Homo sapiens

121 known processes

SYK

spleen tyrosine kinase

(Aliases: DKFZp313N1010,FLJ25043,FLJ37489)

SYK biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of myeloid leukocyte mediated immunity GO:0002886 4 1.000
Mouse Rat
leukocyte activation GO:0045321 164 1.000
Human Mouse Rat
menstrual cycle phase GO:0022601 2 1.000
regulation of humoral immune response mediated by circulating immunoglobulin GO:0002923 3 1.000
lymphocyte activation GO:0046649 133 1.000
Human Mouse
cell activation GO:0001775 213 0.999
Human Mouse Rat
mast cell activation involved in immune response GO:0002279 4 0.999
Mouse Rat
amine metabolic process GO:0009308 44 0.999
regulation of cellular amine metabolic process GO:0033238 11 0.999
positive regulation of cellular amine metabolic process GO:0033240 7 0.999
cell chemotaxis GO:0060326 112 0.999
regulation of acute inflammatory response to antigenic stimulus GO:0002864 1 0.999
positive regulation of cell proliferation GO:0008284 301 0.999
Mouse
regulation of cellular amino acid metabolic process GO:0006521 6 0.999
positive regulation of myeloid leukocyte mediated immunity GO:0002888 1 0.998
Mouse Rat
regulation of cell cell adhesion GO:0022407 57 0.998
Mouse
regulation of leukocyte activation GO:0002694 115 0.998
Human Mouse Rat
positive regulation of alpha beta t cell proliferation GO:0046641 5 0.998
Mouse
positive regulation of mast cell activation GO:0033005 2 0.997
Mouse Rat
positive regulation of phosphorylation GO:0042327 394 0.997
Mouse
phagocytosis recognition GO:0006910 3 0.997
negative regulation of leukocyte apoptotic process GO:2000107 16 0.996
regulation of cell activation GO:0050865 125 0.996
Human Mouse Rat
positive regulation of leukocyte activation GO:0002696 80 0.996
Human Mouse Rat
regulation of hemostasis GO:1900046 42 0.996
Mouse
myeloid leukocyte activation GO:0002274 34 0.996
Mouse Rat
mononuclear cell proliferation GO:0032943 71 0.996
Mouse
leukocyte proliferation GO:0070661 74 0.996
Mouse
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.996
Mouse
positive regulation of immunoglobulin mediated immune response GO:0002891 4 0.996
t cell receptor signaling pathway GO:0050852 21 0.995
positive regulation of protein kinase b signaling GO:0051897 42 0.995
regulation of blood coagulation GO:0030193 42 0.995
Mouse
monoamine transport GO:0015844 10 0.994
Mouse
fc receptor signaling pathway GO:0038093 2 0.994
regulation of cytokine production GO:0001817 232 0.994
Mouse
nerve development GO:0021675 4 0.994
negative regulation of homeostatic process GO:0032845 59 0.993
cellular amino acid metabolic process GO:0006520 116 0.993
immune response activating signal transduction GO:0002757 90 0.992
Mouse
negative regulation of apoptotic process GO:0043066 316 0.991
mast cell degranulation GO:0043303 4 0.991
Mouse Rat
anatomical structure formation involved in morphogenesis GO:0048646 284 0.991
Zebrafish Fly
epithelial cell migration GO:0010631 119 0.989
Zebrafish
divalent inorganic cation homeostasis GO:0072507 136 0.989
chemotaxis GO:0006935 157 0.988
positive regulation of acute inflammatory response GO:0002675 2 0.988
positive regulation of cytokine production GO:0001819 167 0.988
Mouse
tumor necrosis factor superfamily cytokine production GO:0071706 45 0.987
negative regulation of cell death GO:0060548 345 0.985
enzyme linked receptor protein signaling pathway GO:0007167 303 0.984
Mouse
leukocyte chemotaxis GO:0030595 76 0.984
immune response activating cell surface receptor signaling pathway GO:0002429 45 0.983
Mouse
t cell activation GO:0042110 99 0.983
Human Mouse
cellular ketone metabolic process GO:0042180 80 0.982
