Homo sapiens

108 known processes

TLK2

tousled-like kinase 2

(Aliases: PKU-ALPHA,MGC44450)

TLK2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromatin modification GO:0016568 298 0.538
Fly
covalent chromatin modification GO:0016569 254 0.440
Fly
histone modification GO:0016570 251 0.431
Fly
macromolecule methylation GO:0043414 97 0.251
Worm
positive regulation of phosphorylation GO:0042327 394 0.230
Worm
internal protein amino acid acetylation GO:0006475 101 0.206
positive regulation of cellular amine metabolic process GO:0033240 7 0.180
protein ubiquitination GO:0016567 314 0.174
regulation of cellular amine metabolic process GO:0033238 11 0.170
regulation of cellular amino acid metabolic process GO:0006521 6 0.168
chromatin organization GO:0006325 351 0.156
post embryonic development GO:0009791 2 0.149
regulation of cell cycle GO:0051726 393 0.148
Fly
histone acetylation GO:0016573 93 0.148
cellular amino acid metabolic process GO:0006520 116 0.146
cellular component morphogenesis GO:0032989 314 0.140
Fly
chromatin assembly or disassembly GO:0006333 78 0.135
female gamete generation GO:0007292 2 0.135
cellular ketone metabolic process GO:0042180 80 0.134
cellular macromolecule catabolic process GO:0044265 380 0.133
methylation GO:0032259 106 0.130
Worm
regulation of anatomical structure morphogenesis GO:0022603 286 0.125
Fly
protein catabolic process GO:0030163 325 0.121
oogenesis GO:0048477 2 0.120
regulation of cellular ketone metabolic process GO:0010565 50 0.112
histone ubiquitination GO:0016574 31 0.111
cellular amine metabolic process GO:0044106 41 0.110
cellular response to dna damage stimulus GO:0006974 379 0.105
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.099
protein modification by small protein conjugation GO:0032446 342 0.096
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.092
positive regulation of cellular component organization GO:0051130 376 0.090
positive regulation of transferase activity GO:0051347 227 0.089
Worm
amine metabolic process GO:0009308 44 0.084
positive regulation of developmental process GO:0051094 314 0.083
Worm
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.082
peptidyl lysine modification GO:0018205 144 0.078
internal peptidyl lysine acetylation GO:0018393 97 0.077
peptidyl lysine acetylation GO:0018394 101 0.076
cell morphogenesis GO:0000902 296 0.073
Fly
small gtpase mediated signal transduction GO:0007264 78 0.073
dna conformation change GO:0071103 113 0.071
cellular protein catabolic process GO:0044257 261 0.071
protein acetylation GO:0006473 116 0.070
purine ribonucleoside catabolic process GO:0046130 398 0.068
regulation of protein maturation GO:1903317 150 0.067
cell development GO:0048468 328 0.066
purine nucleoside triphosphate metabolic process GO:0009144 412 0.065
embryo development GO:0009790 123 0.063
Worm Fly
regulation of transferase activity GO:0051338 355 0.060
Worm
multicellular organismal aging GO:0010259 3 0.059
protein acylation GO:0043543 138 0.058
modification dependent protein catabolic process GO:0019941 209 0.057
nucleoside phosphate catabolic process GO:1901292 412 0.056
purine nucleotide catabolic process GO:0006195 405 0.056
ribonucleotide catabolic process GO:0009261 405 0.055
regulation of cell differentiation GO:0045595 393 0.054
regulation of proteasomal protein catabolic process GO:0061136 87 0.053
peptidyl serine phosphorylation GO:0018105 101 0.053
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.052
positive regulation of protein kinase activity GO:0045860 190 0.052
Worm
cell part morphogenesis GO:0032990 137 0.051
purine nucleoside catabolic process GO:0006152 398 0.050
vesicle mediated transport GO:0016192 371 0.050
protein autophosphorylation GO:0046777 123 0.049
Worm Fly
regulation of intracellular transport GO:0032386 195 0.048
regulation of chromatin organization GO:1902275 56 0.048
intracellular protein transport GO:0006886 270 0.048
Human
ribonucleoside triphosphate catabolic process GO:0009203 391 0.047
nucleotide catabolic process GO:0009166 408 0.047
growth GO:0040007 202 0.046
Worm
positive regulation of protein phosphorylation GO:0001934 313 0.046
Worm
nucleoside triphosphate metabolic process GO:0009141 422 0.045
regulation of protein kinase activity GO:0045859 289 0.044
Worm
mitotic cell cycle GO:0000278 326 0.044
Fly
