Homo sapiens

74 known processes

SLX4

SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)

(Aliases: MUS312,FANCP,KIAA1987,KIAA1784,BTBD12)

SLX4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nucleotide excision repair dna incision GO:0033683 7 1.000
regulation of telomere maintenance GO:0032204 13 1.000
nucleotide excision repair GO:0006289 31 0.999
negative regulation of telomere maintenance GO:0032205 9 0.999
response to dna integrity checkpoint signaling GO:0072402 4 0.998
dna catabolic process GO:0006308 49 0.998
cellular response to dna damage stimulus GO:0006974 379 0.995
dna repair GO:0006281 198 0.994
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.993
double strand break repair via homologous recombination GO:0000724 50 0.992
response to intra s dna damage checkpoint signaling GO:0072429 4 0.989
recombinational repair GO:0000725 50 0.987
response to cell cycle checkpoint signaling GO:0072396 4 0.985
telomere organization GO:0032200 33 0.984
response to dna damage checkpoint signaling GO:0072423 4 0.965
telomere maintenance GO:0000723 32 0.964
negative regulation of homeostatic process GO:0032845 59 0.957
negative regulation of chromosome organization GO:2001251 48 0.949
negative regulation of dna metabolic process GO:0051053 57 0.949
dna catabolic process endonucleolytic GO:0000737 37 0.942
anatomical structure homeostasis GO:0060249 100 0.925
negative regulation of organelle organization GO:0010639 126 0.819
regulation of dna metabolic process GO:0051052 153 0.816
regulation of chromosome organization GO:0033044 103 0.802
negative regulation of cellular component organization GO:0051129 235 0.776
cellular macromolecule catabolic process GO:0044265 380 0.713
double strand break repair GO:0006302 101 0.706
dna recombination GO:0006310 77 0.643
response to biotic stimulus GO:0009607 276 0.638
regulation of cell cycle process GO:0010564 266 0.543
cellular response to biotic stimulus GO:0071216 71 0.469
sex determination GO:0007530 3 0.461
regulation of homeostatic process GO:0032844 121 0.451
regulation of mitotic cell cycle GO:0007346 189 0.395
dna integrity checkpoint GO:0031570 71 0.283
positive regulation of telomere maintenance GO:0032206 4 0.267
positive regulation of hydrolase activity GO:0051345 331 0.260
negative regulation of cell cycle GO:0045786 193 0.235
non recombinational repair GO:0000726 14 0.233
purine ribonucleoside metabolic process GO:0046128 437 0.225
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.213
nucleoside triphosphate metabolic process GO:0009141 422 0.210
response to uv GO:0009411 73 0.200
protein localization to chromosome telomeric region GO:0070198 6 0.197
mitotic cell cycle process GO:1903047 286 0.180
morphogenesis of embryonic epithelium GO:0016331 4 0.176
negative regulation of cell cycle process GO:0010948 121 0.171
post embryonic development GO:0009791 2 0.165
mitotic cell cycle GO:0000278 326 0.144
dna damage checkpoint GO:0000077 68 0.132
cellular protein complex assembly GO:0043623 188 0.131
guanosine containing compound metabolic process GO:1901068 244 0.128
microtubule polymerization GO:0046785 18 0.125
purine ribonucleoside catabolic process GO:0046130 398 0.117
response to radiation GO:0009314 151 0.117
regulation of cell cycle GO:0051726 393 0.113
mitotic cell cycle checkpoint GO:0007093 68 0.103
neural tube formation GO:0001841 3 0.098
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.098
negative regulation of mitotic cell cycle GO:0045930 102 0.090
telomere maintenance via telomerase GO:0007004 8 0.089
mitotic g2 dna damage checkpoint GO:0007095 7 0.088
histone modification GO:0016570 251 0.086
purine ribonucleotide catabolic process GO:0009154 404 0.086
nucleotide catabolic process GO:0009166 408 0.082
response to light stimulus GO:0009416 87 0.081
uv protection GO:0009650 5 0.081
negative regulation of cell cycle phase transition GO:1901988 89 0.080
organic anion transport GO:0015711 103 0.080
glycosyl compound catabolic process GO:1901658 413 0.072
embryo development GO:0009790 123 0.072
cellular response to endogenous stimulus GO:0071495 336 0.072
nucleoside phosphate catabolic process GO:1901292 412 0.072
dephosphorylation GO:0016311 209 0.072
purine nucleotide catabolic process GO:0006195 405 0.071