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 28 0.982
response to growth factor GO:0070848 205 0.982
regulation of epithelial cell migration GO:0010632 93 0.981
Zebrafish
regulation of immune response GO:0050776 201 0.981
Mouse Rat
activation of immune response GO:0002253 114 0.980
Mouse
positive regulation of phagocytosis GO:0050766 15 0.979
neutrophil migration GO:1990266 25 0.978
positive regulation of leukocyte degranulation GO:0043302 3 0.976
Mouse Rat
cation homeostasis GO:0055080 189 0.974
acute inflammatory response to antigenic stimulus GO:0002438 1 0.974
positive regulation of interferon gamma mediated signaling pathway GO:0060335 2 0.973
tyrosine phosphorylation of stat protein GO:0007260 33 0.973
hemopoiesis GO:0030097 180 0.972
Human Mouse
leukocyte migration GO:0050900 107 0.971
cellular homeostasis GO:0019725 196 0.970
single organismal cell cell adhesion GO:0016337 148 0.969
lymphocyte proliferation GO:0046651 70 0.969
Mouse
metal ion homeostasis GO:0055065 169 0.969
positive regulation of cell activation GO:0050867 81 0.968
Human Mouse Rat
wound healing GO:0042060 115 0.965
Mouse
positive regulation of b cell mediated immunity GO:0002714 4 0.963
phospholipid metabolic process GO:0006644 99 0.961
peptidyl tyrosine modification GO:0018212 170 0.961
regulation of leukocyte proliferation GO:0070663 67 0.960
Mouse
positive regulation of leukocyte mediated immunity GO:0002705 24 0.960
Mouse Rat
positive regulation of cellular component organization GO:0051130 376 0.958
negative regulation of myeloid cell apoptotic process GO:0033033 4 0.954
cellular response to growth factor stimulus GO:0071363 197 0.953
regulation of ion homeostasis GO:2000021 73 0.951
tyrosine phosphorylation of stat5 protein GO:0042506 13 0.950
antigen receptor mediated signaling pathway GO:0050851 38 0.948
Mouse
biological adhesion GO:0022610 331 0.946
positive regulation of lipid kinase activity GO:0090218 13 0.945
positive regulation of immune response GO:0050778 159 0.945
Mouse Rat
cation transport GO:0006812 331 0.944
Mouse
regulation of leukocyte mediated immunity GO:0002703 38 0.941
Mouse Rat
cellular amine metabolic process GO:0044106 41 0.941
nitrogen compound transport GO:0071705 191 0.936
Mouse
regulation of b cell mediated immunity GO:0002712 7 0.935
negative regulation of homotypic cell cell adhesion GO:0034111 3 0.935
regulation of cytokine biosynthetic process GO:0042035 35 0.933
Mouse
regulation of leukocyte apoptotic process GO:2000106 25 0.930
positive regulation of endothelial cell migration GO:0010595 39 0.929
Zebrafish
positive regulation of map kinase activity GO:0043406 80 0.927
Mouse
immune system development GO:0002520 195 0.926
Human Mouse
positive regulation of immune system process GO:0002684 283 0.926
Human Mouse Rat
negative regulation of programmed cell death GO:0043069 321 0.925
regulation of protein serine threonine kinase activity GO:0071900 179 0.924
Mouse
regulation of cellular ketone metabolic process GO:0010565 50 0.921
regulation of body fluid levels GO:0050878 99 0.921
Mouse
positive regulation of leukocyte proliferation GO:0070665 48 0.920
Mouse
cellular lipid metabolic process GO:0044255 303 0.917
Mouse
cytokine production GO:0001816 247 0.916
Mouse
leukocyte apoptotic process GO:0071887 31 0.914
neutrophil activation involved in immune response GO:0002283 3 0.914
Mouse
actin filament organization GO:0007015 128 0.912
positive regulation of exocytosis GO:0045921 35 0.911
Mouse Rat
positive regulation of t cell proliferation GO:0042102 33 0.909
Mouse
neuron projection development GO:0031175 106 0.908
Fly
platelet activation GO:0030168 44 0.899
Mouse
jak stat cascade GO:0007259 46 0.899
