 0.017
negative regulation of protein processing GO:0010955 142 0.017
neuron projection development GO:0031175 106 0.017
translation GO:0006412 132 0.017
golgi vesicle transport GO:0048193 80 0.017
negative regulation of transferase activity GO:0051348 124 0.016
generation of neurons GO:0048699 152 0.016
cation transport GO:0006812 331 0.016
tube development GO:0035295 125 0.016
response to oxidative stress GO:0006979 121 0.016
phosphate ion transmembrane transport GO:0035435 4 0.016
organelle assembly GO:0070925 176 0.016
mitochondrial respiratory chain complex i assembly GO:0032981 16 0.016
cellular response to reactive oxygen species GO:0034614 50 0.016
endocytosis GO:0006897 159 0.016
Worm
autophagy GO:0006914 88 0.016
negative regulation of nucleotide catabolic process GO:0030812 16 0.016
mitochondrial atp synthesis coupled electron transport GO:0042775 4 0.016
cell part morphogenesis GO:0032990 137 0.016
positive regulation of transport GO:0051050 336 0.016
cellular metal ion homeostasis GO:0006875 146 0.016
cell morphogenesis involved in differentiation GO:0000904 144 0.015
regeneration GO:0031099 4 0.015
positive regulation of rab gtpase activity GO:0032851 39 0.015
regulation of proteolysis GO:0030162 293 0.015
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.015
actin mediated cell contraction GO:0070252 12 0.015
positive regulation of ras gtpase activity GO:0032320 117 0.015
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.015
regulation of growth GO:0040008 165 0.015
regulation of transferase activity GO:0051338 355 0.015
reproductive process GO:0022414 106 0.015
metal ion homeostasis GO:0055065 169 0.015
regulation of membrane permeability GO:0090559 25 0.015
negative regulation of cellular amine metabolic process GO:0033239 3 0.014
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.014
positive regulation of cell death GO:0010942 263 0.014
organic anion transport GO:0015711 103 0.014
chemical homeostasis GO:0048878 306 0.014
negative regulation of hydrolase activity GO:0051346 182 0.014
small molecule biosynthetic process GO:0044283 157 0.014
single organism cellular localization GO:1902580 332 0.014
nadh metabolic process GO:0006734 1 0.014
defense response to bacterium GO:0042742 63 0.014
endomembrane system organization GO:0010256 196 0.014
icosanoid metabolic process GO:0006690 35 0.014
regulation of gtpase activity GO:0043087 180 0.014
negative regulation of phosphorus metabolic process GO:0010563 267 0.014
anatomical structure formation involved in morphogenesis GO:0048646 284 0.014
regulation of apoptotic signaling pathway GO:2001233 175 0.014
regulation of protein maturation GO:1903317 150 0.014
regulation of cellular response to stress GO:0080135 244 0.014
positive regulation of mitochondrial membrane permeability GO:0035794 17 0.014
positive regulation of gtpase activity GO:0043547 166 0.014
regulation of secretion by cell GO:1903530 177 0.014
negative regulation of proteolysis GO:0045861 132 0.014
regulation of anatomical structure morphogenesis GO:0022603 286 0.014
apoptotic mitochondrial changes GO:0008637 57 0.014
nucleoside monophosphate catabolic process GO:0009125 159 0.014
negative regulation of intracellular transport GO:0032387 60 0.014
negative regulation of stem cell proliferation GO:2000647 3 0.014
peripheral nervous system development GO:0007422 2 0.014
response to nitrogen compound GO:1901698 184 0.014
Mouse
purine nucleoside monophosphate biosynthetic process GO:0009127 16 0.014
glycosyl compound catabolic process GO:1901658 413 0.014
reproductive structure development GO:0048608 55 0.013
regulation of necrotic cell death GO:0010939 9 0.013
single organism reproductive process GO:0044702 98 0.013
regulation of intracellular transport GO:0032386 195 0.013
cytokine production GO:0001816 247 0.013
regulation of peptidase activity GO:0052547 180 0.013
tissue morphogenesis GO:0048729 96 0.013
glycosyl compound biosynthetic process GO:1901659 27 0.013
atp catabolic process GO:0006200 157 0.013
regulation of endopeptidase activity GO:0052548 170 0.013
regulation of ras gtpase activity GO:0032318 128 0.013
spermatid differentiation GO:0048515 4 0.013
cellular response to oxygen levels GO:0071453 55 0.013
protein catabolic process GO:0030163 325 0.013
cellular response to endogenous stimulus GO:0071495 336 0.013
positive regulation of cellular catabolic process GO:0031331 284 0.013
guanosine containing compound catabolic process GO:1901069 239 0.013
memory GO:0007613 3 0.013
