Homo sapiens

117 known processes

OPTN

optineurin

(Aliases: NRP,TFIIIA-INTP,HYPL,FIP2,ALS12,HIP7,GLC1E)

OPTN biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
autophagy GO:0006914 88 0.816
positive regulation of cellular component organization GO:0051130 376 0.775
protein k48 linked ubiquitination GO:0070936 38 0.740
cellular macromolecule catabolic process GO:0044265 380 0.737
endosomal transport GO:0016197 129 0.698
negative regulation of programmed cell death GO:0043069 321 0.663
intracellular protein transport GO:0006886 270 0.641
regulation of interferon beta biosynthetic process GO:0045357 4 0.635
intrinsic apoptotic signaling pathway GO:0097193 127 0.557
regulation of synaptic plasticity GO:0048167 3 0.523
protein polyubiquitination GO:0000209 110 0.507
regulation of cellular ketone metabolic process GO:0010565 50 0.460
cellular response to external stimulus GO:0071496 111 0.417
negative regulation of developmental process GO:0051093 247 0.414
extrinsic apoptotic signaling pathway GO:0097191 119 0.396
membrane fusion GO:0061025 43 0.382
macroautophagy GO:0016236 39 0.367
single organism cellular localization GO:1902580 332 0.350
regulation of cell motility GO:2000145 299 0.338
membrane organization GO:0061024 292 0.335
cellular response to dna damage stimulus GO:0006974 379 0.335
regulation of cell migration GO:0030334 289 0.334
mitochondrion organization GO:0007005 156 0.332
post golgi vesicle mediated transport GO:0006892 36 0.330
regulation of cytoskeleton organization GO:0051493 177 0.320
negative regulation of cell death GO:0060548 345 0.315
cytoplasmic transport GO:0016482 379 0.313
organelle assembly GO:0070925 176 0.302
protein catabolic process GO:0030163 325 0.297
purine nucleoside triphosphate metabolic process GO:0009144 412 0.288
microtubule based process GO:0007017 210 0.269
actin filament organization GO:0007015 128 0.269
negative regulation of intracellular signal transduction GO:1902532 183 0.264
positive regulation of interferon beta biosynthetic process GO:0045359 4 0.262
system process GO:0003008 349 0.259
cellular ketone metabolic process GO:0042180 80 0.255
regulation of defense response GO:0031347 154 0.252
response to other organism GO:0051707 261 0.252
regulation of cellular component movement GO:0051270 334 0.248
regulation of proteolysis GO:0030162 293 0.224
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.223
vesicle mediated transport GO:0016192 371 0.219
regulation of cofactor metabolic process GO:0051193 3 0.218
golgi organization GO:0007030 38 0.218
endocytic recycling GO:0032456 12 0.216
protein maturation GO:0051604 233 0.215
interferon beta biosynthetic process GO:0045350 4 0.213
determination of adult lifespan GO:0008340 2 0.213
axon cargo transport GO:0008088 2 0.209
nucleocytoplasmic transport GO:0006913 176 0.207
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.199
negative regulation of apoptotic process GO:0043066 316 0.198
fatty acid metabolic process GO:0006631 115 0.196
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.195
regulation of establishment of protein localization GO:0070201 242 0.186
actin cytoskeleton organization GO:0030036 207 0.185
epithelium development GO:0060429 227 0.185
secretion GO:0046903 254 0.183
ubiquitin dependent protein catabolic process GO:0006511 206 0.181
i kappab kinase nf kappab signaling GO:0007249 166 0.181
cellular response to extracellular stimulus GO:0031668 72 0.173
regulation of protein transport GO:0051223 213 0.170
response to growth factor GO:0070848 205 0.169
cellular response to starvation GO:0009267 58 0.168
protein localization to organelle GO:0033365 280 0.163
actin filament polymerization GO:0030041 45 0.157
regulation of cellular response to stress GO:0080135 244 0.156
regulation of actin filament polymerization GO:0030833 50 0.153
cell projection organization GO:0030030 252 0.141
apoptotic signaling pathway GO:0097190 268 0.138
