Homo sapiens

45 known processes

MAP3K3

mitogen-activated protein kinase kinase kinase 3

(Aliases: MAPKKK3,MEKK3)

MAP3K3 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of mapk cascade GO:0043408 262 0.995
Mouse
apoptotic signaling pathway GO:0097190 268 0.994
positive regulation of kinase activity GO:0033674 204 0.988
positive regulation of protein kinase activity GO:0045860 190 0.986
response to cytokine GO:0034097 232 0.986
activation of protein kinase activity GO:0032147 90 0.980
positive regulation of protein phosphorylation GO:0001934 313 0.980
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.980
positive regulation of mapk cascade GO:0043410 190 0.979
Mouse
positive regulation of transferase activity GO:0051347 227 0.971
positive regulation of cell death GO:0010942 263 0.966
regulation of cell migration GO:0030334 289 0.965
regulation of kinase activity GO:0043549 314 0.937
positive regulation of phosphorylation GO:0042327 394 0.937
Mouse
negative regulation of transport GO:0051051 176 0.935
regulation of ion transmembrane transport GO:0034765 132 0.934
protein autophosphorylation GO:0046777 123 0.931
protein processing GO:0016485 226 0.926
erk5 cascade GO:0070375 1 0.925
regulation of protein kinase activity GO:0045859 289 0.923
regulation of apoptotic signaling pathway GO:2001233 175 0.909
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.889
stem cell division GO:0017145 2 0.877
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.876
cellular response to cytokine stimulus GO:0071345 181 0.873
asymmetric stem cell division GO:0098722 1 0.871
mapk cascade GO:0000165 288 0.864
Mouse
i kappab kinase nf kappab signaling GO:0007249 166 0.861
regulation of protein serine threonine kinase activity GO:0071900 179 0.855
negative regulation of apoptotic process GO:0043066 316 0.853
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.851
intracellular protein transport GO:0006886 270 0.832
negative regulation of apoptotic signaling pathway GO:2001234 97 0.827
neuroblast division GO:0055057 1 0.824
regulation of proteolysis GO:0030162 293 0.810
regulation of locomotion GO:0040012 329 0.785
regulation of protein targeting GO:1903533 91 0.773
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.768
positive regulation of map kinase activity GO:0043406 80 0.762
interleukin 8 production GO:0032637 51 0.758
activation of mapk activity GO:0000187 45 0.756
signal transduction by phosphorylation GO:0023014 297 0.735
Mouse
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.735
peptidyl serine phosphorylation GO:0018105 101 0.731
cell fate determination GO:0001709 3 0.723
asymmetric neuroblast division GO:0055059 1 0.712
positive regulation of apoptotic process GO:0043065 246 0.712
regulation of cell motility GO:2000145 299 0.700
cation transport GO:0006812 331 0.700
negative regulation of programmed cell death GO:0043069 321 0.685
growth GO:0040007 202 0.677
endothelial cell migration GO:0043542 86 0.675
regulation of transporter activity GO:0032409 82 0.667
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.664
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 16 0.660
regulation of cysteine type endopeptidase activity GO:2000116 127 0.654
regulation of transmembrane transporter activity GO:0022898 74 0.647
negative regulation of chemokine c x c motif ligand 2 production GO:2000342 1 0.643
negative regulation of cell death GO:0060548 345 0.639
negative regulation of peptidase activity GO:0010466 91 0.639
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.635
blood vessel endothelial cell migration GO:0043534 42 0.628
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 20 0.623
activation of mapkkk activity GO:0000185 7 0.622
regulation of transferase activity GO:0051338 355 0.620
regulation of cell cell adhesion involved in gastrulation GO:0070587 6 0.619
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.608
post embryonic development GO:0009791 2 0.606
nuclear transport GO:0051169 179 0.598
