IMP

Process View

Homo sapiens

22 genes annotated in human

Multi-species View

negative regulation of blood coagulation

GO:0030195

Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of blood coagulation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of blood coagulation" (in gray)

Name	Description	Probability	Func Analog Organism
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	1.000
VEGFA	vascular endothelial growth factor A	0.999	Human
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.999	Human
C1QA	complement component 1, q subcomponent, A chain	0.998	Human
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.994
NRP1	neuropilin 1	0.980
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.956
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.942	Human
ALB	albumin	0.918
PLAU	plasminogen activator, urokinase	0.869	Human Mouse
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.862
FGA	fibrinogen alpha chain	0.850
C1QC	complement component 1, q subcomponent, C chain	0.846	Human
C1R	complement component 1, r subcomponent	0.717
HP	haptoglobin	0.704
CDH5	cadherin 5, type 2 (vascular endothelium)	0.640
PGF	placental growth factor	0.629	Human
PLG	plasminogen	0.608
S100A10	S100 calcium binding protein A10	0.605
PDGFA	platelet-derived growth factor alpha polypeptide	0.583
EGFR	epidermal growth factor receptor	0.576
KNG1	kininogen 1	0.572
PCYT2	phosphate cytidylyltransferase 2, ethanolamine	0.543
C1QB	complement component 1, q subcomponent, B chain	0.534	Human
SYK	spleen tyrosine kinase	0.505
PLAT	plasminogen activator, tissue	0.498	Human
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.416
FGB	fibrinogen beta chain	0.410
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.372
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.366	Human
PDGFC	platelet derived growth factor C	0.348
APOC1	apolipoprotein C-I	0.307
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.277
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.250
A2M	alpha-2-macroglobulin	0.247
PLCG1	phospholipase C, gamma 1	0.238
NCF1	neutrophil cytosolic factor 1	0.214
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.173
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.169
F11	coagulation factor XI	0.169
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.158
HRG	histidine-rich glycoprotein	0.151	Mouse
CDCP1	CUB domain containing protein 1	0.143
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.142
AXL	AXL receptor tyrosine kinase	0.139
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.135
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.127
APOA2	apolipoprotein A-II	0.126
PLAUR	plasminogen activator, urokinase receptor	0.121
F2	coagulation factor II (thrombin)	0.112
C3	complement component 3	0.107
MAPT	microtubule-associated protein tau	0.105
HSPG2	heparan sulfate proteoglycan 2	0.102
LRP1	low density lipoprotein receptor-related protein 1	0.100
APOC3	apolipoprotein C-III	0.092
COL4A1	collagen, type IV, alpha 1	0.090
PTPRB	protein tyrosine phosphatase, receptor type, B	0.088
LDLR	low density lipoprotein receptor	0.085
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.084
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.080	Human
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.076
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.074
MASP2	mannan-binding lectin serine peptidase 2	0.072
C8A	complement component 8, alpha polypeptide	0.069
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.067
COL6A1	collagen, type VI, alpha 1	0.067
AHSG	alpha-2-HS-glycoprotein	0.067
LAT	linker for activation of T cells	0.067
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.066
FN1	fibronectin 1	0.063
APOB	apolipoprotein B (including Ag(x) antigen)	0.056
MSN	moesin	0.053
SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	0.052
ANXA1	annexin A1	0.051
BGN	biglycan	0.049
F10	coagulation factor X	0.049	Human