protein polymerization GO:0051258 71 0.138
regulation of vesicle mediated transport GO:0060627 130 0.135
cytoskeleton dependent intracellular transport GO:0030705 21 0.135
regulation of endopeptidase activity GO:0052548 170 0.134
response to cytokine GO:0034097 232 0.133
cellular macromolecular complex assembly GO:0034622 324 0.133
negative regulation of multicellular organismal process GO:0051241 317 0.132
cell activation GO:0001775 213 0.130
positive regulation of phosphorylation GO:0042327 394 0.128
actin filament bundle organization GO:0061572 54 0.126
monocarboxylic acid metabolic process GO:0032787 185 0.124
protein modification by small protein conjugation GO:0032446 342 0.124
positive regulation of apoptotic process GO:0043065 246 0.121
organelle localization GO:0051640 84 0.121
positive regulation of transport GO:0051050 336 0.118
defense response to gram positive bacterium GO:0050830 29 0.117
establishment of protein localization to endoplasmic reticulum membrane GO:0097051 3 0.114
protein localization to membrane GO:0072657 160 0.113
negative regulation of protein metabolic process GO:0051248 391 0.112
cellular protein catabolic process GO:0044257 261 0.111
compound eye development GO:0048749 1 0.111
single organism membrane fusion GO:0044801 37 0.108
regulation of response to wounding GO:1903034 101 0.107
anatomical structure formation involved in morphogenesis GO:0048646 284 0.106
positive regulation of programmed cell death GO:0043068 249 0.106
nuclear transport GO:0051169 179 0.099
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.099
activation of innate immune response GO:0002218 55 0.099
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.098
regulation of dephosphorylation GO:0035303 96 0.097
negative regulation of response to external stimulus GO:0032102 83 0.096
defense response to bacterium GO:0042742 63 0.096
regulation of proteasomal protein catabolic process GO:0061136 87 0.093
reactive nitrogen species metabolic process GO:2001057 3 0.092
regulation of protein localization GO:0032880 296 0.091
negative regulation of cellular component organization GO:0051129 235 0.089
protein targeting GO:0006605 187 0.089
regulation of secretion GO:0051046 194 0.088
base excision repair GO:0006284 21 0.088
oxidation reduction process GO:0055114 396 0.088
amine metabolic process GO:0009308 44 0.087
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.087
response to external biotic stimulus GO:0043207 261 0.086
innate immune response GO:0045087 178 0.085
regulation of apoptotic signaling pathway GO:2001233 175 0.084
response to drug GO:0042493 81 0.083
establishment of protein localization to organelle GO:0072594 172 0.082
positive regulation of interferon beta production GO:0032728 17 0.081
regulation of cellular amino acid metabolic process GO:0006521 6 0.081
protein localization to plasma membrane GO:0072659 93 0.080
response to bacterium GO:0009617 144 0.080
inorganic ion transmembrane transport GO:0098660 231 0.079
regulation of transferase activity GO:0051338 355 0.078
regulation of response to external stimulus GO:0032101 222 0.078
regulation of actin filament based process GO:0032970 141 0.078
positive regulation of response to wounding GO:1903036 28 0.077
retrograde transport endosome to golgi GO:0042147 45 0.077
negative regulation of phosphate metabolic process GO:0045936 267 0.076
anion transport GO:0006820 161 0.075
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.074
regulation of cellular response to growth factor stimulus GO:0090287 76 0.072
actin polymerization or depolymerization GO:0008154 56 0.072
regulation of anatomical structure size GO:0090066 101 0.072
ion transmembrane transport GO:0034220 338 0.071
positive regulation of immune response GO:0050778 159 0.070
microtubule cytoskeleton organization GO:0000226 176 0.069
chromatin organization GO:0006325 351 0.068
multicellular organismal aging GO:0010259 3 0.068
