Homo sapiens

45 known processes

FEN1

flap structure-specific endonuclease 1

(Aliases: FEN-1,MF1,RAD2)

FEN1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna repair GO:0006281 198 0.999
Yeast Mouse
dna replication GO:0006260 116 0.975
cellular response to dna damage stimulus GO:0006974 379 0.950
Yeast Mouse
dna dependent dna replication GO:0006261 44 0.874
mitotic cell cycle process GO:1903047 286 0.804
post embryonic development GO:0009791 2 0.741
nuclear division GO:0000280 128 0.706
double strand break repair via homologous recombination GO:0000724 50 0.639
organelle fission GO:0048285 149 0.626
double strand break repair GO:0006302 101 0.597
Yeast
cellular macromolecule catabolic process GO:0044265 380 0.553
microtubule based process GO:0007017 210 0.513
mitotic cell cycle phase transition GO:0044772 162 0.477
mitotic cell cycle GO:0000278 326 0.449
meiosis i GO:0007127 4 0.364
embryo development GO:0009790 123 0.319
Worm
regulation of dna replication GO:0006275 68 0.300
ubiquitin dependent protein catabolic process GO:0006511 206 0.274
determination of adult lifespan GO:0008340 2 0.267
cellular macromolecular complex assembly GO:0034622 324 0.253
chromosome segregation GO:0007059 114 0.252
microtubule cytoskeleton organization GO:0000226 176 0.244
multicellular organismal aging GO:0010259 3 0.240
negative regulation of cell cycle process GO:0010948 121 0.236
regulation of dna metabolic process GO:0051052 153 0.234
proteasomal protein catabolic process GO:0010498 176 0.233
recombinational repair GO:0000725 50 0.222
mitotic nuclear division GO:0007067 119 0.222
dna conformation change GO:0071103 113 0.204
chromatin organization GO:0006325 351 0.192
spindle organization GO:0007051 53 0.182
reproductive process GO:0022414 106 0.168
Yeast Worm
cell cell signaling GO:0007267 155 0.167
cellular protein complex assembly GO:0043623 188 0.164
protein catabolic process GO:0030163 325 0.150
regulation of cell cycle process GO:0010564 266 0.139
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.134
sex differentiation GO:0007548 45 0.132
Worm
regulation of mitotic cell cycle GO:0007346 189 0.125
modification dependent protein catabolic process GO:0019941 209 0.123
dna biosynthetic process GO:0071897 40 0.119
Yeast
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.118
nucleoside catabolic process GO:0009164 408 0.116
carbohydrate derivative biosynthetic process GO:1901137 207 0.114
positive regulation of cellular component organization GO:0051130 376 0.112
positive regulation of developmental process GO:0051094 314 0.110
cell division GO:0051301 168 0.106
regulation of meiotic cell cycle GO:0051445 4 0.104
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.103
mitotic sister chromatid segregation GO:0000070 53 0.101
regulation of cell cycle GO:0051726 393 0.097
reproductive structure development GO:0048608 55 0.096
Worm
cellular protein catabolic process GO:0044257 261 0.093
negative regulation of cell cycle GO:0045786 193 0.091
regulation of mitosis GO:0007088 63 0.090
cellular response to endogenous stimulus GO:0071495 336 0.089
endocytosis GO:0006897 159 0.087
Worm
mitotic cell cycle checkpoint GO:0007093 68 0.086
ras protein signal transduction GO:0007265 73 0.083
positive regulation of organelle organization GO:0010638 195 0.079
nucleoside triphosphate metabolic process GO:0009141 422 0.078
protein localization to organelle GO:0033365 280 0.078
vesicle mediated transport GO:0016192 371 0.077
Worm
modification dependent macromolecule catabolic process GO:0043632 212 0.075
behavior GO:0007610 112 0.075
response to abiotic stimulus GO:0009628 336 0.073
regeneration GO:0031099 4 0.072
embryo development ending in birth or egg hatching GO:0009792 34 0.071
Worm
single organism reproductive process GO:0044702 98 0.070
Yeast Worm
heart development GO:0007507 95 0.068
sister chromatid segregation GO:0000819 54 0.068
mitotic dna integrity checkpoint GO:0044774 30 0.067
reproduction GO:0000003 63 0.066
Yeast Worm
mitotic sister chromatid separation GO:0051306 18 0.065
cell cycle phase transition GO:0044770 173 0.064
dna recombination GO:0006310 77 0.063
Yeast
response to oxygen containing compound GO:1901700 369 0.062
nucleoside monophosphate metabolic process GO:0009123 191 0.060
oogenesis GO:0048477 2 0.060
mrna processing GO:0006397 133 0.060
response to biotic stimulus GO:0009607 276 0.059
single organism cellular localization GO:1902580 332 0.059
