IMP

Process View

Homo sapiens

30 genes annotated in human

protein depolymerization

The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "protein depolymerization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "protein depolymerization" (in gray)

Name	Description	Probability	Func Analog Organism
ACTG1	actin, gamma 1	0.990
ACTB	actin, beta	0.928
BIRC5	baculoviral IAP repeat containing 5	0.594
FLNA	filamin A, alpha	0.579
ATP13A2	ATPase type 13A2	0.494
CFL1	cofilin 1 (non-muscle)	0.461	Human Yeast Mouse
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.455
MYH9	myosin, heavy chain 9, non-muscle	0.436
CDK1	cyclin-dependent kinase 1	0.391
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.371
SQSTM1	sequestosome 1	0.346
HSPA1B	heat shock 70kDa protein 1B	0.344	Yeast
CCNB2	cyclin B2	0.325	Human
ERBB2IP	erbb2 interacting protein	0.321
CENPE	centromere protein E, 312kDa	0.313
TADA3	transcriptional adaptor 3	0.307
KIF23	kinesin family member 23	0.301
HSPA1A	heat shock 70kDa protein 1A	0.301	Yeast
RACGAP1	Rac GTPase activating protein 1	0.285
TEX11	testis expressed 11	0.282
KIF20A	kinesin family member 20A	0.279
SOS1	son of sevenless homolog 1 (Drosophila)	0.234
ITGB4	integrin, beta 4	0.232
WDR48	WD repeat domain 48	0.216
CDCA8	cell division cycle associated 8	0.195
INCENP	inner centromere protein antigens 135/155kDa	0.194
KIF5B	kinesin family member 5B	0.189
CKAP5	cytoskeleton associated protein 5	0.189
MARK2	MAP/microtubule affinity-regulating kinase 2	0.186
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.185
DLGAP5	discs, large (Drosophila) homolog-associated protein 5	0.182
TUBA1C	tubulin, alpha 1c	0.179
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.168
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.156
NUF2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.153
HMMR	hyaluronan-mediated motility receptor (RHAMM)	0.143
AURKA	aurora kinase A	0.142
TRIM63	tripartite motif containing 63	0.140
AURKB	aurora kinase B	0.135
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.134
CDKN3	cyclin-dependent kinase inhibitor 3	0.126
ACTN1	actinin, alpha 1	0.125
PSEN2	presenilin 2 (Alzheimer disease 4)	0.118
DNM1	dynamin 1	0.117
TTK	TTK protein kinase	0.115
CKS2	CDC28 protein kinase regulatory subunit 2	0.111
CENPF	centromere protein F, 350/400kDa (mitosin)	0.108
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.108
PDLIM7	PDZ and LIM domain 7 (enigma)	0.107
RIPK3	receptor-interacting serine-threonine kinase 3	0.105
KIF11	kinesin family member 11	0.099	Fly
KIF4A	kinesin family member 4A	0.096
TPM4	tropomyosin 4	0.095	Worm
SMC4	structural maintenance of chromosomes 4	0.092
SCP2	sterol carrier protein 2	0.091
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.088
SNX9	sorting nexin 9	0.088
EXOC1	exocyst complex component 1	0.087
RFX1	regulatory factor X, 1 (influences HLA class II expression)	0.076
TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	0.075
TTN	titin	0.074
CEP55	centrosomal protein 55kDa	0.074
FUNDC2	FUN14 domain containing 2	0.072
CORO1C	coronin, actin binding protein, 1C	0.071
NCAPG	non-SMC condensin I complex, subunit G	0.071
ZYX	zyxin	0.069
KIF1B	kinesin family member 1B	0.068
AMPH	amphiphysin	0.066
XPO1	exportin 1 (CRM1 homolog, yeast)	0.066
CDK2	cyclin-dependent kinase 2	0.064
DISC1	disrupted in schizophrenia 1	0.062
GAS2L3	growth arrest-specific 2 like 3	0.062	Human
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.061
ANKRD28	ankyrin repeat domain 28	0.060
GPSM2	G-protein signaling modulator 2	0.059
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.058
SMC3	structural maintenance of chromosomes 3	0.058
ROD1	ROD1 regulator of differentiation 1 (S. pombe)	0.055
MYPN	myopalladin	0.055
GLIS2	GLIS family zinc finger 2	0.055
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.054
