|
|
macroautophagy
|
GO:0016236 |
39 |
1.000
|
|
|
|
autophagy
|
GO:0006914 |
88 |
0.999
|
Human Worm |
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.996
|
Worm |
|
|
vacuole organization
|
GO:0007033 |
44 |
0.995
|
|
|
|
regulation of autophagy
|
GO:0010506 |
52 |
0.985
|
|
|
|
autophagic vacuole assembly
|
GO:0000045 |
19 |
0.982
|
|
|
|
positive regulation of autophagy
|
GO:0010508 |
24 |
0.981
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.980
|
|
|
|
cellular response to starvation
|
GO:0009267 |
58 |
0.975
|
|
|
|
response to starvation
|
GO:0042594 |
59 |
0.971
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.967
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.964
|
|
|
|
cellular response to extracellular stimulus
|
GO:0031668 |
72 |
0.960
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.923
|
Worm |
|
|
mitochondrion degradation
|
GO:0000422 |
8 |
0.917
|
Human |
|
|
growth
|
GO:0040007 |
202 |
0.900
|
Worm |
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.886
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.880
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.875
|
|
|
|
response to extracellular stimulus
|
GO:0009991 |
85 |
0.870
|
|
|
|
positive regulation of mitochondrial fission
|
GO:0090141 |
7 |
0.869
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.818
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.785
|
|
|
|
positive regulation of mitochondrion organization
|
GO:0010822 |
30 |
0.766
|
|
|
|
cellular response to nutrient levels
|
GO:0031669 |
69 |
0.763
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.761
|
|
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.746
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.744
|
Human |
|
|
c terminal protein amino acid modification
|
GO:0018410 |
1 |
0.740
|
|
|
|
hydrogen peroxide mediated programmed cell death
|
GO:0010421 |
4 |
0.738
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.715
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.714
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.707
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.658
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.607
|
Human |
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.605
|
|
|
|
apoptotic mitochondrial changes
|
GO:0008637 |
57 |
0.601
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.600
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.496
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.493
|
|
|
|
regulation of proteasomal protein catabolic process
|
GO:0061136 |
87 |
0.479
|
Human |
|
|
regulation of synaptic transmission dopaminergic
|
GO:0032225 |
4 |
0.454
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.451
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.450
|
|
|
|
negative regulation of organelle organization
|
GO:0010639 |
126 |
0.449
|
|
|
|
establishment of vesicle localization
|
GO:0051650 |
23 |
0.402
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.400
|
|
|
|
regulation of mitochondrial fission
|
GO:0090140 |
8 |
0.392
|
|
|
|
negative regulation of mitochondrial fusion
|
GO:0010637 |
4 |
0.392
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.387
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.385
|
|
|
|
vacuolar transport
|
GO:0007034 |
34 |
0.377
|
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.372
|
Human |
|
|
microtubule based process
|
GO:0007017 |
210 |
0.371
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.366
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.358
|
|
|
|
positive regulation of release of cytochrome c from mitochondria
|
GO:0090200 |
18 |
0.357
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.356
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.355
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.349
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.340
|
Human |
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.332
|
|
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
96 |
0.327
|
Human |
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.317
|
Human |
|
|
membrane fusion
|
GO:0061025 |
43 |
0.317
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.315
|
Human |
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.315
|
Human |
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.311
|
Mouse |
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
91 |
0.302
|
Human |
|
|
actin filament organization