positive regulation of catabolic process GO:0009896 310 0.069
modification dependent macromolecule catabolic process GO:0043632 212 0.068
regulation of meiotic cell cycle GO:0051445 4 0.067
meiosis i GO:0007127 4 0.067
positive regulation of cell cycle process GO:0090068 106 0.067
telomere maintenance via telomere lengthening GO:0010833 9 0.065
ribonucleotide catabolic process GO:0009261 405 0.064
negative regulation of catabolic process GO:0009895 104 0.063
regulation of gtp catabolic process GO:0033124 180 0.062
positive regulation of cell death GO:0010942 263 0.062
mitotic recombination GO:0006312 8 0.060
mitochondrion organization GO:0007005 156 0.058
embryonic epithelial tube formation GO:0001838 4 0.058
g2 m transition of mitotic cell cycle GO:0000086 41 0.058
response to wounding GO:0009611 168 0.058
negative regulation of catalytic activity GO:0043086 335 0.055
ribonucleoside triphosphate metabolic process GO:0009199 412 0.054
protein localization to chromosome GO:0034502 30 0.053
cell cycle phase transition GO:0044770 173 0.052
protein maturation GO:0051604 233 0.052
negative regulation of protein metabolic process GO:0051248 391 0.050
positive regulation of programmed cell death GO:0043068 249 0.048
epithelium development GO:0060429 227 0.047
protein localization to organelle GO:0033365 280 0.047
ribonucleoside triphosphate catabolic process GO:0009203 391 0.046
cell cycle g2 m phase transition GO:0044839 43 0.046
chromatin modification GO:0016568 298 0.046
regulation of cell cycle phase transition GO:1901987 126 0.045
mitotic dna integrity checkpoint GO:0044774 30 0.044
negative regulation of cellular catabolic process GO:0031330 83 0.044
response to metal ion GO:0010038 84 0.044
purine nucleoside catabolic process GO:0006152 398 0.043
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.043
primary neural tube formation GO:0014020 3 0.040
cellular amino acid metabolic process GO:0006520 116 0.040
purine containing compound catabolic process GO:0072523 411 0.040
regulation of meiosis GO:0040020 3 0.039
somatic recombination of immunoglobulin gene segments GO:0016447 4 0.039
nuclear division GO:0000280 128 0.039
regulation of mitotic cell cycle phase transition GO:1901990 118 0.038
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.038
tube closure GO:0060606 3 0.036
transmembrane transport GO:0055085 399 0.036
purine nucleoside triphosphate metabolic process GO:0009144 412 0.036
response to other organism GO:0051707 261 0.035
replicative cell aging GO:0001302 3 0.034
negative regulation of transferase activity GO:0051348 124 0.034
protein oligomerization GO:0051259 173 0.034
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.034
gene conversion GO:0035822 1 0.033
organophosphate catabolic process GO:0046434 430 0.032
response to oxidative stress GO:0006979 121 0.032
protein homooligomerization GO:0051260 100 0.032
amine metabolic process GO:0009308 44 0.032
regulation of purine nucleotide metabolic process GO:1900542 264 0.032
dna catabolic process exonucleolytic GO:0000738 17 0.032
multicellular organismal aging GO:0010259 3 0.032
cell type specific apoptotic process GO:0097285 125 0.031
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.031
adaptive immune response GO:0002250 49 0.030
microtubule based process GO:0007017 210 0.030
regulation of ras protein signal transduction GO:0046578 155 0.030
negative regulation of cellular protein metabolic process GO:0032269 353 0.030
positive regulation of apoptotic process GO:0043065 246 0.030
mismatch repair GO:0006298 15 0.029
negative regulation of dna replication GO:0008156 29 0.029
positive regulation of nucleoside metabolic process GO:0045979 186 0.029
response to oxygen containing compound GO:1901700 369 0.029
microtubule cytoskeleton organization GO:0000226 176 0.028
mitotic cell cycle phase transition GO:0044772 162 0.028
regulation of telomere maintenance via telomerase GO:0032210 6 0.028
oogenesis GO:0048477 2 0.028
positive regulation of mitotic cell cycle GO:0045931 60 0.028
regulation of cellular ketone metabolic process GO:0010565 50 0.028
negative regulation of phosphorus metabolic process GO:0010563 267 0.027
determination of adult lifespan GO:0008340 2 0.027
organic acid transport GO:0015849 65 0.027