SMC1A	structural maintenance of chromosomes 1A	0.054
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.053
FLNB	filamin B, beta	0.051
LMNA	lamin A/C	0.051
CFL2	cofilin 2 (muscle)	0.050
SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	0.046
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.045
NBR1	neighbor of BRCA1 gene 1	0.045
KIF20B	kinesin family member 20B	0.044
NCAPD2	non-SMC condensin I complex, subunit D2	0.043
APC	adenomatous polyposis coli	0.042
BAG3	BCL2-associated athanogene 3	0.041
PALLD	palladin, cytoskeletal associated protein	0.040
TAGLN2	transgelin 2	0.039
COX17	COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)	0.039
GAPDH	glyceraldehyde-3-phosphate dehydrogenase	0.039
FHL2	four and a half LIM domains 2	0.038
EXOC2	exocyst complex component 2	0.038
SCRIB	scribbled homolog (Drosophila)	0.038
BAG2	BCL2-associated athanogene 2	0.037
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.035
EIF2AK4	eukaryotic translation initiation factor 2 alpha kinase 4	0.035
SUFU	suppressor of fused homolog (Drosophila)	0.034
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.034
MRPL20	mitochondrial ribosomal protein L20	0.034
TPM1	tropomyosin 1 (alpha)	0.034	Worm
SGOL2	shugoshin-like 2 (S. pombe)	0.034
PLDN	pallidin homolog (mouse)	0.033
DNAJB1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.033
RAD21	RAD21 homolog (S. pombe)	0.033
ACTA1	actin, alpha 1, skeletal muscle	0.033
SMC2	structural maintenance of chromosomes 2	0.032
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.032
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.032
MSN	moesin	0.031
STIL	SCL/TAL1 interrupting locus	0.031
DSTN	destrin (actin depolymerizing factor)	0.031	Human Yeast Mouse
EXOC7	exocyst complex component 7	0.031
EFHD2	EF-hand domain family, member D2	0.031
STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	0.030
OPTN	optineurin	0.030
SHOC2	soc-2 suppressor of clear homolog (C. elegans)	0.029
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.029
DST	dystonin	0.029	Fly
TUBB	tubulin, beta	0.028
SEPT2	septin 2	0.027
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.027
PRC1	protein regulator of cytokinesis 1	0.027	Worm Fly
KIF14	kinesin family member 14	0.027
CCDC85A	coiled-coil domain containing 85A	0.027
STAMBP	STAM binding protein	0.026
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.026
PHLPP1	PH domain and leucine rich repeat protein phosphatase 1	0.026
WDR20	WD repeat domain 20	0.026
DEK	DEK oncogene	0.025
USP20	ubiquitin specific peptidase 20	0.025
TSPO	translocator protein (18kDa)	0.025
TWF2	twinfilin, actin-binding protein, homolog 2 (Drosophila)	0.024
ZRANB1	zinc finger, RAN-binding domain containing 1	0.024
SPTBN1	spectrin, beta, non-erythrocytic 1	0.024
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.024
SH3GL2	SH3-domain GRB2-like 2	0.024
ARF3	ADP-ribosylation factor 3	0.023
RHOA	ras homolog gene family, member A	0.023
SPAG5	sperm associated antigen 5	0.022
TNIK	TRAF2 and NCK interacting kinase	0.022
KIF2C	kinesin family member 2C	0.022
STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	0.022
SVIL	supervillin	0.022
MAP4K3	mitogen-activated protein kinase kinase kinase kinase 3	0.022
SKA1	spindle and kinetochore associated complex subunit 1	0.021
MZT1	mitotic spindle organizing protein 1	0.021
EPS8	epidermal growth factor receptor pathway substrate 8	0.021	Mouse Worm
WDR1	WD repeat domain 1	0.021	Yeast Worm
COL17A1	collagen, type XVII, alpha 1	0.021
CHMP1B	chromatin modifying protein 1B	0.021
SCYL2	SCY1-like 2 (S. cerevisiae)	0.021
DEPDC1	DEP domain containing 1	0.021
VCL	vinculin	0.020
RAB11A	RAB11A, member RAS oncogene family	0.020
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.020
CNN2	calponin 2	0.020
MIS18BP1	MIS18 binding protein 1	0.020
