Homo sapiens

16 known processes

HMGCR

3-hydroxy-3-methylglutaryl-CoA reductase

(Aliases: LDLCQ3)

HMGCR biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
steroid metabolic process GO:0008202 94 0.999
Mouse
alcohol metabolic process GO:0006066 114 0.996
Mouse
lipid biosynthetic process GO:0008610 177 0.995
Mouse
cellular lipid metabolic process GO:0044255 303 0.986
lipid metabolic process GO:0006629 381 0.976
Mouse
organic hydroxy compound metabolic process GO:1901615 147 0.960
Mouse
small molecule biosynthetic process GO:0044283 157 0.922
Mouse
sterol metabolic process GO:0016125 28 0.910
Mouse
monocarboxylic acid biosynthetic process GO:0072330 67 0.908
organic hydroxy compound biosynthetic process GO:1901617 71 0.890
Mouse
phospholipid metabolic process GO:0006644 99 0.881
cellular biogenic amine metabolic process GO:0006576 34 0.873
phospholipid biosynthetic process GO:0008654 44 0.858
alcohol biosynthetic process GO:0046165 52 0.833
Mouse
organophosphate biosynthetic process GO:0090407 163 0.718
cellular response to cholesterol GO:0071397 4 0.639
anion transport GO:0006820 161 0.632
sterol biosynthetic process GO:0016126 10 0.584
Mouse
response to lipid GO:0033993 206 0.499
regulation of vesicle mediated transport GO:0060627 130 0.485
long chain fatty acid import GO:0044539 5 0.452
response to organic cyclic compound GO:0014070 204 0.427
carboxylic acid biosynthetic process GO:0046394 97 0.395
regulation of icosanoid secretion GO:0032303 4 0.393
regulation of cytoplasmic transport GO:1903649 149 0.384
inner ear morphogenesis GO:0042472 4 0.347
response to drug GO:0042493 81 0.278
terpenoid biosynthetic process GO:0016114 2 0.258
glycerolipid metabolic process GO:0046486 107 0.250
positive regulation of golgi to plasma membrane protein transport GO:0042998 2 0.245
acylglycerol metabolic process GO:0006639 27 0.234
negative regulation of growth of symbiont involved in interaction with host GO:0044146 2 0.227
membrane budding GO:0006900 28 0.224
cholesterol metabolic process GO:0008203 28 0.222
Mouse
srebp signaling pathway GO:0032933 4 0.158
negative regulation of lipid metabolic process GO:0045833 38 0.151
steroid biosynthetic process GO:0006694 46 0.145
Mouse
head development GO:0060322 108 0.145
cellular response to gonadotropin stimulus GO:0071371 4 0.130
regulation of protein complex assembly GO:0043254 147 0.121
response to sterol depletion GO:0006991 4 0.120
cellular response to sterol depletion GO:0071501 4 0.118
amine metabolic process GO:0009308 44 0.117
sphingolipid metabolic process GO:0006665 38 0.106
terpenoid metabolic process GO:0006721 27 0.103
cellular amine metabolic process GO:0044106 41 0.100
regulation of cellular ketone metabolic process GO:0010565 50 0.097
growth GO:0040007 202 0.089
vesicle organization GO:0016050 62 0.087
sensory organ morphogenesis GO:0090596 21 0.081
membrane organization GO:0061024 292 0.080
single organism cellular localization GO:1902580 332 0.078
sulfur compound metabolic process GO:0006790 101 0.076
regulation of lipid metabolic process GO:0019216 96 0.073
regulation of cell growth GO:0001558 135 0.072
positive regulation of cellular amine metabolic process GO:0033240 7 0.070
cellular response to organic cyclic compound GO:0071407 127 0.070
cytoplasmic transport GO:0016482 379 0.069
triglyceride metabolic process GO:0006641 23 0.068
fatty acid elongation polyunsaturated fatty acid GO:0034626 4 0.066
golgi vesicle transport GO:0048193 80 0.065
organonitrogen compound biosynthetic process GO:1901566 200 0.063
very long chain fatty acid biosynthetic process GO:0042761 7 0.062
organic acid biosynthetic process GO:0016053 97 0.061
determination of adult lifespan GO:0008340 2 0.061
monocarboxylic acid metabolic process GO:0032787 185 0.060
fatty acid metabolic process GO:0006631 115 0.059
regulation of golgi to plasma membrane protein transport GO:0042996 3 0.059
regulation of intracellular transport GO:0032386 195 0.058
positive regulation of phospholipid biosynthetic process GO:0071073 4 0.054
negative regulation of cellular component organization GO:0051129 235 0.054
nervous system development GO:0007399 293 0.052
cellular response to oxygen containing compound GO:1901701 276 0.050
endomembrane system organization GO:0010256 196 0.048
purine containing compound catabolic process GO:0072523 411 0.047
regulation of er to golgi vesicle mediated transport GO:0060628 5 0.047
