IMP

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Homo sapiens

30 genes annotated in human

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positive regulation of chromatin modification

GO:1903310

Any process that activates or increases the frequency, rate or extent of chromatin modification.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of chromatin modification"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of chromatin modification" (in gray)

Name	Description	Probability	Func Analog Organism
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.701
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.645
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.620
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.595
CBX5	chromobox homolog 5	0.590	Fly
ASH2L	ash2 (absent, small, or homeotic)-like (Drosophila)	0.562
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.549
HIST1H3B	histone cluster 1, H3b	0.521
LEO1	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.512
TP53	tumor protein p53	0.507	Mouse
NRIP1	nuclear receptor interacting protein 1	0.466
CBX3	chromobox homolog 3	0.444	Fly
DNMT1	DNA (cytosine-5-)-methyltransferase 1	0.434
HDAC3	histone deacetylase 3	0.422
WDR5	WD repeat domain 5	0.398
MAPK1	mitogen-activated protein kinase 1	0.380	Human
CREBBP	CREB binding protein	0.369
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.361
MAPK14	mitogen-activated protein kinase 14	0.344
NCOR1	nuclear receptor corepressor 1	0.333	Mouse
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.308
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.304
LIN9	lin-9 homolog (C. elegans)	0.292
IRF2BP1	interferon regulatory factor 2 binding protein 1	0.288
ZNF496	zinc finger protein 496	0.286
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.266
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.264	Yeast
MED15	mediator complex subunit 15	0.260
VEGFA	vascular endothelial growth factor A	0.243
RBBP5	retinoblastoma binding protein 5	0.240
PARP1	poly (ADP-ribose) polymerase 1	0.225
TGIF1	TGFB-induced factor homeobox 1	0.223
RB1	retinoblastoma 1	0.214
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.201	Human
DUSP1	dual specificity phosphatase 1	0.197
VAC14	Vac14 homolog (S. cerevisiae)	0.175
EP300	E1A binding protein p300	0.170
NCOR2	nuclear receptor corepressor 2	0.162
HDAC7	histone deacetylase 7	0.137
TOP1	topoisomerase (DNA) I	0.118
MAPK3	mitogen-activated protein kinase 3	0.113
NRP1	neuropilin 1	0.110
TONSL	tonsoku-like, DNA repair protein	0.109
SUV39H1	suppressor of variegation 3-9 homolog 1 (Drosophila)	0.103
PIAS4	protein inhibitor of activated STAT, 4	0.101
MBIP	MAP3K12 binding inhibitory protein 1	0.093
GSK3B	glycogen synthase kinase 3 beta	0.088
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.086
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.085
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.080
NBN	nibrin	0.079
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.077
HDAC1	histone deacetylase 1	0.076
IK	IK cytokine, down-regulator of HLA II	0.076
EZH2	enhancer of zeste homolog 2 (Drosophila)	0.075
COASY	CoA synthase	0.072
ARRB2	arrestin, beta 2	0.071	Human
HDGF	hepatoma-derived growth factor	0.071
RXRA	retinoid X receptor, alpha	0.071
NCOA1	nuclear receptor coactivator 1	0.070
RTF1	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.069
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.068
HCFC1	host cell factor C1 (VP16-accessory protein)	0.067
H2AFX	H2A histone family, member X	0.062
SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)	0.061
CDCA4	cell division cycle associated 4	0.061
PML	promyelocytic leukemia	0.060
HEXIM1	hexamethylene bis-acetamide inducible 1	0.057
ENG	endoglin	0.056
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.056
HIST2H3C	histone cluster 2, H3c	0.056
HDAC5	histone deacetylase 5	0.053
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.052
