IMP

Process View

Homo sapiens

29 genes annotated in human

fatty acid catabolic process

The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "fatty acid catabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "fatty acid catabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
PEX19	peroxisomal biogenesis factor 19	1.000
PEX14	peroxisomal biogenesis factor 14	0.999
ETFB	electron-transfer-flavoprotein, beta polypeptide	0.946
DECR1	2,4-dienoyl CoA reductase 1, mitochondrial	0.945
SCP2	sterol carrier protein 2	0.936
CAT	catalase	0.927
INSR	insulin receptor	0.927
ECH1	enoyl CoA hydratase 1, peroxisomal	0.871
SQSTM1	sequestosome 1	0.820
ACAA1	acetyl-CoA acyltransferase 1	0.785
ETFDH	electron-transferring-flavoprotein dehydrogenase	0.770
NCF1	neutrophil cytosolic factor 1	0.730
HADHB	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	0.723	Rat Fly
CPT2	carnitine palmitoyltransferase 2	0.655
HADH	hydroxyacyl-CoA dehydrogenase	0.649	Rat
PEX3	peroxisomal biogenesis factor 3	0.605
PEX12	peroxisomal biogenesis factor 12	0.589
ACAT1	acetyl-CoA acetyltransferase 1	0.574
GRB10	growth factor receptor-bound protein 10	0.425
ABCD3	ATP-binding cassette, sub-family D (ALD), member 3	0.370
PEX11B	peroxisomal biogenesis factor 11 beta	0.342
ACADVL	acyl-CoA dehydrogenase, very long chain	0.331	Mouse Rat
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.326
RPTOR	regulatory associated protein of MTOR, complex 1	0.319
IGF1R	insulin-like growth factor 1 receptor	0.305
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.274
PEX13	peroxisomal biogenesis factor 13	0.260	Mouse
NOXA1	NADPH oxidase activator 1	0.216
HADHA	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	0.204	Mouse Fly
PRKCZ	protein kinase C, zeta	0.203	Human
PHYH	phytanoyl-CoA 2-hydroxylase	0.201
ACADSB	acyl-CoA dehydrogenase, short/branched chain	0.183
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.166
SETD8	SET domain containing (lysine methyltransferase) 8	0.161
HIBCH	3-hydroxyisobutyryl-CoA hydrolase	0.157
PEX16	peroxisomal biogenesis factor 16	0.150
GABARAPL1	GABA(A) receptor-associated protein like 1	0.149
MCCC1	methylcrotonoyl-CoA carboxylase 1 (alpha)	0.140
BCKDHB	branched chain keto acid dehydrogenase E1, beta polypeptide	0.131
MUT	methylmalonyl CoA mutase	0.126
PEX5	peroxisomal biogenesis factor 5	0.116	Mouse
NDUFB5	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa	0.110
ADH5	alcohol dehydrogenase 5 (class III), chi polypeptide	0.109
HSDL2	hydroxysteroid dehydrogenase like 2	0.109
NME2	non-metastatic cells 2, protein (NM23B) expressed in	0.105
TST	thiosulfate sulfurtransferase (rhodanese)	0.100
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.098
IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	0.098
ULK1	unc-51-like kinase 1 (C. elegans)	0.096
GABARAPL2	GABA(A) receptor-associated protein-like 2	0.092
FAM82B	family with sequence similarity 82, member B	0.090
NNT	nicotinamide nucleotide transhydrogenase	0.090
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.090
CBWD2	COBW domain containing 2	0.090
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.087
HMGCL	3-hydroxymethyl-3-methylglutaryl-CoA lyase	0.083
ACADM	acyl-CoA dehydrogenase, C-4 to C-12 straight chain	0.081
PDPK1	3-phosphoinositide dependent protein kinase-1	0.080
CDCP1	CUB domain containing protein 1	0.077
ECI2	enoyl-CoA delta isomerase 2	0.077
AKT1S1	AKT1 substrate 1 (proline-rich)	0.075
SLC25A20	solute carrier family 25 (carnitine/acylcarnitine translocase), member 20	0.074
ECI1	enoyl-CoA delta isomerase 1	0.073
IRS1	insulin receptor substrate 1	0.072