negative regulation of secretion GO:0051048 58 0.046
purine nucleoside triphosphate catabolic process GO:0009146 392 0.045
mitotic cell cycle process GO:1903047 286 0.045
single organism membrane organization GO:0044802 268 0.043
cellular alcohol metabolic process GO:0044107 7 0.042
sterol transport GO:0015918 39 0.041
negative regulation of protein complex assembly GO:0031333 43 0.041
regulation of ion transport GO:0043269 189 0.041
oogenesis GO:0048477 2 0.041
neuromuscular junction development GO:0007528 3 0.040
cellular protein complex assembly GO:0043623 188 0.039
cholesterol biosynthetic process GO:0006695 10 0.039
Mouse
regulation of cellular component biogenesis GO:0044087 281 0.039
central nervous system development GO:0007417 123 0.039
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.039
regulation of protein localization to plasma membrane GO:1903076 40 0.038
ion transmembrane transport GO:0034220 338 0.038
ribonucleoside triphosphate metabolic process GO:0009199 412 0.037
male sex differentiation GO:0046661 25 0.037
regulation of cellular amine metabolic process GO:0033238 11 0.037
ketone body metabolic process GO:1902224 2 0.037
nucleotide catabolic process GO:0009166 408 0.036
2 oxoglutarate metabolic process GO:0006103 4 0.035
lipid transport GO:0006869 90 0.035
secretion GO:0046903 254 0.035
organophosphate catabolic process GO:0046434 430 0.034
post embryonic development GO:0009791 2 0.033
Worm
positive regulation of cell growth GO:0030307 48 0.033
negative regulation of protein metabolic process GO:0051248 391 0.033
Mouse
prostaglandin secretion GO:0032310 2 0.032
er to golgi vesicle mediated transport GO:0006888 19 0.032
glycerophospholipid metabolic process GO:0006650 84 0.032
reproductive system development GO:0061458 56 0.031
negative regulation of growth of symbiont in host GO:0044130 1 0.031
fatty acid biosynthetic process GO:0006633 46 0.031
cellular response to hormone stimulus GO:0032870 125 0.031
response to external biotic stimulus GO:0043207 261 0.031
response to light stimulus GO:0009416 87 0.031
Mouse
negative regulation of cellular protein metabolic process GO:0032269 353 0.030
Mouse
inorganic ion transmembrane transport GO:0098660 231 0.030
regulation of cell cycle GO:0051726 393 0.030
locomotory behavior GO:0007626 1 0.030
glycerolipid biosynthetic process GO:0045017 51 0.030
female gamete generation GO:0007292 2 0.029
localization within membrane GO:0051668 14 0.029
negative regulation of catalytic activity GO:0043086 335 0.029
Mouse
cellular response to lipid GO:0071396 127 0.029
brain development GO:0007420 97 0.029
embryo development GO:0009790 123 0.029
Mouse Worm
positive regulation of cytoplasmic transport GO:1903651 82 0.028
regulation of cellular amino acid metabolic process GO:0006521 6 0.028
cation transmembrane transport GO:0098655 238 0.027
regulation of steroid biosynthetic process GO:0050810 23 0.027
regulation of growth GO:0040008 165 0.027
glycerophospholipid biosynthetic process GO:0046474 40 0.027
cholesterol transport GO:0030301 39 0.027
cellular amino acid metabolic process GO:0006520 116 0.026
positive regulation of secretion GO:0051047 116 0.026
positive regulation of transport GO:0051050 336 0.026
cell growth GO:0016049 160 0.026
vesicle mediated transport GO:0016192 371 0.026
Worm
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.026
response to abiotic stimulus GO:0009628 336 0.025
Mouse
negative regulation of icosanoid secretion GO:0032304 2 0.024
response to nutrient levels GO:0031667 81 0.024
ion homeostasis GO:0050801 230 0.024
divalent inorganic cation homeostasis GO:0072507 136 0.023
inorganic cation transmembrane transport GO:0098662 194 0.023
regulation of lipid biosynthetic process GO:0046890 47 0.023
single organism membrane budding GO:1902591 10 0.023
regulation of establishment of protein localization GO:0070201 242 0.023
defense response GO:0006952 315 0.022
nucleoside catabolic process GO:0009164 408 0.022
response to biotic stimulus GO:0009607 276 0.022
multicellular organismal aging GO:0010259 3 0.022
regulation of protein localization GO:0032880 296 0.022
ribonucleoside catabolic process GO:0042454 406 0.022
embryonic morphogenesis GO:0048598 85 0.022
regulation of cell differentiation GO:0045595 393 0.021
transmembrane transport GO:0055085 399 0.021
ribonucleoside triphosphate catabolic process GO:0009203 391 0.021
segmentation GO:0035282 4 0.021
