IMP

Process View

Homo sapiens

29 genes annotated in human

proteoglycan metabolic process

The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "proteoglycan metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "proteoglycan metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.993
BMPR1A	bone morphogenetic protein receptor, type IA	0.970
PCYT2	phosphate cytidylyltransferase 2, ethanolamine	0.799
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.777
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.742
ELN	elastin	0.565
IGF2R	insulin-like growth factor 2 receptor	0.497
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.481
CTNNBIP1	catenin, beta interacting protein 1	0.468
JUP	junction plakoglobin	0.456	Human
ITGB1BP3	integrin beta 1 binding protein 3	0.408
GLIS2	GLIS family zinc finger 2	0.325
EMD	emerin	0.174
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.158
LUM	lumican	0.141
COMP	cartilage oligomeric matrix protein	0.138
CNTF	ciliary neurotrophic factor	0.138
VCAN	versican	0.117
PSEN1	presenilin 1	0.110
COL6A1	collagen, type VI, alpha 1	0.102
HIC1	hypermethylated in cancer 1	0.089
ACAN	aggrecan	0.081	Mouse
ZNF431	zinc finger protein 431	0.081
COL14A1	collagen, type XIV, alpha 1	0.078
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.076	Human
PKP4	plakophilin 4	0.073
APC	adenomatous polyposis coli	0.072
FSTL1	follistatin-like 1	0.070
MXRA5	matrix-remodelling associated 5	0.070
PRELP	proline/arginine-rich end leucine-rich repeat protein	0.069
MXRA8	matrix-remodelling associated 8	0.066
BMP1	bone morphogenetic protein 1	0.065
THY1	Thy-1 cell surface antigen	0.062
TCF4	transcription factor 4	0.060
COL5A1	collagen, type V, alpha 1	0.056
GPR124	G protein-coupled receptor 124	0.045
LRRC15	leucine rich repeat containing 15	0.042
IGF2	insulin-like growth factor 2 (somatomedin A)	0.042	Human
SOAT1	sterol O-acyltransferase 1	0.041
MAN1B1	mannosidase, alpha, class 1B, member 1	0.041
IGFBP5	insulin-like growth factor binding protein 5	0.040
SCARB2	scavenger receptor class B, member 2	0.039
TMEM127	transmembrane protein 127	0.039
PTK7	PTK7 protein tyrosine kinase 7	0.039
FAF1	Fas (TNFRSF6) associated factor 1	0.038
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.037
APOB	apolipoprotein B (including Ag(x) antigen)	0.037
WISP1	WNT1 inducible signaling pathway protein 1	0.036
RGS4	regulator of G-protein signaling 4	0.036
TNIK	TRAF2 and NCK interacting kinase	0.036
FBLN1	fibulin 1	0.035
EDNRA	endothelin receptor type A	0.035
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.035
HMGXB3	HMG box domain containing 3	0.035
COPZ2	coatomer protein complex, subunit zeta 2	0.034
OLFML3	olfactomedin-like 3	0.034
MFAP2	microfibrillar-associated protein 2	0.034
WNT6	wingless-type MMTV integration site family, member 6	0.033
CTNND1	catenin (cadherin-associated protein), delta 1	0.032
HEXB	hexosaminidase B (beta polypeptide)	0.032
WDYHV1	WDYHV motif containing 1	0.032
PCOLCE	procollagen C-endopeptidase enhancer	0.031
SFRP4	secreted frizzled-related protein 4	0.030
PKD1	polycystic kidney disease 1 (autosomal dominant)	0.030
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.029