mapk cascade GO:0000165 288 0.068
protein monoubiquitination GO:0006513 39 0.067
negative regulation of canonical wnt signaling pathway GO:0090090 55 0.066
dna repair GO:0006281 198 0.066
regulation of actin polymerization or depolymerization GO:0008064 56 0.066
transmembrane transport GO:0055085 399 0.065
negative regulation of actin filament polymerization GO:0030837 10 0.065
vesicle localization GO:0051648 26 0.065
regulation of cellular amine metabolic process GO:0033238 11 0.065
regulation of actin cytoskeleton organization GO:0032956 116 0.064
protein processing GO:0016485 226 0.063
cellular component morphogenesis GO:0032989 314 0.063
neuron differentiation GO:0030182 138 0.063
regulation of ion transport GO:0043269 189 0.061
negative regulation of cytoskeleton organization GO:0051494 45 0.061
negative regulation of sodium ion transport GO:0010766 3 0.060
purine ribonucleotide catabolic process GO:0009154 404 0.060
positive regulation of cellular amine metabolic process GO:0033240 7 0.059
regulation of canonical wnt signaling pathway GO:0060828 88 0.057
cation transport GO:0006812 331 0.057
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.057
cell morphogenesis GO:0000902 296 0.056
positive regulation of mucus secretion GO:0070257 1 0.056
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.056
divalent metal ion transport GO:0070838 152 0.055
cellular response to oxidative stress GO:0034599 85 0.055
cellular response to growth factor stimulus GO:0071363 197 0.055
establishment of vesicle localization GO:0051650 23 0.055
cellular response to abiotic stimulus GO:0071214 117 0.055
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.055
histone ubiquitination GO:0016574 31 0.054
cilium assembly GO:0042384 63 0.054
negative regulation of response to wounding GO:1903035 47 0.054
cellular carbohydrate metabolic process GO:0044262 84 0.054
defense response to other organism GO:0098542 129 0.053
positive regulation of secretion GO:0051047 116 0.053
cell adhesion GO:0007155 325 0.052
positive regulation of cellular component biogenesis GO:0044089 158 0.052
response to abiotic stimulus GO:0009628 336 0.052
positive regulation of innate immune response GO:0045089 79 0.051
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.051
chemical homeostasis GO:0048878 306 0.051
positive regulation of cell death GO:0010942 263 0.051
ribonucleoside monophosphate metabolic process GO:0009161 187 0.050
regulation of transmembrane transport GO:0034762 139 0.050
regulation of epithelial cell migration GO:0010632 93 0.050
regulation of ion transmembrane transport GO:0034765 132 0.050
cellular component assembly involved in morphogenesis GO:0010927 73 0.049
negative regulation of cell proliferation GO:0008285 228 0.049
adaptive immune response GO:0002250 49 0.049
regulation of protein polymerization GO:0032271 63 0.048
endoplasmic reticulum tubular network organization GO:0071786 8 0.048
regulation of cysteine type endopeptidase activity GO:2000116 127 0.048
nucleoside triphosphate metabolic process GO:0009141 422 0.048
organic acid transport GO:0015849 65 0.048
cellular amine metabolic process GO:0044106 41 0.047
regulation of protein serine threonine kinase activity GO:0071900 179 0.047
carboxylic acid transport GO:0046942 63 0.047
protein targeting to nucleus GO:0044744 104 0.047
cellular response to nutrient levels GO:0031669 69 0.046
defense response GO:0006952 315 0.046
regulation of intracellular transport GO:0032386 195 0.045
regulation of protein complex assembly GO:0043254 147 0.045
metal ion transport GO:0030001 272 0.044
regulation of ketone biosynthetic process GO:0010566 7 0.044
regulation of actin filament length GO:0030832 56 0.044
regulation of locomotion GO:0040012 329 0.044
regulation of protein kinase activity GO:0045859 289 0.043
positive regulation of release of cytochrome c from mitochondria GO:0090200 18 0.043
cell development GO:0048468 328 0.043