neurogenesis GO:0022008 169 0.058
nucleotide biosynthetic process GO:0009165 109 0.056
multi organism reproductive process GO:0044703 54 0.053
organophosphate biosynthetic process GO:0090407 163 0.052
regulation of cell cycle phase transition GO:1901987 126 0.050
organophosphate catabolic process GO:0046434 430 0.047
regulation of mitotic cell cycle phase transition GO:1901990 118 0.046
cellular response to radiation GO:0071478 65 0.046
reproductive system development GO:0061458 56 0.046
Worm
cellular response to oxygen containing compound GO:1901701 276 0.045
regulation of meiosis GO:0040020 3 0.045
purine nucleoside catabolic process GO:0006152 398 0.042
dna catabolic process GO:0006308 49 0.041
oocyte development GO:0048599 1 0.041
multicellular organism reproduction GO:0032504 42 0.041
female gamete generation GO:0007292 2 0.041
metaphase anaphase transition of mitotic cell cycle GO:0007091 21 0.040
small gtpase mediated signal transduction GO:0007264 78 0.040
oocyte differentiation GO:0009994 2 0.040
developmental process involved in reproduction GO:0003006 66 0.039
Yeast Worm
cell activation GO:0001775 213 0.038
gonad development GO:0008406 34 0.038
Worm
microtubule polymerization GO:0046785 18 0.038
meiotic chromosome segregation GO:0045132 4 0.037
regulation of nuclear division GO:0051783 65 0.036
establishment of organelle localization GO:0051656 59 0.032
cellular component morphogenesis GO:0032989 314 0.032
growth GO:0040007 202 0.032
positive regulation of apoptotic process GO:0043065 246 0.032
positive regulation of transport GO:0051050 336 0.031
protein modification by small protein conjugation GO:0032446 342 0.030
regulation of growth GO:0040008 165 0.030
response to external biotic stimulus GO:0043207 261 0.029
negative regulation of mitotic cell cycle GO:0045930 102 0.029
regulation of response to dna damage stimulus GO:2001020 94 0.028
cell morphogenesis GO:0000902 296 0.028
response to ionizing radiation GO:0010212 65 0.028
protein ubiquitination GO:0016567 314 0.027
mitotic spindle organization GO:0007052 27 0.027
ribonucleotide catabolic process GO:0009261 405 0.027
positive regulation of cell cycle process GO:0090068 106 0.027
regulation of mitotic sister chromatid separation GO:0010965 27 0.026
cellular response to organic cyclic compound GO:0071407 127 0.026
cell fate commitment GO:0045165 27 0.026
Yeast
nucleotide catabolic process GO:0009166 408 0.026
development of primary sexual characteristics GO:0045137 35 0.026
Worm
positive regulation of dna metabolic process GO:0051054 73 0.026
ribonucleoside triphosphate metabolic process GO:0009199 412 0.026
translesion synthesis GO:0019985 8 0.026
positive regulation of cell proliferation GO:0008284 301 0.026
sexual reproduction GO:0019953 37 0.026
base excision repair GO:0006284 21 0.026
Yeast
immune system development GO:0002520 195 0.025
organelle localization GO:0051640 84 0.025
nervous system development GO:0007399 293 0.025
protein dna complex assembly GO:0065004 64 0.025
nucleoside triphosphate catabolic process GO:0009143 394 0.025
positive regulation of catabolic process GO:0009896 310 0.025
regulation of cellular response to stress GO:0080135 244 0.025
centrosome organization GO:0051297 58 0.024
non recombinational repair GO:0000726 14 0.024
Yeast
cell development GO:0048468 328 0.024
dna integrity checkpoint GO:0031570 71 0.024
purine nucleoside triphosphate metabolic process GO:0009144 412 0.024
response to organic cyclic compound GO:0014070 204 0.023
cellular response to abiotic stimulus GO:0071214 117 0.023
purine ribonucleoside metabolic process GO:0046128 437 0.023
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.023
atp metabolic process GO:0046034 176 0.023
membrane organization GO:0061024 292 0.022
nucleoside phosphate catabolic process GO:1901292 412 0.022
regulation of binding GO:0051098 111 0.022
cytokinesis GO:0000910 96 0.021
meiotic nuclear division GO:0007126 10 0.021
purine nucleotide catabolic process GO:0006195 405 0.021
positive regulation of cellular component biogenesis GO:0044089 158 0.021
multicellular organismal reproductive process GO:0048609 40 0.021
positive regulation of hydrolase activity GO:0051345 331 0.020
regulation of proteolysis GO:0030162 293 0.020
positive regulation of programmed cell death GO:0043068 249 0.020
response to uv GO:0009411 73 0.020
regulation of chromosome segregation GO:0051983 44 0.020
positive regulation of immune system process GO:0002684 283 0.020