|
GO:0007015 |
128 |
0.287
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.280
|
|
|
|
system process
|
GO:0003008 |
349 |
0.271
|
|
|
|
taxis
|
GO:0042330 |
157 |
0.270
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.269
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.267
|
Human |
|
|
vesicle localization
|
GO:0051648 |
26 |
0.263
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.261
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.261
|
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.259
|
|
|
|
embryo development
|
GO:0009790 |
123 |
0.251
|
Worm |
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.245
|
Human |
|
|
positive regulation of synaptic transmission
|
GO:0050806 |
4 |
0.239
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.238
|
Human |
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.234
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.232
|
|
|
|
aging
|
GO:0007568 |
66 |
0.232
|
Worm |
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.226
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.223
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.222
|
Human |
|
|
cell development
|
GO:0048468 |
328 |
0.218
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.216
|
|
|
|
lipoprotein metabolic process
|
GO:0042157 |
42 |
0.214
|
|
|
|
organelle localization
|
GO:0051640 |
84 |
0.212
|
|
|
|
mitochondrial fission
|
GO:0000266 |
14 |
0.208
|
|
|
|
negative regulation of proteasomal protein catabolic process
|
GO:1901799 |
32 |
0.204
|
Human |
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.202
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.200
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.198
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.190
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.189
|
Worm |
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.186
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.183
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
147 |
0.181
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.180
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.177
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.172
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.168
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.168
|
|
|
|
developmental programmed cell death
|
GO:0010623 |
3 |
0.167
|
|
|
|
regulation of mitochondrion organization
|
GO:0010821 |
54 |
0.163
|
|
|
|
release of cytochrome c from mitochondria
|
GO:0001836 |
35 |
0.162
|
|
|
|
extrinsic apoptotic signaling pathway via death domain receptors
|
GO:0008625 |
42 |
0.156
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.153
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.152
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.150
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.150
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.149
|
|
|
|
cellular component assembly involved in morphogenesis
|
GO:0010927 |
73 |
0.147
|
|
|
|
axon extension
|
GO:0048675 |
13 |
0.146
|
|
|
|
fatty acid metabolic process
|
GO:0006631 |
115 |
0.145
|
|
|
|
endosomal transport
|
GO:0016197 |
129 |
0.145
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.144
|
|
|
|
positive regulation of response to extracellular stimulus
|
GO:0032106 |
14 |
0.144
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.143
|
|
|
|
striated muscle cell differentiation
|
GO:0051146 |
43 |
0.141
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.140
|
|
|
|
establishment of protein localization to membrane
|
GO:0090150 |
121 |
0.140
|
|
|
|
cellular response to oxygen levels
|
GO:0071453 |
55 |
0.136
|
|
|
|
response to nutrient levels
|
GO:0031667 |
81 |
0.132
|
|
|
|
organelle assembly
|
GO:0070925 |
176 |
0.130
|
|
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.126
|
Worm |
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.125
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.122
|
Human |
|
|
protein targeting to vacuole
|
GO:0006623 |
8 |
0.122
|
|
|
|
protein polyubiquitination
|
GO:0000209 |
110 |
0.121
|
|
|
|
protein lipidation
|
GO:0006497 |
33 |
0.121
|
|
|
|
regulation of release of cytochrome c from mitochondria
|
GO:0090199 |
29 |
0.119
|
|
|
|
negative regulation of actin filament polymerization
|
GO:0030837 |
10 |
0.119
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.116
|
|
|
|
golgi ribbon formation
|
GO:0090161 |