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 21 0.043
regulation of transporter activity GO:0032409 82 0.043
negative regulation of protein maturation GO:1903318 142 0.042
establishment of organelle localization GO:0051656 59 0.042
signal transduction by p53 class mediator GO:0072331 72 0.042
immune response GO:0006955 307 0.041
vacuole organization GO:0007033 44 0.041
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.041
regulation of mapk cascade GO:0043408 262 0.041
ribonucleoprotein complex assembly GO:0022618 78 0.041
golgi vesicle fusion to target membrane GO:0048210 2 0.041
somatic muscle development GO:0007525 1 0.041
negative regulation of phosphorylation GO:0042326 174 0.041
regulation of cytoplasmic transport GO:1903649 149 0.040
regulation of erk1 and erk2 cascade GO:0070372 99 0.040
nervous system development GO:0007399 293 0.040
establishment of protein localization to plasma membrane GO:0090002 68 0.040
lipid metabolic process GO:0006629 381 0.040
organic acid catabolic process GO:0016054 71 0.039
cell projection assembly GO:0030031 126 0.039
growth GO:0040007 202 0.039
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.039
regulation of cell differentiation GO:0045595 393 0.037
response to oxygen containing compound GO:1901700 369 0.036
negative regulation of peptidase activity GO:0010466 91 0.036
single organism membrane organization GO:0044802 268 0.035
cell cell junction organization GO:0045216 69 0.035
synaptic vesicle recycling GO:0036465 3 0.035
cell cell signaling GO:0007267 155 0.035
response to interferon gamma GO:0034341 39 0.034
negative regulation of cellular protein metabolic process GO:0032269 353 0.034
regulation of protein depolymerization GO:1901879 22 0.034
neurogenesis GO:0022008 169 0.034
negative regulation of protein kinase activity GO:0006469 98 0.033
signal transduction by phosphorylation GO:0023014 297 0.033
negative regulation of cellular response to growth factor stimulus GO:0090288 41 0.033
regulation of autophagy GO:0010506 52 0.033
cilium organization GO:0044782 68 0.033
ribonucleoprotein complex biogenesis GO:0022613 116 0.033
male meiosis GO:0007140 1 0.032
regulation of neuron differentiation GO:0045664 70 0.032
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.032
regulation of cell cycle GO:0051726 393 0.032
positive regulation of cell projection organization GO:0031346 64 0.032
neuromuscular junction development GO:0007528 3 0.032
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.031
interaction with host GO:0051701 42 0.031
negative regulation of wnt signaling pathway GO:0030178 69 0.031
positive regulation of secretion by cell GO:1903532 108 0.030
nucleoside catabolic process GO:0009164 408 0.030
protein depolymerization GO:0051261 30 0.030
mrna transport GO:0051028 30 0.030
positive regulation of cell migration GO:0030335 172 0.029
peptidyl serine modification GO:0018209 106 0.029
negative regulation of protein polymerization GO:0032272 16 0.029
regulation of intracellular protein transport GO:0033157 123 0.029
secretion by cell GO:0032940 226 0.029
amino acid transport GO:0006865 28 0.028
regulation of mitochondrial membrane potential GO:0051881 23 0.028
positive regulation of apoptotic signaling pathway GO:2001235 70 0.028
regulation of small gtpase mediated signal transduction GO:0051056 156 0.028
actin filament based process GO:0030029 224 0.028
sensory perception GO:0007600 103 0.028
amino acid import GO:0043090 4 0.028
nitrogen compound transport GO:0071705 191 0.028
maintenance of location GO:0051235 112 0.028
dicarboxylic acid biosynthetic process GO:0043650 4 0.027
positive regulation of response to external stimulus GO:0032103 88 0.027
negative regulation of transmembrane transport GO:0034763 29 0.027
protein import into nucleus GO:0006606 104 0.027
regulation of lipid metabolic process GO:0019216 96 0.027
cell division GO:0051301 168 0.026