MOBKL1A	MOB1, Mps One Binder kinase activator-like 1A (yeast)	0.020
SMAD9	SMAD family member 9	0.020
SH3BGRL3	SH3 domain binding glutamic acid-rich protein like 3	0.020
TLK1	tousled-like kinase 1	0.020
ATF7IP	activating transcription factor 7 interacting protein	0.019
UBE2L3	ubiquitin-conjugating enzyme E2L 3	0.019
CCNA2	cyclin A2	0.019
RAD51AP1	RAD51 associated protein 1	0.019
MYL6	myosin, light chain 6, alkali, smooth muscle and non-muscle	0.019
ITM2B	integral membrane protein 2B	0.019
PRMT2	protein arginine methyltransferase 2	0.019
SASS6	spindle assembly 6 homolog (C. elegans)	0.019
UBASH3B	ubiquitin associated and SH3 domain containing B	0.019
KIF18A	kinesin family member 18A	0.019
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.018
NCAPH	non-SMC condensin I complex, subunit H	0.018
MTHFD1L	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	0.018
ITGA6	integrin, alpha 6	0.018
ECT2	epithelial cell transforming sequence 2 oncogene	0.018
CD2AP	CD2-associated protein	0.018
DYNC2H1	dynein, cytoplasmic 2, heavy chain 1	0.018
PBK	PDZ binding kinase	0.018
MAPT	microtubule-associated protein tau	0.018
GGH	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	0.018
PRKD2	protein kinase D2	0.018
PTTG1	pituitary tumor-transforming 1	0.017
TUBGCP5	tubulin, gamma complex associated protein 5	0.017
PPP5C	protein phosphatase 5, catalytic subunit	0.017
ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	0.017
TOM1L1	target of myb1 (chicken)-like 1	0.017
CAPNS1	calpain, small subunit 1	0.017
MYO1E	myosin IE	0.017
COTL1	coactosin-like 1 (Dictyostelium)	0.017
PDS5A	PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)	0.016
NUSAP1	nucleolar and spindle associated protein 1	0.016
PINK1	PTEN induced putative kinase 1	0.016
SNX2	sorting nexin 2	0.016
ASCC2	activating signal cointegrator 1 complex subunit 2	0.016
FNBP1L	formin binding protein 1-like	0.016
KIF15	kinesin family member 15	0.016
ZFAND5	zinc finger, AN1-type domain 5	0.016
APOBEC3B	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B	0.016
JUP	junction plakoglobin	0.016
PHLPP2	PH domain and leucine rich repeat protein phosphatase 2	0.016
EHD1	EH-domain containing 1	0.016
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.016
HMGB2	high mobility group box 2	0.015
CAV1	caveolin 1, caveolae protein, 22kDa	0.015
TRIO	triple functional domain (PTPRF interacting)	0.015
WDR67	WD repeat domain 67	0.015
CREB1	cAMP responsive element binding protein 1	0.015
DCK	deoxycytidine kinase	0.015
PEA15	phosphoprotein enriched in astrocytes 15	0.015
ZFP106	zinc finger protein 106 homolog (mouse)	0.015
S100A11	S100 calcium binding protein A11	0.015
TAX1BP3	Tax1 (human T-cell leukemia virus type I) binding protein 3	0.015
PSRC1	proline/serine-rich coiled-coil 1	0.015
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.015
IGF2R	insulin-like growth factor 2 receptor	0.015
LBR	lamin B receptor	0.015
ARID1A	AT rich interactive domain 1A (SWI-like)	0.015
BAG1	BCL2-associated athanogene	0.015
CAPG	capping protein (actin filament), gelsolin-like	0.015
ST3GAL3	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	0.014
AKAP9	A kinase (PRKA) anchor protein (yotiao) 9	0.014
ADAM9	ADAM metallopeptidase domain 9	0.014
PFN1	profilin 1	0.014
CSRP1	cysteine and glycine-rich protein 1	0.014
KBTBD10	kelch repeat and BTB (POZ) domain containing 10	0.014
RAB10	RAB10, member RAS oncogene family	0.014
ATXN3	ataxin 3	0.014
EXOC5	exocyst complex component 5	0.014
SPC25	SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.014
WDFY3	WD repeat and FYVE domain containing 3	0.014
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.014
BCL2L1	BCL2-like 1	0.013
MEOX2	mesenchyme homeobox 2	0.013
THBS1	thrombospondin 1	0.013
ACTN4	actinin, alpha 4	0.013
INPP5A	inositol polyphosphate-5-phosphatase, 40kDa	0.013