protein ubiquitination GO:0016567 314 0.591
cell migration involved in sprouting angiogenesis GO:0002042 19 0.589
regulation of establishment of protein localization GO:0070201 242 0.587
transmembrane transport GO:0055085 399 0.580
regulation of protein import into nucleus GO:0042306 78 0.576
potassium ion transmembrane transport GO:0071805 60 0.555
metal ion transport GO:0030001 272 0.553
positive regulation of programmed cell death GO:0043068 249 0.550
organelle localization GO:0051640 84 0.550
cell development GO:0048468 328 0.549
protein targeting to nucleus GO:0044744 104 0.547
cytoplasmic transport GO:0016482 379 0.542
extrinsic apoptotic signaling pathway GO:0097191 119 0.542
regulation of peptidase activity GO:0052547 180 0.539
response to growth factor GO:0070848 205 0.538
regulation of protein localization GO:0032880 296 0.533
regulation of cellular component movement GO:0051270 334 0.528
regulation of endopeptidase activity GO:0052548 170 0.527
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.518
regulation of heterotypic cell cell adhesion GO:0034114 14 0.516
nucleocytoplasmic transport GO:0006913 176 0.515
cytokine production GO:0001816 247 0.514
cellular amine metabolic process GO:0044106 41 0.512
positive regulation of protein sumoylation GO:0033235 7 0.498
regulation of gastrulation GO:0010470 12 0.494
negative regulation of cellular protein metabolic process GO:0032269 353 0.482
nucleoside monophosphate metabolic process GO:0009123 191 0.477
vasculature development GO:0001944 181 0.476
Mouse
purine containing compound catabolic process GO:0072523 411 0.474
cellular amino acid metabolic process GO:0006520 116 0.471
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.471
regulation of protein transport GO:0051223 213 0.467
single organism cellular localization GO:1902580 332 0.465
sprouting angiogenesis GO:0002040 29 0.459
regulation of cell morphogenesis GO:0022604 153 0.457
ribonucleoside triphosphate metabolic process GO:0009199 412 0.445
single organism membrane organization GO:0044802 268 0.443
negative regulation of epithelial cell migration GO:0010633 38 0.441
positive regulation of vascular endothelial growth factor signaling pathway GO:1900748 3 0.437
regulation of protein sumoylation GO:0033233 13 0.435
regulation of cell migration involved in sprouting angiogenesis GO:0090049 9 0.434
protein modification by small protein conjugation GO:0032446 342 0.425
regulation of ion transmembrane transporter activity GO:0032412 72 0.419
regulation of transmembrane transport GO:0034762 139 0.418
negative regulation of protein transport GO:0051224 75 0.411
tissue migration GO:0090130 119 0.406
neuronal stem cell division GO:0036445 1 0.402
dephosphorylation GO:0016311 209 0.395
cellular response to growth factor stimulus GO:0071363 197 0.393
regulation of intracellular protein transport GO:0033157 123 0.393
negative regulation of locomotion GO:0040013 118 0.389
biological adhesion GO:0022610 331 0.386
regulation of anatomical structure morphogenesis GO:0022603 286 0.383
neuroblast proliferation GO:0007405 4 0.369
positive regulation of intracellular protein transport GO:0090316 76 0.368
negative regulation of developmental process GO:0051093 247 0.363
negative regulation of hydrolase activity GO:0051346 182 0.360
protein sumoylation GO:0016925 25 0.355
intrinsic apoptotic signaling pathway GO:0097193 127 0.352
negative regulation of multicellular organismal process GO:0051241 317 0.347
regulation of proteasomal protein catabolic process GO:0061136 87 0.340
regulation of epithelial cell migration GO:0010632 93 0.339
nucleus localization GO:0051647 1 0.338
regulation of map kinase activity GO:0043405 108 0.335
regulation of cellular ketone metabolic process GO:0010565 50 0.332
protein import into nucleus GO:0006606 104 0.331
regulation of cell differentiation GO:0045595 393 0.325
cell type specific apoptotic process GO:0097285 125 0.323
peptidyl tyrosine modification GO:0018212 170 0.322
nucleoside monophosphate catabolic process GO:0009125 159 0.319