3 |
0.109
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.106
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.105
|
|
|
|
regulation of cellular component size
|
GO:0032535 |
82 |
0.105
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.104
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.104
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.103
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.103
|
|
|
|
regulation of mitochondrial membrane permeability
|
GO:0046902 |
25 |
0.100
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.100
|
|
|
|
memory
|
GO:0007613 |
3 |
0.099
|
|
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.099
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.096
|
|
|
|
protein localization to membrane
|
GO:0072657 |
160 |
0.095
|
|
|
|
catecholamine secretion
|
GO:0050432 |
1 |
0.094
|
|
|
|
negative regulation of hydrogen peroxide mediated programmed cell death
|
GO:1901299 |
3 |
0.094
|
|
|
|
organelle fission
|
GO:0048285 |
149 |
0.092
|
|
|
|
compound eye development
|
GO:0048749 |
1 |
0.092
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.090
|
|
|
|
embryo development ending in birth or egg hatching
|
GO:0009792 |
34 |
0.090
|
Worm |
|
|
regulation of neurotransmitter secretion
|
GO:0046928 |
3 |
0.089
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.087
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.086
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.086
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.084
|
|
|
|
cellular component disassembly
|
GO:0022411 |
92 |
0.084
|
|
|
|
protein localization to vacuole
|
GO:0072665 |
11 |
0.083
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.081
|
|
|
|
establishment of organelle localization
|
GO:0051656 |
59 |
0.080
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.079
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.077
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.074
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.071
|
|
|
|
mitochondrial transport
|
GO:0006839 |
60 |
0.070
|
|
|
|
neuron projection extension
|
GO:1990138 |
14 |
0.070
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.070
|
|
|
|
nucleoside phosphate biosynthetic process
|
GO:1901293 |
109 |
0.068
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.068
|
Worm |
|
|
regulation of catecholamine secretion
|
GO:0050433 |
1 |
0.066
|
|
|
|
regulation of immune effector process
|
GO:0002697 |
91 |
0.065
|
|
|
|
response to endoplasmic reticulum stress
|
GO:0034976 |
49 |
0.063
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.063
|
|
|
|
negative regulation of axonogenesis
|
GO:0050771 |
4 |
0.063
|
|
|
|
positive regulation of protein binding
|
GO:0032092 |
24 |
0.063
|
Rat |
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.063
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.062
|
|
|
|
cellular response to mechanical stimulus
|
GO:0071260 |
39 |
0.061
|
|
|
|
symbiosis encompassing mutualism through parasitism
|
GO:0044403 |
156 |
0.059
|
|
|
|
post golgi vesicle mediated transport
|
GO:0006892 |
36 |
0.059
|
|
|
|
single organism membrane fusion
|
GO:0044801 |
37 |
0.058
|
|
|
|
regulation of extent of cell growth
|
GO:0061387 |
9 |
0.058
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.058
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.058
|
|
|
|
cellular ion homeostasis
|
GO:0006873 |
168 |
0.057
|
|
|
|
negative regulation of catabolic process
|
GO:0009895 |
104 |
0.056
|
Human |
|
|
carbohydrate derivative biosynthetic process
|
GO:1901137 |
207 |
0.056
|
|
|
|
cell death in response to oxidative stress
|
GO:0036473 |
29 |
0.054
|
|
|
|
cilium assembly
|
GO:0042384 |
63 |
0.054
|
|
|
|
regulation of membrane permeability
|
GO:0090559 |
25 |
0.053
|
|
|
|
actomyosin structure organization
|
GO:0031032 |
59 |
0.052
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.052
|
Worm |
|
|
early endosome to late endosome transport
|
GO:0045022 |
21 |
0.052
|
|
|
|
regulation of oxidative stress induced neuron death
|
GO:1903203 |
9 |
0.051
|
|
|
|
neurotransmitter secretion
|
GO:0007269 |
4 |
0.051
|
|
|
|
regulation of cellular response to growth factor stimulus
|
GO:0090287 |
76 |
0.051
|
|
|
|
negative regulation of protein catabolic process
|
GO:0042177 |
59 |
0.051
|
Human |
|
|
copii vesicle coating
|
GO:0048208 |
2 |
0.050
|
|
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.050
|
|