HIPK2	homeodomain interacting protein kinase 2	0.051
MAPK10	mitogen-activated protein kinase 10	0.051
HDAC9	histone deacetylase 9	0.050
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.050
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.050	Human
PGF	placental growth factor	0.049	Human
RICTOR	RPTOR independent companion of MTOR, complex 2	0.048
NCOA6	nuclear receptor coactivator 6	0.048
CDAN1	congenital dyserythropoietic anemia, type I	0.047
MAP2K1	mitogen-activated protein kinase kinase 1	0.047
DUSP3	dual specificity phosphatase 3	0.046
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.046
VAMP2	vesicle-associated membrane protein 2 (synaptobrevin 2)	0.045
CHAF1B	chromatin assembly factor 1, subunit B (p60)	0.044
CTBP1	C-terminal binding protein 1	0.043
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.042
PUM2	pumilio homolog 2 (Drosophila)	0.042
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.041
TRIM28	tripartite motif containing 28	0.041
CTBP2	C-terminal binding protein 2	0.041	Human
ARRB1	arrestin, beta 1	0.040
SETDB1	SET domain, bifurcated 1	0.040
LARP7	La ribonucleoprotein domain family, member 7	0.040
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.040
CXXC1	CXXC finger protein 1	0.039
JUB	jub, ajuba homolog (Xenopus laevis)	0.039
EED	embryonic ectoderm development	0.038	Mouse Fly
PLCG1	phospholipase C, gamma 1	0.038
PPARA	peroxisome proliferator-activated receptor alpha	0.037
PKN1	protein kinase N1	0.037
ADNP	activity-dependent neuroprotector homeobox	0.037
MED1	mediator complex subunit 1	0.037
CCNT1	cyclin T1	0.036
MBNL1	muscleblind-like (Drosophila)	0.036
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.036
TLK1	tousled-like kinase 1	0.035
CDC73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.034
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.034
PRKCA	protein kinase C, alpha	0.034
MBD1	methyl-CpG binding domain protein 1	0.033
MYST1	MYST histone acetyltransferase 1	0.033
EEF2K	eukaryotic elongation factor-2 kinase	0.033
WDR61	WD repeat domain 61	0.032
HIST1H3A	histone cluster 1, H3a	0.032
KAT5	K(lysine) acetyltransferase 5	0.031
STAG2	stromal antigen 2	0.031
RAD51L1	RAD51-like 1 (S. cerevisiae)	0.031
IRF3	interferon regulatory factor 3	0.031
LRIF1	ligand dependent nuclear receptor interacting factor 1	0.030
PAF1	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	0.030
H3F3A	H3 histone, family 3A	0.030
BRCA1	breast cancer 1, early onset	0.030
TRRAP	transformation/transcription domain-associated protein	0.030
GNMT	glycine N-methyltransferase	0.029
AFF1	AF4/FMR2 family, member 1	0.029
MAP2K4	mitogen-activated protein kinase kinase 4	0.029
CREB1	cAMP responsive element binding protein 1	0.029
HAUS1	HAUS augmin-like complex, subunit 1	0.028
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.028
CHD3	chromodomain helicase DNA binding protein 3	0.028
ATN1	atrophin 1	0.028
ARID1A	AT rich interactive domain 1A (SWI-like)	0.027
PEA15	phosphoprotein enriched in astrocytes 15	0.027
CCDC101	coiled-coil domain containing 101	0.026
CHD8	chromodomain helicase DNA binding protein 8	0.025
BAZ2B	bromodomain adjacent to zinc finger domain, 2B	0.025
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.025
TPR	translocated promoter region (to activated MET oncogene)	0.024
HIST1H3D	histone cluster 1, H3d	0.024
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.024
RBBP4	retinoblastoma binding protein 4	0.023
PDGFA	platelet-derived growth factor alpha polypeptide	0.023	Human
CFL1	cofilin 1 (non-muscle)	0.023
JUN	jun proto-oncogene	0.023
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.022
USP5	ubiquitin specific peptidase 5 (isopeptidase T)	0.022
CUL4A	cullin 4A	0.022
UBE2E1	ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)	0.022
SOCS1	suppressor of cytokine signaling 1	0.021
STC1	stanniocalcin 1	0.021
KDM1A	lysine (K)-specific demethylase 1A	0.021
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.021
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.021