positive regulation of protein kinase activity GO:0045860 190 0.898
Mouse
positive regulation of lymphocyte activation GO:0051251 73 0.896
Human Mouse
cellular divalent inorganic cation homeostasis GO:0072503 128 0.895
b cell receptor signaling pathway GO:0050853 18 0.893
Mouse
phosphatidylinositol mediated signaling GO:0048015 55 0.891
b cell activation GO:0042113 33 0.891
Mouse
positive regulation of cytokine mediated signaling pathway GO:0001961 12 0.889
regulation of mononuclear cell proliferation GO:0032944 65 0.888
Mouse
positive regulation of locomotion GO:0040017 186 0.885
Zebrafish
cell type specific apoptotic process GO:0097285 125 0.880
regulation of cell adhesion GO:0030155 166 0.880
Mouse
serotonin secretion GO:0001820 1 0.880
Mouse
organelle localization GO:0051640 84 0.878
Mouse Rat
regulation of t cell activation GO:0050863 77 0.877
Human Mouse
calcium ion homeostasis GO:0055074 122 0.867
response to wounding GO:0009611 168 0.866
Mouse
regulation of lymphocyte proliferation GO:0050670 64 0.864
Mouse
calcium mediated signaling GO:0019722 44 0.864
Mouse
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.864
regulation of intracellular transport GO:0032386 195 0.862
Mouse Rat
cellular ion homeostasis GO:0006873 168 0.859
regulation of cell migration GO:0030334 289 0.857
Zebrafish
vesicle mediated transport GO:0016192 371 0.854
Mouse Rat Fly
t cell selection GO:0045058 4 0.854
Human Mouse
regulation of sequestering of calcium ion GO:0051282 41 0.851
regulation of immunoglobulin mediated immune response GO:0002889 7 0.851
myeloid leukocyte migration GO:0097529 62 0.843
actin filament bundle organization GO:0061572 54 0.840
regulation of response to external stimulus GO:0032101 222 0.835
Mouse
maintenance of location GO:0051235 112 0.827
positive regulation of lymphocyte proliferation GO:0050671 46 0.825
Mouse
taxis GO:0042330 157 0.820
cell projection organization GO:0030030 252 0.815
Fly
mast cell activation GO:0045576 6 0.813
Mouse Rat
regulation of mast cell activation involved in immune response GO:0033006 3 0.813
Mouse Rat
positive regulation of regulated secretory pathway GO:1903307 8 0.810
Mouse Rat
positive regulation of endocytosis GO:0045807 42 0.809
positive regulation of kinase activity GO:0033674 204 0.808
Mouse
membrane organization GO:0061024 292 0.805
oogenesis GO:0048477 2 0.803
Fly
multicellular organismal aging GO:0010259 3 0.799
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 22 0.794
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 28 0.789
positive regulation of protein phosphorylation GO:0001934 313 0.784
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.778
negative regulation of cell activation GO:0050866 33 0.775
cytokine biosynthetic process GO:0042089 37 0.773
Mouse
granulocyte migration GO:0097530 40 0.773
cellular chemical homeostasis GO:0055082 180 0.768
granulocyte chemotaxis GO:0071621 37 0.767
positive regulation of lipid metabolic process GO:0045834 50 0.766
metal ion transport GO:0030001 272 0.763
regulation of immune effector process GO:0002697 91 0.762
Mouse Rat
endoderm formation GO:0001706 33 0.759
azole transport GO:0045117 4 0.759
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.758
lipid metabolic process GO:0006629 381 0.758
Mouse
positive regulation of intracellular transport GO:0032388 104 0.757
Mouse Rat
positive regulation of interferon gamma production GO:0032729 26 0.756
b cell mediated immunity GO:0019724 10 0.755
leukocyte activation involved in immune response GO:0002366 30 0.753
Mouse Rat
regulation of lymphocyte activation GO:0051249 103 0.751
Human Mouse
regulation of anatomical structure morphogenesis GO:0022603 286 0.749