|
|
axon cargo transport
|
GO:0008088 |
2 |
0.050
|
|
|
|
regulation of actin polymerization or depolymerization
|
GO:0008064 |
56 |
0.050
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.049
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.049
|
Human |
|
|
regulation of dephosphorylation
|
GO:0035303 |
96 |
0.048
|
|
|
|
jnk cascade
|
GO:0007254 |
80 |
0.048
|
|
|
|
positive regulation of i kappab kinase nf kappab signaling
|
GO:0043123 |
132 |
0.048
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
70 |
0.047
|
|
|
|
methylation
|
GO:0032259 |
106 |
0.046
|
|
|
|
reproductive process
|
GO:0022414 |
106 |
0.045
|
|
|
|
tissue morphogenesis
|
GO:0048729 |
96 |
0.045
|
|
|
|
anatomical structure homeostasis
|
GO:0060249 |
100 |
0.045
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.044
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.044
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.043
|
|
|
|
multicellular organismal reproductive process
|
GO:0048609 |
40 |
0.043
|
|
|
|
post translational protein modification
|
GO:0043687 |
7 |
0.043
|
|
|
|
negative regulation of cytoskeleton organization
|
GO:0051494 |
45 |
0.043
|
|
|
|
negative regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903051 |
35 |
0.042
|
Human |
|
|
golgi vesicle transport
|
GO:0048193 |
80 |
0.042
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.042
|
Worm |
|
|
single organism reproductive process
|
GO:0044702 |
98 |
0.042
|
|
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.041
|
|
|
|
macromolecule methylation
|
GO:0043414 |
97 |
0.041
|
|
|
|
cellular response to toxic substance
|
GO:0097237 |
4 |
0.041
|
|
|
|
protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:0042787 |
37 |
0.041
|
|
|
|
covalent chromatin modification
|
GO:0016569 |
254 |
0.040
|
|
|
|
erythrocyte development
|
GO:0048821 |
3 |
0.040
|
|
|
|
neuron death in response to oxidative stress
|
GO:0036475 |
9 |
0.040
|
|
|
|
negative regulation of cellular protein catabolic process
|
GO:1903363 |
38 |
0.040
|
Human |
|
|
positive regulation of stress activated protein kinase signaling cascade
|
GO:0070304 |
61 |
0.040
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.039
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.039
|
|
|
|
regulation of actin filament based process
|
GO:0032970 |
141 |
0.038
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.038
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.038
|
|
|
|
regulation of mitochondrial membrane potential
|
GO:0051881 |
23 |
0.037
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.037
|
|
|
|
organophosphate biosynthetic process
|
GO:0090407 |
163 |
0.037
|
|
|
|
reproduction
|
GO:0000003 |
63 |
0.037
|
|
|
|
dopaminergic neuron differentiation
|
GO:0071542 |
1 |
0.037
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
95 |
0.037
|
|
|
|
phospholipid metabolic process
|
GO:0006644 |
99 |
0.036
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.036
|
|
|
|
cilium morphogenesis
|
GO:0060271 |
75 |
0.036
|
|
|
|
actin filament capping
|
GO:0051693 |
4 |
0.035
|
|
|
|
nuclear transport
|
GO:0051169 |
179 |
0.035
|
|
|
|
defense response to gram positive bacterium
|
GO:0050830 |
29 |
0.035
|
Worm |
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.034
|
|
|
|
regulation of actin filament polymerization
|
GO:0030833 |
50 |
0.034
|
|
|
|
positive regulation of peptidyl serine phosphorylation
|
GO:0033138 |
42 |
0.033
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.033
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.033
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.033
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.033
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.033
|
|
|
|
negative regulation of protein complex assembly
|
GO:0031333 |
43 |
0.032
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
85 |
0.032
|
|
|
|
cell projection morphogenesis
|
GO:0048858 |
129 |
0.032
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.032
|
Human |
|
|
protein localization to mitochondrion
|
GO:0070585 |
25 |
0.031
|
|
|
|
cellular response to hypoxia
|
GO:0071456 |
51 |
0.031
|
|
|
|
neuron cellular homeostasis
|
GO:0070050 |
3 |
0.031
|
|
|
|
mrna 3 end processing
|
GO:0031124 |
24 |
0.031
|
|
|
|
head development
|
GO:0060322 |
108 |
0.031
|
|
|
|
regulation of mitochondrial fusion
|
GO:0010635 |
5 |
0.031
|
|
|
|
muscle cell differentiation
|
GO:0042692 |
63 |