FGFR1	fibroblast growth factor receptor 1	0.047
C8B	complement component 8, beta polypeptide	0.047
STAB1	stabilin 1	0.046
VWF	von Willebrand factor	0.046
SOS1	son of sevenless homolog 1 (Drosophila)	0.045
LPA	lipoprotein, Lp(a)	0.044	Human
TEK	TEK tyrosine kinase, endothelial	0.044
VTN	vitronectin	0.042
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.041
LCAT	lecithin-cholesterol acyltransferase	0.041
S100A11	S100 calcium binding protein A11	0.037
SERPINA5	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	0.035
ENG	endoglin	0.035
SLC38A3	solute carrier family 38, member 3	0.034
TGFBI	transforming growth factor, beta-induced, 68kDa	0.034
PRKCB	protein kinase C, beta	0.033
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.033
KITLG	KIT ligand	0.033
PLTP	phospholipid transfer protein	0.032
GAB1	GRB2-associated binding protein 1	0.031
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.031
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.030
F7	coagulation factor VII (serum prothrombin conversion accelerator)	0.030	Human
ITIH1	inter-alpha (globulin) inhibitor H1	0.030
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.028
PTEN	phosphatase and tensin homolog	0.028
NNMT	nicotinamide N-methyltransferase	0.028
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.028
DCN	decorin	0.028
C6	complement component 6	0.027
COL5A1	collagen, type V, alpha 1	0.027
APOC4	apolipoprotein C-IV	0.027
COL1A1	collagen, type I, alpha 1	0.027
APOA1	apolipoprotein A-I	0.026	Human
F3	coagulation factor III (thromboplastin, tissue factor)	0.025
CD63	CD63 molecule	0.025
CYBA	cytochrome b-245, alpha polypeptide	0.025
GPLD1	glycosylphosphatidylinositol specific phospholipase D1	0.025
ASGR2	asialoglycoprotein receptor 2	0.024
VEGFC	vascular endothelial growth factor C	0.024	Human
SLC10A1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.024
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.024
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.023	Human
APOC2	apolipoprotein C-II	0.023
ADH6	alcohol dehydrogenase 6 (class V)	0.023
CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	0.022
FGG	fibrinogen gamma chain	0.022
TUBB6	tubulin, beta 6	0.022
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.022
CHRD	chordin	0.021
LGALS1	lectin, galactoside-binding, soluble, 1	0.021
ORM1	orosomucoid 1	0.021
PRODH2	proline dehydrogenase (oxidase) 2	0.021
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.021
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.020
CAV1	caveolin 1, caveolae protein, 22kDa	0.020
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.020
MARCO	macrophage receptor with collagenous structure	0.019
RARRES2	retinoic acid receptor responder (tazarotene induced) 2	0.019
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.019
OSMR	oncostatin M receptor	0.019
HPN	hepsin	0.018
SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	0.018
STC1	stanniocalcin 1	0.018
ARRDC3	arrestin domain containing 3	0.018
WNT2	wingless-type MMTV integration site family member 2	0.018
SPP2	secreted phosphoprotein 2, 24kDa	0.018
DPYS	dihydropyrimidinase	0.018
C1S	complement component 1, s subcomponent	0.018
LIPC	lipase, hepatic	0.018
SERPIND1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	0.018
SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	0.018
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.018	Human
C2	complement component 2	0.018
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.017
HPX	hemopexin	0.017
AFM	afamin	0.017
ANGPTL3	angiopoietin-like 3	0.017
ITIH2	inter-alpha (globulin) inhibitor H2	0.017
CPN1	carboxypeptidase N, polypeptide 1	0.017
NCF4	neutrophil cytosolic factor 4, 40kDa	0.017
VIM	vimentin	0.016
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.016
ITIH3	inter-alpha (globulin) inhibitor H3	0.016
SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.016
ROBO4	roundabout homolog 4, magic roundabout (Drosophila)	0.016
SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	0.016	Human
TRIM9	tripartite motif containing 9	0.016
CLEC4G	C-type lectin domain family 4, member G	0.016
COL2A1	collagen, type II, alpha 1	0.016
SPHK1	sphingosine kinase 1	0.016
AKR1D1	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	0.016
GP1BA	glycoprotein Ib (platelet), alpha polypeptide	0.015
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.015
CPN2	carboxypeptidase N, polypeptide 2	0.015
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.015
F13A1	coagulation factor XIII, A1 polypeptide	0.015
APCS	amyloid P component, serum	0.015
TGFB1	transforming growth factor, beta 1	0.015
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.015
GAB2	GRB2-associated binding protein 2	0.015
MYH9	myosin, heavy chain 9, non-muscle	0.015
SERPING1	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	0.015	Human
HGFAC	HGF activator	0.015	Human
ARG1	arginase, liver	0.015
RDH16	retinol dehydrogenase 16 (all-trans)	0.014
F13B	coagulation factor XIII, B polypeptide	0.014
ITIH4	inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)	0.014
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.014
TMSB4X	thymosin beta 4, X-linked	0.014
PROC	protein C (inactivator of coagulation factors Va and VIIIa)	0.014	Human Mouse
CYP2A7	cytochrome P450, family 2, subfamily A, polypeptide 7	0.014
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.014
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.014
FETUB	fetuin B	0.013
EMP3	epithelial membrane protein 3	0.013
OLFML2B	olfactomedin-like 2B	0.013
PKLR	pyruvate kinase, liver and RBC	0.013
CAV2	caveolin 2	0.013
MRC1	mannose receptor, C type 1	0.013
IGFALS	insulin-like growth factor binding protein, acid labile subunit	0.013
AGXT	alanine-glyoxylate aminotransferase	0.013
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.013
VSIG4	V-set and immunoglobulin domain containing 4	0.013
UGT2B15	UDP glucuronosyltransferase 2 family, polypeptide B15	0.013
F9	coagulation factor IX	0.013	Human
NRP2	neuropilin 2	0.012
TIMP3	TIMP metallopeptidase inhibitor 3	0.012
CPB2	carboxypeptidase B2 (plasma)	0.012	Rat
STAB2	stabilin 2	0.012
PON3	paraoxonase 3	0.012
TIMP1	TIMP metallopeptidase inhibitor 1	0.012
CD93	CD93 molecule	0.012
IGFBP5	insulin-like growth factor binding protein 5	0.012
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.012
TMEM176B	transmembrane protein 176B	0.012
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.012
INHBA	inhibin, beta A	0.012
EMP1	epithelial membrane protein 1	0.012
AKR1C4	aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)	0.012
TGFB3	transforming growth factor, beta 3	0.012
CFHR4	complement factor H-related 4	0.012
ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)	0.011
ANGPTL2	angiopoietin-like 2	0.011
TPM4	tropomyosin 4	0.011
CRP	C-reactive protein, pentraxin-related	0.011
CCL2	chemokine (C-C motif) ligand 2	0.011
IL32	interleukin 32	0.011
CFHR2	complement factor H-related 2	0.011
FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)	0.011
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.011
AMBP	alpha-1-microglobulin/bikunin precursor	0.011
HMGCL	3-hydroxymethyl-3-methylglutaryl-CoA lyase	0.011
COL1A2	collagen, type I, alpha 2	0.011
KLKB1	kallikrein B, plasma (Fletcher factor) 1	0.011
KRT5	keratin 5	0.011
IGFBP1	insulin-like growth factor binding protein 1	0.011
CSF1	colony stimulating factor 1 (macrophage)	0.011
TMEM176A	transmembrane protein 176A	0.010
SRPX	sushi-repeat containing protein, X-linked	0.010
NID1	nidogen 1	0.010
AMT	aminomethyltransferase	0.010
APOF	apolipoprotein F	0.010
MBL2	mannose-binding lectin (protein C) 2, soluble	0.010
CRHBP	corticotropin releasing hormone binding protein	0.010
CD248	CD248 molecule, endosialin	0.010
CFH	complement factor H	0.010
CA5A	carbonic anhydrase VA, mitochondrial	0.010
IGFBP7	insulin-like growth factor binding protein 7	0.010
DAO	D-amino-acid oxidase	0.010