Homo sapiens

104 known processes

CNTF

ciliary neurotrophic factor

(Aliases: HCNTF)

CNTF biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular polysaccharide metabolic process GO:0044264 27 0.575
leukemia inhibitory factor signaling pathway GO:0048861 3 0.520
ciliary neurotrophic factor mediated signaling pathway GO:0070120 5 0.427
single organism carbohydrate metabolic process GO:0044723 193 0.364
carbohydrate metabolic process GO:0005975 207 0.257
cellular amine metabolic process GO:0044106 41 0.208
ossification GO:0001503 121 0.203
regulation of cellular amine metabolic process GO:0033238 11 0.200
sulfur compound biosynthetic process GO:0044272 38 0.179
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.171
cellular carbohydrate metabolic process GO:0044262 84 0.166
regulation of cellular amino acid metabolic process GO:0006521 6 0.165
interleukin 27 mediated signaling pathway GO:0070106 1 0.156
sulfur compound metabolic process GO:0006790 101 0.152
regulation of cellular ketone metabolic process GO:0010565 50 0.140
proteoglycan metabolic process GO:0006029 29 0.138
cellular carbohydrate biosynthetic process GO:0034637 21 0.118
oncostatin m mediated signaling pathway GO:0038165 3 0.111
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 18 0.111
cellular amino acid metabolic process GO:0006520 116 0.107
amine metabolic process GO:0009308 44 0.106
positive regulation of cellular amine metabolic process GO:0033240 7 0.104
cellular ketone metabolic process GO:0042180 80 0.098
polysaccharide metabolic process GO:0005976 33 0.096
glycoprotein biosynthetic process GO:0009101 91 0.094
enzyme linked receptor protein signaling pathway GO:0007167 303 0.091
cellular component morphogenesis GO:0032989 314 0.085
glycoprotein metabolic process GO:0009100 110 0.083
cell projection organization GO:0030030 252 0.079
peptidyl tyrosine modification GO:0018212 170 0.073
carbohydrate derivative biosynthetic process GO:1901137 207 0.069
cellular response to cytokine stimulus GO:0071345 181 0.063
positive regulation of tyrosine phosphorylation of stat3 protein GO:0042517 16 0.063
positive regulation of phosphorylation GO:0042327 394 0.061
heparan sulfate proteoglycan biosynthetic process GO:0015012 8 0.061
regeneration GO:0031099 4 0.061
cellular polysaccharide biosynthetic process GO:0033692 21 0.054
polysaccharide biosynthetic process GO:0000271 27 0.053
multicellular organismal aging GO:0010259 3 0.050
heparin metabolic process GO:0030202 1 0.050
positive regulation of cytokine production GO:0001819 167 0.049
cytokine mediated signaling pathway GO:0019221 109 0.048
regulation of cytokine production GO:0001817 232 0.047
negative regulation of cytokine mediated signaling pathway GO:0001960 22 0.046
regulation of interleukin 6 mediated signaling pathway GO:0070103 3 0.046
neuron differentiation GO:0030182 138 0.045
cytokine production GO:0001816 247 0.045
oxidation reduction process GO:0055114 396 0.045
determination of adult lifespan GO:0008340 2 0.044
osteoblast differentiation GO:0001649 92 0.044
positive regulation of osteoblast differentiation GO:0045669 23 0.043
tyrosine phosphorylation of stat protein GO:0007260 33 0.042
organonitrogen compound biosynthetic process GO:1901566 200 0.042
female gamete generation GO:0007292 2 0.041
oogenesis GO:0048477 2 0.041
neuron projection development GO:0031175 106 0.041
taxis GO:0042330 157 0.041
wnt signaling pathway GO:0016055 156 0.040
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.040
post embryonic development GO:0009791 2 0.039
positive regulation of protein phosphorylation GO:0001934 313 0.038
myeloid cell differentiation GO:0030099 117 0.037
response to cytokine GO:0034097 232 0.037
aminoglycan metabolic process GO:0006022 39 0.036
jak stat cascade GO:0007259 46 0.036
carbohydrate biosynthetic process GO:0016051 42 0.036
cell development GO:0048468 328 0.035
regulation of ossification GO:0030278 58 0.035
proteoglycan biosynthetic process GO:0030166 20 0.035
heparan sulfate proteoglycan metabolic process GO:0030201 12 0.035
lipid metabolic process GO:0006629 381 0.034
positive regulation of leukocyte proliferation GO:0070665 48 0.034
single organism cellular localization GO:1902580 332 0.033
myeloid leukocyte differentiation GO:0002573 60 0.033
response to axon injury GO:0048678 1 0.032
cell type specific apoptotic process GO:0097285 125 0.032