0.031
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.031
|
|
|
|
hindbrain development
|
GO:0030902 |
3 |
0.030
|
|
|
|
microtubule based movement
|
GO:0007018 |
32 |
0.030
|
|
|
|
negative regulation of intrinsic apoptotic signaling pathway
|
GO:2001243 |
40 |
0.030
|
|
|
|
developmental growth
|
GO:0048589 |
48 |
0.029
|
|
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.029
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
125 |
0.029
|
|
|
|
positive regulation of nervous system development
|
GO:0051962 |
54 |
0.028
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.028
|
|
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
63 |
0.028
|
|
|
|
glucose metabolic process
|
GO:0006006 |
45 |
0.028
|
|
|
|
glycerolipid metabolic process
|
GO:0046486 |
107 |
0.028
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.028
|
|
|
|
multi organism cellular process
|
GO:0044764 |
156 |
0.028
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.028
|
|
|
|
negative regulation of oxidative stress induced cell death
|
GO:1903202 |
17 |
0.027
|
|
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.027
|
|
|
|
tube morphogenesis
|
GO:0035239 |
95 |
0.027
|
|
|
|
developmental cell growth
|
GO:0048588 |
18 |
0.027
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.027
|
|
|
|
behavior
|
GO:0007610 |
112 |
0.027
|
|
|
|
renal sodium ion transport
|
GO:0003096 |
2 |
0.027
|
|
|
|
cytosolic calcium ion homeostasis
|
GO:0051480 |
89 |
0.027
|
|
|
|
macromolecular complex disassembly
|
GO:0032984 |
60 |
0.027
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.026
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.026
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.026
|
|
|
|
protein polymerization
|
GO:0051258 |
71 |
0.026
|
|
|
|
regulation of protein polymerization
|
GO:0032271 |
63 |
0.026
|
|
|
|
necrotic cell death
|
GO:0070265 |
21 |
0.026
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.026
|
|
|
|
actin filament bundle assembly
|
GO:0051017 |
54 |
0.026
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.026
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.026
|
|
|
|
negative regulation of cell cycle process
|
GO:0010948 |
121 |
0.026
|
|
|
|
establishment of protein localization to plasma membrane
|
GO:0090002 |
68 |
0.026
|
|
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
0.026
|
|
|
|
regulation of synaptic plasticity
|
GO:0048167 |
3 |
0.025
|
|
|
|
lipid biosynthetic process
|
GO:0008610 |
177 |
0.025
|
|
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.025
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.025
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.025
|
|
|
|
regulation of actin filament length
|
GO:0030832 |
56 |
0.025
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.025
|
|
|
|
peptidyl lysine modification
|
GO:0018205 |
144 |
0.025
|
|
|
|
protein monoubiquitination
|
GO:0006513 |
39 |
0.025
|
|
|
|
protein complex disassembly
|
GO:0043241 |
52 |
0.025
|
|
|
|
actin filament bundle organization
|
GO:0061572 |
54 |
0.025
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.025
|
|
|
|
small molecule catabolic process
|
GO:0044282 |
92 |
0.024
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.024
|
|
|
|
interspecies interaction between organisms
|
GO:0044419 |
156 |
0.024
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.024
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.024
|
|
|
|
positive regulation of synaptic transmission dopaminergic
|
GO:0032226 |
1 |
0.024
|
|
|
|
energy derivation by oxidation of organic compounds
|
GO:0015980 |
43 |
0.024
|
|
|
|
negative regulation of cellular response to oxidative stress
|
GO:1900408 |
18 |
0.023
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.023
|
Worm |
|
|
response to hypoxia
|
GO:0001666 |
96 |
0.023
|
|
|
|
neuron development
|
GO:0048666 |
113 |
0.023
|
|
|
|
autophagic cell death
|
GO:0048102 |
3 |
0.023
|
|
|
|
regulation of macroautophagy
|
GO:0016241 |
19 |
0.023
|
|
|
|
cellular lipid catabolic process
|
GO:0044242 |
65 |
0.022
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.022
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.022
|
|
|
|
negative regulation of protein polymerization
|
GO:0032272 |
16 |
0.022
|
|
|
|
regulation of histone acetylation
|
GO:0035065 |
19 |
0.022
|
|
|
|
endosome transport via multivesicular body sorting pathway
|
GO:0032509 |
3 |
0.022
|
|
|
|