Zebrafish Fly
tyrosine phosphorylation of stat3 protein GO:0042503 20 0.749
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 44 0.749
thymic t cell selection GO:0045061 2 0.748
Human
regulation of lipid kinase activity GO:0043550 19 0.746
positive regulation of adaptive immune response GO:0002821 21 0.745
cell activation involved in immune response GO:0002263 30 0.744
Mouse Rat
inositol lipid mediated signaling GO:0048017 55 0.743
divalent inorganic cation transport GO:0072511 158 0.742
regulation of mast cell activation GO:0033003 5 0.733
Mouse Rat
cellular component morphogenesis GO:0032989 314 0.733
Fly
leukocyte differentiation GO:0002521 98 0.732
Human Mouse
hematopoietic or lymphoid organ development GO:0048534 186 0.730
Human Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.730
granulocyte activation GO:0036230 10 0.729
Mouse
single organism cellular localization GO:1902580 332 0.727
regulation of cell projection organization GO:0031344 107 0.725
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.722
exocytosis GO:0006887 71 0.712
Mouse Rat
positive regulation of immune effector process GO:0002699 40 0.710
Mouse Rat
endodermal cell fate commitment GO:0001711 4 0.705
regulation of phagocytosis GO:0050764 21 0.702
Mouse
cellular metal ion homeostasis GO:0006875 146 0.698
negative regulation of platelet aggregation GO:0090331 3 0.695
interferon gamma production GO:0032609 39 0.683
protein kinase b signaling GO:0043491 69 0.683
behavior GO:0007610 112 0.680
negative regulation of multicellular organismal process GO:0051241 317 0.680
organic hydroxy compound transport GO:0015850 63 0.677
Mouse
negative regulation of b cell mediated immunity GO:0002713 3 0.676
cell development GO:0048468 328 0.675
Fly
positive regulation of tyrosine phosphorylation of stat5 protein GO:0042523 11 0.673
regulation of cell motility GO:2000145 299 0.673
Zebrafish
positive regulation of transport GO:0051050 336 0.662
Mouse Rat
leukocyte mediated immunity GO:0002443 59 0.661
Mouse Rat
ameboidal type cell migration GO:0001667 135 0.659
Zebrafish
dephosphorylation GO:0016311 209 0.653
response to bacterium GO:0009617 144 0.652
Mouse
negative regulation of anoikis GO:2000811 15 0.651
response to transforming growth factor beta GO:0071559 94 0.649
inflammatory response to antigenic stimulus GO:0002437 4 0.648
immunoglobulin mediated immune response GO:0016064 10 0.645
cellular response to dna damage stimulus GO:0006974 379 0.637
positive regulation of t cell activation GO:0050870 54 0.634
Human Mouse
response to other organism GO:0051707 261 0.633
Mouse
regulation of adaptive immune response GO:0002819 33 0.632
peptidyl tyrosine dephosphorylation GO:0035335 36 0.632
mast cell mediated immunity GO:0002448 5 0.626
Mouse Rat
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.621
Mouse
regulation of homeostatic process GO:0032844 121 0.620
Mouse
response to lipid GO:0033993 206 0.619
positive regulation of tumor necrosis factor production GO:0032760 21 0.610
negative regulation of humoral immune response GO:0002921 7 0.608
positive regulation of jak stat cascade GO:0046427 35 0.607
peptidyl serine phosphorylation GO:0018105 101 0.601
Mouse
regulation of calcium ion transport GO:0051924 79 0.595
antigen processing and presentation of exogenous peptide antigen GO:0002478 4 0.594
cellular response to oxygen containing compound GO:1901701 276 0.592
ion homeostasis GO:0050801 230 0.589
regulation of apoptotic signaling pathway GO:2001233 175 0.583
regulation of wound healing GO:0061041 56 0.577
Mouse
actin cytoskeleton organization GO:0030036 207 0.577
regulation of interferon gamma production GO:0032649 36 0.575