positive regulation of tyrosine phosphorylation of stat5 protein GO:0042523 11 0.032
mitochondrion organization GO:0007005 156 0.032
positive regulation of cellular component organization GO:0051130 376 0.032
embryonic skeletal joint development GO:0072498 2 0.031
cytoplasmic transport GO:0016482 379 0.031
synaptic vesicle endocytosis GO:0048488 2 0.031
regulation of leukocyte activation GO:0002694 115 0.030
positive regulation of lymphocyte activation GO:0051251 73 0.030
interferon gamma production GO:0032609 39 0.029
regulation of t cell activation GO:0050863 77 0.029
positive regulation of interferon gamma production GO:0032729 26 0.029
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 28 0.029
cell morphogenesis GO:0000902 296 0.029
protein maturation GO:0051604 233 0.029
neuron development GO:0048666 113 0.029
positive regulation of immune system process GO:0002684 283 0.029
response to organic cyclic compound GO:0014070 204 0.029
regulation of cytokine mediated signaling pathway GO:0001959 41 0.028
immune system development GO:0002520 195 0.028
generation of neurons GO:0048699 152 0.028
negative regulation of programmed cell death GO:0043069 321 0.028
neurogenesis GO:0022008 169 0.028
single organism membrane organization GO:0044802 268 0.028
axon regeneration GO:0031103 1 0.027
tyrosine phosphorylation of stat3 protein GO:0042503 20 0.027
regulation of cell cycle GO:0051726 393 0.027
lymphocyte activation GO:0046649 133 0.027
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.027
ion homeostasis GO:0050801 230 0.026
aminoglycan biosynthetic process GO:0006023 29 0.026
hematopoietic or lymphoid organ development GO:0048534 186 0.026
nervous system development GO:0007399 293 0.026
regulation of osteoblast differentiation GO:0045667 38 0.026
regulation of cellular component movement GO:0051270 334 0.025
hemopoiesis GO:0030097 180 0.025
regulation of cellular response to stress GO:0080135 244 0.025
mitochondrion distribution GO:0048311 3 0.025
blood vessel development GO:0001568 172 0.025
synaptic vesicle recycling GO:0036465 3 0.025
purine containing compound catabolic process GO:0072523 411 0.025
neuron projection regeneration GO:0031102 1 0.025
negative regulation of protein metabolic process GO:0051248 391 0.024
negative regulation of cytosolic calcium ion concentration GO:0051481 1 0.024
t cell activation GO:0042110 99 0.024
positive regulation of ossification GO:0045778 32 0.024
intracellular protein transport GO:0006886 270 0.023
regulation of lymphocyte activation GO:0051249 103 0.023
regulation of jak stat cascade GO:0046425 44 0.023
cell part morphogenesis GO:0032990 137 0.023
nucleotide catabolic process GO:0009166 408 0.023
protein processing GO:0016485 226 0.023
regulation of cell cycle process GO:0010564 266 0.023
cell projection morphogenesis GO:0048858 129 0.022
cellular macromolecule catabolic process GO:0044265 380 0.022
response to abiotic stimulus GO:0009628 336 0.022
protein localization to organelle GO:0033365 280 0.022
cell morphogenesis involved in differentiation GO:0000904 144 0.022
positive regulation of mononuclear cell proliferation GO:0032946 47 0.021
t cell proliferation GO:0042098 45 0.021
chemotaxis GO:0006935 157 0.021
cellular protein catabolic process GO:0044257 261 0.021
positive regulation of cell motility GO:2000147 177 0.021
leukocyte differentiation GO:0002521 98 0.021
positive regulation of cell proliferation GO:0008284 301 0.021
cellular metal ion homeostasis GO:0006875 146 0.021
mucopolysaccharide metabolic process GO:1903510 27 0.021
apoptotic signaling pathway GO:0097190 268 0.021
positive regulation of lymphocyte proliferation GO:0050671 46 0.021
positive regulation of t cell activation GO:0050870 54 0.021
negative regulation of cellular component organization GO:0051129 235 0.020
negative regulation of catalytic activity GO:0043086 335 0.020
ras protein signal transduction GO:0007265 73 0.020
mononuclear cell proliferation GO:0032943 71 0.020
regulation of cell motility GO:2000145 299 0.020
glycosaminoglycan biosynthetic process GO:0006024 27 0.020
cellular homeostasis GO:0019725 196 0.020
protein catabolic process GO:0030163 325 0.020
rho protein signal transduction GO:0007266 26 0.020
regulation of leukocyte proliferation GO:0070663 67 0.020
purine nucleoside catabolic process GO:0006152 398 0.020
