Homo sapiens

12 known processes

IARS

isoleucyl-tRNA synthetase

(Aliases: ILERS,IARS1,IRS,ILRS,FLJ20736,PRO0785)

IARS biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
trna aminoacylation for protein translation GO:0006418 8 1.000
Yeast
amino acid activation GO:0043038 12 1.000
Yeast
trna aminoacylation GO:0043039 12 1.000
Yeast
cellular amino acid metabolic process GO:0006520 116 1.000
Yeast
ncrna metabolic process GO:0034660 108 0.997
Yeast
translation GO:0006412 132 0.994
Yeast
post embryonic development GO:0009791 2 0.987
Worm
trna metabolic process GO:0006399 35 0.899
Yeast
organonitrogen compound biosynthetic process GO:1901566 200 0.898
alpha amino acid metabolic process GO:1901605 72 0.818
regulation of translation GO:0006417 89 0.760
protein folding GO:0006457 38 0.747
mitochondrial translation GO:0032543 17 0.604
nucleoside phosphate biosynthetic process GO:1901293 109 0.527
mitochondrial rna metabolic process GO:0000959 15 0.509
response to amino acid GO:0043200 14 0.414
response to nitrogen compound GO:1901698 184 0.356
alpha amino acid biosynthetic process GO:1901607 23 0.332
response to hormone GO:0009725 175 0.311
embryo development GO:0009790 123 0.278
Worm
positive regulation of response to dna damage stimulus GO:2001022 43 0.222
negative regulation of apoptotic process GO:0043066 316 0.221
cellular response to cytokine stimulus GO:0071345 181 0.214
aspartate family amino acid biosynthetic process GO:0009067 6 0.213
hindbrain development GO:0030902 3 0.210
l serine metabolic process GO:0006563 5 0.182
nervous system development GO:0007399 293 0.181
determination of adult lifespan GO:0008340 2 0.167
response to organonitrogen compound GO:0010243 156 0.149
embryo development ending in birth or egg hatching GO:0009792 34 0.137
Worm
positive regulation of mitotic cell cycle GO:0045931 60 0.133
multicellular organismal aging GO:0010259 3 0.133
nucleotide biosynthetic process GO:0009165 109 0.117
cellular response to topologically incorrect protein GO:0035967 19 0.102
ribonucleoside monophosphate metabolic process GO:0009161 187 0.100
innate immune response GO:0045087 178 0.095
positive regulation of hydrolase activity GO:0051345 331 0.088
nucleobase biosynthetic process GO:0046112 4 0.085
small molecule biosynthetic process GO:0044283 157 0.079
cellular response to endogenous stimulus GO:0071495 336 0.078
regeneration GO:0031099 4 0.068
hepaticobiliary system development GO:0061008 10 0.064
purine ribonucleoside metabolic process GO:0046128 437 0.062
intracellular mrna localization GO:0008298 1 0.056
reproduction GO:0000003 63 0.055
Worm
serine family amino acid metabolic process GO:0009069 12 0.054
positive regulation of cellular catabolic process GO:0031331 284 0.046
central nervous system development GO:0007417 123 0.045
rna processing GO:0006396 255 0.044
cellular protein catabolic process GO:0044257 261 0.043
response to cytokine GO:0034097 232 0.043
purine nucleoside monophosphate catabolic process GO:0009128 158 0.042
cellular macromolecule catabolic process GO:0044265 380 0.041
cellular amino acid catabolic process GO:0009063 31 0.041
cellular response to hormone stimulus GO:0032870 125 0.038
immune response GO:0006955 307 0.037
organophosphate biosynthetic process GO:0090407 163 0.037
response to organic cyclic compound GO:0014070 204 0.037
cellular amide metabolic process GO:0043603 69 0.037
apoptotic signaling pathway GO:0097190 268 0.036
vesicle mediated transport GO:0016192 371 0.035
Worm
protein catabolic process GO:0030163 325 0.035
dna templated transcription termination GO:0006353 3 0.034
response to virus GO:0009615 126 0.032
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.031
response to wounding GO:0009611 168 0.031
oogenesis GO:0048477 2 0.031
regulation of endopeptidase activity GO:0052548 170 0.031
negative regulation of programmed cell death GO:0043069 321 0.030
leukocyte proliferation GO:0070661 74 0.030
tissue regeneration GO:0042246 3 0.030
negative regulation of cell death GO:0060548 345 0.030
protein maturation GO:0051604 233 0.030
response to oxygen containing compound GO:1901700 369 0.028
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.028
head development GO:0060322 108 0.027
one carbon metabolic process GO:0006730 1 0.027
lung epithelial cell differentiation GO:0060487 1 0.027
carboxylic acid biosynthetic process GO:0046394 97 0.026
segmentation GO:0035282 4 0.026
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.026
nuclear export GO:0051168 69 0.025
coenzyme metabolic process GO:0006732 65 0.024
positive regulation of protein transport GO:0051222 135 0.024
ribonucleoprotein complex export from nucleus GO:0071426 4 0.023
ncrna processing GO:0034470 83 0.023
organic anion transport GO:0015711 103 0.023
protein processing GO:0016485 226 0.023
establishment of protein localization to organelle GO:0072594 172 0.022
organic acid biosynthetic process GO:0016053 97 0.022
regulation of neuron death GO:1901214 56 0.022
peroxisome fission GO:0016559 10 0.022
maturation of 5 8s rrna GO:0000460 8 0.021
hemopoiesis GO:0030097 180 0.021
regulation of peptidase activity GO:0052547 180 0.020
negative regulation of protein metabolic process GO:0051248 391 0.020
defense response GO:0006952 315 0.019
negative regulation of cellular protein metabolic process GO:0032269 353 0.019