regulation of protein processing GO:0070613 150 0.026
regulation of immune effector process GO:0002697 91 0.026
coenzyme biosynthetic process GO:0009108 24 0.026
positive regulation of cellular catabolic process GO:0031331 284 0.026
response to biotic stimulus GO:0009607 276 0.025
negative regulation of neuron apoptotic process GO:0043524 23 0.025
protein import GO:0017038 130 0.025
regulation of inflammatory response GO:0050727 46 0.025
rab protein signal transduction GO:0032482 4 0.025
positive regulation of cell motility GO:2000147 177 0.025
regulation of peptidase activity GO:0052547 180 0.025
regulation of cellular protein catabolic process GO:1903362 96 0.025
negative regulation of transferase activity GO:0051348 124 0.024
wound healing GO:0042060 115 0.024
trna transport GO:0051031 1 0.024
regulation of cellular component size GO:0032535 82 0.024
regulation of reactive oxygen species metabolic process GO:2000377 41 0.024
regulation of wnt signaling pathway GO:0030111 123 0.024
endoplasmic reticulum organization GO:0007029 20 0.024
regulation of steroid biosynthetic process GO:0050810 23 0.024
negative regulation of protein transport GO:0051224 75 0.024
isoprenoid metabolic process GO:0006720 39 0.024
positive regulation of ion transport GO:0043270 87 0.024
nucleobase containing compound transport GO:0015931 51 0.023
nucleoside phosphate catabolic process GO:1901292 412 0.023
vesicle fusion GO:0006906 17 0.023
ubiquitin dependent endocytosis GO:0070086 1 0.023
cellular amino acid metabolic process GO:0006520 116 0.023
positive regulation of autophagy GO:0010508 24 0.023
response to radiation GO:0009314 151 0.023
carbohydrate derivative biosynthetic process GO:1901137 207 0.023
golgi localization GO:0051645 4 0.023
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.022
endosome transport via multivesicular body sorting pathway GO:0032509 3 0.022
positive regulation of peptidyl serine phosphorylation GO:0033138 42 0.022
striated muscle cell apoptotic process GO:0010658 3 0.022
negative regulation of i kappab kinase nf kappab signaling GO:0043124 32 0.022
biological adhesion GO:0022610 331 0.022
peptidyl serine phosphorylation GO:0018105 101 0.022
organic anion transport GO:0015711 103 0.022
regulation of membrane potential GO:0042391 95 0.022
regulation of cellular response to oxidative stress GO:1900407 26 0.021
regulation of protein catabolic process GO:0042176 155 0.021
rna transport GO:0050658 39 0.021
regulation of mrna export from nucleus GO:0010793 3 0.021
polyprenol biosynthetic process GO:0016094 1 0.021
cellular response to tumor necrosis factor GO:0071356 63 0.021
renal sodium ion absorption GO:0070294 2 0.021
ribonucleoside triphosphate metabolic process GO:0009199 412 0.021
negative regulation of immune system process GO:0002683 136 0.021
negative regulation of cell activation GO:0050866 33 0.021
negative regulation of striated muscle cell apoptotic process GO:0010664 2 0.021
lymphocyte homeostasis GO:0002260 4 0.021
plasma membrane organization GO:0007009 115 0.021
response to wounding GO:0009611 168 0.021
response to light stimulus GO:0009416 87 0.021
positive regulation of protein complex assembly GO:0031334 86 0.021
epithelial cell proliferation GO:0050673 128 0.020
negative regulation of transport GO:0051051 176 0.020
regulation of isoprenoid metabolic process GO:0019747 1 0.020
vesicle organization GO:0016050 62 0.020
negative regulation of protein processing GO:0010955 142 0.020
leukocyte activation GO:0045321 164 0.020
regulation of cellular carbohydrate metabolic process GO:0010675 47 0.020
positive regulation of intracellular transport GO:0032388 104 0.020
ncrna processing GO:0034470 83 0.020
stress activated protein kinase signaling cascade GO:0031098 94 0.020
positive regulation of immune system process GO:0002684 283 0.020
response to nitrogen compound GO:1901698 184 0.020
epidermis development GO:0008544 59 0.020