cytoskeleton dependent intracellular transport
|
GO:0030705 |
21 |
0.022
|
|
|
|
monocarboxylic acid metabolic process
|
GO:0032787 |
185 |
0.021
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.021
|
|
|
|
monovalent inorganic cation transport
|
GO:0015672 |
128 |
0.021
|
|
|
|
intrinsic apoptotic signaling pathway in response to oxidative stress
|
GO:0008631 |
21 |
0.021
|
|
|
|
epithelial cell differentiation
|
GO:0030855 |
141 |
0.021
|
|
|
|
positive regulation of neurogenesis
|
GO:0050769 |
49 |
0.021
|
|
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.021
|
|
|
|
regulation of neurogenesis
|
GO:0050767 |
82 |
0.021
|
|
|
|
establishment of protein localization to mitochondrion
|
GO:0072655 |
22 |
0.021
|
|
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
57 |
0.021
|
|
|
|
regulation of protein binding
|
GO:0043393 |
66 |
0.021
|
Rat |
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.021
|
Human |
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.021
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.021
|
Human |
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.021
|
|
|
|
cellular response to hydrogen peroxide
|
GO:0070301 |
37 |
0.020
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.020
|
|
|
|
multi organism reproductive process
|
GO:0044703 |
54 |
0.020
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.020
|
|
|
|
regulation of peptidyl lysine acetylation
|
GO:2000756 |
22 |
0.020
|
|
|
|
regulation of synaptic transmission
|
GO:0050804 |
11 |
0.020
|
|
|
|
mitochondrial membrane organization
|
GO:0007006 |
40 |
0.020
|
|
|
|
cellular protein complex disassembly
|
GO:0043624 |
36 |
0.020
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.020
|
|
|
|
vasodilation
|
GO:0042311 |
4 |
0.020
|
|
|
|
organelle fusion
|
GO:0048284 |
36 |
0.020
|
|
|
|
negative regulation of peptidase activity
|
GO:0010466 |
91 |
0.020
|
|
|
|
protein acylation
|
GO:0043543 |
138 |
0.020
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.020
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.019
|
|
|
|
erythrocyte differentiation
|
GO:0030218 |
28 |
0.019
|
|
|
|
vesicle targeting rough er to cis golgi
|
GO:0048207 |
2 |
0.019
|
|
|
|
electron transport chain
|
GO:0022900 |
8 |
0.019
|
|
|
|
positive regulation of amine transport
|
GO:0051954 |
2 |
0.019
|
|
|
|
protein dna complex subunit organization
|
GO:0071824 |
80 |
0.019
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.019
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.019
|
|
|
|
cellular carbohydrate metabolic process
|
GO:0044262 |
84 |
0.019
|
|
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.019
|
|
|
|
regulation of translation
|
GO:0006417 |
89 |
0.019
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.018
|
|
|
|
monosaccharide transport
|
GO:0015749 |
32 |
0.018
|
|
|
|
regulation of cellular carbohydrate metabolic process
|
GO:0010675 |
47 |
0.018
|
|
|
|
semicircular canal development
|
GO:0060872 |
1 |
0.018
|
|
|
|
regulation of vascular endothelial growth factor signaling pathway
|
GO:1900746 |
6 |
0.018
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.018
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.018
|
|
|
|
response to decreased oxygen levels
|
GO:0036293 |
96 |
0.018
|
|
|
|
actin filament polymerization
|
GO:0030041 |
45 |
0.018
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.018
|
|
|
|
regulation of protein stability
|
GO:0031647 |
87 |
0.018
|
|
|
|
chromatin organization
|
GO:0006325 |
351 |
0.017
|
|
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.017
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.017
|
|
|
|
distal tubule development
|
GO:0072017 |
4 |
0.017
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.017
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.017
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
74 |
0.017
|
|
|
|
anion transport
|
GO:0006820 |
161 |
0.017
|
|
|
|
erythrocyte homeostasis
|
GO:0034101 |
31 |
0.017
|
|
|
|
response to fungus
|
GO:0009620 |
4 |
0.017
|
|
|
|
regulation of response to oxidative stress
|
GO:1902882 |
26 |
0.017
|
|
|
|
natural killer cell mediated immunity
|
GO:0002228 |
23 |
0.017
|
|
|
|
chromosome segregation
|
GO:0007059 |
114 |
0.017
|
|
|
|
positive regulation of necrotic cell death
|
GO:0010940 |
4 |
0.017
|
|
|
|
response to hyperoxia
|
GO:0055093 |
4 |
0.017
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.017
|
|
|
|