cellular amine metabolic process GO:0044106 41 0.019
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.019
aspartate metabolic process GO:0006531 4 0.019
posttranscriptional regulation of gene expression GO:0010608 213 0.019
blastoderm segmentation GO:0007350 2 0.019
positive regulation of cellular amine metabolic process GO:0033240 7 0.019
response to radiation GO:0009314 151 0.018
organophosphate catabolic process GO:0046434 430 0.018
positive regulation of protein complex assembly GO:0031334 86 0.018
regulation of signal transduction by p53 class mediator GO:1901796 26 0.017
lipid localization GO:0010876 106 0.017
cell type specific apoptotic process GO:0097285 125 0.017
purine ribonucleoside catabolic process GO:0046130 398 0.017
gmp metabolic process GO:0046037 4 0.016
positive regulation of apoptotic process GO:0043065 246 0.016
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.016
female gamete generation GO:0007292 2 0.016
positive regulation of cellular component organization GO:0051130 376 0.016
response to purine containing compound GO:0014074 40 0.015
organic acid transport GO:0015849 65 0.015
positive regulation of peptidase activity GO:0010952 88 0.015
neurogenesis GO:0022008 169 0.015
aging GO:0007568 66 0.015
amine metabolic process GO:0009308 44 0.015
hematopoietic or lymphoid organ development GO:0048534 186 0.015
protein import into nucleus GO:0006606 104 0.015
positive regulation of dna metabolic process GO:0051054 73 0.015
rna transport GO:0050658 39 0.014
glutamine family amino acid metabolic process GO:0009064 17 0.014
cellular response to interferon gamma GO:0071346 24 0.014
atp catabolic process GO:0006200 157 0.014
carbohydrate derivative biosynthetic process GO:1901137 207 0.014
nucleoside monophosphate catabolic process GO:0009125 159 0.013
positive regulation of innate immune response GO:0045089 79 0.013
nucleoside catabolic process GO:0009164 408 0.013
response to gonadotropin GO:0034698 5 0.013
single organism nuclear import GO:1902593 104 0.013
actin filament based process GO:0030029 224 0.013
anterior posterior axis specification GO:0009948 2 0.013
maintenance of location GO:0051235 112 0.013
cellular amino acid biosynthetic process GO:0008652 30 0.013
cellular response to nitrogen compound GO:1901699 144 0.013
positive regulation of cytokine production GO:0001819 167 0.013
peptidyl serine modification GO:0018209 106 0.013
response to acid chemical GO:0001101 66 0.013
positive regulation of cell cycle GO:0045787 140 0.013
ribonucleoprotein complex biogenesis GO:0022613 116 0.012
system process GO:0003008 349 0.012
immune effector process GO:0002252 159 0.012
establishment of organelle localization GO:0051656 59 0.012
reactive oxygen species metabolic process GO:0072593 75 0.012
intracellular protein transport GO:0006886 270 0.012
organic hydroxy compound metabolic process GO:1901615 147 0.012
positive regulation of immune system process GO:0002684 283 0.012
regulation of protein localization GO:0032880 296 0.012
ribonucleotide catabolic process GO:0009261 405 0.012
atp metabolic process GO:0046034 176 0.012
binding of sperm to zona pellucida GO:0007339 3 0.012
organelle fission GO:0048285 149 0.012
positive regulation of cellular component biogenesis GO:0044089 158 0.012
anterior posterior axis specification embryo GO:0008595 2 0.012
mitotic cell cycle GO:0000278 326 0.011
positive regulation of interferon gamma production GO:0032729 26 0.011
peptidyl serine phosphorylation GO:0018105 101 0.011
response to topologically incorrect protein GO:0035966 29 0.011
positive regulation of programmed cell death GO:0043068 249 0.011
positive regulation of endopeptidase activity GO:0010950 84 0.011
brain development GO:0007420 97 0.011
purine nucleoside triphosphate metabolic process GO:0009144 412 0.011
response to abiotic stimulus GO:0009628 336 0.011
regulation of proteolysis GO:0030162 293 0.011
ribonucleoside triphosphate metabolic process GO:0009199 412 0.011
tissue homeostasis GO:0001894 63 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.011
response to interferon gamma GO:0034341 39 0.011
ribonucleoprotein complex localization GO:0071166 4 0.011
nucleobase containing compound transport GO:0015931 51 0.011
purine nucleobase biosynthetic process GO:0009113 3 0.010
regulation of cell development GO:0060284 161 0.010
ribonucleoside triphosphate catabolic process GO:0009203 391 0.010
purine containing compound catabolic process GO:0072523 411 0.010
nucleocytoplasmic transport GO:0006913 176 0.010
protein tetramerization GO:0051262 47 0.010
response to light stimulus GO:0009416 87 0.010
regulation of mitotic cell cycle GO:0007346 189 0.010

IARS disease predictions

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 431 0.983
neuropathy DOID:870 52 0.983
neuromuscular disease DOID:440 38 0.883
charcot marie tooth disease DOID:10595 33 0.770
central nervous system disease DOID:331 186 0.432
disease of metabolism DOID:0014667 295 0.386
amino acid metabolic disorder DOID:9252 50 0.386
inherited metabolic disorder DOID:655 242 0.386
motor neuron disease DOID:231 27 0.319
motor neuritis DOID:683 5 0.319
neurodegenerative disease DOID:1289 102 0.319
immune system disease DOID:2914 155 0.021
distal hereditary motor neuropathy DOID:0050582 5 0.011