LTBP2	latent transforming growth factor beta binding protein 2	0.029
COL1A2	collagen, type I, alpha 2	0.029
LAMP1	lysosomal-associated membrane protein 1	0.029
BTRC	beta-transducin repeat containing	0.029
ISLR	immunoglobulin superfamily containing leucine-rich repeat	0.029
LEF1	lymphoid enhancer-binding factor 1	0.029	Human
KLF10	Kruppel-like factor 10	0.029
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.028
SVEP1	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	0.027
MFAP5	microfibrillar associated protein 5	0.027
NOV	nephroblastoma overexpressed gene	0.027
TGOLN2	trans-golgi network protein 2	0.027
PALM	paralemmin	0.026
UNC5B	unc-5 homolog B (C. elegans)	0.026
TWIST1	twist homolog 1 (Drosophila)	0.026
HMGCL	3-hydroxymethyl-3-methylglutaryl-CoA lyase	0.026
TGFB2	transforming growth factor, beta 2	0.026
FNDC3B	fibronectin type III domain containing 3B	0.024
OLFML2B	olfactomedin-like 2B	0.024
DSP	desmoplakin	0.024
FNDC1	fibronectin type III domain containing 1	0.024
NGFR	nerve growth factor receptor	0.024
COL13A1	collagen, type XIII, alpha 1	0.023
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.023
COL11A1	collagen, type XI, alpha 1	0.023	Mouse
DIO2	deiodinase, iodothyronine, type II	0.023
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.022
SPOCK1	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	0.022
DPY19L4	dpy-19-like 4 (C. elegans)	0.022
TMEM119	transmembrane protein 119	0.021
ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)	0.021
P2RX2	purinergic receptor P2X, ligand-gated ion channel, 2	0.021
OSTM1	osteopetrosis associated transmembrane protein 1	0.021
SFRP2	secreted frizzled-related protein 2	0.020
PIGK	phosphatidylinositol glycan anchor biosynthesis, class K	0.020
CCDC40	coiled-coil domain containing 40	0.020
FASTK	Fas-activated serine/threonine kinase	0.020
PLXNB3	plexin B3	0.020
GPR153	G protein-coupled receptor 153	0.020
SLC38A6	solute carrier family 38, member 6	0.019
COL4A5	collagen, type IV, alpha 5	0.019
C7orf42	chromosome 7 open reading frame 42	0.019
THBS2	thrombospondin 2	0.019
THBS4	thrombospondin 4	0.019
ASPN	asporin	0.019
FMO1	flavin containing monooxygenase 1	0.019
MAGEL2	MAGE-like 2	0.018
SLC35B2	solute carrier family 35, member B2	0.018
POSTN	periostin, osteoblast specific factor	0.018
DCN	decorin	0.018	Zebrafish Mouse
CD248	CD248 molecule, endosialin	0.018
GJA4	gap junction protein, alpha 4, 37kDa	0.018
GREM1	gremlin 1	0.018
ARL15	ADP-ribosylation factor-like 15	0.018
OMD	osteomodulin	0.017
PRRX1	paired related homeobox 1	0.017
INHBA	inhibin, beta A	0.017
CHPF	chondroitin polymerizing factor	0.017	Human Mouse
CRLF1	cytokine receptor-like factor 1	0.017
PRRX2	paired related homeobox 2	0.017
MRC2	mannose receptor, C type 2	0.017
COL5A3	collagen, type V, alpha 3	0.017
SMO	smoothened homolog (Drosophila)	0.017
ODZ4	odz, odd Oz/ten-m homolog 4 (Drosophila)	0.017
SMOC2	SPARC related modular calcium binding 2	0.017
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.016
LAMA2	laminin, alpha 2	0.016
B4GALT7	xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)	0.016
ZNF267	zinc finger protein 267	0.016