protein acetylation
|
GO:0006473 |
116 |
0.016
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.016
|
|
|
|
dopamine transport
|
GO:0015872 |
5 |
0.016
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.016
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.016
|
|
|
|
negative regulation of neuron death
|
GO:1901215 |
32 |
0.016
|
|
|
|
receptor localization to synapse
|
GO:0097120 |
1 |
0.016
|
|
|
|
protein localization to plasma membrane
|
GO:0072659 |
93 |
0.016
|
|
|
|
regulation of developmental growth
|
GO:0048638 |
30 |
0.016
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.016
|
|
|
|
regulation of mitochondrial membrane permeability involved in apoptotic process
|
GO:1902108 |
18 |
0.016
|
|
|
|
rac protein signal transduction
|
GO:0016601 |
12 |
0.016
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.016
|
Rat |
|
|
negative regulation of cellular catabolic process
|
GO:0031330 |
83 |
0.016
|
Human |
|
|
regulation of cellular response to oxidative stress
|
GO:1900407 |
26 |
0.016
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.016
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.016
|
|
|
|
actin polymerization or depolymerization
|
GO:0008154 |
56 |
0.016
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.015
|
|
|
|
cell part morphogenesis
|
GO:0032990 |
137 |
0.015
|
|
|
|
protein k33 linked ubiquitination
|
GO:1990390 |
1 |
0.015
|
|
|
|
negative regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway
|
GO:1903377 |
5 |
0.015
|
|
|
|
lipoprotein biosynthetic process
|
GO:0042158 |
33 |
0.015
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.015
|
|
|
|
regulation of glucose metabolic process
|
GO:0010906 |
28 |
0.015
|
|
|
|
carboxylic acid catabolic process
|
GO:0046395 |
71 |
0.015
|
|
|
|
axonogenesis
|
GO:0007409 |
31 |
0.015
|
|
|
|
myeloid cell homeostasis
|
GO:0002262 |
34 |
0.015
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.015
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.015
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.015
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.015
|
|
|
|
negative regulation of protein complex disassembly
|
GO:0043242 |
20 |
0.015
|
|
|
|
short term memory
|
GO:0007614 |
1 |
0.015
|
|
|
|
programmed cell death in response to reactive oxygen species
|
GO:0097468 |
4 |
0.015
|
|
|
|
phosphatidic acid biosynthetic process
|
GO:0006654 |
4 |
0.015
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.015
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.015
|
|
|
|
protein targeting to golgi
|
GO:0000042 |
3 |
0.015
|
|
|
|
adult locomotory behavior
|
GO:0008344 |
1 |
0.015
|
|
|
|
regulation of response to extracellular stimulus
|
GO:0032104 |
22 |
0.015
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.015
|
|
|
|
plasma membrane organization
|
GO:0007009 |
115 |
0.014
|
|
|
|
mitotic nuclear division
|
GO:0007067 |
119 |
0.014
|
|
|
|
meiotic chromosome segregation
|
GO:0045132 |
4 |
0.014
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.014
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.014
|
|
|
|
protein stabilization
|
GO:0050821 |
64 |
0.014
|
|
|
|
regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway
|
GO:1903376 |
7 |
0.014
|
|
|
|
positive regulation of macroautophagy
|
GO:0016239 |
12 |
0.014
|
|
|
|
tube development
|
GO:0035295 |
125 |
0.014
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.014
|
|
|
|
regulation of synaptic vesicle transport
|
GO:1902803 |
3 |
0.014
|
|
|
|
ribose phosphate biosynthetic process
|
GO:0046390 |
82 |
0.013
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.013
|
|
|
|
response to virus
|
GO:0009615 |
126 |
0.013
|
|
|
|
mitochondrial outer membrane permeabilization
|
GO:0097345 |
15 |
0.013
|
|
|
|
synaptic transmission
|
GO:0007268 |
61 |
0.013
|
|
|
|
regulation of cell growth
|
GO:0001558 |
135 |
0.013
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.013
|
|
|
|
skin development
|
GO:0043588 |
76 |
0.013
|
|
|
|
chromatin modification
|
GO:0016568 |
298 |
0.013
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.013
|
|
|
|
protein k48 linked ubiquitination
|
GO:0070936 |
38 |
0.013
|
|
|
|
cellular response to inorganic substance
|
GO:0071241 |
45 |
0.013
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.013
|
|
|
|
purine nucleoside monophosphate metabolic process
|
GO:0009126 |
186 |
0.013
|
|
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.013
|
|