IMP

Process View

Homo sapiens

18 genes annotated in human

positive regulation of release of cytochrome c from mitochondria

Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of release of cytochrome c from mitochondria"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of release of cytochrome c from mitochondria" (in gray)

Name	Description	Probability	Func Analog Organism
BCL2	B-cell CLL/lymphoma 2	1.000	Human
BCL2L1	BCL2-like 1	1.000	Human
CASP8	caspase 8, apoptosis-related cysteine peptidase	1.000
BCL2L11	BCL2-like 11 (apoptosis facilitator)	1.000
BAX	BCL2-associated X protein	0.996
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	0.994
CFLAR	CASP8 and FADD-like apoptosis regulator	0.990
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.988	Human
BID	BH3 interacting domain death agonist	0.980
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.975
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.968
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.967
FAS	Fas (TNF receptor superfamily, member 6)	0.954
FADD	Fas (TNFRSF6)-associated via death domain	0.906
BAK1	BCL2-antagonist/killer 1	0.888	Human Rat
TP53BP2	tumor protein p53 binding protein, 2	0.855
BECN1	beclin 1, autophagy related	0.848
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.754
TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy	0.721
FKBP8	FK506 binding protein 8, 38kDa	0.594
VDAC2	voltage-dependent anion channel 2	0.542
BBC3	BCL2 binding component 3	0.416
BAD	BCL2-associated agonist of cell death	0.391
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.357
FBXO7	F-box protein 7	0.346
NLRC4	NLR family, CARD domain containing 4	0.328
AMBRA1	autophagy/beclin-1 regulator 1	0.288
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.241
SMCR7	Smith-Magenis syndrome chromosome region, candidate 7	0.227
MEFV	Mediterranean fever	0.224
BIK	BCL2-interacting killer (apoptosis-inducing)	0.202
WWOX	WW domain containing oxidoreductase	0.175
BNIP3L	BCL2/adenovirus E1B 19kDa interacting protein 3-like	0.145	Human
ZFYVE1	zinc finger, FYVE domain containing 1	0.130
SQSTM1	sequestosome 1	0.114
KRT5	keratin 5	0.110
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.073
MAPK8	mitogen-activated protein kinase 8	0.073
CABLES1	Cdk5 and Abl enzyme substrate 1	0.065
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.064
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.060
SATB2	SATB homeobox 2	0.058
OPTN	optineurin	0.043
BCL2L2	BCL2-like 2	0.042
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.040
C1orf93	chromosome 1 open reading frame 93	0.038
GABARAPL2	GABA(A) receptor-associated protein-like 2	0.033
FASLG	Fas ligand (TNF superfamily, member 6)	0.032	Human
HUWE1	HECT, UBA and WWE domain containing 1	0.031
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.031
CEBPZ	CCAAT/enhancer binding protein (C/EBP), zeta	0.030
SMCR7L	Smith-Magenis syndrome chromosome region, candidate 7-like	0.030
NAF1	nuclear assembly factor 1 homolog (S. cerevisiae)	0.030
MAPK1	mitogen-activated protein kinase 1	0.029
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	0.028
SPNS1	spinster homolog 1 (Drosophila)	0.027
C4orf14	chromosome 4 open reading frame 14	0.026
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.025
BBS10	Bardet-Biedl syndrome 10	0.025
MAGEH1	melanoma antigen family H, 1	0.024
S1PR5	sphingosine-1-phosphate receptor 5	0.023
KRT6C	keratin 6C	0.022
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.022
PPP3R1	protein phosphatase 3, regulatory subunit B, alpha	0.021
RGS2	regulator of G-protein signaling 2, 24kDa	0.020
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.020
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.019
GBP2	guanylate binding protein 2, interferon-inducible	0.019
NBR1	neighbor of BRCA1 gene 1	0.018
HSPH1	heat shock 105kDa/110kDa protein 1	0.018
YPEL5	yippee-like 5 (Drosophila)	0.018
GNB5	guanine nucleotide binding protein (G protein), beta 5	0.017
VDAC1	voltage-dependent anion channel 1	0.017
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.017
RNF144B	ring finger protein 144B	0.016
TSPYL4	TSPY-like 4	0.016
HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.015
PSEN2	presenilin 2 (Alzheimer disease 4)	0.015
HNRNPCL1	heterogeneous nuclear ribonucleoprotein C-like 1	0.015
SNX9	sorting nexin 9	0.012
GBAS	glioblastoma amplified sequence	0.012
ROBO2	roundabout, axon guidance receptor, homolog 2 (Drosophila)	0.012
KLHDC2	kelch domain containing 2	0.011
PDPK1	3-phosphoinositide dependent protein kinase-1	0.011
TMEM11	transmembrane protein 11	0.011
ITK	IL2-inducible T-cell kinase	0.011
PLD3	phospholipase D family, member 3	0.011
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.010
ATG4B	ATG4 autophagy related 4 homolog B (S. cerevisiae)	0.010
FNBP1	formin binding protein 1	0.010