GRHPR	glyoxylate reductase/hydroxypyruvate reductase	0.069
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.068
C21orf33	chromosome 21 open reading frame 33	0.068
SLC25A17	solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17	0.063
RUNX1	runt-related transcription factor 1	0.062
ALDH4A1	aldehyde dehydrogenase 4 family, member A1	0.058
HSD17B4	hydroxysteroid (17-beta) dehydrogenase 4	0.058
PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	0.053
GATA2	GATA binding protein 2	0.051
ZNF277	zinc finger protein 277	0.049
UQCRC2	ubiquinol-cytochrome c reductase core protein II	0.048
UBA5	ubiquitin-like modifier activating enzyme 5	0.047
LAT	linker for activation of T cells	0.042
TRIM9	tripartite motif containing 9	0.041
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.040
PPP2R4	protein phosphatase 2A activator, regulatory subunit 4	0.039
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.039
ALDH9A1	aldehyde dehydrogenase 9 family, member A1	0.039
HIBADH	3-hydroxyisobutyrate dehydrogenase	0.039
CYB5A	cytochrome b5 type A (microsomal)	0.039
ACOX1	acyl-CoA oxidase 1, palmitoyl	0.039
BAG3	BCL2-associated athanogene 3	0.038
ALDH6A1	aldehyde dehydrogenase 6 family, member A1	0.038
KDM1A	lysine (K)-specific demethylase 1A	0.038
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.034
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.034
ACAA2	acetyl-CoA acyltransferase 2	0.033	Rat
CCL14	chemokine (C-C motif) ligand 14	0.032
DEPTOR	DEP domain containing MTOR-interacting protein	0.032
SLC25A1	solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1	0.032
ALDH3A2	aldehyde dehydrogenase 3 family, member A2	0.032
ATG13	ATG13 autophagy related 13 homolog (S. cerevisiae)	0.031
SH3RF1	SH3 domain containing ring finger 1	0.030
HRSP12	heat-responsive protein 12	0.030
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.029	Rat
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.028
F11R	F11 receptor	0.028
IRS2	insulin receptor substrate 2	0.028
CRAT	carnitine O-acetyltransferase	0.028	Human
GBAS	glioblastoma amplified sequence	0.027
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	0.027
DLD	dihydrolipoamide dehydrogenase	0.026
RETSAT	retinol saturase (all-trans-retinol 13,14-reductase)	0.026
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.026
PRR5	proline rich 5 (renal)	0.026
PGM1	phosphoglucomutase 1	0.026
PHKB	phosphorylase kinase, beta	0.026
EHHADH	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	0.025
ACADS	acyl-CoA dehydrogenase, C-2 to C-3 short chain	0.025	Rat
PXMP2	peroxisomal membrane protein 2, 22kDa	0.023
COQ5	coenzyme Q5 homolog, methyltransferase (S. cerevisiae)	0.023
SUCLG2	succinate-CoA ligase, GDP-forming, beta subunit	0.023
SH2D1A	SH2 domain containing 1A	0.022
F8	coagulation factor VIII, procoagulant component	0.022
RAB4A	RAB4A, member RAS oncogene family	0.022
SUOX	sulfite oxidase	0.022
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.021
CCDC115	coiled-coil domain containing 115	0.021
SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	0.021
BCKDHA	branched chain keto acid dehydrogenase E1, alpha polypeptide	0.021
FABP1	fatty acid binding protein 1, liver	0.021	Rat
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.021
BCKDK	branched chain ketoacid dehydrogenase kinase	0.021
GABARAP	GABA(A) receptor-associated protein	0.021
LRBA	LPS-responsive vesicle trafficking, beach and anchor containing	0.021
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.020
TOM1L1	target of myb1 (chicken)-like 1	0.020
ISOC1	isochorismatase domain containing 1	0.020