proteasomal protein catabolic process GO:0010498 176 0.044
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.043
neuromuscular junction development GO:0007528 3 0.043
nervous system development GO:0007399 293 0.043
response to biotic stimulus GO:0009607 276 0.043
Fly
neurogenesis GO:0022008 169 0.042
determination of adult lifespan GO:0008340 2 0.042
peptidyl serine modification GO:0018209 106 0.041
dna repair GO:0006281 198 0.041
regulation of proteolysis GO:0030162 293 0.041
mapk cascade GO:0000165 288 0.040
cell projection organization GO:0030030 252 0.040
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.040
negative regulation of cellular protein metabolic process GO:0032269 353 0.039
nucleosome organization GO:0034728 66 0.039
nucleoside catabolic process GO:0009164 408 0.038
ras protein signal transduction GO:0007265 73 0.038
regulation of mapk cascade GO:0043408 262 0.038
negative regulation of phosphate metabolic process GO:0045936 267 0.038
modification dependent macromolecule catabolic process GO:0043632 212 0.038
immune response GO:0006955 307 0.038
Fly
rho protein signal transduction GO:0007266 26 0.037
ribonucleoside triphosphate metabolic process GO:0009199 412 0.037
negative regulation of cellular component organization GO:0051129 235 0.036
cellular response to abiotic stimulus GO:0071214 117 0.035
purine containing compound catabolic process GO:0072523 411 0.035
cell morphogenesis involved in differentiation GO:0000904 144 0.035
regulation of protein processing GO:0070613 150 0.035
circulatory system development GO:0072359 262 0.035
neurological system process GO:0050877 163 0.034
negative regulation of cell cycle GO:0045786 193 0.034
glycosyl compound catabolic process GO:1901658 413 0.034
cellular macromolecular complex assembly GO:0034622 324 0.034
regulation of cellular response to stress GO:0080135 244 0.034
protein localization to organelle GO:0033365 280 0.034
organophosphate catabolic process GO:0046434 430 0.034
dephosphorylation GO:0016311 209 0.033
neuroblast proliferation GO:0007405 4 0.033
neural tube formation GO:0001841 3 0.033
canonical wnt signaling pathway GO:0060070 116 0.033
biological adhesion GO:0022610 331 0.033
Fly
purine ribonucleoside metabolic process GO:0046128 437 0.033
response to abiotic stimulus GO:0009628 336 0.032
locomotory behavior GO:0007626 1 0.032
response to external biotic stimulus GO:0043207 261 0.031
Fly
regulation of cell development GO:0060284 161 0.031
cytoplasmic transport GO:0016482 379 0.031
protein processing GO:0016485 226 0.031
guanosine containing compound catabolic process GO:1901069 239 0.030
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.030
negative regulation of protein metabolic process GO:0051248 391 0.030
regulation of small gtpase mediated signal transduction GO:0051056 156 0.030
positive regulation of cell differentiation GO:0045597 211 0.030
spermatid differentiation GO:0048515 4 0.029
morphogenesis of embryonic epithelium GO:0016331 4 0.029
negative regulation of proteolysis GO:0045861 132 0.029
purine ribonucleotide catabolic process GO:0009154 404 0.029
purine nucleoside triphosphate catabolic process GO:0009146 392 0.029
nucleoside triphosphate catabolic process GO:0009143 394 0.029
microtubule cytoskeleton organization GO:0000226 176 0.029
signal transduction by phosphorylation GO:0023014 297 0.028
histone h3 acetylation GO:0043966 45 0.028
regulation of binding GO:0051098 111 0.028
cell projection morphogenesis GO:0048858 129 0.028
positive regulation of kinase activity GO:0033674 204 0.028
Worm
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.028
segmentation GO:0035282 4 0.028
regulation of cell morphogenesis GO:0022604 153 0.028
Fly
negative regulation of phosphorus metabolic process GO:0010563 267 0.028
single organism membrane organization GO:0044802 268 0.027
epithelium development GO:0060429 227 0.027
mrna metabolic process GO:0016071 175 0.026
mitotic cell cycle process GO:1903047 286 0.026
microtubule organizing center organization GO:0031023 62 0.026
negative regulation of hydrolase activity GO:0051346 182 0.026
memory GO:0007613 3 0.026
regulation of response to external stimulus GO:0032101 222 0.026
regulation of nucleotide metabolic process GO:0006140 269 0.026
regulation of kinase activity GO:0043549 314 0.026
Worm
