IMP

Process View

Homo sapiens

27 genes annotated in human

positive regulation of nuclear division

Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of nuclear division"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of nuclear division" (in gray)

Name	Description	Probability	Func Analog Organism
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.817
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.722
IL1R1	interleukin 1 receptor, type I	0.398
CDK2	cyclin-dependent kinase 2	0.393
EGFR	epidermal growth factor receptor	0.368
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.325
ANAPC4	anaphase promoting complex subunit 4	0.305
GRB10	growth factor receptor-bound protein 10	0.270
CCNA2	cyclin A2	0.250
CD80	CD80 molecule	0.247
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.246
CAV1	caveolin 1, caveolae protein, 22kDa	0.216
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.168
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.148
AURKB	aurora kinase B	0.144
SMC6	structural maintenance of chromosomes 6	0.118
CCNB1	cyclin B1	0.111
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.087
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.082
IGF1R	insulin-like growth factor 1 receptor	0.082	Human Mouse
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.080	Mouse
IRS1	insulin receptor substrate 1	0.078
CDC26	cell division cycle 26 homolog (S. cerevisiae)	0.073
PLK1	polo-like kinase 1	0.066
JAK2	Janus kinase 2	0.066
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.064	Yeast Fly
RB1	retinoblastoma 1	0.063
RBL2	retinoblastoma-like 2 (p130)	0.062	Human
ANAPC5	anaphase promoting complex subunit 5	0.062
ANAPC7	anaphase promoting complex subunit 7	0.054
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.052
CDKN3	cyclin-dependent kinase inhibitor 3	0.051
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	0.051
APP	amyloid beta (A4) precursor protein	0.050
NRP1	neuropilin 1	0.050
AXIN1	axin 1	0.049
GSK3B	glycogen synthase kinase 3 beta	0.048	Fly
GHR	growth hormone receptor	0.048
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.047	Yeast
PTTG1	pituitary tumor-transforming 1	0.047
MKNK1	MAP kinase interacting serine/threonine kinase 1	0.046
GAB1	GRB2-associated binding protein 1	0.042
DAZ1	deleted in azoospermia 1	0.039
INSR	insulin receptor	0.039
RBL1	retinoblastoma-like 1 (p107)	0.037	Human
CCNB2	cyclin B2	0.033
SIRT2	sirtuin 2	0.032	Mouse
ITGB1BP3	integrin beta 1 binding protein 3	0.031
PRRC2C	proline-rich coiled-coil 2C	0.028
MIS18BP1	MIS18 binding protein 1	0.028
PGF	placental growth factor	0.027	Human
GRAP2	GRB2-related adaptor protein 2	0.027
ANAPC1	anaphase promoting complex subunit 1	0.027
ANAPC11	anaphase promoting complex subunit 11	0.026
CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	0.026
HDAC6	histone deacetylase 6	0.025
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.025
PDGFA	platelet-derived growth factor alpha polypeptide	0.025	Human
CKS2	CDC28 protein kinase regulatory subunit 2	0.024
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.024
IER3	immediate early response 3	0.024
ENG	endoglin	0.024
CDCA8	cell division cycle associated 8	0.023
TERF2IP	telomeric repeat binding factor 2, interacting protein	0.022
CENPF	centromere protein F, 350/400kDa (mitosin)	0.022
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	0.022
TTK	TTK protein kinase	0.021
CLSPN	claspin	0.021
MBNL1	muscleblind-like (Drosophila)	0.021
VEGFA	vascular endothelial growth factor A	0.021	Human
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.020
THBS1	thrombospondin 1	0.020
RBBP8	retinoblastoma binding protein 8	0.020
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.019
PLCG1	phospholipase C, gamma 1	0.019
GAS2L3	growth arrest-specific 2 like 3	0.019
BCAR1	breast cancer anti-estrogen resistance 1	0.018
MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.018
NSMCE1	non-SMC element 1 homolog (S. cerevisiae)	0.018
UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	0.018
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.017
HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	0.017
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.017
ORC1	origin recognition complex, subunit 1	0.017
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.017
PTBP2	polypyrimidine tract binding protein 2	0.017
CCNE1	cyclin E1	0.017
TGFB3	transforming growth factor, beta 3	0.017
PRC1	protein regulator of cytokinesis 1	0.017
STAT5B	signal transducer and activator of transcription 5B	0.017
CAPRIN2	caprin family member 2	0.016
PTPRZ1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	0.016
KIF20A	kinesin family member 20A	0.016
PRKCA	protein kinase C, alpha	0.016
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.016
CDK1	cyclin-dependent kinase 1	0.016	Worm
TNRC6C	trinucleotide repeat containing 6C	0.016
TOP3A	topoisomerase (DNA) III alpha	0.016
SMC3	structural maintenance of chromosomes 3	0.015
ADRBK1	adrenergic, beta, receptor kinase 1	0.015
IGF2R	insulin-like growth factor 2 receptor	0.015
E2F5	E2F transcription factor 5, p130-binding	0.015
INCENP	inner centromere protein antigens 135/155kDa	0.015
MSX1	msh homeobox 1	0.015	Mouse
MSX2	msh homeobox 2	0.014	Mouse
EPOR	erythropoietin receptor	0.014
LAT	linker for activation of T cells	0.014
CDT1	chromatin licensing and DNA replication factor 1	0.014
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.014
MAK	male germ cell-associated kinase	0.014
PAIP2	poly(A) binding protein interacting protein 2	0.014
ANKRD32	ankyrin repeat domain 32	0.014
MTF2	metal response element binding transcription factor 2	0.014
AXIN2	axin 2	0.014
ESPL1	extra spindle pole bodies homolog 1 (S. cerevisiae)	0.013
TOP1	topoisomerase (DNA) I	0.013
CCND1	cyclin D1	0.013
FBXO5	F-box protein 5	0.013
FOXM1	forkhead box M1	0.013
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.013
ORC2	origin recognition complex, subunit 2	0.013
CCL20	chemokine (C-C motif) ligand 20	0.013
PDGFC	platelet derived growth factor C	0.013
CEP110	centrosomal protein 110kDa	0.013
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.012
IRS2	insulin receptor substrate 2	0.012
NCAPG	non-SMC condensin I complex, subunit G	0.012
RIF1	RAP1 interacting factor homolog (yeast)	0.012
FUBP1	far upstream element (FUSE) binding protein 1	0.012
PLAUR	plasminogen activator, urokinase receptor	0.012
KIF18A	kinesin family member 18A	0.012
TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	0.012
LDLR	low density lipoprotein receptor	0.012
E2F4	E2F transcription factor 4, p107/p130-binding	0.012
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.012
BRCA2	breast cancer 2, early onset	0.012
FAM83D	family with sequence similarity 83, member D	0.011
CD86	CD86 molecule	0.011
ZNF133	zinc finger protein 133	0.011	Human
FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)	0.011
FGFR1	fibroblast growth factor receptor 1	0.011
SH3KBP1	SH3-domain kinase binding protein 1	0.011
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.011
AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.011
IGFBP5	insulin-like growth factor binding protein 5	0.011
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.011
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.011	Rat
SH2B2	SH2B adaptor protein 2	0.011
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.011
SLX4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)	0.010
MAD2L1BP	MAD2L1 binding protein	0.010
ZNF337	zinc finger protein 337	0.010	Human
TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	0.010
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.010
SPOP	speckle-type POZ protein	0.010