ROR2	receptor tyrosine kinase-like orphan receptor 2	0.016
MGP	matrix Gla protein	0.016
ITGA11	integrin, alpha 11	0.016
BMP8A	bone morphogenetic protein 8a	0.015
TCF7	transcription factor 7 (T-cell specific, HMG-box)	0.015	Human
SLIT2	slit homolog 2 (Drosophila)	0.015
LOX	lysyl oxidase	0.015
COCH	coagulation factor C homolog, cochlin (Limulus polyphemus)	0.015
FBLN5	fibulin 5	0.015
ADAMTS12	ADAM metallopeptidase with thrombospondin type 1 motif, 12	0.015
HYAL1	hyaluronoglucosaminidase 1	0.015
ZDHHC24	zinc finger, DHHC-type containing 24	0.015
CRIP2	cysteine-rich protein 2	0.015
RUNX3	runt-related transcription factor 3	0.015
IGFBP1	insulin-like growth factor binding protein 1	0.015
TBXA2R	thromboxane A2 receptor	0.015
FKBP10	FK506 binding protein 10, 65 kDa	0.015
SLC4A3	solute carrier family 4, anion exchanger, member 3	0.015
ACSL4	acyl-CoA synthetase long-chain family member 4	0.015
ADAM12	ADAM metallopeptidase domain 12	0.015
ATP2C1	ATPase, Ca++ transporting, type 2C, member 1	0.015
EXTL2	exostoses (multiple)-like 2	0.015
NOX4	NADPH oxidase 4	0.015
CHSY1	chondroitin sulfate synthase 1	0.015
TSPAN31	tetraspanin 31	0.015
FAM3A	family with sequence similarity 3, member A	0.015
LIMS2	LIM and senescent cell antigen-like domains 2	0.015
CXCL12	chemokine (C-X-C motif) ligand 12	0.015
VTN	vitronectin	0.015
TF	transferrin	0.014
OBSL1	obscurin-like 1	0.014
IGFBP3	insulin-like growth factor binding protein 3	0.014
CILP	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	0.014
COL10A1	collagen, type X, alpha 1	0.014
CCND2	cyclin D2	0.014
SCARF2	scavenger receptor class F, member 2	0.014
LEPREL4	leprecan-like 4	0.014
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	0.014
HCN2	hyperpolarization activated cyclic nucleotide-gated potassium channel 2	0.014
GLI3	GLI family zinc finger 3	0.014
TGFB3	transforming growth factor, beta 3	0.014
IGFBP2	insulin-like growth factor binding protein 2, 36kDa	0.014
HOXD8	homeobox D8	0.014
VPS41	vacuolar protein sorting 41 homolog (S. cerevisiae)	0.014
COL12A1	collagen, type XII, alpha 1	0.014
APCDD1L	adenomatosis polyposis coli down-regulated 1-like	0.014
EXTL1	exostoses (multiple)-like 1	0.014
FAP	fibroblast activation protein, alpha	0.013
COL8A1	collagen, type VIII, alpha 1	0.013
EDN2	endothelin 2	0.013
LOXL2	lysyl oxidase-like 2	0.013
TMEM184B	transmembrane protein 184B	0.013
NTM	neurotrimin	0.013
AXIN1	axin 1	0.013
AR	androgen receptor	0.013
VWA1	von Willebrand factor A domain containing 1	0.013
ECM2	extracellular matrix protein 2, female organ and adipocyte specific	0.013
ADORA1	adenosine A1 receptor	0.013
FGFR1	fibroblast growth factor receptor 1	0.013
CRELD2	cysteine-rich with EGF-like domains 2	0.013
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.013
ARHGEF5	Rho guanine nucleotide exchange factor (GEF) 5	0.013
TUBA1A	tubulin, alpha 1a	0.013
EFNB3	ephrin-B3	0.013
CD34	CD34 molecule	0.013
ACTC1	actin, alpha, cardiac muscle 1	0.013
KCNIP3	Kv channel interacting protein 3, calsenilin	0.013
DPYSL3	dihydropyrimidinase-like 3	0.013
STOML1	stomatin (EPB72)-like 1	0.013
PFDN1	prefoldin subunit 1	0.013
CCNA1	cyclin A1	0.013
BMPR1B	bone morphogenetic protein receptor, type IB	0.013