nucleoside triphosphate catabolic process GO:0009143 394 0.020
chemical homeostasis GO:0048878 306 0.020
regulation of astrocyte differentiation GO:0048710 3 0.020
regulation of cell differentiation GO:0045595 393 0.019
positive regulation of response to external stimulus GO:0032103 88 0.019
regulation of locomotion GO:0040012 329 0.019
regulation of glial cell differentiation GO:0045685 3 0.019
negative regulation of phosphorus metabolic process GO:0010563 267 0.019
regulation of transferase activity GO:0051338 355 0.019
positive regulation of leukocyte activation GO:0002696 80 0.019
glycosaminoglycan metabolic process GO:0030203 35 0.019
glycerolipid metabolic process GO:0046486 107 0.019
leukocyte activation GO:0045321 164 0.018
purine nucleoside triphosphate catabolic process GO:0009146 392 0.018
peptidyl tyrosine phosphorylation GO:0018108 170 0.018
regulation of cell development GO:0060284 161 0.018
regulation of kinase activity GO:0043549 314 0.018
blastoderm segmentation GO:0007350 2 0.018
positive regulation of cell activation GO:0050867 81 0.018
regulation of mononuclear cell proliferation GO:0032944 65 0.018
purine ribonucleoside catabolic process GO:0046130 398 0.018
positive regulation of gliogenesis GO:0014015 4 0.018
immune response GO:0006955 307 0.017
protein targeting GO:0006605 187 0.017
positive regulation of catabolic process GO:0009896 310 0.017
nucleocytoplasmic transport GO:0006913 176 0.017
negative regulation of t cell apoptotic process GO:0070233 4 0.017
regulation of cellular component biogenesis GO:0044087 281 0.017
mapk cascade GO:0000165 288 0.017
ribonucleoside triphosphate catabolic process GO:0009203 391 0.017
ribonucleoside triphosphate metabolic process GO:0009199 412 0.017
locomotory behavior GO:0007626 1 0.017
protein targeting to nucleus GO:0044744 104 0.017
membrane organization GO:0061024 292 0.017
positive regulation of programmed cell death GO:0043068 249 0.017
negative regulation of phosphate metabolic process GO:0045936 267 0.017
regulation of cell activation GO:0050865 125 0.017
nucleoside phosphate catabolic process GO:1901292 412 0.017
negative regulation of cellular amine metabolic process GO:0033239 3 0.017
protein modification by small protein conjugation GO:0032446 342 0.016
regulation of mitotic cell cycle GO:0007346 189 0.016
segmentation GO:0035282 4 0.016
regulation of response to cytokine stimulus GO:0060759 46 0.016
memory GO:0007613 3 0.016
cellular lipid metabolic process GO:0044255 303 0.016
endocytosis GO:0006897 159 0.016
lymphocyte proliferation GO:0046651 70 0.016
spermatid differentiation GO:0048515 4 0.016
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.016
guanosine containing compound catabolic process GO:1901069 239 0.016
negative regulation of cell death GO:0060548 345 0.016
regulation of t cell proliferation GO:0042129 42 0.016
cellular ion homeostasis GO:0006873 168 0.016
regulation of purine nucleotide metabolic process GO:1900542 264 0.016
positive regulation of mapk cascade GO:0043410 190 0.016
purine ribonucleotide catabolic process GO:0009154 404 0.016
dephosphorylation GO:0016311 209 0.016
ribonucleotide catabolic process GO:0009261 405 0.016
neuromuscular junction development GO:0007528 3 0.016
single organism reproductive process GO:0044702 98 0.016
astrocyte differentiation GO:0048708 4 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.016
organelle localization GO:0051640 84 0.016
central nervous system development GO:0007417 123 0.016
peripheral nervous system development GO:0007422 2 0.015
vesicle mediated transport GO:0016192 371 0.015
regulation of purine nucleotide catabolic process GO:0033121 205 0.015
positive regulation of cellular catabolic process GO:0031331 284 0.015
proteasomal protein catabolic process GO:0010498 176 0.015
regulation of protein localization GO:0032880 296 0.015
regulation of protein catabolic process GO:0042176 155 0.015
regulation of proteolysis GO:0030162 293 0.015
cell adhesion GO:0007155 325 0.015
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.015
positive regulation of t cell proliferation GO:0042102 33 0.015
regulation of establishment of protein localization GO:0070201 242 0.015
mitotic cell cycle process GO:1903047 286 0.015
generation of precursor metabolites and energy GO:0006091 68 0.014
regulation of interferon gamma production GO:0032649 36 0.014