MLL2	myeloid/lymphoid or mixed-lineage leukemia 2	0.021	Fly
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.020
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.020
CBX1	chromobox homolog 1	0.020	Fly
RUVBL1	RuvB-like 1 (E. coli)	0.020
YY1	YY1 transcription factor	0.020
MT2A	metallothionein 2A	0.020
L3MBTL1	l(3)mbt-like 1 (Drosophila)	0.019
USP22	ubiquitin specific peptidase 22	0.019
PTPRB	protein tyrosine phosphatase, receptor type, B	0.019
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.019
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.019
MAPK8	mitogen-activated protein kinase 8	0.019
ELK1	ELK1, member of ETS oncogene family	0.019
MAPT	microtubule-associated protein tau	0.019
DDAH2	dimethylarginine dimethylaminohydrolase 2	0.019
PDGFC	platelet derived growth factor C	0.018
AR	androgen receptor	0.018
THBS1	thrombospondin 1	0.018
HELLS	helicase, lymphoid-specific	0.018
CDK2	cyclin-dependent kinase 2	0.018
NLK	nemo-like kinase	0.018
HIST1H2BD	histone cluster 1, H2bd	0.018
CEP70	centrosomal protein 70kDa	0.018
CASP8AP2	caspase 8 associated protein 2	0.018
PCDH9	protocadherin 9	0.018
EIF3C	eukaryotic translation initiation factor 3, subunit C	0.017
PRKD2	protein kinase D2	0.017
RNF40	ring finger protein 40	0.017
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.017
SMS	spermine synthase	0.017
FOXO3	forkhead box O3	0.017
DUSP7	dual specificity phosphatase 7	0.017
BANP	BTG3 associated nuclear protein	0.016
COL6A1	collagen, type VI, alpha 1	0.016
PUM1	pumilio homolog 1 (Drosophila)	0.016
ATF3	activating transcription factor 3	0.016
MCRS1	microspherule protein 1	0.016
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.016
PPAP2B	phosphatidic acid phosphatase type 2B	0.016
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.016
PTPRR	protein tyrosine phosphatase, receptor type, R	0.015
C19orf46	chromosome 19 open reading frame 46	0.015
SUV39H2	suppressor of variegation 3-9 homolog 2 (Drosophila)	0.015
SMC3	structural maintenance of chromosomes 3	0.015
HIC1	hypermethylated in cancer 1	0.015
RBM39	RNA binding motif protein 39	0.015
COL4A1	collagen, type IV, alpha 1	0.015
PPM1D	protein phosphatase, Mg2+/Mn2+ dependent, 1D	0.015
PRKCE	protein kinase C, epsilon	0.015
ASXL1	additional sex combs like 1 (Drosophila)	0.015
ACTL6A	actin-like 6A	0.015
PTPN7	protein tyrosine phosphatase, non-receptor type 7	0.015
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.014
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.014
ARID2	AT rich interactive domain 2 (ARID, RFX-like)	0.014
HSPA8	heat shock 70kDa protein 8	0.014
CNOT6	CCR4-NOT transcription complex, subunit 6	0.014
LMNA	lamin A/C	0.014
CDC5L	CDC5 cell division cycle 5-like (S. pombe)	0.014
HIST1H4F	histone cluster 1, H4f	0.014
LIMK1	LIM domain kinase 1	0.014
SMAD2	SMAD family member 2	0.014
DAXX	death-domain associated protein	0.014	Rat
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.013
FZD5	frizzled homolog 5 (Drosophila)	0.013
MAP4K3	mitogen-activated protein kinase kinase kinase kinase 3	0.013
LGALS8	lectin, galactoside-binding, soluble, 8	0.013
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.013
TXN	thioredoxin	0.013
RPL39	ribosomal protein L39	0.013
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.013
GRINA	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	0.013
MAGOH	mago-nashi homolog, proliferation-associated (Drosophila)	0.013
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.013
ING5	inhibitor of growth family, member 5	0.013
EML4	echinoderm microtubule associated protein like 4	0.013
CAPRIN1	cell cycle associated protein 1	0.013
MFAP1	microfibrillar-associated protein 1	0.013
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.013
ZMYND11	zinc finger, MYND-type containing 11	0.013
FOSL1	FOS-like antigen 1	0.013
NEK6	NIMA (never in mitosis gene a)-related kinase 6	0.013
SNIP1	Smad nuclear interacting protein 1	0.013