positive regulation of secretion by cell GO:1903532 108 0.574
Mouse Rat
regulation of cellular component movement GO:0051270 334 0.569
Zebrafish
innate immune response GO:0045087 178 0.564
Mouse
positive regulation of calcium mediated signaling GO:0050850 10 0.563
Mouse
cellular response to endogenous stimulus GO:0071495 336 0.559
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 20 0.557
negative regulation of coagulation GO:0050819 24 0.555
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 28 0.547
regulation of cell development GO:0060284 161 0.547
positive regulation of neuron differentiation GO:0045666 40 0.544
hemostasis GO:0007599 76 0.537
Mouse
anoikis GO:0043276 22 0.537
antigen processing and presentation of peptide antigen via mhc class ii GO:0002495 11 0.534
cellular response to lipid GO:0071396 127 0.531
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 8 0.529
phagocytosis GO:0006909 42 0.522
Mouse Fly
negative regulation of phosphate metabolic process GO:0045936 267 0.522
stress fiber assembly GO:0043149 40 0.519
regulation of podosome assembly GO:0071801 5 0.518
apoptotic signaling pathway GO:0097190 268 0.517
myeloid leukocyte mediated immunity GO:0002444 10 0.515
Mouse Rat
regulation of neuron differentiation GO:0045664 70 0.513
response to organic cyclic compound GO:0014070 204 0.512
tumor necrosis factor production GO:0032640 43 0.511
female gamete generation GO:0007292 2 0.506
Fly
negative regulation of blood coagulation GO:0030195 22 0.505
endodermal cell fate specification GO:0001714 4 0.504
regulation of mast cell degranulation GO:0043304 3 0.503
Mouse Rat
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.502
Mouse
cytokine metabolic process GO:0042107 38 0.496
Mouse
regulation of neutrophil apoptotic process GO:0033029 1 0.494
actin filament based process GO:0030029 224 0.488
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.488
myeloid cell activation involved in immune response GO:0002275 10 0.485
Mouse Rat
regulation of tyrosine phosphorylation of stat protein GO:0042509 30 0.484
coagulation GO:0050817 78 0.478
Mouse
immune effector process GO:0002252 159 0.477
Mouse Rat
negative regulation of adaptive immune response GO:0002820 9 0.471
regulation of cytokine mediated signaling pathway GO:0001959 41 0.468
adaptive immune response GO:0002250 49 0.467
neuron projection morphogenesis GO:0048812 50 0.464
Fly
regulation of b cell proliferation GO:0030888 18 0.459
release of sequestered calcium ion into cytosol GO:0051209 41 0.456
production of molecular mediator of immune response GO:0002440 37 0.454
dna replication GO:0006260 116 0.450
homeostasis of number of cells GO:0048872 40 0.449
positive regulation of developmental process GO:0051094 314 0.444
Human Zebrafish Mouse
cytoplasmic transport GO:0016482 379 0.443
negative regulation of protein homooligomerization GO:0032463 4 0.442
cellular calcium ion homeostasis GO:0006874 117 0.439
regulation of defense response GO:0031347 154 0.431
endocytosis GO:0006897 159 0.428
Mouse Fly
neutrophil apoptotic process GO:0001781 2 0.425
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.421
negative regulation of response to wounding GO:1903035 47 0.418
integrin mediated signaling pathway GO:0007229 32 0.417
Mouse
antigen processing and presentation of peptide antigen GO:0048002 18 0.414
neuron development GO:0048666 113 0.411
Fly
chemical homeostasis GO:0048878 306 0.411
regulation of protein localization GO:0032880 296 0.407
Mouse
negative regulation of protein phosphorylation GO:0001933 140 0.406
regulation of locomotion GO:0040012 329 0.405
Zebrafish
regulation of mitotic cell cycle GO:0007346 189 0.405