covalent chromatin modification GO:0016569 254 0.026
reactive oxygen species metabolic process GO:0072593 75 0.026
ubiquitin dependent protein catabolic process GO:0006511 206 0.026
positive regulation of intracellular protein transport GO:0090316 76 0.025
positive regulation of gtpase activity GO:0043547 166 0.025
regulation of nucleotide metabolic process GO:0006140 269 0.025
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.025
single organism cell adhesion GO:0098602 179 0.024
gtp metabolic process GO:0046039 239 0.024
positive regulation of cellular amine metabolic process GO:0033240 7 0.024
immune response GO:0006955 307 0.024
negative regulation of chromosome segregation GO:0051985 18 0.023
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.023
negative regulation of protein phosphorylation GO:0001933 140 0.023
regulation of transferase activity GO:0051338 355 0.023
regulation of microtubule cytoskeleton organization GO:0070507 61 0.023
single organismal cell cell adhesion GO:0016337 148 0.023
regulation of nucleotide catabolic process GO:0030811 205 0.023
positive regulation of nucleotide catabolic process GO:0030813 185 0.023
neural tube closure GO:0001843 3 0.022
i kappab kinase nf kappab signaling GO:0007249 166 0.022
protein ubiquitination GO:0016567 314 0.022
regulation of cytoskeleton organization GO:0051493 177 0.022
anion transport GO:0006820 161 0.022
oocyte differentiation GO:0009994 2 0.022
actin filament based process GO:0030029 224 0.022
regulation of cellular amino acid metabolic process GO:0006521 6 0.022
cellular response to radiation GO:0071478 65 0.022
gtp catabolic process GO:0006184 237 0.022
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.022
female gamete generation GO:0007292 2 0.022
tissue regeneration GO:0042246 3 0.022
regulation of protein processing GO:0070613 150 0.021
assembly of actomyosin apparatus involved in cytokinesis GO:0000912 1 0.021
negative regulation of telomere maintenance via telomerase GO:0032211 5 0.021
negative regulation of protein modification process GO:0031400 200 0.021
mitotic g2 m transition checkpoint GO:0044818 9 0.021
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.020
oocyte development GO:0048599 1 0.020
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.020
regulation of protein kinase activity GO:0045859 289 0.020
morphogenesis of a polarized epithelium GO:0001738 3 0.019
spermatid development GO:0007286 4 0.019
cell activation GO:0001775 213 0.019
positive regulation of nucleotide metabolic process GO:0045981 230 0.019
positive regulation of cellular catabolic process GO:0031331 284 0.019
nervous system development GO:0007399 293 0.019
rho protein signal transduction GO:0007266 26 0.019
cell division GO:0051301 168 0.019
male meiosis GO:0007140 1 0.019
signal transduction by phosphorylation GO:0023014 297 0.019
purine nucleoside monophosphate metabolic process GO:0009126 186 0.019
salivary gland morphogenesis GO:0007435 4 0.018
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.018
organelle fission GO:0048285 149 0.018
intracellular protein transport GO:0006886 270 0.018
carboxylic acid transport GO:0046942 63 0.018
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.018
single organism reproductive process GO:0044702 98 0.018
immune effector process GO:0002252 159 0.018
leukocyte activation GO:0045321 164 0.018
glycoprotein metabolic process GO:0009100 110 0.018
sequestering of calcium ion GO:0051208 17 0.018
cell fate commitment GO:0045165 27 0.018
immune system development GO:0002520 195 0.017
negative regulation of kinase activity GO:0033673 106 0.017
protein processing GO:0016485 226 0.017
cellular ketone metabolic process GO:0042180 80 0.017
positive regulation of dna metabolic process GO:0051054 73 0.017
positive regulation of mitosis GO:0045840 25 0.017
regulation of proteasomal protein catabolic process GO:0061136 87 0.017
segmentation GO:0035282 4 0.017
neuroblast proliferation GO:0007405 4 0.017
negative regulation of stem cell proliferation GO:2000647 3 0.017
cell aging GO:0007569 52 0.017
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 3 0.017
developmental programmed cell death GO:0010623 3 0.017
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.017