atp synthesis coupled electron transport GO:0042773 4 0.013
cofactor metabolic process GO:0051186 87 0.013
response to salt stress GO:0009651 3 0.013
defense response GO:0006952 315 0.013
lung epithelial cell differentiation GO:0060487 1 0.012
protein modification by small protein conjugation GO:0032446 342 0.012
terpenoid metabolic process GO:0006721 27 0.012
monovalent inorganic cation transport GO:0015672 128 0.012
leukotriene metabolic process GO:0006691 10 0.012
regulation of hormone levels GO:0010817 125 0.012
cell projection morphogenesis GO:0048858 129 0.012
morphogenesis of embryonic epithelium GO:0016331 4 0.012
protein ubiquitination GO:0016567 314 0.012
response to hypoxia GO:0001666 96 0.012
positive regulation of nucleoside metabolic process GO:0045979 186 0.012
response to cytokine GO:0034097 232 0.012
negative regulation of protein maturation GO:1903318 142 0.012
regulation of neuroblast proliferation GO:1902692 3 0.012
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.012
regulation of ras protein signal transduction GO:0046578 155 0.012
2 oxoglutarate metabolic process GO:0006103 4 0.012
regulation of membrane potential GO:0042391 95 0.012
cell cell signaling GO:0007267 155 0.012
maintenance of location GO:0051235 112 0.012
Worm
positive regulation of protein phosphorylation GO:0001934 313 0.012
necrotic cell death GO:0070265 21 0.012
purine ribonucleoside monophosphate biosynthetic process GO:0009168 16 0.011
regulation of feeding behavior GO:0060259 3 0.011
hematopoietic or lymphoid organ development GO:0048534 186 0.011
tube morphogenesis GO:0035239 95 0.011
neurological system process GO:0050877 163 0.011
response to oxygen levels GO:0070482 100 0.011
regulation of protein localization GO:0032880 296 0.011
tetrapyrrole biosynthetic process GO:0033014 7 0.011
amide transport GO:0042886 76 0.011
negative regulation of cellular protein metabolic process GO:0032269 353 0.011
regulation of protein processing GO:0070613 150 0.011
protein targeting GO:0006605 187 0.011
negative regulation of developmental process GO:0051093 247 0.011
negative regulation of intracellular signal transduction GO:1902532 183 0.011
regulation of protein transport GO:0051223 213 0.011
cell projection organization GO:0030030 252 0.011
compound eye development GO:0048749 1 0.011
response to hormone GO:0009725 175 0.011
Mouse
response to light stimulus GO:0009416 87 0.011
inorganic cation transmembrane transport GO:0098662 194 0.011
protein localization to plasma membrane GO:0072659 93 0.011
rna interference GO:0016246 4 0.011
membrane fusion GO:0061025 43 0.011
biological adhesion GO:0022610 331 0.011
innate immune response GO:0045087 178 0.011
positive regulation of kinase activity GO:0033674 204 0.011
multi organism cellular process GO:0044764 156 0.011
microtubule based process GO:0007017 210 0.011
negative regulation of endopeptidase activity GO:0010951 84 0.010
negative regulation of catabolic process GO:0009895 104 0.010
anion transmembrane transport GO:0098656 76 0.010
response to axon injury GO:0048678 1 0.010
tetrapyrrole metabolic process GO:0033013 11 0.010
negative regulation of phosphate metabolic process GO:0045936 267 0.010
single organism carbohydrate metabolic process GO:0044723 193 0.010
interspecies interaction between organisms GO:0044419 156 0.010
regulation of gtp catabolic process GO:0033124 180 0.010
motor neuron axon guidance GO:0008045 2 0.010
midbrain development GO:0030901 45 0.010
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.010

HADHA disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.813
inherited metabolic disorder DOID:655 242 0.813
amino acid metabolic disorder DOID:9252 50 0.047
sensory system disease DOID:0050155 203 0.042
eye and adnexa disease DOID:1492 150 0.042
nervous system disease DOID:863 431 0.042
eye disease DOID:5614 149 0.042
central nervous system disease DOID:331 186 0.039
kidney disease DOID:557 36 0.033
urinary system disease DOID:18 40 0.033
hyperinsulinemic hypoglycemia DOID:13317 7 0.033
carbohydrate metabolic disorder DOID:2978 55 0.033
disease of cellular proliferation DOID:14566 174 0.027
retinal disease DOID:5679 118 0.020
cancer DOID:162 167 0.020
neurodegenerative disease DOID:1289 102 0.020
cardiovascular system disease DOID:1287 106 0.020
organ system cancer DOID:0050686 164 0.019
endocrine gland cancer DOID:170 26 0.019
musculoskeletal system disease DOID:17 223 0.013
retinal degeneration DOID:8466 89 0.013
retinitis pigmentosa DOID:10584 51 0.013