negative regulation of wound healing GO:0061045 25 0.404
neuromuscular junction development GO:0007528 3 0.403
positive regulation of cellular component movement GO:0051272 181 0.398
Zebrafish
tissue migration GO:0090130 119 0.396
Zebrafish
positive regulation of inflammatory response GO:0050729 10 0.395
response to biotic stimulus GO:0009607 276 0.395
Mouse
regulation of alpha beta t cell activation GO:0046634 13 0.394
Mouse
regulation of lipid metabolic process GO:0019216 96 0.392
negative regulation of phagocytosis GO:0050765 4 0.391
startle response GO:0001964 3 0.390
negative regulation of cellular amine metabolic process GO:0033239 3 0.390
aging GO:0007568 66 0.387
regulation of cell differentiation GO:0045595 393 0.384
Human Mouse
positive regulation of response to external stimulus GO:0032103 88 0.383
lipid biosynthetic process GO:0008610 177 0.382
Mouse
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.381
negative regulation of transport GO:0051051 176 0.381
positive regulation of epithelial cell migration GO:0010634 55 0.379
Zebrafish
regulation of actin cytoskeleton organization GO:0032956 116 0.376
regulation of protein kinase b signaling GO:0051896 61 0.374
positive regulation of neuron projection development GO:0010976 34 0.368
regulation of transferase activity GO:0051338 355 0.367
Mouse
epithelium migration GO:0090132 119 0.367
Zebrafish
regulation of mitochondrial membrane potential GO:0051881 23 0.364
b cell proliferation GO:0042100 22 0.361
cytokine mediated signaling pathway GO:0019221 109 0.361
regulation of reactive oxygen species metabolic process GO:2000377 41 0.359
Mouse
salivary gland morphogenesis GO:0007435 4 0.358
regulation of acute inflammatory response GO:0002673 13 0.353
regulation of cell morphogenesis GO:0022604 153 0.353
Fly
neutrophil chemotaxis GO:0030593 24 0.353
formation of primary germ layer GO:0001704 42 0.351
cytosolic calcium ion homeostasis GO:0051480 89 0.351
regulation of actin filament based process GO:0032970 141 0.348
humoral immune response GO:0006959 49 0.347
secretion GO:0046903 254 0.347
Mouse Rat
establishment of cell polarity GO:0030010 22 0.346
antigen processing and presentation of exogenous antigen GO:0019884 4 0.345
t cell proliferation GO:0042098 45 0.340
Mouse
regulation of release of sequestered calcium ion into cytosol GO:0051279 27 0.337
cranial nerve development GO:0021545 4 0.331
intrinsic apoptotic signaling pathway GO:0097193 127 0.330
regulation of coagulation GO:0050818 44 0.329
Mouse
associative learning GO:0008306 1 0.328
protein autophosphorylation GO:0046777 123 0.327
Mouse Rat
negative regulation of phosphorus metabolic process GO:0010563 267 0.325
neurological system process GO:0050877 163 0.323
immune response regulating signaling pathway GO:0002764 97 0.323
Mouse
peptide transport GO:0015833 74 0.321
protein localization to membrane GO:0072657 160 0.317
second messenger mediated signaling GO:0019932 78 0.316
Mouse
neuron differentiation GO:0030182 138 0.316
Fly
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.316
negative regulation of protein oligomerization GO:0032460 8 0.315
defense response GO:0006952 315 0.315
Mouse
zinc ion homeostasis GO:0055069 12 0.315
regulation of response to wounding GO:1903034 101 0.313
Mouse
epithelial cell cell adhesion GO:0090136 7 0.313
t cell differentiation GO:0030217 29 0.307
Human Mouse
response to acid chemical GO:0001101 66 0.306
endodermal cell differentiation GO:0035987 31 0.306
regulation of b cell activation GO:0050864 24 0.306
Mouse
immune response GO:0006955 307 0.303
Human Mouse Rat
regulation of jak stat cascade GO:0046425 44 0.300