cellular amine metabolic process GO:0044106 41 0.017
regulation of carbohydrate metabolic process GO:0006109 54 0.017
spindle midzone assembly GO:0051255 4 0.017
ribonucleoside catabolic process GO:0042454 406 0.016
endosomal transport GO:0016197 129 0.016
myosin filament assembly GO:0031034 2 0.016
ion transmembrane transport GO:0034220 338 0.016
nucleoside monophosphate metabolic process GO:0009123 191 0.016
negative regulation of phosphorylation GO:0042326 174 0.016
response to ionizing radiation GO:0010212 65 0.016
purine nucleoside triphosphate catabolic process GO:0009146 392 0.016
regulation of nucleoside metabolic process GO:0009118 209 0.016
regulation of cellular protein catabolic process GO:1903362 96 0.016
epithelial cell proliferation GO:0050673 128 0.016
nucleoside triphosphate catabolic process GO:0009143 394 0.015
regulation of cellular carbohydrate metabolic process GO:0010675 47 0.015
regulation of kinase activity GO:0043549 314 0.015
hematopoietic or lymphoid organ development GO:0048534 186 0.015
nitrogen compound transport GO:0071705 191 0.015
nucleoside catabolic process GO:0009164 408 0.015
protein polymerization GO:0051258 71 0.015
negative regulation of jun kinase activity GO:0043508 4 0.015
chromatin organization GO:0006325 351 0.015
positive regulation of organelle organization GO:0010638 195 0.015
positive regulation of protein transport GO:0051222 135 0.015
spermatid differentiation GO:0048515 4 0.015
developmental process involved in reproduction GO:0003006 66 0.015
regeneration GO:0031099 4 0.015
tissue migration GO:0090130 119 0.015
protein methylation GO:0006479 74 0.015
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.014
sequestering of metal ion GO:0051238 24 0.014
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.014
positive regulation of cell cycle GO:0045787 140 0.014
cellular component disassembly GO:0022411 92 0.014
negative regulation of phosphate metabolic process GO:0045936 267 0.014
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.014
negative regulation of programmed cell death GO:0043069 321 0.014
wound healing GO:0042060 115 0.014
regulation of phosphatase activity GO:0010921 81 0.014
negative regulation of neural precursor cell proliferation GO:2000178 1 0.014
single organism membrane organization GO:0044802 268 0.014
midgut development GO:0007494 1 0.014
ribonucleoside monophosphate metabolic process GO:0009161 187 0.014
aging GO:0007568 66 0.014
nucleus organization GO:0006997 28 0.014
lymphocyte activation GO:0046649 133 0.014
regulation of establishment of protein localization GO:0070201 242 0.014
regulation of microtubule based process GO:0032886 74 0.014
regulation of purine nucleotide catabolic process GO:0033121 205 0.014
hemostasis GO:0007599 76 0.014
actin filament based movement GO:0030048 17 0.014
morphogenesis of an epithelium GO:0002009 60 0.014
reproductive process GO:0022414 106 0.014
anatomical structure formation involved in morphogenesis GO:0048646 284 0.014
apoptotic process involved in morphogenesis GO:0060561 3 0.014
vesicle mediated transport GO:0016192 371 0.014
negative regulation of protein kinase activity GO:0006469 98 0.014
actin cytoskeleton organization GO:0030036 207 0.013
negative regulation of intracellular signal transduction GO:1902532 183 0.013
purine nucleotide biosynthetic process GO:0006164 84 0.013
positive regulation of chromosome organization GO:2001252 41 0.013
neurotransmitter secretion GO:0007269 4 0.013
negative regulation of gliogenesis GO:0014014 3 0.013
regulation of cellular amine metabolic process GO:0033238 11 0.013
rna processing GO:0006396 255 0.013
mitochondrial rna metabolic process GO:0000959 15 0.013
organonitrogen compound biosynthetic process GO:1901566 200 0.013
negative regulation of dna recombination GO:0045910 6 0.013
epithelium migration GO:0090132 119 0.013
regulation of neuroblast proliferation GO:1902692 3 0.013
cytokinesis GO:0000910 96 0.013
negative regulation of epithelial cell proliferation GO:0050680 48 0.012
mrna metabolic process GO:0016071 175 0.012
cellular response to organic cyclic compound GO:0071407 127 0.012
regulation of growth GO:0040008 165 0.012
regulation of mitotic sister chromatid separation GO:0010965 27 0.012