purine nucleoside catabolic process GO:0006152 398 0.314
regulation of dephosphorylation GO:0035303 96 0.314
ion transmembrane transport GO:0034220 338 0.314
regulation of nucleocytoplasmic transport GO:0046822 98 0.309
calcium ion transport GO:0006816 147 0.305
cellular macromolecule catabolic process GO:0044265 380 0.303
regulation of ion transport GO:0043269 189 0.303
regulation of cytokine production GO:0001817 232 0.300
negative regulation of phosphatase activity GO:0010923 61 0.296
regulation of metal ion transport GO:0010959 120 0.293
regulation of growth GO:0040008 165 0.291
actin filament based process GO:0030029 224 0.287
negative regulation of protein processing GO:0010955 142 0.287
negative regulation of vasculature development GO:1901343 43 0.286
negative regulation of phosphate metabolic process GO:0045936 267 0.286
anatomical structure formation involved in morphogenesis GO:0048646 284 0.285
cell adhesion GO:0007155 325 0.284
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.281
regulation of protein maturation GO:1903317 150 0.281
regulation of phosphatase activity GO:0010921 81 0.276
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 22 0.276
negative regulation of catalytic activity GO:0043086 335 0.275
embryo development GO:0009790 123 0.272
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.263
nucleoside triphosphate metabolic process GO:0009141 422 0.259
regulation of intracellular transport GO:0032386 195 0.255
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 43 0.244
myeloid cell differentiation GO:0030099 117 0.234
inorganic cation transmembrane transport GO:0098662 194 0.234
angiogenesis GO:0001525 147 0.234
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.233
peptidyl serine modification GO:0018209 106 0.233
positive regulation of apoptotic signaling pathway GO:2001235 70 0.230
protein targeting GO:0006605 187 0.228
blood vessel development GO:0001568 172 0.225
Mouse
purine nucleotide catabolic process GO:0006195 405 0.218
epithelium migration GO:0090132 119 0.214
purine ribonucleotide catabolic process GO:0009154 404 0.214
atp metabolic process GO:0046034 176 0.213
atp catabolic process GO:0006200 157 0.213
signal transduction in absence of ligand GO:0038034 22 0.213
negative regulation of cell migration GO:0030336 102 0.209
response to abiotic stimulus GO:0009628 336 0.202
Human
regulation of protein localization to nucleus GO:1900180 85 0.202
nervous system development GO:0007399 293 0.202
regulation of actin filament polymerization GO:0030833 50 0.202
circulatory system development GO:0072359 262 0.201
Mouse
negative regulation of chemokine production GO:0032682 9 0.200
g protein coupled acetylcholine receptor signaling pathway GO:0007213 1 0.199
microtubule cytoskeleton organization GO:0000226 176 0.198
regulation of cellular protein catabolic process GO:1903362 96 0.197
purine nucleoside monophosphate metabolic process GO:0009126 186 0.197
neurological system process GO:0050877 163 0.196
negative regulation of heterotypic cell cell adhesion GO:0034115 6 0.196
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.195
negative regulation of interleukin 8 production GO:0032717 12 0.193
positive regulation of developmental process GO:0051094 314 0.193
cellular potassium ion transport GO:0071804 60 0.190
ribonucleoside monophosphate catabolic process GO:0009158 158 0.190
negative regulation of intracellular signal transduction GO:1902532 183 0.190
establishment of nucleus localization GO:0040023 1 0.188
negative regulation of dephosphorylation GO:0035305 63 0.187
nucleoside phosphate catabolic process GO:1901292 412 0.184
amine metabolic process GO:0009308 44 0.183
regulation of cytoskeleton organization GO:0051493 177 0.180
vesicle mediated transport GO:0016192 371 0.179
negative regulation of endothelial cell migration GO:0010596 29 0.179
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.174
actin filament organization GO:0007015 128 0.173