regulation of lymphocyte mediated immunity GO:0002706 33 0.300
positive regulation of defense response GO:0031349 87 0.299
negative regulation of mitochondrial depolarization GO:0051902 2 0.296
cellular cation homeostasis GO:0030003 163 0.296
cytosolic calcium ion transport GO:0060401 48 0.295
myeloid cell homeostasis GO:0002262 34 0.292
regulation of receptor mediated endocytosis GO:0048259 32 0.288
positive regulation of mononuclear cell proliferation GO:0032946 47 0.284
Mouse
antigen processing and presentation of peptide antigen via mhc class i GO:0002474 6 0.284
negative regulation of platelet activation GO:0010544 7 0.283
regulation of map kinase activity GO:0043405 108 0.283
Mouse
caveolin mediated endocytosis GO:0072584 4 0.281
negative regulation of sequestering of calcium ion GO:0051283 41 0.281
establishment of spindle orientation GO:0051294 9 0.281
negative regulation of intracellular signal transduction GO:1902532 183 0.278
regulation of vesicle mediated transport GO:0060627 130 0.275
Mouse Rat
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.275
phosphatidylinositol 3 kinase signaling GO:0014065 48 0.274
positive regulation of cytokine biosynthetic process GO:0042108 25 0.269
Mouse
peptidyl threonine phosphorylation GO:0018107 41 0.268
single organism cell adhesion GO:0098602 179 0.261
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 19 0.260
cellular response to biotic stimulus GO:0071216 71 0.259
Mouse
mapk cascade GO:0000165 288 0.258
Mouse Fly
sequestering of calcium ion GO:0051208 17 0.255
defense response to bacterium GO:0042742 63 0.251
Mouse
cell part morphogenesis GO:0032990 137 0.250
Fly
regulation of inflammatory response to antigenic stimulus GO:0002861 2 0.250
regulation of tyrosine phosphorylation of stat5 protein GO:0042522 12 0.250
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.247
negative regulation of acute inflammatory response GO:0002674 3 0.244
homotypic cell cell adhesion GO:0034109 47 0.244
Mouse
cell morphogenesis involved in differentiation GO:0000904 144 0.243
mitotic cell cycle process GO:1903047 286 0.241
positive regulation of mapk cascade GO:0043410 190 0.238
Mouse
microtubule based process GO:0007017 210 0.238
regulation of establishment of protein localization GO:0070201 242 0.238
Mouse
humoral immune response mediated by circulating immunoglobulin GO:0002455 5 0.237
response to retinoic acid GO:0032526 33 0.236
system process GO:0003008 349 0.235
negative regulation of kinase activity GO:0033673 106 0.235
gland development GO:0048732 48 0.234
regulation of antigen receptor mediated signaling pathway GO:0050854 10 0.231
negative regulation of map kinase activity GO:0043407 27 0.231
positive regulation of cell development GO:0010720 92 0.231
mitotic cell cycle GO:0000278 326 0.230
positive regulation of cell motility GO:2000147 177 0.228
Zebrafish
negative regulation of humoral immune response mediated by circulating immunoglobulin GO:0002924 3 0.227
regulation of organelle assembly GO:1902115 40 0.224
response to external biotic stimulus GO:0043207 261 0.222
Mouse
calcium ion transport GO:0006816 147 0.222
positive regulation of peptidyl serine phosphorylation GO:0033138 42 0.219
regulation of endocytosis GO:0030100 72 0.213
Mouse
regulation of peptidase activity GO:0052547 180 0.212
post embryonic development GO:0009791 2 0.211
cellular macromolecular complex assembly GO:0034622 324 0.210
regulation of secretion by cell GO:1903530 177 0.208
Mouse Rat
divalent metal ion transport GO:0070838 152 0.207
response to estrogen GO:0043627 47 0.206
regulation of kinase activity GO:0043549 314 0.205
Mouse
inflammatory response GO:0006954 79 0.204