system process GO:0003008 349 0.026
vasculature development GO:0001944 181 0.025
generation of neurons GO:0048699 152 0.025
cell growth GO:0016049 160 0.025
negative regulation of programmed cell death GO:0043069 321 0.025
protein methylation GO:0006479 74 0.025
Worm
regulation of dna metabolic process GO:0051052 153 0.024
positive regulation of cellular catabolic process GO:0031331 284 0.024
organelle localization GO:0051640 84 0.024
anatomical structure formation involved in morphogenesis GO:0048646 284 0.024
developmental growth GO:0048589 48 0.024
Worm
neuron differentiation GO:0030182 138 0.024
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.024
mitotic nuclear division GO:0007067 119 0.024
chromatin assembly GO:0031497 61 0.024
regulation of cytoskeleton organization GO:0051493 177 0.024
dna replication GO:0006260 116 0.024
histone exchange GO:0043486 3 0.023
nucleocytoplasmic transport GO:0006913 176 0.023
ribonucleoside catabolic process GO:0042454 406 0.023
cell cycle phase transition GO:0044770 173 0.023
hematopoietic or lymphoid organ development GO:0048534 186 0.023
actin filament based process GO:0030029 224 0.023
cell adhesion GO:0007155 325 0.022
Fly
negative regulation of binding GO:0051100 57 0.022
actin cytoskeleton organization GO:0030036 207 0.022
regulation of ras protein signal transduction GO:0046578 155 0.022
negative regulation of apoptotic process GO:0043066 316 0.022
response to ionizing radiation GO:0010212 65 0.022
neuron development GO:0048666 113 0.021
cell cell signaling GO:0007267 155 0.021
reproductive process GO:0022414 106 0.021
regulation of nervous system development GO:0051960 88 0.021
negative regulation of synaptic transmission GO:0050805 2 0.021
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.021
mitotic cell cycle phase transition GO:0044772 162 0.021
neuron projection development GO:0031175 106 0.021
protein maturation GO:0051604 233 0.021
regulation of histone modification GO:0031056 47 0.021
protein alkylation GO:0008213 74 0.020
Worm
regulation of growth GO:0040008 165 0.020
Worm
positive regulation of transport GO:0051050 336 0.020
single organism cellular localization GO:1902580 332 0.020
regulation of cellular component biogenesis GO:0044087 281 0.020
negative regulation of cell differentiation GO:0045596 171 0.020
regulation of purine nucleotide metabolic process GO:1900542 264 0.019
negative regulation of cellular protein catabolic process GO:1903363 38 0.019
negative regulation of protein modification process GO:0031400 200 0.019
stem cell development GO:0048864 69 0.019
spermatid development GO:0007286 4 0.019
positive regulation of organelle organization GO:0010638 195 0.019
negative regulation of organelle organization GO:0010639 126 0.019
regulation of anatomical structure size GO:0090066 101 0.019
carbohydrate metabolic process GO:0005975 207 0.019
negative regulation of cellular catabolic process GO:0031330 83 0.018
regulation of dephosphorylation GO:0035303 96 0.018
adult locomotory behavior GO:0008344 1 0.018
response to other organism GO:0051707 261 0.018
Fly
rna processing GO:0006396 255 0.018
regulation of mitotic cell cycle GO:0007346 189 0.018
regulation of establishment of protein localization GO:0070201 242 0.018
regulation of nucleocytoplasmic transport GO:0046822 98 0.018
neural tube closure GO:0001843 3 0.018
glycoprotein biosynthetic process GO:0009101 91 0.018
negative regulation of catabolic process GO:0009895 104 0.018
positive regulation of hydrolase activity GO:0051345 331 0.018
regulation of cell migration GO:0030334 289 0.018
nitrogen compound transport GO:0071705 191 0.018
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 35 0.018
nuclear transport GO:0051169 179 0.018
regulation of cellular component movement GO:0051270 334 0.018
microtubule based process GO:0007017 210 0.018
behavior GO:0007610 112 0.017
regulation of chromosome organization GO:0033044 103 0.017
stem cell differentiation GO:0048863 93 0.017
stem cell division GO:0017145 2 0.017
organelle fission GO:0048285 149 0.017
negative regulation of protein maturation GO:1903318 142 0.017
positive regulation of growth GO:0045927 58 0.017
Worm
regulation of cytokine production GO:0001817 232 0.017
response to radiation GO:0009314 151 0.017
establishment of protein localization to organelle GO:0072594 172 0.017
