IMP

Process View

Homo sapiens

21 genes annotated in human

protein k63 linked deubiquitination

A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "protein k63 linked deubiquitination"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "protein k63 linked deubiquitination" (in gray)

Name	Description	Probability	Func Analog Organism
FAM175A	family with sequence similarity 175, member A	0.957
PSMD4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.936
BRE	brain and reproductive organ-expressed (TNFRSF1A modulator)	0.728
USP15	ubiquitin specific peptidase 15	0.721
TBK1	TANK-binding kinase 1	0.583
UBQLN1	ubiquilin 1	0.522
C16orf70	chromosome 16 open reading frame 70	0.464
VCP	valosin containing protein	0.457
NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	0.443
RAD23B	RAD23 homolog B (S. cerevisiae)	0.416
TAX1BP1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.405
PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	0.393
RAD23A	RAD23 homolog A (S. cerevisiae)	0.322
NBR1	neighbor of BRCA1 gene 1	0.319
PSMC5	proteasome (prosome, macropain) 26S subunit, ATPase, 5	0.284
TRAF6	TNF receptor-associated factor 6	0.278
TADA3	transcriptional adaptor 3	0.256
PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.252
TNIP1	TNFAIP3 interacting protein 1	0.231
PSMC2	proteasome (prosome, macropain) 26S subunit, ATPase, 2	0.204
USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	0.201
TUBA1A	tubulin, alpha 1a	0.198
ZFAND5	zinc finger, AN1-type domain 5	0.198
ATXN3	ataxin 3	0.180
ZFR	zinc finger RNA binding protein	0.179
BRCC3	BRCA1/BRCA2-containing complex, subunit 3	0.157
ADRBK1	adrenergic, beta, receptor kinase 1	0.155
USP25	ubiquitin specific peptidase 25	0.137
FUNDC2	FUN14 domain containing 2	0.129
PSMA1	proteasome (prosome, macropain) subunit, alpha type, 1	0.128
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.123
UIMC1	ubiquitin interaction motif containing 1	0.107
FAM175B	family with sequence similarity 175, member B	0.104
RING1	ring finger protein 1	0.103
SQSTM1	sequestosome 1	0.098
AMFR	autocrine motility factor receptor	0.096
UFD1L	ubiquitin fusion degradation 1 like (yeast)	0.093
NSFL1C	NSFL1 (p97) cofactor (p47)	0.080
STRN	striatin, calmodulin binding protein	0.075
UBE4B	ubiquitination factor E4B (UFD2 homolog, yeast)	0.074
USP28	ubiquitin specific peptidase 28	0.073	Human
UBC	ubiquitin C	0.072
KLF5	Kruppel-like factor 5 (intestinal)	0.064
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.061
SLMAP	sarcolemma associated protein	0.056
PSMD12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12	0.053
UBXN1	UBX domain protein 1	0.052
POLH	polymerase (DNA directed), eta	0.049
MARK2	MAP/microtubule affinity-regulating kinase 2	0.048
MARCH5	membrane-associated ring finger (C3HC4) 5	0.046
STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	0.046
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.045
SELENBP1	selenium binding protein 1	0.042
PSMC6	proteasome (prosome, macropain) 26S subunit, ATPase, 6	0.041
ERN1	endoplasmic reticulum to nucleus signaling 1	0.036
SNAPC5	small nuclear RNA activating complex, polypeptide 5, 19kDa	0.036
STAMBP	STAM binding protein	0.035
ZRANB1	zinc finger, RAN-binding domain containing 1	0.034
RYBP	RING1 and YY1 binding protein	0.034
USP21	ubiquitin specific peptidase 21	0.032	Human
STRN3	striatin, calmodulin binding protein 3	0.031
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.030
PIAS4	protein inhibitor of activated STAT, 4	0.030
PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	0.029
DYNC2H1	dynein, cytoplasmic 2, heavy chain 1	0.029
HDAC6	histone deacetylase 6	0.029
USP20	ubiquitin specific peptidase 20	0.028
CHMP1B	chromatin modifying protein 1B	0.028
RIPK2	receptor-interacting serine-threonine kinase 2	0.027
HERC2	hect domain and RLD 2	0.027
SNX9	sorting nexin 9	0.026
KCTD10	potassium channel tetramerisation domain containing 10	0.026
TSC2	tuberous sclerosis 2	0.026
UCHL3	ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)	0.026
NEURL4	neuralized homolog 4 (Drosophila)	0.026
TP53BP1	tumor protein p53 binding protein 1	0.025
GSK3B	glycogen synthase kinase 3 beta	0.024
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.024
PHAX	phosphorylated adaptor for RNA export	0.024