innate immune response GO:0045087 178 0.021
negative regulation of transport GO:0051051 176 0.021
positive regulation of intracellular transport GO:0032388 104 0.021
chemical homeostasis GO:0048878 306 0.021
response to inorganic substance GO:0010035 127 0.020
negative regulation of organelle organization GO:0010639 126 0.020
microtubule based process GO:0007017 210 0.020
positive regulation of lipid biosynthetic process GO:0046889 22 0.020
ethanolamine containing compound metabolic process GO:0042439 26 0.020
positive regulation of protein transport GO:0051222 135 0.020
positive regulation of cellular component organization GO:0051130 376 0.020
purine nucleotide catabolic process GO:0006195 405 0.020
regulation of steroid metabolic process GO:0019218 32 0.020
purine nucleoside triphosphate metabolic process GO:0009144 412 0.020
ribonucleotide catabolic process GO:0009261 405 0.020
metal ion transport GO:0030001 272 0.019
glycosyl compound catabolic process GO:1901658 413 0.019
intracellular protein transport GO:0006886 270 0.019
negative regulation of protein processing GO:0010955 142 0.019
cell fate determination GO:0001709 3 0.019
cellular divalent inorganic cation homeostasis GO:0072503 128 0.019
protein targeting GO:0006605 187 0.019
cellular macromolecular complex assembly GO:0034622 324 0.018
response to extracellular stimulus GO:0009991 85 0.018
regulation of fatty acid transport GO:2000191 8 0.018
dna repair GO:0006281 198 0.018
spermatid differentiation GO:0048515 4 0.018
phosphatidylcholine catabolic process GO:0034638 3 0.018
organ morphogenesis GO:0009887 147 0.017
nucleoside triphosphate catabolic process GO:0009143 394 0.017
cellular macromolecule catabolic process GO:0044265 380 0.017
dephosphorylation GO:0016311 209 0.017
ras protein signal transduction GO:0007265 73 0.017
positive regulation of cell cycle GO:0045787 140 0.016
fatty acid elongation monounsaturated fatty acid GO:0034625 3 0.016
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.016
establishment of protein localization to membrane GO:0090150 121 0.016
negative regulation of phosphate metabolic process GO:0045936 267 0.016
Mouse
mitotic cell cycle GO:0000278 326 0.016
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.016
regulation of neuronal synaptic plasticity GO:0048168 1 0.016
regulation of protein kinase activity GO:0045859 289 0.016
Mouse
stem cell division GO:0017145 2 0.016
regulation of protein transport GO:0051223 213 0.016
purine ribonucleoside metabolic process GO:0046128 437 0.016
ear morphogenesis GO:0042471 7 0.015
ribonucleoside monophosphate catabolic process GO:0009158 158 0.015
immune system development GO:0002520 195 0.015
nucleoside phosphate catabolic process GO:1901292 412 0.015
cell part morphogenesis GO:0032990 137 0.015
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.015
posttranscriptional regulation of gene expression GO:0010608 213 0.015
response to nutrient GO:0007584 20 0.015
regulation of fatty acid metabolic process GO:0019217 24 0.015
negative regulation of proteolysis GO:0045861 132 0.015
cellular response to sterol GO:0036315 7 0.015
endocytosis GO:0006897 159 0.015
Worm
establishment of protein localization to organelle GO:0072594 172 0.015
bone morphogenesis GO:0060349 10 0.015
cellular chemical homeostasis GO:0055082 180 0.015
glycoprotein metabolic process GO:0009100 110 0.015
positive regulation of catabolic process GO:0009896 310 0.015
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.014
nucleoside triphosphate metabolic process GO:0009141 422 0.014
purine ribonucleotide catabolic process GO:0009154 404 0.014
protein processing GO:0016485 226 0.014
regulation of proteolysis GO:0030162 293 0.014
golgi to plasma membrane transport GO:0006893 21 0.014
lipid storage GO:0019915 28 0.014
Worm
negative regulation of protein kinase activity GO:0006469 98 0.014
Mouse
actin cytoskeleton organization GO:0030036 207 0.014
negative regulation of developmental process GO:0051093 247 0.014
carboxylic acid transport GO:0046942 63 0.014
protein import into nucleus GO:0006606 104 0.014
monocarboxylic acid transport GO:0015718 32 0.013
very long chain fatty acid metabolic process GO:0000038 19 0.013
protein localization to plasma membrane GO:0072659 93 0.013
negative regulation of cytoplasmic transport GO:1903650 46 0.013
nucleoside monophosphate metabolic process GO:0009123 191 0.013
protein import GO:0017038 130 0.013