establishment of protein localization to organelle GO:0072594 172 0.012
organelle inheritance GO:0048308 2 0.012
protein dephosphorylation GO:0006470 81 0.012
positive regulation of apoptotic signaling pathway GO:2001235 70 0.012
negative regulation of mitotic sister chromatid separation GO:2000816 17 0.012
positive regulation of gtp catabolic process GO:0033126 166 0.012
regulation of cellular component biogenesis GO:0044087 281 0.012
regulation of neural precursor cell proliferation GO:2000177 4 0.012
macromolecule glycosylation GO:0043413 63 0.012
nuclear transport GO:0051169 179 0.012
proteasomal protein catabolic process GO:0010498 176 0.012
protein glycosylation GO:0006486 62 0.012
regulation of small gtpase mediated signal transduction GO:0051056 156 0.012
organelle assembly GO:0070925 176 0.012
protein catabolic process GO:0030163 325 0.012
regulation of gtpase activity GO:0043087 180 0.012
ameboidal type cell migration GO:0001667 135 0.012
activation of mitotic anaphase promoting complex activity GO:0007092 2 0.012
positive regulation of protein phosphorylation GO:0001934 313 0.012
positive regulation of transferase activity GO:0051347 227 0.012
organ morphogenesis GO:0009887 147 0.011
dna replication GO:0006260 116 0.011
membrane organization GO:0061024 292 0.011
guanosine containing compound catabolic process GO:1901069 239 0.011
cell matrix adhesion GO:0007160 85 0.011
inner ear morphogenesis GO:0042472 4 0.011
regulation of cell migration GO:0030334 289 0.011
retrograde transport endosome to golgi GO:0042147 45 0.011
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.011
thymus development GO:0048538 3 0.011
regulation of rho protein signal transduction GO:0035023 79 0.011
mitotic dna damage checkpoint GO:0044773 28 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.011
regulation of protein catabolic process GO:0042176 155 0.011
protein localization to adherens junction GO:0071896 2 0.011
myeloid leukocyte differentiation GO:0002573 60 0.011
regulation of cell division GO:0051302 116 0.011
purine nucleoside monophosphate catabolic process GO:0009128 158 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.011
regulation of dephosphorylation GO:0035303 96 0.011
positive regulation of ras gtpase activity GO:0032320 117 0.011
epithelial cell differentiation GO:0030855 141 0.011
protein polyubiquitination GO:0000209 110 0.011
positive regulation of cell proliferation GO:0008284 301 0.011
cellular response to cytokine stimulus GO:0071345 181 0.011
engulfment of apoptotic cell GO:0043652 2 0.010
regulation of cellular response to stress GO:0080135 244 0.010
positive regulation of nuclear division GO:0051785 27 0.010
protein localization to cell junction GO:1902414 3 0.010
somatic hypermutation of immunoglobulin genes GO:0016446 1 0.010
positive regulation of proteolysis GO:0045862 142 0.010
regulation of proteolysis GO:0030162 293 0.010
negative regulation of hydrolase activity GO:0051346 182 0.010
endocytosis GO:0006897 159 0.010
mitotic spindle assembly checkpoint GO:0007094 14 0.010
establishment of planar polarity GO:0001736 3 0.010
mitochondrial transport GO:0006839 60 0.010
regulation of protein transport GO:0051223 213 0.010

SLX4 disease predictions

Disease DO term ID Size Probability Func Analog Org
xeroderma pigmentosum DOID:0050427 8 0.968
immune system disease DOID:2914 155 0.749
hematopoietic system disease DOID:74 100 0.749
aplastic anemia DOID:12449 30 0.667
bone marrow disease DOID:4961 31 0.667
anemia DOID:2355 55 0.667
disease of metabolism DOID:0014667 295 0.110
inherited metabolic disorder DOID:655 242 0.110
musculoskeletal system disease DOID:17 223 0.029
connective tissue disease DOID:65 109 0.029
bone development disease DOID:0080006 55 0.018
bone disease DOID:0080001 88 0.018
amino acid metabolic disorder DOID:9252 50 0.016
disease of cellular proliferation DOID:14566 174 0.015
sensory system disease DOID:0050155 203 0.014
nervous system disease DOID:863 431 0.014
artery disease DOID:0050828 23 0.014
vascular disease DOID:178 25 0.014
cardiovascular system disease DOID:1287 106 0.014
osteochondrodysplasia DOID:2256 35 0.012
central nervous system disease DOID:331 186 0.011
congenital hypoplastic anemia DOID:1342 26 0.004
fanconi s anemia DOID:13636 16 0.004