negative regulation of cellular protein metabolic process GO:0032269 353 0.014
signal transduction by phosphorylation GO:0023014 297 0.014
mitotic cell cycle phase transition GO:0044772 162 0.014
actin filament based process GO:0030029 224 0.014
cellular glucan metabolic process GO:0006073 22 0.014
protein ubiquitination GO:0016567 314 0.014
regulation of nucleotide metabolic process GO:0006140 269 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.014
purine nucleotide catabolic process GO:0006195 405 0.014
response to hormone GO:0009725 175 0.014
regulation of cell growth GO:0001558 135 0.014
ribonucleoside catabolic process GO:0042454 406 0.014
positive regulation of nucleoside metabolic process GO:0045979 186 0.014
cell activation GO:0001775 213 0.014
blood vessel morphogenesis GO:0048514 162 0.014
nuclear import GO:0051170 106 0.014
oocyte development GO:0048599 1 0.014
hindbrain development GO:0030902 3 0.014
triglyceride metabolic process GO:0006641 23 0.013
neutral lipid metabolic process GO:0006638 27 0.013
cellular macromolecular complex assembly GO:0034622 324 0.013
positive regulation of transferase activity GO:0051347 227 0.013
oocyte differentiation GO:0009994 2 0.013
spermatid development GO:0007286 4 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.013
protein localization to nucleus GO:0034504 136 0.013
tube morphogenesis GO:0035239 95 0.013
regulation of meiotic cell cycle GO:0051445 4 0.013
organophosphate catabolic process GO:0046434 430 0.013
regulation of tyrosine phosphorylation of stat protein GO:0042509 30 0.013
cellular divalent inorganic cation homeostasis GO:0072503 128 0.013
lung alveolus development GO:0048286 4 0.013
gtp metabolic process GO:0046039 239 0.013
anterior posterior axis specification embryo GO:0008595 2 0.013
cellular response to endogenous stimulus GO:0071495 336 0.013
positive regulation of cellular component movement GO:0051272 181 0.013
regulation of gtpase activity GO:0043087 180 0.013
regulation of gtp catabolic process GO:0033124 180 0.013
regulation of cell division GO:0051302 116 0.013
positive regulation of cell projection organization GO:0031346 64 0.013
divalent inorganic cation homeostasis GO:0072507 136 0.013
head development GO:0060322 108 0.013
chromatin modification GO:0016568 298 0.013
metal ion homeostasis GO:0055065 169 0.013
tripartite regional subdivision GO:0007351 2 0.013
negative regulation of response to cytokine stimulus GO:0060761 25 0.013
modification dependent protein catabolic process GO:0019941 209 0.013
response to external biotic stimulus GO:0043207 261 0.013
regulation of chromosome organization GO:0033044 103 0.012
establishment of organelle localization GO:0051656 59 0.012
nerve development GO:0021675 4 0.012
response to oxygen containing compound GO:1901700 369 0.012
cell growth GO:0016049 160 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.012
protein import GO:0017038 130 0.012
epithelium migration GO:0090132 119 0.012
positive regulation of hydrolase activity GO:0051345 331 0.012
positive regulation of cell cycle GO:0045787 140 0.012
nucleoside triphosphate metabolic process GO:0009141 422 0.012
regulation of secretion by cell GO:1903530 177 0.012
protein import into nucleus GO:0006606 104 0.012
neurological system process GO:0050877 163 0.012
purine ribonucleoside metabolic process GO:0046128 437 0.012
neuroblast proliferation GO:0007405 4 0.012
anterior posterior axis specification GO:0009948 2 0.012
negative regulation of phosphorylation GO:0042326 174 0.012
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.012
modification dependent macromolecule catabolic process GO:0043632 212 0.012
positive regulation of protein kinase activity GO:0045860 190 0.012
regulation of mapk cascade GO:0043408 262 0.012
digestive system development GO:0055123 75 0.012
dna repair GO:0006281 198 0.012
cellular cation homeostasis GO:0030003 163 0.012
establishment of vesicle localization GO:0051650 23 0.012
regulation of response to external stimulus GO:0032101 222 0.012
positive regulation of cell differentiation GO:0045597 211 0.012
skeletal system development GO:0001501 79 0.012
negative regulation of cell cycle GO:0045786 193 0.012
digestive tract morphogenesis GO:0048546 56 0.012
cation transport GO:0006812 331 0.012
response to biotic stimulus GO:0009607 276 0.012