DHX34	DEAH (Asp-Glu-Ala-His) box polypeptide 34	0.013
PKN2	protein kinase N2	0.012
MLL4	myeloid/lymphoid or mixed-lineage leukemia 4	0.012
MLL5	myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)	0.012
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.012
HIST1H1D	histone cluster 1, H1d	0.012	Human
ZNF219	zinc finger protein 219	0.012
CCNE1	cyclin E1	0.012
MAGEA2	melanoma antigen family A, 2	0.012
PHF3	PHD finger protein 3	0.012
H1FX	H1 histone family, member X	0.012
SORBS3	sorbin and SH3 domain containing 3	0.012
MTF2	metal response element binding transcription factor 2	0.012	Human Mouse
BARD1	BRCA1 associated RING domain 1	0.012
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.012
POGZ	pogo transposable element with ZNF domain	0.012
COPS4	COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)	0.012
THAP11	THAP domain containing 11	0.012
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.012
ANKRD17	ankyrin repeat domain 17	0.012
RRBP1	ribosome binding protein 1 homolog 180kDa (dog)	0.012
TRIM27	tripartite motif containing 27	0.012
NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.012
UBR5	ubiquitin protein ligase E3 component n-recognin 5	0.012
NCL	nucleolin	0.012
FSTL1	follistatin-like 1	0.012
ARIH2	ariadne homolog 2 (Drosophila)	0.011
RYBP	RING1 and YY1 binding protein	0.011
DPCD	deleted in primary ciliary dyskinesia homolog (mouse)	0.011
HIST2H2AB	histone cluster 2, H2ab	0.011
WHSC1L1	Wolf-Hirschhorn syndrome candidate 1-like 1	0.011
ZC3H11A	zinc finger CCCH-type containing 11A	0.011
PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	0.011
COL5A1	collagen, type V, alpha 1	0.011
SETD1A	SET domain containing 1A	0.011
LNX1	ligand of numb-protein X 1	0.011
NELL2	NEL-like 2 (chicken)	0.011
MBP	myelin basic protein	0.011
TLK2	tousled-like kinase 2	0.011
MEN1	multiple endocrine neoplasia I	0.011	Mouse
RARA	retinoic acid receptor, alpha	0.011
EHMT1	euchromatic histone-lysine N-methyltransferase 1	0.011
JAG2	jagged 2	0.011
TSPYL2	TSPY-like 2	0.011
SETD7	SET domain containing (lysine methyltransferase) 7	0.011
PRRC2C	proline-rich coiled-coil 2C	0.011
INO80E	INO80 complex subunit E	0.011
CCNA2	cyclin A2	0.011
RANBP2	RAN binding protein 2	0.011
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.011
PHF19	PHD finger protein 19	0.011
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.011
PBRM1	polybromo 1	0.011
SPRR2A	small proline-rich protein 2A	0.011
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.011
LBR	lamin B receptor	0.011
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.011
C10orf116	chromosome 10 open reading frame 116	0.011
CRNKL1	crooked neck pre-mRNA splicing factor-like 1 (Drosophila)	0.011
EGR1	early growth response 1	0.011
KDM6A	lysine (K)-specific demethylase 6A	0.011
NOS1AP	nitric oxide synthase 1 (neuronal) adaptor protein	0.011
IER3	immediate early response 3	0.011
RANGAP1	Ran GTPase activating protein 1	0.010
MAP3K11	mitogen-activated protein kinase kinase kinase 11	0.010
FOSL2	FOS-like antigen 2	0.010
CHD4	chromodomain helicase DNA binding protein 4	0.010
SPSB1	splA/ryanodine receptor domain and SOCS box containing 1	0.010
ZNRF1	zinc and ring finger 1	0.010
GAPVD1	GTPase activating protein and VPS9 domains 1	0.010
HIST1H1E	histone cluster 1, H1e	0.010	Human
HSPG2	heparan sulfate proteoglycan 2	0.010
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.010
FOXM1	forkhead box M1	0.010
HTT	huntingtin	0.010
ANP32A	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	0.010
LDLR	low density lipoprotein receptor	0.010
MKNK2	MAP kinase interacting serine/threonine kinase 2	0.010
RNF168	ring finger protein 168	0.010
DDX23	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	0.010
LIN54	lin-54 homolog (C. elegans)	0.010
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.010
ERN1	endoplasmic reticulum to nucleus signaling 1	0.010
UBE2V2	ubiquitin-conjugating enzyme E2 variant 2	0.010
EXOC8	exocyst complex component 8	0.010
NOTCH1	notch 1	0.010