RAB11FIP5	RAB11 family interacting protein 5 (class I)	0.013
RIMS4	regulating synaptic membrane exocytosis 4	0.013
HAS2	hyaluronan synthase 2	0.013
DOK5	docking protein 5	0.013
FAM155B	family with sequence similarity 155, member B	0.013
ADAMTS14	ADAM metallopeptidase with thrombospondin type 1 motif, 14	0.013	Human
SCRG1	stimulator of chondrogenesis 1	0.012
SYNPO	synaptopodin	0.012
FZD8	frizzled homolog 8 (Drosophila)	0.012
CTSK	cathepsin K	0.012
ZFPM2	zinc finger protein, multitype 2	0.012
COL9A3	collagen, type IX, alpha 3	0.012
DPYSL2	dihydropyrimidinase-like 2	0.012
COL8A2	collagen, type VIII, alpha 2	0.012
OLFML1	olfactomedin-like 1	0.012
DCHS1	dachsous 1 (Drosophila)	0.012
PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	0.012
WFS1	Wolfram syndrome 1 (wolframin)	0.012
HYAL2	hyaluronoglucosaminidase 2	0.012
COL9A1	collagen, type IX, alpha 1	0.012
RAB3IL1	RAB3A interacting protein (rabin3)-like 1	0.012
C17orf62	chromosome 17 open reading frame 62	0.012
HS3ST3A1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	0.012
PLXNA1	plexin A1	0.012
SMAD9	SMAD family member 9	0.012
KLHL2	kelch-like 2, Mayven (Drosophila)	0.012
ATP2B1	ATPase, Ca++ transporting, plasma membrane 1	0.012
TRPV4	transient receptor potential cation channel, subfamily V, member 4	0.012
COL2A1	collagen, type II, alpha 1	0.012	Mouse
CST4	cystatin S	0.012
TDGF1	teratocarcinoma-derived growth factor 1	0.012
ATP6AP2	ATPase, H+ transporting, lysosomal accessory protein 2	0.012
FST	follistatin	0.012
GLI2	GLI family zinc finger 2	0.012
MSLN	mesothelin	0.012
MFAP4	microfibrillar-associated protein 4	0.012
CHST3	carbohydrate (chondroitin 6) sulfotransferase 3	0.012
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.012
TEAD3	TEA domain family member 3	0.012
ZNF469	zinc finger protein 469	0.012
PLXDC1	plexin domain containing 1	0.012
MFGE8	milk fat globule-EGF factor 8 protein	0.012
DGKI	diacylglycerol kinase, iota	0.012
NTN1	netrin 1	0.012
COL3A1	collagen, type III, alpha 1	0.012
AEBP1	AE binding protein 1	0.012
DMPK	dystrophia myotonica-protein kinase	0.012
GPC1	glypican 1	0.012
HSF2BP	heat shock transcription factor 2 binding protein	0.012
CRTAP	cartilage associated protein	0.012
CRYAB	crystallin, alpha B	0.012
LOXL1	lysyl oxidase-like 1	0.012
FGD1	FYVE, RhoGEF and PH domain containing 1	0.012
ACTA2	actin, alpha 2, smooth muscle, aorta	0.011
FAM19A5	family with sequence similarity 19 (chemokine (C-C motif)-like), member A5	0.011
PLEKHA4	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	0.011
CDHR5	cadherin-related family member 5	0.011
FAM57B	family with sequence similarity 57, member B	0.011
C3orf64	chromosome 3 open reading frame 64	0.011
GMPPA	GDP-mannose pyrophosphorylase A	0.011
NRSN2	neurensin 2	0.011
SETD8	SET domain containing (lysine methyltransferase) 8	0.011
AJAP1	adherens junctions associated protein 1	0.011
GLT8D2	glycosyltransferase 8 domain containing 2	0.011
FBXL7	F-box and leucine-rich repeat protein 7	0.011
BOC	Boc homolog (mouse)	0.011
GGA3	golgi-associated, gamma adaptin ear containing, ARF binding protein 3	0.011
COL1A1	collagen, type I, alpha 1	0.011
FGF2	fibroblast growth factor 2 (basic)	0.011