purine nucleoside monophosphate catabolic process GO:0009128 158 0.172
positive regulation of cell motility GO:2000147 177 0.171
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.169
positive regulation of cellular component organization GO:0051130 376 0.168
negative regulation of protein metabolic process GO:0051248 391 0.168
neuron projection development GO:0031175 106 0.166
tube development GO:0035295 125 0.166
regulation of meiotic cell cycle GO:0051445 4 0.164
divalent inorganic cation transport GO:0072511 158 0.163
protein localization to organelle GO:0033365 280 0.162
positive regulation of cellular amine metabolic process GO:0033240 7 0.161
multicellular organismal aging GO:0010259 3 0.161
generation of neurons GO:0048699 152 0.159
regulation of cytoplasmic transport GO:1903649 149 0.159
digestive tract development GO:0048565 75 0.158
cell division GO:0051301 168 0.155
negative regulation of blood vessel endothelial cell migration GO:0043537 16 0.154
cell activation GO:0001775 213 0.152
chemotaxis GO:0006935 157 0.150
protein localization to nucleus GO:0034504 136 0.149
actin cytoskeleton organization GO:0030036 207 0.148
protein maturation GO:0051604 233 0.148
cellular component disassembly GO:0022411 92 0.144
nucleoside triphosphate catabolic process GO:0009143 394 0.144
establishment of protein localization to organelle GO:0072594 172 0.144
negative regulation of organelle organization GO:0010639 126 0.143
regulation of blood vessel endothelial cell migration GO:0043535 30 0.143
cell morphogenesis involved in differentiation GO:0000904 144 0.142
reproductive process GO:0022414 106 0.142
ribonucleoside monophosphate metabolic process GO:0009161 187 0.141
regulation of purine nucleotide metabolic process GO:1900542 264 0.138
chemical homeostasis GO:0048878 306 0.138
peptidyl tyrosine phosphorylation GO:0018108 170 0.137
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.137
cell morphogenesis GO:0000902 296 0.136
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.135
peptidyl threonine phosphorylation GO:0018107 41 0.131
gastrulation GO:0007369 51 0.129
ribonucleoside triphosphate catabolic process GO:0009203 391 0.128
regulation of cellular component biogenesis GO:0044087 281 0.128
purine ribonucleoside catabolic process GO:0046130 398 0.127
negative regulation of angiogenesis GO:0016525 39 0.126
negative regulation of blood vessel morphogenesis GO:2000181 41 0.125
action potential GO:0001508 34 0.125
glycosyl compound catabolic process GO:1901658 413 0.125
ameboidal type cell migration GO:0001667 135 0.125
monovalent inorganic cation transport GO:0015672 128 0.124
cell projection morphogenesis GO:0048858 129 0.123
positive regulation of cell proliferation GO:0008284 301 0.121
regulation of chemokine c x c motif ligand 2 production GO:2000341 2 0.118
ras protein signal transduction GO:0007265 73 0.117
positive regulation of catabolic process GO:0009896 310 0.115
regulation of vasculature development GO:1901342 97 0.115
regulation of cell growth GO:0001558 135 0.113
positive regulation of epithelial cell proliferation GO:0050679 65 0.110
regulation of immune response GO:0050776 201 0.108
single fertilization GO:0007338 11 0.108
regulation of potassium ion transmembrane transport GO:1901379 20 0.107
actin filament bundle organization GO:0061572 54 0.107
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 1 0.106
cell projection organization GO:0030030 252 0.106
chemokine c x c motif ligand 2 production GO:0072567 3 0.105
epithelial cell migration GO:0010631 119 0.103
modification dependent protein catabolic process GO:0019941 209 0.103
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.103
regulation of membrane potential GO:0042391 95 0.103
regulation of stress activated mapk cascade GO:0032872 84 0.103
Mouse
blood vessel morphogenesis GO:0048514 162 0.102
positive regulation of locomotion GO:0040017 186 0.102
regulation of cell development GO:0060284 161 0.100
regulation of angiogenesis GO:0045765 92 0.100