organelle assembly GO:0070925 176 0.020
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.020
response to inorganic substance GO:0010035 127 0.019
chromatin modification GO:0016568 298 0.019
intracellular protein transport GO:0006886 270 0.019
negative regulation of apoptotic process GO:0043066 316 0.019
meiotic cell cycle GO:0051321 13 0.019
neuron differentiation GO:0030182 138 0.018
polynucleotide dephosphorylation GO:0098501 3 0.018
Yeast
regulation of dna repair GO:0006282 47 0.018
oocyte maturation GO:0001556 1 0.018
glycosyl compound catabolic process GO:1901658 413 0.018
body morphogenesis GO:0010171 11 0.018
response to radiation GO:0009314 151 0.018
positive regulation of cytoskeleton organization GO:0051495 83 0.018
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.018
negative regulation of organelle organization GO:0010639 126 0.017
enzyme linked receptor protein signaling pathway GO:0007167 303 0.017
nucleoside phosphate biosynthetic process GO:1901293 109 0.017
purine containing compound catabolic process GO:0072523 411 0.016
nucleoside monophosphate catabolic process GO:0009125 159 0.016
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.016
g2 dna damage checkpoint GO:0031572 26 0.016
cell cycle checkpoint GO:0000075 117 0.015
regulation of protein catabolic process GO:0042176 155 0.015
ribonucleoside catabolic process GO:0042454 406 0.015
lagging strand elongation GO:0006273 3 0.015
ribonucleoside monophosphate metabolic process GO:0009161 187 0.015
cell aging GO:0007569 52 0.015
Yeast
negative regulation of programmed cell death GO:0043069 321 0.015
regulation of cell division GO:0051302 116 0.014
dna damage checkpoint GO:0000077 68 0.014
meiotic cell cycle process GO:1903046 8 0.014
regulation of nucleotide metabolic process GO:0006140 269 0.014
purine nucleoside triphosphate catabolic process GO:0009146 392 0.014
negative regulation of cytoskeleton organization GO:0051494 45 0.013
mature ribosome assembly GO:0042256 5 0.013
ribosome assembly GO:0042255 9 0.013
cardiovascular system development GO:0072358 262 0.013
positive regulation of response to dna damage stimulus GO:2001022 43 0.013
negative regulation of cellular protein metabolic process GO:0032269 353 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.013
negative regulation of cell cycle phase transition GO:1901988 89 0.013
maintenance of location GO:0051235 112 0.013
purine ribonucleotide catabolic process GO:0009154 404 0.013
tube development GO:0035295 125 0.013
cellular process involved in reproduction in multicellular organism GO:0022412 15 0.013
cellular response to growth factor stimulus GO:0071363 197 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.013
single organism membrane organization GO:0044802 268 0.013
positive regulation of cell cycle GO:0045787 140 0.012
purine nucleoside monophosphate metabolic process GO:0009126 186 0.012
actin filament based process GO:0030029 224 0.012
ribonucleoside monophosphate catabolic process GO:0009158 158 0.012
regulation of cellular component biogenesis GO:0044087 281 0.012
positive regulation of cell death GO:0010942 263 0.012
muscle cell differentiation GO:0042692 63 0.012
digestive system development GO:0055123 75 0.012
regulation of purine nucleotide metabolic process GO:1900542 264 0.012
negative regulation of catalytic activity GO:0043086 335 0.012
fertilization GO:0009566 12 0.012
nuclear retention of pre mrna at the site of transcription GO:0071033 1 0.011
negative regulation of phosphorus metabolic process GO:0010563 267 0.011
regulation of cell differentiation GO:0045595 393 0.011
mitotic dna damage checkpoint GO:0044773 28 0.011
chromosome separation GO:0051304 23 0.011
rna catabolic process GO:0006401 71 0.011
immune response GO:0006955 307 0.011
organonitrogen compound biosynthetic process GO:1901566 200 0.011
regulation of transferase activity GO:0051338 355 0.011
regulation of cellular respiration GO:0043457 4 0.011
establishment of protein localization to organelle GO:0072594 172 0.011
regulation of multi organism process GO:0043900 157 0.011
ribonucleoside triphosphate catabolic process GO:0009203 391 0.011
gamete generation GO:0007276 25 0.011
chordate embryonic development GO:0043009 34 0.011
leukocyte activation GO:0045321 164 0.011
lymphocyte activation GO:0046649 133 0.010
cellular response to oxidative stress GO:0034599 85 0.010

FEN1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.016