UBASH3B	ubiquitin associated and SH3 domain containing B	0.023
SRBD1	S1 RNA binding domain 1	0.023
SKIL	SKI-like oncogene	0.023
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.022
BRAP	BRCA1 associated protein	0.021
PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3	0.021
TXNL1	thioredoxin-like 1	0.020
ARHGAP19	Rho GTPase activating protein 19	0.019
DNAJB2	DnaJ (Hsp40) homolog, subfamily B, member 2	0.019
FAF1	Fas (TNFRSF6) associated factor 1	0.019
KIF5B	kinesin family member 5B	0.019
FGFR1OP2	FGFR1 oncogene partner 2	0.019
SLC1A5	solute carrier family 1 (neutral amino acid transporter), member 5	0.019
THOC3	THO complex 3	0.019
TNIP2	TNFAIP3 interacting protein 2	0.019
BEND5	BEN domain containing 5	0.018
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.018
SLC25A13	solute carrier family 25, member 13 (citrin)	0.018
CYLD	cylindromatosis (turban tumor syndrome)	0.018
PSMC1	proteasome (prosome, macropain) 26S subunit, ATPase, 1	0.017
KRR1	KRR1, small subunit (SSU) processome component, homolog (yeast)	0.017
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.017
UBE3A	ubiquitin protein ligase E3A	0.017
HGS	hepatocyte growth factor-regulated tyrosine kinase substrate	0.017
APC	adenomatous polyposis coli	0.017
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.017
FAM40A	family with sequence similarity 40, member A	0.017
MED12	mediator complex subunit 12	0.016
PRUNE	prune homolog (Drosophila)	0.016
RBM45	RNA binding motif protein 45	0.015
YLPM1	YLP motif containing 1	0.015
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	0.015
BTBD9	BTB (POZ) domain containing 9	0.015
PSEN1	presenilin 1	0.014
AMBRA1	autophagy/beclin-1 regulator 1	0.014
HUWE1	HECT, UBA and WWE domain containing 1	0.014
OPTN	optineurin	0.014
MKNK1	MAP kinase interacting serine/threonine kinase 1	0.014
USP24	ubiquitin specific peptidase 24	0.014
MDC1	mediator of DNA-damage checkpoint 1	0.014
CSTF2	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa	0.014
TNKS2	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	0.014
DBT	dihydrolipoamide branched chain transacylase E2	0.014
MTHFD1L	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	0.014
ACTG1	actin, gamma 1	0.014
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.014
PSEN2	presenilin 2 (Alzheimer disease 4)	0.013
DERL1	Der1-like domain family, member 1	0.013
EIF2C3	eukaryotic translation initiation factor 2C, 3	0.013
HERC3	hect domain and RLD 3	0.013
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.013
SIKE1	suppressor of IKBKE 1	0.013
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.013
FTH1	ferritin, heavy polypeptide 1	0.013
HECTD1	HECT domain containing 1	0.012
CTTNBP2NL	CTTNBP2 N-terminal like	0.012
TRAF2	TNF receptor-associated factor 2	0.012
MRPL20	mitochondrial ribosomal protein L20	0.012
GPHN	gephyrin	0.012
CDC37L1	cell division cycle 37 homolog (S. cerevisiae)-like 1	0.012
BAG5	BCL2-associated athanogene 5	0.012
EPS15	epidermal growth factor receptor pathway substrate 15	0.012
SMC1A	structural maintenance of chromosomes 1A	0.012
IGF2R	insulin-like growth factor 2 receptor	0.012
BAP1	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)	0.012
APBA2	amyloid beta (A4) precursor protein-binding, family A, member 2	0.012
CP110	CP110 protein	0.011
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.011
CAMK2D	calcium/calmodulin-dependent protein kinase II delta	0.011
AAAS	achalasia, adrenocortical insufficiency, alacrimia	0.011
HIPK1	homeodomain interacting protein kinase 1	0.011
RIC8A	resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)	0.011
CLK2	CDC-like kinase 2	0.011
GNAS	GNAS complex locus	0.011
NRD1	nardilysin (N-arginine dibasic convertase)	0.011
RGS1	regulator of G-protein signaling 1	0.011
VCPIP1	valosin containing protein (p97)/p47 complex interacting protein 1	0.011
CKAP4	cytoskeleton-associated protein 4	0.011
CCDC101	coiled-coil domain containing 101	0.011
TUBA1C	tubulin, alpha 1c	0.011
MUL1	mitochondrial E3 ubiquitin protein ligase 1	0.011
ZNF282	zinc finger protein 282	0.011
FAF2	Fas associated factor family member 2	0.010
NSF	N-ethylmaleimide-sensitive factor	0.010
C16orf61	chromosome 16 open reading frame 61	0.010
KIAA0467	KIAA0467	0.010
BIRC3	baculoviral IAP repeat containing 3	0.010