neuromuscular junction development GO:0007528 3 0.099
regulation of transcription factor import into nucleus GO:0042990 39 0.098
cation transmembrane transport GO:0098655 238 0.098
regulation of protein ubiquitination GO:0031396 95 0.098
muscle contraction GO:0006936 73 0.096
cellular macromolecular complex assembly GO:0034622 324 0.096
chemokine production GO:0032602 32 0.096
positive regulation of intracellular transport GO:0032388 104 0.095
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.094
negative regulation of cellular component movement GO:0051271 106 0.092
g protein coupled receptor signaling pathway GO:0007186 207 0.092
protein oligomerization GO:0051259 173 0.092
negative regulation of signal transduction in absence of ligand GO:1901099 16 0.091
nucleotide catabolic process GO:0009166 408 0.091
protein catabolic process GO:0030163 325 0.090
negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 6 0.087
regulation of t cell activation GO:0050863 77 0.087
positive regulation of ion transmembrane transport GO:0034767 40 0.085
negative regulation of proteolysis GO:0045861 132 0.085
regulation of interleukin 8 production GO:0032677 49 0.084
negative regulation of cytoskeleton organization GO:0051494 45 0.084
negative regulation of protein maturation GO:1903318 142 0.083
regulation of myeloid cell differentiation GO:0045637 81 0.083
cellular protein catabolic process GO:0044257 261 0.083
negative regulation of phosphorus metabolic process GO:0010563 267 0.083
protein dephosphorylation GO:0006470 81 0.083
cellular protein complex assembly GO:0043623 188 0.082
cell part morphogenesis GO:0032990 137 0.081
regulation of cellular response to stress GO:0080135 244 0.081
Mouse
somatic stem cell division GO:0048103 1 0.081
regulation of vascular endothelial growth factor signaling pathway GO:1900746 6 0.080
locomotory behavior GO:0007626 1 0.080
determination of adult lifespan GO:0008340 2 0.080
establishment of cell polarity GO:0030010 22 0.079
developmental process involved in reproduction GO:0003006 66 0.079
sensory perception GO:0007600 103 0.078
regulation of protein stability GO:0031647 87 0.077
reproductive system development GO:0061458 56 0.076
positive regulation of ion transport GO:0043270 87 0.076
cellular chemical homeostasis GO:0055082 180 0.075
hemopoiesis GO:0030097 180 0.075
purine nucleoside triphosphate metabolic process GO:0009144 412 0.075
leukocyte differentiation GO:0002521 98 0.074
response to hypoxia GO:0001666 96 0.073
negative regulation of ion transport GO:0043271 39 0.073
taxis GO:0042330 157 0.072
negative regulation of protein modification process GO:0031400 200 0.071
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.069
regulation of cytokine biosynthetic process GO:0042035 35 0.069
regulation of nucleotide metabolic process GO:0006140 269 0.067
negative regulation of cytokine production GO:0001818 82 0.067
regulation of small gtpase mediated signal transduction GO:0051056 156 0.066
associative learning GO:0008306 1 0.066
tor signaling GO:0031929 39 0.064
positive regulation of protein transport GO:0051222 135 0.064
nuclear migration GO:0007097 1 0.064
negative regulation of cellular component organization GO:0051129 235 0.064
adenylate cyclase inhibiting g protein coupled receptor signaling pathway GO:0007193 22 0.063
mitotic cell cycle process GO:1903047 286 0.063
calcium ion homeostasis GO:0055074 122 0.063
organic acid catabolic process GO:0016054 71 0.063
neuron differentiation GO:0030182 138 0.062
heterotypic cell cell adhesion GO:0034113 28 0.062
jnk cascade GO:0007254 80 0.061
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 2 0.061
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.061
regulation of cell cycle GO:0051726 393 0.060
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.060
protein complex disassembly GO:0043241 52 0.060
modification dependent macromolecule catabolic process GO:0043632 212 0.060
lymphocyte proliferation GO:0046651 70 0.059
golgi vesicle transport GO:0048193 80 0.059