ion homeostasis GO:0050801 230 0.020
response to uv GO:0009411 73 0.020
negative regulation of cellular amine metabolic process GO:0033239 3 0.020
neurotransmitter secretion GO:0007269 4 0.019
monovalent inorganic cation transport GO:0015672 128 0.019
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 42 0.019
negative regulation of hydrolase activity GO:0051346 182 0.019
negative regulation of protein localization to nucleus GO:1900181 34 0.019
actomyosin structure organization GO:0031032 59 0.019
ribosomal large subunit export from nucleus GO:0000055 3 0.019
cellular lipid catabolic process GO:0044242 65 0.019
ribonucleoprotein complex export from nucleus GO:0071426 4 0.019
generation of precursor metabolites and energy GO:0006091 68 0.019
positive regulation of mapk cascade GO:0043410 190 0.019
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.019
organonitrogen compound biosynthetic process GO:1901566 200 0.019
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.019
negative regulation of proteolysis GO:0045861 132 0.019
regulation of synaptic transmission GO:0050804 11 0.018
cellular response to oxygen levels GO:0071453 55 0.018
negative regulation of immune effector process GO:0002698 38 0.018
canonical wnt signaling pathway GO:0060070 116 0.018
regulation of endocytosis GO:0030100 72 0.018
golgi to plasma membrane transport GO:0006893 21 0.018
cation transmembrane transport GO:0098655 238 0.018
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.018
type i interferon biosynthetic process GO:0045351 4 0.018
striated muscle adaptation GO:0014888 4 0.018
sodium ion transmembrane transport GO:0035725 59 0.018
negative regulation of catabolic process GO:0009895 104 0.018
positive regulation of cellular component movement GO:0051272 181 0.017
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.017
regulation of cell projection assembly GO:0060491 47 0.017
regulation of interferon beta production GO:0032648 22 0.017
catecholamine secretion GO:0050432 1 0.017
positive regulation of defense response GO:0031349 87 0.017
protein palmitoylation GO:0018345 19 0.017
regulation of neurotransmitter secretion GO:0046928 3 0.017
negative regulation of cytoplasmic transport GO:1903650 46 0.017
enzyme linked receptor protein signaling pathway GO:0007167 303 0.017
regulation of cellular component biogenesis GO:0044087 281 0.017
synaptic vesicle endocytosis GO:0048488 2 0.017
positive regulation of endocytosis GO:0045807 42 0.017
cellular response to mechanical stimulus GO:0071260 39 0.017
fatty acid biosynthetic process GO:0006633 46 0.017
ribonucleotide catabolic process GO:0009261 405 0.017
regulation of cell projection organization GO:0031344 107 0.017
positive regulation of synaptic transmission GO:0050806 4 0.017
response to organic cyclic compound GO:0014070 204 0.017
mitochondrion degradation GO:0000422 8 0.017
positive regulation of kinase activity GO:0033674 204 0.017
regulation of immune response GO:0050776 201 0.017
neuron development GO:0048666 113 0.016
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.016
positive regulation of epithelial cell migration GO:0010634 55 0.016
regulation of fatty acid metabolic process GO:0019217 24 0.016
cellular response to cytokine stimulus GO:0071345 181 0.016
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 15 0.016
covalent chromatin modification GO:0016569 254 0.016
negative regulation of protein catabolic process GO:0042177 59 0.016
cellular component disassembly GO:0022411 92 0.016
actin filament bundle assembly GO:0051017 54 0.016
leukocyte migration GO:0050900 107 0.016
purine containing compound catabolic process GO:0072523 411 0.016
cellular protein complex assembly GO:0043623 188 0.016
synaptic transmission GO:0007268 61 0.016
cyclic nucleotide biosynthetic process GO:0009190 61 0.016
epidermis morphogenesis GO:0048730 3 0.016
response to mechanical stimulus GO:0009612 51 0.016