DGAT1	diacylglycerol O-acyltransferase 1	0.020
RICTOR	RPTOR independent companion of MTOR, complex 2	0.019
RARA	retinoic acid receptor, alpha	0.019
MAPKAP1	mitogen-activated protein kinase associated protein 1	0.019
ALDH2	aldehyde dehydrogenase 2 family (mitochondrial)	0.018
DHRS4	dehydrogenase/reductase (SDR family) member 4	0.018
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.018	Human
DDA1	DET1 and DDB1 associated 1	0.018
CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	0.018	Human
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.017
TRAF6	TNF receptor-associated factor 6	0.017
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	0.017
MPST	mercaptopyruvate sulfurtransferase	0.017
AGL	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	0.016
GSTK1	glutathione S-transferase kappa 1	0.016
FHOD3	formin homology 2 domain containing 3	0.016
PRKCI	protein kinase C, iota	0.016	Human
ACAD8	acyl-CoA dehydrogenase family, member 8	0.016
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.016
NIPSNAP1	nipsnap homolog 1 (C. elegans)	0.016
IMPA2	inositol(myo)-1(or 4)-monophosphatase 2	0.015
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.015
ACO2	aconitase 2, mitochondrial	0.015
PHOX2A	paired-like homeobox 2a	0.015
STK4	serine/threonine kinase 4	0.015
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.015
STAT5B	signal transducer and activator of transcription 5B	0.014
ZNF71	zinc finger protein 71	0.014
PDX1	pancreatic and duodenal homeobox 1	0.014
ECHDC2	enoyl CoA hydratase domain containing 2	0.014
ALAD	aminolevulinate dehydratase	0.014
HIPK2	homeodomain interacting protein kinase 2	0.014
PEBP1	phosphatidylethanolamine binding protein 1	0.014
LMO2	LIM domain only 2 (rhombotin-like 1)	0.014
FAH	fumarylacetoacetate hydrolase (fumarylacetoacetase)	0.014
DCTN1	dynactin 1	0.014
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.014
VIM	vimentin	0.014
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.013
SLC2A4RG	SLC2A4 regulator	0.013
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.013
MAPT	microtubule-associated protein tau	0.013
USP50	ubiquitin specific peptidase 50	0.013
MLYCD	malonyl-CoA decarboxylase	0.013
FOXO3	forkhead box O3	0.013
EPHX2	epoxide hydrolase 2, cytoplasmic	0.013
CBR4	carbonyl reductase 4	0.012
HMG20B	high mobility group 20B	0.012
BDH2	3-hydroxybutyrate dehydrogenase, type 2	0.012
ABCD1	ATP-binding cassette, sub-family D (ALD), member 1	0.012
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.012
SH2B1	SH2B adaptor protein 1	0.012
HIST1H3B	histone cluster 1, H3b	0.012
SYK	spleen tyrosine kinase	0.012
GATA4	GATA binding protein 4	0.012
AGPAT2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	0.012
IL17RC	interleukin 17 receptor C	0.012
PRKCB	protein kinase C, beta	0.012
SORD	sorbitol dehydrogenase	0.011
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.011
C8A	complement component 8, alpha polypeptide	0.011
ITFG3	integrin alpha FG-GAP repeat containing 3	0.011
MAT1A	methionine adenosyltransferase I, alpha	0.011
RHEB	Ras homolog enriched in brain	0.011
PLIN4	perilipin 4	0.011
ATPAF1	ATP synthase mitochondrial F1 complex assembly factor 1	0.011
MOCS2	molybdenum cofactor synthesis 2	0.011
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.011
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.011
ACSF2	acyl-CoA synthetase family member 2	0.010
CDK5RAP3	CDK5 regulatory subunit associated protein 3	0.010
IVD	isovaleryl-CoA dehydrogenase	0.010
HAND2	heart and neural crest derivatives expressed 2	0.010	Human
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.010