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.059
neural tube formation GO:0001841 3 0.058
protein depolymerization GO:0051261 30 0.058
regulation of nervous system development GO:0051960 88 0.058
digestive tract morphogenesis GO:0048546 56 0.058
regulation of cellular amino acid metabolic process GO:0006521 6 0.058
reactive oxygen species metabolic process GO:0072593 75 0.057
gonad development GO:0008406 34 0.057
purine ribonucleoside metabolic process GO:0046128 437 0.057
protein localization to membrane GO:0072657 160 0.057
purine nucleoside triphosphate catabolic process GO:0009146 392 0.056
response to oxygen containing compound GO:1901700 369 0.056
regulation of actin cytoskeleton organization GO:0032956 116 0.056
positive regulation of cell migration GO:0030335 172 0.056
t cell apoptotic process GO:0070231 12 0.056
apoptotic mitochondrial changes GO:0008637 57 0.055
negative regulation of cell cell adhesion GO:0022408 27 0.055
epithelial cell proliferation GO:0050673 128 0.055
regulation of epithelial cell proliferation GO:0050678 113 0.055
positive regulation of transport GO:0051050 336 0.054
peptidyl lysine modification GO:0018205 144 0.054
negative regulation of transmembrane transport GO:0034763 29 0.054
cellular polysaccharide metabolic process GO:0044264 27 0.053
cation homeostasis GO:0055080 189 0.053
regulation of neurogenesis GO:0050767 82 0.053
negative regulation of voltage gated calcium channel activity GO:1901386 4 0.053
ribonucleotide catabolic process GO:0009261 405 0.052
response to oxidative stress GO:0006979 121 0.052
positive regulation of ion transmembrane transporter activity GO:0032414 29 0.051
cellular calcium ion homeostasis GO:0006874 117 0.051
hematopoietic or lymphoid organ development GO:0048534 186 0.051
apical junction assembly GO:0043297 19 0.051
cellular component morphogenesis GO:0032989 314 0.050
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.050
maintenance of location GO:0051235 112 0.050
establishment of protein localization to membrane GO:0090150 121 0.050
intracellular receptor signaling pathway GO:0030522 104 0.049
cellular response to oxygen containing compound GO:1901701 276 0.049
heart development GO:0007507 95 0.049
cellular response to endogenous stimulus GO:0071495 336 0.049
negative regulation of protein phosphorylation GO:0001933 140 0.049
organophosphate catabolic process GO:0046434 430 0.049
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.049
behavior GO:0007610 112 0.048
positive regulation of protein targeting to membrane GO:0090314 8 0.048
sex differentiation GO:0007548 45 0.048
regulation of embryonic development GO:0045995 20 0.047
lymphocyte activation GO:0046649 133 0.047
divalent metal ion transport GO:0070838 152 0.047
regulation of cell cell adhesion GO:0022407 57 0.046
regulation of cellular amine metabolic process GO:0033238 11 0.046
positive regulation of calcium ion transport GO:0051928 51 0.046
negative regulation of cell motility GO:2000146 104 0.045
positive regulation of anoikis GO:2000210 4 0.045
regulation of response to cytokine stimulus GO:0060759 46 0.045
cellular response to muramyl dipeptide GO:0071225 3 0.044
endosomal transport GO:0016197 129 0.044
cell cell junction organization GO:0045216 69 0.043
nuclear import GO:0051170 106 0.043
striated muscle contraction GO:0006941 52 0.043
activation of jnkk activity GO:0007256 1 0.043
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.043
lymphocyte apoptotic process GO:0070227 20 0.042
leukocyte apoptotic process GO:0071887 31 0.042
microtubule based process GO:0007017 210 0.042
negative regulation of ion transmembrane transport GO:0034766 26 0.042
positive regulation of cellular component movement GO:0051272 181 0.042
cellular metal ion homeostasis GO:0006875 146 0.042
regulation of tor signaling GO:0032006 30 0.042
negative regulation of protein import into nucleus GO:0042308 30 0.042
leukocyte activation GO:0045321 164 0.042
protein polymerization GO:0051258 71 0.041