cellular response to ionizing radiation GO:0071479 32 0.017
cellular protein complex assembly GO:0043623 188 0.017
regulation of immune response GO:0050776 201 0.017
developmental growth involved in morphogenesis GO:0060560 23 0.017
negative regulation of catalytic activity GO:0043086 335 0.017
negative regulation of cellular amine metabolic process GO:0033239 3 0.017
regulation of wnt signaling pathway GO:0030111 123 0.017
heart development GO:0007507 95 0.017
ubiquitin dependent protein catabolic process GO:0006511 206 0.017
positive regulation of mapk cascade GO:0043410 190 0.017
regulation of purine nucleotide catabolic process GO:0033121 205 0.017
tube closure GO:0060606 3 0.017
positive regulation of cytokine production GO:0001819 167 0.017
protein import GO:0017038 130 0.016
gtp metabolic process GO:0046039 239 0.016
membrane organization GO:0061024 292 0.016
positive regulation of programmed cell death GO:0043068 249 0.016
carbohydrate derivative biosynthetic process GO:1901137 207 0.016
nuclear export GO:0051168 69 0.016
primary neural tube formation GO:0014020 3 0.016
regulation of cellular component size GO:0032535 82 0.016
regulation of cell projection organization GO:0031344 107 0.016
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.016
rna splicing GO:0008380 131 0.016
anterior posterior axis specification GO:0009948 2 0.016
regulation of defense response GO:0031347 154 0.016
central nervous system development GO:0007417 123 0.016
negative regulation of protein catabolic process GO:0042177 59 0.016
centrosome organization GO:0051297 58 0.016
regulation of nucleoside metabolic process GO:0009118 209 0.015
protein glycosylation GO:0006486 62 0.015
regulation of canonical wnt signaling pathway GO:0060828 88 0.015
cell cycle checkpoint GO:0000075 117 0.015
maintenance of location GO:0051235 112 0.015
lipid metabolic process GO:0006629 381 0.015
cellular component disassembly GO:0022411 92 0.015
regulation of chromatin modification GO:1903308 51 0.015
regulation of cytoplasmic transport GO:1903649 149 0.015
protein dephosphorylation GO:0006470 81 0.015
aging GO:0007568 66 0.015
regulation of axon guidance GO:1902667 3 0.015
macromolecule glycosylation GO:0043413 63 0.015
meiotic chromosome segregation GO:0045132 4 0.015
cytokine production GO:0001816 247 0.015
regulation of locomotion GO:0040012 329 0.015
response to growth factor GO:0070848 205 0.014
single organism reproductive process GO:0044702 98 0.014
blood vessel morphogenesis GO:0048514 162 0.014
organ morphogenesis GO:0009887 147 0.014
dna packaging GO:0006323 77 0.014
positive regulation of nucleoside metabolic process GO:0045979 186 0.014
mitochondrion organization GO:0007005 156 0.014
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.014
regulation of ras gtpase activity GO:0032318 128 0.014
oocyte development GO:0048599 1 0.014
organelle assembly GO:0070925 176 0.014
regulation of nucleotide catabolic process GO:0030811 205 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.014
positive regulation of cell death GO:0010942 263 0.014
ribonucleoside monophosphate catabolic process GO:0009158 158 0.014
regulation of cell growth GO:0001558 135 0.014
autophagy GO:0006914 88 0.014
single organism carbohydrate metabolic process GO:0044723 193 0.013
atp catabolic process GO:0006200 157 0.013
angiogenesis GO:0001525 147 0.013
embryonic epithelial tube formation GO:0001838 4 0.013
cellular homeostasis GO:0019725 196 0.013
intracellular receptor signaling pathway GO:0030522 104 0.013
activation of protein kinase activity GO:0032147 90 0.013
regulation of neuron differentiation GO:0045664 70 0.013
antimicrobial humoral response GO:0019730 26 0.013
Fly
negative regulation of phosphatase activity GO:0010923 61 0.013
organophosphate biosynthetic process GO:0090407 163 0.013
regulation of cell shape GO:0008360 48 0.013
Fly
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.013
regulation of microtubule cytoskeleton organization GO:0070507 61 0.013
negative regulation of intracellular signal transduction GO:1902532 183 0.013
negative regulation of dna metabolic process GO:0051053 57 0.013
regulation of actin filament based process GO:0032970 141 0.013
nucleoside monophosphate metabolic process GO:0009123 191 0.013
regulation of protein transport GO:0051223 213 0.013