response to nutrient levels GO:0031667 81 0.012
regulation of small gtpase mediated signal transduction GO:0051056 156 0.012
cellular calcium ion homeostasis GO:0006874 117 0.012
negative regulation of multicellular organismal process GO:0051241 317 0.012
smoothened signaling pathway GO:0007224 14 0.012
ubiquitin dependent protein catabolic process GO:0006511 206 0.012
transmembrane transport GO:0055085 399 0.012
guanosine containing compound metabolic process GO:1901068 244 0.011
establishment of protein localization to organelle GO:0072594 172 0.011
positive regulation of organelle organization GO:0010638 195 0.011
i kappab kinase nf kappab signaling GO:0007249 166 0.011
purine nucleoside triphosphate metabolic process GO:0009144 412 0.011
regulation of protein binding GO:0043393 66 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.011
rna processing GO:0006396 255 0.011
regulation of protein transport GO:0051223 213 0.011
regulation of cellular protein catabolic process GO:1903362 96 0.011
protein autophosphorylation GO:0046777 123 0.011
cellular response to interleukin 6 GO:0071354 14 0.011
regulation of apoptotic signaling pathway GO:2001233 175 0.011
protein acylation GO:0043543 138 0.011
nitrogen compound transport GO:0071705 191 0.011
tyrosine phosphorylation of stat5 protein GO:0042506 13 0.011
cellular response to dna damage stimulus GO:0006974 379 0.011
response to hypoxia GO:0001666 96 0.011
nuclear transport GO:0051169 179 0.011
nucleoside catabolic process GO:0009164 408 0.011
growth GO:0040007 202 0.011
nucleoside monophosphate metabolic process GO:0009123 191 0.011
heparin biosynthetic process GO:0030210 1 0.011
regulation of cytoskeleton organization GO:0051493 177 0.011
regulation of protein complex assembly GO:0043254 147 0.011
negative regulation of protein modification process GO:0031400 200 0.011
chromatin organization GO:0006325 351 0.011
response to radiation GO:0009314 151 0.011
regulation of mitotic cell cycle phase transition GO:1901990 118 0.011
olfactory lobe development GO:0021988 5 0.011
regulation of protein maturation GO:1903317 150 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.011
positive regulation of cell development GO:0010720 92 0.011
brain development GO:0007420 97 0.011
rhythmic behavior GO:0007622 2 0.011
regulation of nucleoside metabolic process GO:0009118 209 0.011
metencephalon development GO:0022037 2 0.011
response to wounding GO:0009611 168 0.011
ribonucleoside monophosphate metabolic process GO:0009161 187 0.011
ion transmembrane transport GO:0034220 338 0.011
response to bacterium GO:0009617 144 0.011
regulation of protein kinase activity GO:0045859 289 0.010
endomembrane system organization GO:0010256 196 0.010
intrinsic apoptotic signaling pathway GO:0097193 127 0.010
leukocyte proliferation GO:0070661 74 0.010
activation of protein kinase activity GO:0032147 90 0.010
nuclear division GO:0000280 128 0.010
meiotic chromosome segregation GO:0045132 4 0.010
response to nitrogen compound GO:1901698 184 0.010
positive regulation of tyrosine phosphorylation of stat1 protein GO:0042511 8 0.010
endoderm development GO:0007492 33 0.010
regulation of angiogenesis GO:0045765 92 0.010
cellular protein complex assembly GO:0043623 188 0.010
regulation of intracellular transport GO:0032386 195 0.010
purine nucleoside monophosphate metabolic process GO:0009126 186 0.010
vesicle localization GO:0051648 26 0.010
negative regulation of protein processing GO:0010955 142 0.010
negative regulation of hydrolase activity GO:0051346 182 0.010
actin cytoskeleton organization GO:0030036 207 0.010
positive regulation of jak stat cascade GO:0046427 35 0.010

CNTF disease predictions

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 223 0.360
bone disease DOID:0080001 88 0.265
connective tissue disease DOID:65 109 0.265
disease of cellular proliferation DOID:14566 174 0.071
bone remodeling disease DOID:0080005 26 0.063
cancer DOID:162 167 0.060
organ system cancer DOID:0050686 164 0.046
sensory system disease DOID:0050155 203 0.023
nervous system disease DOID:863 431 0.023
disease of metabolism DOID:0014667 295 0.017
inherited metabolic disorder DOID:655 242 0.016
eye and adnexa disease DOID:1492 150 0.015
eye disease DOID:5614 149 0.015
central nervous system disease DOID:331 186 0.014
retinal disease DOID:5679 118 0.012