Mouse
regulation of b cell receptor signaling pathway GO:0050855 4 0.200
negative regulation of protein metabolic process GO:0051248 391 0.200
response to molecule of bacterial origin GO:0002237 82 0.197
leukocyte homeostasis GO:0001776 7 0.196
oocyte differentiation GO:0009994 2 0.196
t cell differentiation in thymus GO:0033077 4 0.195
Human
cell cell junction organization GO:0045216 69 0.195
regulation of ion transport GO:0043269 189 0.192
Mouse
activation of cysteine type endopeptidase activity GO:0097202 57 0.189
growth GO:0040007 202 0.186
Fly
positive regulation of response to interferon gamma GO:0060332 2 0.183
cytokine secretion GO:0050663 64 0.182
Mouse
negative regulation of protein complex assembly GO:0031333 43 0.182
regulation of insulin secretion GO:0050796 33 0.181
regulation of nervous system development GO:0051960 88 0.181
reactive oxygen species metabolic process GO:0072593 75 0.178
Mouse
negative regulation of immunoglobulin mediated immune response GO:0002890 3 0.178
regulation of protein complex assembly GO:0043254 147 0.173
glycerophospholipid metabolic process GO:0006650 84 0.172
synapse assembly GO:0007416 8 0.172
actin filament bundle assembly GO:0051017 54 0.170
protein localization to plasma membrane GO:0072659 93 0.169
peptidyl serine modification GO:0018209 106 0.168
Mouse
regulation of peptide hormone secretion GO:0090276 41 0.168
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.168
regulation of mapk cascade GO:0043408 262 0.168
Mouse
regulation of hormone levels GO:0010817 125 0.167
cellular response to acid chemical GO:0071229 44 0.166
positive regulation of dna metabolic process GO:0051054 73 0.165
endocytic recycling GO:0032456 12 0.164
positive regulation of alpha beta t cell activation GO:0046635 10 0.163
Mouse
generation of neurons GO:0048699 152 0.162
Fly
lymphocyte mediated immunity GO:0002449 48 0.162
zymogen activation GO:0031638 70 0.159
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.158
Mouse
positive regulation of proteolysis GO:0045862 142 0.158
defense response to other organism GO:0098542 129 0.157
Mouse
negative regulation of protein processing GO:0010955 142 0.157
determination of adult lifespan GO:0008340 2 0.155
cell projection assembly GO:0030031 126 0.155
regulated secretory pathway GO:0045055 20 0.155
Mouse Rat
transition metal ion homeostasis GO:0055076 31 0.154
cell adhesion GO:0007155 325 0.153
positive regulation of cell projection organization GO:0031346 64 0.153
muscle structure development GO:0061061 98 0.153
cell morphogenesis GO:0000902 296 0.152
Fly
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.152
Mouse
regulation of response to cytokine stimulus GO:0060759 46 0.152
negative regulation of b cell proliferation GO:0030889 5 0.149
negative regulation of smoothened signaling pathway GO:0045879 3 0.148
extrinsic apoptotic signaling pathway GO:0097191 119 0.148
neutrophil activation GO:0042119 9 0.146
Mouse
positive regulation of lymphocyte mediated immunity GO:0002708 23 0.146
negative regulation of immune effector process GO:0002698 38 0.146
leukocyte degranulation GO:0043299 11 0.145
Mouse Rat
positive regulation of myeloid leukocyte cytokine production involved in immune response GO:0061081 1 0.143

SYK disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.994
disease by infectious agent DOID:0050117 34 0.911
hematopoietic system disease DOID:74 100 0.816
parasitic infectious disease DOID:1398 16 0.689
primary immunodeficiency disease DOID:612 36 0.364
b cell deficiency DOID:2115 17 0.364
blood protein disease DOID:620 16 0.360
parasitic protozoa infectious disease DOID:2789 16 0.296
malaria DOID:12365 16 0.249