negative regulation of developmental process GO:0051093 247 0.013
blood vessel development GO:0001568 172 0.013
neuron projection morphogenesis GO:0048812 50 0.013
embryo development ending in birth or egg hatching GO:0009792 34 0.013
Worm
oocyte differentiation GO:0009994 2 0.013
chromatin remodeling GO:0006338 55 0.013
regulation of cell motility GO:2000145 299 0.013
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.013
response to extracellular stimulus GO:0009991 85 0.012
enzyme linked receptor protein signaling pathway GO:0007167 303 0.012
peripheral nervous system development GO:0007422 2 0.012
endocytosis GO:0006897 159 0.012
regulation of mitotic cell cycle phase transition GO:1901990 118 0.012
chemotaxis GO:0006935 157 0.012
engulfment of apoptotic cell GO:0043652 2 0.012
dna damage checkpoint GO:0000077 68 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.012
response to oxygen containing compound GO:1901700 369 0.012
purine nucleoside monophosphate catabolic process GO:0009128 158 0.012
rna splicing via transesterification reactions GO:0000375 90 0.012
head development GO:0060322 108 0.012
reactive oxygen species metabolic process GO:0072593 75 0.012
regulation of jak stat cascade GO:0046425 44 0.012
photoreceptor cell differentiation GO:0046530 2 0.012
cellular response to cytokine stimulus GO:0071345 181 0.012
response to virus GO:0009615 126 0.012
response to cytokine GO:0034097 232 0.012
protein localization to nucleus GO:0034504 136 0.012
negative regulation of cell cycle process GO:0010948 121 0.012
regulation of phosphatase activity GO:0010921 81 0.012
limbic system development GO:0021761 3 0.012
cellular response to external stimulus GO:0071496 111 0.012
positive regulation of canonical wnt signaling pathway GO:0090263 33 0.012
embryonic placenta development GO:0001892 1 0.011
positive regulation of cell development GO:0010720 92 0.011
male meiosis GO:0007140 1 0.011
hindbrain development GO:0030902 3 0.011
positive regulation of apoptotic process GO:0043065 246 0.011
regulation of cell cycle process GO:0010564 266 0.011
humoral immune response GO:0006959 49 0.011
Fly
epithelial cell differentiation GO:0030855 141 0.011
cytokinesis GO:0000910 96 0.011
regeneration GO:0031099 4 0.011
positive regulation of chromatin modification GO:1903310 30 0.011
axon extension GO:0048675 13 0.011
meiosis i GO:0007127 4 0.011
chemical homeostasis GO:0048878 306 0.011
regulation of actin cytoskeleton organization GO:0032956 116 0.011
cellular chemical homeostasis GO:0055082 180 0.011
dna integrity checkpoint GO:0031570 71 0.011
rhythmic behavior GO:0007622 2 0.011
regulation of secretion GO:0051046 194 0.011
protein polyubiquitination GO:0000209 110 0.011
double strand break repair GO:0006302 101 0.011
regulation of protein catabolic process GO:0042176 155 0.011
regulation of stress activated mapk cascade GO:0032872 84 0.011
endomembrane system organization GO:0010256 196 0.011
myeloid cell differentiation GO:0030099 117 0.011
regulation of neurogenesis GO:0050767 82 0.011
atp metabolic process GO:0046034 176 0.011
peptidyl tyrosine phosphorylation GO:0018108 170 0.011
defense response GO:0006952 315 0.010
positive regulation of immune system process GO:0002684 283 0.010
immune system development GO:0002520 195 0.010
protein targeting to nucleus GO:0044744 104 0.010
nucleoside phosphate biosynthetic process GO:1901293 109 0.010
posttranscriptional regulation of gene expression GO:0010608 213 0.010
guanosine containing compound metabolic process GO:1901068 244 0.010
transmembrane transport GO:0055085 399 0.010
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.010
developmental process involved in reproduction GO:0003006 66 0.010
positive regulation of axon extension GO:0045773 4 0.010
protein targeting GO:0006605 187 0.010
regulation of microtubule based process GO:0032886 74 0.010
gtp catabolic process GO:0006184 237 0.010
cardiovascular system development GO:0072358 262 0.010
positive regulation of nucleotide metabolic process GO:0045981 230 0.010
regulation of neural precursor cell proliferation GO:2000177 4 0.010
blastoderm segmentation GO:0007350 2 0.010

TLK2 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.013
disease of cellular proliferation DOID:14566 174 0.013
organ system cancer DOID:0050686 164 0.012