rab protein signal transduction GO:0032482 4 0.013
skin development GO:0043588 76 0.013
isocitrate metabolic process GO:0006102 1 0.013
cellular metal ion homeostasis GO:0006875 146 0.013
cellular ion homeostasis GO:0006873 168 0.013
regulation of cell motility GO:2000145 299 0.013
response to hormone GO:0009725 175 0.013
membrane lipid metabolic process GO:0006643 53 0.013
neurogenesis GO:0022008 169 0.013
regulation of synaptic plasticity GO:0048167 3 0.013
reproductive process GO:0022414 106 0.013
protein localization to membrane GO:0072657 160 0.013
spermatid development GO:0007286 4 0.013
organelle localization GO:0051640 84 0.013
neuron projection development GO:0031175 106 0.013
protein catabolic process GO:0030163 325 0.012
purine ribonucleoside catabolic process GO:0046130 398 0.012
calcium ion homeostasis GO:0055074 122 0.012
response to oxygen containing compound GO:1901700 369 0.012
neurological system process GO:0050877 163 0.012
Mouse
cardiovascular system development GO:0072358 262 0.012
cation homeostasis GO:0055080 189 0.012
neutral lipid metabolic process GO:0006638 27 0.012
regulation of protein serine threonine kinase activity GO:0071900 179 0.012
Mouse
oocyte development GO:0048599 1 0.012
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.012
response to steroid hormone GO:0048545 80 0.012
blastoderm segmentation GO:0007350 2 0.012
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.012
monovalent inorganic cation transport GO:0015672 128 0.012
regulation of anion transport GO:0044070 25 0.012
long chain fatty acid transport GO:0015909 18 0.011
regulation of kinase activity GO:0043549 314 0.011
Mouse
anterior posterior axis specification GO:0009948 2 0.011
peripheral nervous system development GO:0007422 2 0.011
neurotransmitter secretion GO:0007269 4 0.011
meiotic chromosome segregation GO:0045132 4 0.011
regulation of cell division GO:0051302 116 0.011
multicellular organismal response to stress GO:0033555 1 0.011
adult locomotory behavior GO:0008344 1 0.011
atp metabolic process GO:0046034 176 0.011
organic anion transport GO:0015711 103 0.011
morphogenesis of embryonic epithelium GO:0016331 4 0.011
cholesterol import GO:0070508 4 0.011
cellular homeostasis GO:0019725 196 0.011
neuroblast proliferation GO:0007405 4 0.011
lipid catabolic process GO:0016042 84 0.011
coenzyme metabolic process GO:0006732 65 0.011
fatty acid derivative transport GO:1901571 11 0.011
positive regulation of intracellular protein transport GO:0090316 76 0.011
protein lipid complex subunit organization GO:0071825 24 0.011
positive regulation of nucleotide metabolic process GO:0045981 230 0.011
positive regulation of immune system process GO:0002684 283 0.010
guanosine containing compound catabolic process GO:1901069 239 0.010
guanosine containing compound metabolic process GO:1901068 244 0.010
positive regulation of cell migration GO:0030335 172 0.010
regulation of protein processing GO:0070613 150 0.010
neural tube formation GO:0001841 3 0.010
gtp catabolic process GO:0006184 237 0.010
negative regulation of cell differentiation GO:0045596 171 0.010
regulation of organic acid transport GO:0032890 8 0.010
regulation of response to external stimulus GO:0032101 222 0.010
single organism reproductive process GO:0044702 98 0.010
negative regulation of transferase activity GO:0051348 124 0.010
Mouse
oocyte differentiation GO:0009994 2 0.010
negative regulation of phosphorylation GO:0042326 174 0.010
Mouse
reactive nitrogen species metabolic process GO:2001057 3 0.010
negative regulation of cellular amine metabolic process GO:0033239 3 0.010
regulation of meiotic cell cycle GO:0051445 4 0.010
regulation of cell cycle process GO:0010564 266 0.010
regulation of purine nucleotide catabolic process GO:0033121 205 0.010
negative regulation of apoptotic process GO:0043066 316 0.010
system process GO:0003008 349 0.010
Mouse
response to cytokine GO:0034097 232 0.010

HMGCR disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.076
disease of metabolism DOID:0014667 295 0.029
lipid metabolism disorder DOID:3146 26 0.029
inherited metabolic disorder DOID:655 242 0.029
familial hyperlipidemia DOID:1168 9 0.024
cancer DOID:162 167 0.021
disease of mental health DOID:150 70 0.014
immune system disease DOID:2914 155 0.014
central nervous system disease DOID:331 186 0.011
nervous system disease DOID:863 431 0.011
sensory system disease DOID:0050155 203 0.011