PRKCA	protein kinase C, alpha	0.013
MYLK	myosin light chain kinase	0.013
DTNBP1	dystrobrevin binding protein 1	0.013
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.013
ANXA4	annexin A4	0.013
BEND5	BEN domain containing 5	0.013
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.013
MPRIP	myosin phosphatase Rho interacting protein	0.013
RANBP2	RAN binding protein 2	0.013
KIAA1217	KIAA1217	0.013
STK10	serine/threonine kinase 10	0.013
CAPZB	capping protein (actin filament) muscle Z-line, beta	0.013	Yeast Fly
DYNC1H1	dynein, cytoplasmic 1, heavy chain 1	0.013
SIRT2	sirtuin 2	0.013
UBE2C	ubiquitin-conjugating enzyme E2C	0.013
ADAM10	ADAM metallopeptidase domain 10	0.013
MYL9	myosin, light chain 9, regulatory	0.013
HIST1H4C	histone cluster 1, H4c	0.013
ARL6IP1	ADP-ribosylation factor-like 6 interacting protein 1	0.013
RHOC	ras homolog gene family, member C	0.013
GSK3B	glycogen synthase kinase 3 beta	0.013
MYL12B	myosin, light chain 12B, regulatory	0.012
PRUNE	prune homolog (Drosophila)	0.012
KRT15	keratin 15	0.012
CNN1	calponin 1, basic, smooth muscle	0.012
UTRN	utrophin	0.012
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.012
G2E3	G2/M-phase specific E3 ubiquitin protein ligase	0.012
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.012
STRN3	striatin, calmodulin binding protein 3	0.012
SEC23A	Sec23 homolog A (S. cerevisiae)	0.012
SCAMP1	secretory carrier membrane protein 1	0.012
ANKRD17	ankyrin repeat domain 17	0.012
C13orf34	chromosome 13 open reading frame 34	0.012
MPHOSPH9	M-phase phosphoprotein 9	0.012
DNM2	dynamin 2	0.012
BIRC6	baculoviral IAP repeat containing 6	0.012
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.012
MAPRE3	microtubule-associated protein, RP/EB family, member 3	0.012
CENPQ	centromere protein Q	0.012
SPTLC1	serine palmitoyltransferase, long chain base subunit 1	0.012
ARHGAP19	Rho GTPase activating protein 19	0.012
HJURP	Holliday junction recognition protein	0.012
PHLDB2	pleckstrin homology-like domain, family B, member 2	0.012
GIGYF2	GRB10 interacting GYF protein 2	0.012
NCOA2	nuclear receptor coactivator 2	0.011
ANLN	anillin, actin binding protein	0.011
GULP1	GULP, engulfment adaptor PTB domain containing 1	0.011
DES	desmin	0.011
CCDC11	coiled-coil domain containing 11	0.011
NEK6	NIMA (never in mitosis gene a)-related kinase 6	0.011
TRAF2	TNF receptor-associated factor 2	0.011
PARG	poly (ADP-ribose) glycohydrolase	0.011
MKI67	antigen identified by monoclonal antibody Ki-67	0.011
USP15	ubiquitin specific peptidase 15	0.011
PTK2	PTK2 protein tyrosine kinase 2	0.011
TUBA1A	tubulin, alpha 1a	0.011
CSNK2B	casein kinase 2, beta polypeptide	0.011
ZNF414	zinc finger protein 414	0.011
BCL2L12	BCL2-like 12 (proline rich)	0.011
CSNK1G3	casein kinase 1, gamma 3	0.011
ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	0.011
IQGAP1	IQ motif containing GTPase activating protein 1	0.011
PPP6C	protein phosphatase 6, catalytic subunit	0.011
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.011
ANK2	ankyrin 2, neuronal	0.011
NCK1	NCK adaptor protein 1	0.011
TRAF3IP1	TNF receptor-associated factor 3 interacting protein 1	0.011
AGPS	alkylglycerone phosphate synthase	0.011
C6orf211	chromosome 6 open reading frame 211	0.011
EXOC8	exocyst complex component 8	0.011
WEE1	WEE1 homolog (S. pombe)	0.010
TMSB10	thymosin beta 10	0.010
ARL6IP5	ADP-ribosylation-like factor 6 interacting protein 5	0.010
GNB2	guanine nucleotide binding protein (G protein), beta polypeptide 2	0.010
C6orf136	chromosome 6 open reading frame 136	0.010
NPTN	neuroplastin	0.010
FAM193A	family with sequence similarity 193, member A	0.010
CYB5R3	cytochrome b5 reductase 3	0.010
MAP3K4	mitogen-activated protein kinase kinase kinase 4	0.010
MYOF	myoferlin	0.010
DYNLT3	dynein, light chain, Tctex-type 3	0.010
RFX7	regulatory factor X, 7	0.010