CHMP6	chromatin modifying protein 6	0.011
HAPLN1	hyaluronan and proteoglycan link protein 1	0.011
HEYL	hairy/enhancer-of-split related with YRPW motif-like	0.011
DOCK7	dedicator of cytokinesis 7	0.011
MINPP1	multiple inositol-polyphosphate phosphatase 1	0.011
CSPG4	chondroitin sulfate proteoglycan 4	0.011
ABTB1	ankyrin repeat and BTB (POZ) domain containing 1	0.011
C10orf72	chromosome 10 open reading frame 72	0.011
C17orf70	chromosome 17 open reading frame 70	0.011
EPO	erythropoietin	0.011
CACNA1I	calcium channel, voltage-dependent, T type, alpha 1I subunit	0.011
CLIP3	CAP-GLY domain containing linker protein 3	0.011
ALG12	asparagine-linked glycosylation 12, alpha-1,6-mannosyltransferase homolog (S. cerevisiae)	0.011
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.011
SEZ6L2	seizure related 6 homolog (mouse)-like 2	0.011
CD7	CD7 molecule	0.011
OXTR	oxytocin receptor	0.011
KCNE4	potassium voltage-gated channel, Isk-related family, member 4	0.011
CFHR2	complement factor H-related 2	0.011
COLEC12	collectin sub-family member 12	0.011
FZD1	frizzled homolog 1 (Drosophila)	0.011
KCNC4	potassium voltage-gated channel, Shaw-related subfamily, member 4	0.011
SCUBE3	signal peptide, CUB domain, EGF-like 3	0.011
RCN1	reticulocalbin 1, EF-hand calcium binding domain	0.011
FGF5	fibroblast growth factor 5	0.010
SLC16A2	solute carrier family 16, member 2 (monocarboxylic acid transporter 8)	0.010
SFRP1	secreted frizzled-related protein 1	0.010
SEMA4F	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F	0.010
MAST2	microtubule associated serine/threonine kinase 2	0.010
MAG	myelin associated glycoprotein	0.010
YIPF2	Yip1 domain family, member 2	0.010
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.010
C5orf15	chromosome 5 open reading frame 15	0.010
EPHB3	EPH receptor B3	0.010
TSKU	tsukushi small leucine rich proteoglycan homolog (Xenopus laevis)	0.010
PAM	peptidylglycine alpha-amidating monooxygenase	0.010
FBLN2	fibulin 2	0.010
SAMD3	sterile alpha motif domain containing 3	0.010
RIN1	Ras and Rab interactor 1	0.010
CREB3L1	cAMP responsive element binding protein 3-like 1	0.010
GPR64	G protein-coupled receptor 64	0.010
SIL1	SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)	0.010
RHOJ	ras homolog gene family, member J	0.010
JAG1	jagged 1	0.010
C7orf10	chromosome 7 open reading frame 10	0.010
DACT1	dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)	0.010
FMOD	fibromodulin	0.010
GPR176	G protein-coupled receptor 176	0.010
ZMYND15	zinc finger, MYND-type containing 15	0.010
EMILIN2	elastin microfibril interfacer 2	0.010
PODNL1	podocan-like 1	0.010
KIAA0284	KIAA0284	0.010
BGN	biglycan	0.010	Mouse
CEP170	centrosomal protein 170kDa	0.010
GNAZ	guanine nucleotide binding protein (G protein), alpha z polypeptide	0.010
CHPF2	chondroitin polymerizing factor 2	0.010
LAMA1	laminin, alpha 1	0.010
GIPC1	GIPC PDZ domain containing family, member 1	0.010
C1QTNF1	C1q and tumor necrosis factor related protein 1	0.010
NFATC4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.010
ARFGAP1	ADP-ribosylation factor GTPase activating protein 1	0.010
SH2D2A	SH2 domain containing 2A	0.010