regulation of response to biotic stimulus GO:0002831 55 0.016
response to virus GO:0009615 126 0.016
cell type specific apoptotic process GO:0097285 125 0.016
response to extracellular stimulus GO:0009991 85 0.016
alcohol biosynthetic process GO:0046165 52 0.015
negative regulation of alpha beta t cell activation GO:0046636 3 0.015
negative regulation of defense response GO:0031348 47 0.015
immune response regulating signaling pathway GO:0002764 97 0.015
small molecule biosynthetic process GO:0044283 157 0.015
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.015
macromolecular complex disassembly GO:0032984 60 0.015
posttranscriptional regulation of gene expression GO:0010608 213 0.015
positive regulation of protein polymerization GO:0032273 45 0.015
dolichol biosynthetic process GO:0019408 1 0.015
regulation of protein binding GO:0043393 66 0.015
epithelial cell migration GO:0010631 119 0.015
purine nucleoside catabolic process GO:0006152 398 0.015
regulation of sodium ion transmembrane transport GO:1902305 23 0.015
establishment of protein localization to peroxisome GO:0072663 15 0.015
polysaccharide metabolic process GO:0005976 33 0.015
regulation of microtubule based process GO:0032886 74 0.015
purine nucleotide catabolic process GO:0006195 405 0.015
vasodilation GO:0042311 4 0.015
modification dependent protein catabolic process GO:0019941 209 0.015
dolichol metabolic process GO:0019348 3 0.014
protein k63 linked deubiquitination GO:0070536 21 0.014
regulation of endosome size GO:0051036 3 0.014
positive regulation of axon extension GO:0045773 4 0.014
negative regulation of apoptotic signaling pathway GO:2001234 97 0.014
response to fungus GO:0009620 4 0.014
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.014
lymphocyte activation GO:0046649 133 0.014
cation homeostasis GO:0055080 189 0.014
regulation of neuronal synaptic plasticity GO:0048168 1 0.014
negative regulation of protein depolymerization GO:1901880 17 0.014
ribonucleoprotein complex subunit organization GO:0071826 81 0.014
regulation of innate immune response GO:0045088 97 0.014
monosaccharide transport GO:0015749 32 0.014
regulation of interferon alpha production GO:0032647 11 0.014
positive regulation of actin filament polymerization GO:0030838 38 0.014
negative regulation of protein import into nucleus GO:0042308 30 0.014
regulation of coenzyme metabolic process GO:0051196 3 0.014
mucus secretion GO:0070254 1 0.014
l amino acid import GO:0043092 4 0.014
negative regulation of ion transmembrane transport GO:0034766 26 0.014
erythrocyte development GO:0048821 3 0.014
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.014
protein localization to nucleus GO:0034504 136 0.014
endomembrane system organization GO:0010256 196 0.013
generation of neurons GO:0048699 152 0.013
cofactor biosynthetic process GO:0051188 31 0.013
wnt signaling pathway GO:0016055 156 0.013
regulation of phosphatase activity GO:0010921 81 0.013
organ morphogenesis GO:0009887 147 0.013
membrane budding GO:0006900 28 0.013

OPTN disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.063
nervous system disease DOID:863 431 0.063
musculoskeletal system disease DOID:17 223 0.047
connective tissue disease DOID:65 109 0.047
myopathy DOID:423 104 0.044
muscular disease DOID:0080000 114 0.044
muscle tissue disease DOID:66 113 0.044
bone remodeling disease DOID:0080005 26 0.034
bone disease DOID:0080001 88 0.034
auditory system disease DOID:2742 53 0.030
autosomal recessive nonsyndromic deafness DOID:0050565 33 0.030
nonsyndromic deafness DOID:0050563 50 0.030
sensory system disease DOID:0050155 203 0.030
disease of metabolism DOID:0014667 295 0.023
cancer DOID:162 167 0.016
disease of cellular proliferation DOID:14566 174 0.016
organ system cancer DOID:0050686 164 0.016
autosomal dominant nonsyndromic deafness DOID:0050564 23 0.015
cardiovascular system disease DOID:1287 106 0.015
neurodegenerative disease DOID:1289 102 0.014