neuron projection morphogenesis GO:0048812 50 0.041
ribonucleoside catabolic process GO:0042454 406 0.041
positive regulation of nucleoside metabolic process GO:0045979 186 0.041
regulation of calcium ion transport GO:0051924 79 0.041
secretion by cell GO:0032940 226 0.041
cellular protein complex disassembly GO:0043624 36 0.040
cellular response to mechanical stimulus GO:0071260 39 0.040
Human
single organismal cell cell adhesion GO:0016337 148 0.040
urogenital system development GO:0001655 65 0.040
regulation of immune effector process GO:0002697 91 0.040
maintenance of location in cell GO:0051651 62 0.040
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.040
immune system development GO:0002520 195 0.039
cytokinesis GO:0000910 96 0.039
negative regulation of protein localization to nucleus GO:1900181 34 0.039
membrane organization GO:0061024 292 0.039
negative regulation of intracellular protein transport GO:0090317 42 0.039
regulation of leukocyte mediated immunity GO:0002703 38 0.039
response to wounding GO:0009611 168 0.039
negative regulation of cytoplasmic transport GO:1903650 46 0.038
positive regulation of cell development GO:0010720 92 0.038
cellular divalent inorganic cation homeostasis GO:0072503 128 0.038
guanosine containing compound catabolic process GO:1901069 239 0.038
adenylate cyclase activating adrenergic receptor signaling pathway GO:0071880 3 0.038
adult locomotory behavior GO:0008344 1 0.038
inorganic ion transmembrane transport GO:0098660 231 0.038
mitotic cell cycle GO:0000278 326 0.038
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 44 0.037
positive regulation of gtpase activity GO:0043547 166 0.037
skeletal muscle contraction GO:0003009 16 0.037
nuclear division GO:0000280 128 0.036
regulation of protein processing GO:0070613 150 0.036
embryonic pattern specification GO:0009880 5 0.036
cellular response to external stimulus GO:0071496 111 0.035
Human
proteasomal protein catabolic process GO:0010498 176 0.035
response to other organism GO:0051707 261 0.034
maintenance of protein location in cell GO:0032507 56 0.034
muscle system process GO:0003012 81 0.034
oocyte differentiation GO:0009994 2 0.034
sodium ion transmembrane transport GO:0035725 59 0.034
digestive system development GO:0055123 75 0.034
cardiovascular system development GO:0072358 262 0.034
Mouse
cytokine biosynthetic process GO:0042089 37 0.033
embryonic morphogenesis GO:0048598 85 0.033
mitotic nuclear division GO:0007067 119 0.033
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.033
fertilization GO:0009566 12 0.032
calcium ion transmembrane transport GO:0070588 76 0.032
cellular response to abiotic stimulus GO:0071214 117 0.032
Human
cell chemotaxis GO:0060326 112 0.032
regulation of mitotic cell cycle GO:0007346 189 0.032
midbrain development GO:0030901 45 0.032
regulation of reactive oxygen species metabolic process GO:2000377 41 0.032
positive regulation of immune system process GO:0002684 283 0.031
negative regulation of phosphorylation GO:0042326 174 0.031
regulation of protein complex assembly GO:0043254 147 0.031
organelle assembly GO:0070925 176 0.031
granulocyte migration GO:0097530 40 0.031
negative regulation of nucleocytoplasmic transport GO:0046823 37 0.031
cellular homeostasis GO:0019725 196 0.031
female gamete generation GO:0007292 2 0.031
posttranscriptional regulation of gene expression GO:0010608 213 0.031
regulation of lymphocyte activation GO:0051249 103 0.030
regulation of peptidyl serine phosphorylation GO:0033135 50 0.030
neurogenesis GO:0022008 169 0.030
transmission of nerve impulse GO:0019226 11 0.030
cellular response to tumor necrosis factor GO:0071356 63 0.030
brain development GO:0007420 97 0.030
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.030

MAP3K3 disease predictions

Disease DO term ID Size Probability Func Analog Org
auditory system disease DOID:2742 53 0.058
sensory system disease DOID:0050155 203 0.058
nervous system disease DOID:863 431 0.058
nonsyndromic deafness DOID:0050563 50 0.036